Click here to switch to the map view.

The map label for this gene is ptxR [H]

Identifier: 94312572

GI number: 94312572

Start: 175023

End: 175889

Strand: Direct

Name: ptxR [H]

Synonym: Rmet_3640

Alternate gene names: 94312572

Gene position: 175023-175889 (Clockwise)

Preceding gene: 94312570

Following gene: 94312575

Centisome position: 6.78

GC content: 66.44

Gene sequence:

>867_bases
GTGATCGAGCAGGGCACTTTCACGGCGGCAGCCGCGGCACTCGATTGCCCGAAGTCGCGCGTCTCGGCGGCAGTGGCCCG
ACTGGAAACGGCCATCGGCGCCAAGCTGCTGGAGCGCACCACGCGACGGATGCGGCTGACCGACGCTGGCGGCGCGGTCT
ATCGCGACGTCGCGCCGCTGTTCGCGCGACTGCGCGAGATCCGGCAGGAGACCCTGGCTCGCGAGGAGCGCGTGCAGGGG
ATGTTGCGCATCGCCACGCCTTATGAGTTCGGCGCCCAGCAACTCGGCGGTGTGATCTGTCGGACACTGGCGGCGCACCC
CGCGCTCGACATCACCGTGGAGATCTCCCAGGGCCTGGTCGATCCGATCCGCGAAGGCTTCGACATCGCCTTCGTCACGG
TGGATACCGACCTGCCGGATTCAGGCACCATCGCCCGACGCATCTGGCATATAGAAAGGGGCCTCGTGGCGGCACCGTCG
CTGGCGGCCAGCCTGCCGGCGCAGATGCAGCCGGAAGATCTGTCGCACATGCCGACGTTGGCCACGCCTGGCGTCTCGGT
GTGGGAGTTCTCGCGGGATGGGGAACGTATCTCCGTGCCGATTCGTCCGCGAATGCAGACCTATAACGCCGAGCTGCGCA
TGCAGGCAGCGCTGGCTGGAATCGGAATCGCGCGTGTGCCGATGGCAACAGCGGAGGCGGAGATTGCGCAGGGCAGGCTG
GTGCGGATGATGCCCGACTGGCCTTTGCCACCGCTGAGGGTCTTTGCGTTACTGCCCGACCGTCGCTTGCAGCCGCGCAA
GGTGCGCGCATTCATGGAAGCGATTGAATCGATGATGGGGGCCGATCTCGATGATCTCGGGCAGTAA

Upstream 100 bases:

>100_bases
ACAATGGTGGACAGATAGTCGGGACAACAAGGGTCAGCAAAGGAAACAGGGTCCGGTGAACGAAACAATTCAGTGGAACG
ATTGGGAGGCATTCTGCTGC

Downstream 100 bases:

>100_bases
CTTGCGCTGTGTACTGCTGACGGGGCAGGGGGAGCGCCCCGTCTGACTTGCCTGGATCAGGCAGGCGAGGCTCAGGCGCC
TTCGCTGTAGACGTCGCGCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIEQGTFTAAAAALDCPKSRVSAAVARLETAIGAKLLERTTRRMRLTDAGGAVYRDVAPLFARLREIRQETLAREERVQG
MLRIATPYEFGAQQLGGVICRTLAAHPALDITVEISQGLVDPIREGFDIAFVTVDTDLPDSGTIARRIWHIERGLVAAPS
LAASLPAQMQPEDLSHMPTLATPGVSVWEFSRDGERISVPIRPRMQTYNAELRMQAALAGIGIARVPMATAEAEIAQGRL
VRMMPDWPLPPLRVFALLPDRRLQPRKVRAFMEAIESMMGADLDDLGQ

Sequences:

>Translated_288_residues
MIEQGTFTAAAAALDCPKSRVSAAVARLETAIGAKLLERTTRRMRLTDAGGAVYRDVAPLFARLREIRQETLAREERVQG
MLRIATPYEFGAQQLGGVICRTLAAHPALDITVEISQGLVDPIREGFDIAFVTVDTDLPDSGTIARRIWHIERGLVAAPS
LAASLPAQMQPEDLSHMPTLATPGVSVWEFSRDGERISVPIRPRMQTYNAELRMQAALAGIGIARVPMATAEAEIAQGRL
VRMMPDWPLPPLRVFALLPDRRLQPRKVRAFMEAIESMMGADLDDLGQ
>Mature_288_residues
MIEQGTFTAAAAALDCPKSRVSAAVARLETAIGAKLLERTTRRMRLTDAGGAVYRDVAPLFARLREIRQETLAREERVQG
MLRIATPYEFGAQQLGGVICRTLAAHPALDITVEISQGLVDPIREGFDIAFVTVDTDLPDSGTIARRIWHIERGLVAAPS
LAASLPAQMQPEDLSHMPTLATPGVSVWEFSRDGERISVPIRPRMQTYNAELRMQAALAGIGIARVPMATAEAEIAQGRL
VRMMPDWPLPPLRVFALLPDRRLQPRKVRAFMEAIESMMGADLDDLGQ

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693193, Length=287, Percent_Identity=27.5261324041812, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081978, Length=280, Percent_Identity=28.9285714285714, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789440, Length=255, Percent_Identity=24.7058823529412, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789639, Length=278, Percent_Identity=28.4172661870504, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786401, Length=280, Percent_Identity=27.5, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787589, Length=259, Percent_Identity=29.7297297297297, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787128, Length=282, Percent_Identity=23.758865248227, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31588; Mature: 31588

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEQGTFTAAAAALDCPKSRVSAAVARLETAIGAKLLERTTRRMRLTDAGGAVYRDVAPL
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHH
FARLREIRQETLAREERVQGMLRIATPYEFGAQQLGGVICRTLAAHPALDITVEISQGLV
HHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHH
DPIREGFDIAFVTVDTDLPDSGTIARRIWHIERGLVAAPSLAASLPAQMQPEDLSHMPTL
HHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHCCCCC
ATPGVSVWEFSRDGERISVPIRPRMQTYNAELRMQAALAGIGIARVPMATAEAEIAQGRL
CCCCCEEEEECCCCCEEEECCCCCHHHHCHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCE
VRMMPDWPLPPLRVFALLPDRRLQPRKVRAFMEAIESMMGADLDDLGQ
EEECCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MIEQGTFTAAAAALDCPKSRVSAAVARLETAIGAKLLERTTRRMRLTDAGGAVYRDVAPL
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHH
FARLREIRQETLAREERVQGMLRIATPYEFGAQQLGGVICRTLAAHPALDITVEISQGLV
HHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHH
DPIREGFDIAFVTVDTDLPDSGTIARRIWHIERGLVAAPSLAASLPAQMQPEDLSHMPTL
HHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHCCCCC
ATPGVSVWEFSRDGERISVPIRPRMQTYNAELRMQAALAGIGIARVPMATAEAEIAQGRL
CCCCCEEEEECCCCCEEEECCCCCHHHHCHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCE
VRMMPDWPLPPLRVFALLPDRRLQPRKVRAFMEAIESMMGADLDDLGQ
EEECCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]