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The map label for this gene is ggt [H]

Identifier: 94312974

GI number: 94312974

Start: 612866

End: 614740

Strand: Direct

Name: ggt [H]

Synonym: Rmet_4046

Alternate gene names: 94312974

Gene position: 612866-614740 (Clockwise)

Preceding gene: 94312969

Following gene: 94312975

Centisome position: 23.75

GC content: 68.8

Gene sequence:

>1875_bases
ATGGTGCAGTCGTCTTCTGAAAATGACACATTGCGCGCACACTTCATGTTCACGACACGCCCCGAGATCGTCGGCACGTT
CGGCGTTGCCGCTTCCACCCACTGGCTTGCGACGCAGACCGCCATGGGCGTGCTCGAACGCGGCGGCAATGCGTTCGATG
CCGCCGTGGCAGCCGGCTTCGTGCTGCAGGTGGTGGAGCCACATCTGAACGGGCCTGGCGGTGAGGTGCCGATCCTGTTC
TGGAGCGAGCGTGAGCGTGCCGCGCGCTCGGTCTGCGGCCAGGGCCCCGCCCCGGCGCTGGCTGATCCGGAAGCGCTGCG
GAAGATGGGCATGGAGATGATGCCCGGCATCGGGCTGATGCCGGCGACGGTGCCGGGGGCGTTCGGCGCATGGATGACGA
TGCTGCGTGATCACGGCACCTGGTCGCTCGCCGACGTGCTTGAGCCGGCCATCGGCTACGCGCGCGATGGCTTTCCGCTC
GTGCCTCGCATCTCGCAGGCAATCCTTGCCGTGCAGGCGCTGTTCCGCGACGAATGGCACAGCTCGGCCGATACCTGGCT
GCCGGACGGCAAGGTGCCGCGCCCCGGCAGTTTGCACACGCTGCCGGTGCTGGCCGATACCTATACGCGCATCGTGACGA
CTGCGATCGCGCAGAGCGACACCCGCGAGGGCCAGATCGACGCGGCCATGCGCTGCTGGTATCAGGGCTTCGTGGCCGAG
GAGATCGACGCGTACTGCCGCAACACGCCGGTACGCGACACCACTGGCGAAAAGCACGTCGGCCTGCTGCGCTTCGAGGA
CATGGAGCACTGGCAAGCCACGGTCGAGGCGCCTGTCTCGCTGGACTTTGGCCGTTACAGCGTGGCCAAGTGCGATATCT
GGAGCCAGGGCCCGGTGTTCCTGCAGCAACTCGGGATGCTGCGCCATGCGGGGCTGGAGGCGCACGCGCCAACATCGCCC
GAGTTCGTCCACACGATCGCCGAGGCTGCCAAGCTGGCGATGGCCGACCGCGCCGCCTGGTATGGCGATCCGCGCTTCGT
CGATAGCCCGCTGGCCGCGCTGCTCAATCCGCACTATCTGGCCAGCCGCGCGGCGCTGATCGGTGATCGGGCGGCGCTGA
CGATGTTCCCCGGCGCGCTGGGTGGCCGCGCGCCGCGTATGCCTGACCCCGCCGTGGCCGAGCGCACGCTGACTGCCGCC
GATACGCGCTTCGGCGTGGGCGAGCCGACCTTCGCCGCGCTGCCGCCGGTAACCGAATGGGCCGAACGCGAGCTGTTCGT
CGGCGACACCTGCCATATCGACGTGATCGACCGCCACGGCAACATGGTGGCGGCCACGCCCTCGGGCGGCTGGCTGTCGT
CGAGCCCGACGATTCCGTCGCTCGGCTTCGCGCTCAACACGCGCCTGCAGATGACGTGGCTCGAACCGGGCCTGCCCAAC
ACGCTGGCGCCGGGCAAGCGGCCCTGCACCACGCTGTCGCCGTCACTGGCGATGCGCGACGGCGAGCCCTACATGGTGTT
CGGCACGCCCGGCGGCGACCAGCAGGACCAGTGGTCGTTGGCATTCTTCATGCGCCACGCGGTGCATGGCATGAACCTGC
AGGAATCCATCGACGCGCCCGCCTGGCATATCGACCACTTCCCGCAGTCGTTCTGGCCGCGCCAGACCACACTGAACCGC
ATCACCGTCGAATCGCGCTTTCCCGCTGCCACGATCGAAGCGCTGCGTGCCCGTGGGCACGAGGTTCGCGTCGGTGATGA
CTGGTCGGAGGGCCGCATGTCGGCATGCACACGCGAGCGCGATGCCAGAGGGCGGCTCGTGCTGCGCGCCGGCGCCAACG
CGCGCGGCATGCAGGGCTATGCCGTCGGCCGCTGA

Upstream 100 bases:

>100_bases
TGGTGCACACGAGTATTGAGCATAGACGAGTTTCGTGCAGAGGAGTCCTGATATCTGGCTGTCAGGAGCCGTATGCACAA
GAGGCTTCAAACCGCGCTGA

Downstream 100 bases:

>100_bases
TACACACACGACATTACCGAAGACCGAGACAGAAACAGAAACCGAAGGGGGTTGGAGATGAAGTCCGAGATGAAGTCCGT
ATTGAGAAGCCTGCTGTGCG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MVQSSSENDTLRAHFMFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAVAAGFVLQVVEPHLNGPGGEVPILF
WSERERAARSVCGQGPAPALADPEALRKMGMEMMPGIGLMPATVPGAFGAWMTMLRDHGTWSLADVLEPAIGYARDGFPL
VPRISQAILAVQALFRDEWHSSADTWLPDGKVPRPGSLHTLPVLADTYTRIVTTAIAQSDTREGQIDAAMRCWYQGFVAE
EIDAYCRNTPVRDTTGEKHVGLLRFEDMEHWQATVEAPVSLDFGRYSVAKCDIWSQGPVFLQQLGMLRHAGLEAHAPTSP
EFVHTIAEAAKLAMADRAAWYGDPRFVDSPLAALLNPHYLASRAALIGDRAALTMFPGALGGRAPRMPDPAVAERTLTAA
DTRFGVGEPTFAALPPVTEWAERELFVGDTCHIDVIDRHGNMVAATPSGGWLSSSPTIPSLGFALNTRLQMTWLEPGLPN
TLAPGKRPCTTLSPSLAMRDGEPYMVFGTPGGDQQDQWSLAFFMRHAVHGMNLQESIDAPAWHIDHFPQSFWPRQTTLNR
ITVESRFPAATIEALRARGHEVRVGDDWSEGRMSACTRERDARGRLVLRAGANARGMQGYAVGR

Sequences:

>Translated_624_residues
MVQSSSENDTLRAHFMFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAVAAGFVLQVVEPHLNGPGGEVPILF
WSERERAARSVCGQGPAPALADPEALRKMGMEMMPGIGLMPATVPGAFGAWMTMLRDHGTWSLADVLEPAIGYARDGFPL
VPRISQAILAVQALFRDEWHSSADTWLPDGKVPRPGSLHTLPVLADTYTRIVTTAIAQSDTREGQIDAAMRCWYQGFVAE
EIDAYCRNTPVRDTTGEKHVGLLRFEDMEHWQATVEAPVSLDFGRYSVAKCDIWSQGPVFLQQLGMLRHAGLEAHAPTSP
EFVHTIAEAAKLAMADRAAWYGDPRFVDSPLAALLNPHYLASRAALIGDRAALTMFPGALGGRAPRMPDPAVAERTLTAA
DTRFGVGEPTFAALPPVTEWAERELFVGDTCHIDVIDRHGNMVAATPSGGWLSSSPTIPSLGFALNTRLQMTWLEPGLPN
TLAPGKRPCTTLSPSLAMRDGEPYMVFGTPGGDQQDQWSLAFFMRHAVHGMNLQESIDAPAWHIDHFPQSFWPRQTTLNR
ITVESRFPAATIEALRARGHEVRVGDDWSEGRMSACTRERDARGRLVLRAGANARGMQGYAVGR
>Mature_624_residues
MVQSSSENDTLRAHFMFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAVAAGFVLQVVEPHLNGPGGEVPILF
WSERERAARSVCGQGPAPALADPEALRKMGMEMMPGIGLMPATVPGAFGAWMTMLRDHGTWSLADVLEPAIGYARDGFPL
VPRISQAILAVQALFRDEWHSSADTWLPDGKVPRPGSLHTLPVLADTYTRIVTTAIAQSDTREGQIDAAMRCWYQGFVAE
EIDAYCRNTPVRDTTGEKHVGLLRFEDMEHWQATVEAPVSLDFGRYSVAKCDIWSQGPVFLQQLGMLRHAGLEAHAPTSP
EFVHTIAEAAKLAMADRAAWYGDPRFVDSPLAALLNPHYLASRAALIGDRAALTMFPGALGGRAPRMPDPAVAERTLTAA
DTRFGVGEPTFAALPPVTEWAERELFVGDTCHIDVIDRHGNMVAATPSGGWLSSSPTIPSLGFALNTRLQMTWLEPGLPN
TLAPGKRPCTTLSPSLAMRDGEPYMVFGTPGGDQQDQWSLAFFMRHAVHGMNLQESIDAPAWHIDHFPQSFWPRQTTLNR
ITVESRFPAATIEALRARGHEVRVGDDWSEGRMSACTRERDARGRLVLRAGANARGMQGYAVGR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=564, Percent_Identity=23.5815602836879, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI73915090, Length=564, Percent_Identity=23.5815602836879, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI73915096, Length=564, Percent_Identity=23.5815602836879, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI73915094, Length=564, Percent_Identity=23.5815602836879, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI113429324, Length=312, Percent_Identity=25.3205128205128, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI113429326, Length=313, Percent_Identity=24.6006389776358, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI109148539, Length=566, Percent_Identity=25.7950530035336, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789856, Length=576, Percent_Identity=25, Blast_Score=152, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 67951; Mature: 67951

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSSSENDTLRAHFMFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAVAAGF
CCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLQVVEPHLNGPGGEVPILFWSERERAARSVCGQGPAPALADPEALRKMGMEMMPGIGLM
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCCCCCCC
PATVPGAFGAWMTMLRDHGTWSLADVLEPAIGYARDGFPLVPRISQAILAVQALFRDEWH
CCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
SSADTWLPDGKVPRPGSLHTLPVLADTYTRIVTTAIAQSDTREGQIDAAMRCWYQGFVAE
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EIDAYCRNTPVRDTTGEKHVGLLRFEDMEHWQATVEAPVSLDFGRYSVAKCDIWSQGPVF
HHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEECCCCEEEEEECCCCCCHHH
LQQLGMLRHAGLEAHAPTSPEFVHTIAEAAKLAMADRAAWYGDPRFVDSPLAALLNPHYL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHH
ASRAALIGDRAALTMFPGALGGRAPRMPDPAVAERTLTAADTRFGVGEPTFAALPPVTEW
HHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
AERELFVGDTCHIDVIDRHGNMVAATPSGGWLSSSPTIPSLGFALNTRLQMTWLEPGLPN
HCCCEEECCEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEECCEEEEEEECCCCCC
TLAPGKRPCTTLSPSLAMRDGEPYMVFGTPGGDQQDQWSLAFFMRHAVHGMNLQESIDAP
CCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCC
AWHIDHFPQSFWPRQTTLNRITVESRFPAATIEALRARGHEVRVGDDWSEGRMSACTRER
CEEHHCCCHHHCCCCHHHCEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHC
DARGRLVLRAGANARGMQGYAVGR
CCCCCEEEEECCCCCCCCCEECCC
>Mature Secondary Structure
MVQSSSENDTLRAHFMFTTRPEIVGTFGVAASTHWLATQTAMGVLERGGNAFDAAVAAGF
CCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLQVVEPHLNGPGGEVPILFWSERERAARSVCGQGPAPALADPEALRKMGMEMMPGIGLM
HHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHCCCCCCC
PATVPGAFGAWMTMLRDHGTWSLADVLEPAIGYARDGFPLVPRISQAILAVQALFRDEWH
CCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
SSADTWLPDGKVPRPGSLHTLPVLADTYTRIVTTAIAQSDTREGQIDAAMRCWYQGFVAE
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EIDAYCRNTPVRDTTGEKHVGLLRFEDMEHWQATVEAPVSLDFGRYSVAKCDIWSQGPVF
HHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCEEECCCCEEEEEECCCCCCHHH
LQQLGMLRHAGLEAHAPTSPEFVHTIAEAAKLAMADRAAWYGDPRFVDSPLAALLNPHYL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHH
ASRAALIGDRAALTMFPGALGGRAPRMPDPAVAERTLTAADTRFGVGEPTFAALPPVTEW
HHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
AERELFVGDTCHIDVIDRHGNMVAATPSGGWLSSSPTIPSLGFALNTRLQMTWLEPGLPN
HCCCEEECCEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEECCEEEEEEECCCCCC
TLAPGKRPCTTLSPSLAMRDGEPYMVFGTPGGDQQDQWSLAFFMRHAVHGMNLQESIDAP
CCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCC
AWHIDHFPQSFWPRQTTLNRITVESRFPAATIEALRARGHEVRVGDDWSEGRMSACTRER
CEEHHCCCHHHCCCCHHHCEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHC
DARGRLVLRAGANARGMQGYAVGR
CCCCCEEEEECCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]