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The map label for this gene is cynR [H]

Identifier: 291481592

GI number: 291481592

Start: 2361500

End: 2362486

Strand: Direct

Name: cynR [H]

Synonym: NA

Alternate gene names: 291481592

Gene position: 2361500-2362486 (Clockwise)

Preceding gene: 94314523

Following gene: 94314527

Centisome position: 91.53

GC content: 65.45

Gene sequence:

>987_bases
ATGGCTCCAGCATGGCGGCGAACAGCTATTGGGTCAAAGACCGGTTTATTATCCTCGTCATTGGCAACACCAATAGTTAC
CACCATGCTGCTGCGCCACGTTCGCTATTTCCTGGCCGTCGCCGACGCCGGCAACTTCACCCGAGCGGCCGAGGCACTCC
ATGTCTCGCAGCCGACACTGTCGCAGCAGATCCGCCAGCTCGAGGAATCACTCGGCGCGCCGTTGTTCGATCGCAGCGGC
CGCACCGTGCGACTGACTGACGCCGGCGAAGCGTACTACGTGCACGCACGCCGCGCGCTGCAGGACCTCGAAGCCGGGCG
ACGCGCCATCCATGACGTGGGAGAACTCACGCGCGGCAACCTCCGGCTGGCGATCACGCCGACGTTCACGCCCTATCTGG
TGGCGCCGCTGATCGTGGCGTTTAACTCGGCGTATCCGAATATCACGCTGAGTCTGCGCGAAATGCCACAAGAGCGCGTG
GAACCATTGCTGGCCGATGACGAGGTCGATATCGGCATCGCCTTCGACGATATCCATCTGCCCGATCTGGACGCCACACC
GTTGATGGAGGAACCGCTGGCCTACATGGTCGGCGCCACACACGCGCTGGCGCGTCGACGCACGGCACTGCGCGCCGACG
TGCTCGCGGCGCAATCCATGGCCATGCTGACGCGGGAATTTGCCACACGGGGTTATATCGCCCGCTACTTCGGGGCGCTA
GGGATCGAGCCGCGTATCACGTTCGAGGCCAACTCGGTCAGCGCCGTGCTTGACGCCGTGCGCAGCGGACGCCACGCCAC
GGTGCTGCCGGCGGCCATTGCCGCCGGACATCCGGATCTGTGCGTCCTCAAGCTGGAACTGCCGCTGCCGCCGCGCCGTG
CCGCGCTACTGCAACGGCGTGGCGCCTATCGCACTGCCGCGGCGCGCGCGTTCGTGGCATTTGCGCTCGATGAGGTCAAT
CGTCGGGGGTCCCCAGCGCACGGTTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:
NA

Sequences:

>Translated_328_residues
MAPAWRRTAIGSKTGLLSSSLATPIVTTMLLRHVRYFLAVADAGNFTRAAEALHVSQPTLSQQIRQLEESLGAPLFDRSG
RTVRLTDAGEAYYVHARRALQDLEAGRRAIHDVGELTRGNLRLAITPTFTPYLVAPLIVAFNSAYPNITLSLREMPQERV
EPLLADDEVDIGIAFDDIHLPDLDATPLMEEPLAYMVGATHALARRRTALRADVLAAQSMAMLTREFATRGYIARYFGAL
GIEPRITFEANSVSAVLDAVRSGRHATVLPAAIAAGHPDLCVLKLELPLPPRRAALLQRRGAYRTAAARAFVAFALDEVN
RRGSPAHG
>Mature_327_residues
APAWRRTAIGSKTGLLSSSLATPIVTTMLLRHVRYFLAVADAGNFTRAAEALHVSQPTLSQQIRQLEESLGAPLFDRSGR
TVRLTDAGEAYYVHARRALQDLEAGRRAIHDVGELTRGNLRLAITPTFTPYLVAPLIVAFNSAYPNITLSLREMPQERVE
PLLADDEVDIGIAFDDIHLPDLDATPLMEEPLAYMVGATHALARRRTALRADVLAAQSMAMLTREFATRGYIARYFGALG
IEPRITFEANSVSAVLDAVRSGRHATVLPAAIAAGHPDLCVLKLELPLPPRRAALLQRRGAYRTAAARAFVAFALDEVNR
RGSPAHG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=292, Percent_Identity=55.4794520547945, Blast_Score=314, Evalue=4e-87,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=29.0102389078498, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=27.9352226720648, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=30.4526748971193, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693105, Length=298, Percent_Identity=24.8322147651007, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=31.6205533596838, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788748, Length=307, Percent_Identity=27.3615635179153, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=34.9693251533742, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789204, Length=236, Percent_Identity=27.9661016949153, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081904, Length=182, Percent_Identity=32.4175824175824, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790208, Length=124, Percent_Identity=38.7096774193548, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786401, Length=154, Percent_Identity=34.4155844155844, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367136, Length=242, Percent_Identity=30.1652892561983, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=124, Percent_Identity=33.0645161290323, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082184, Length=248, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787806, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=30.327868852459, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787949, Length=278, Percent_Identity=25.1798561151079, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788296, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786713, Length=114, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788481, Length=288, Percent_Identity=25.3472222222222, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=223, Percent_Identity=21.9730941704036, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081684, Length=289, Percent_Identity=21.4532871972318, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI145693193, Length=240, Percent_Identity=27.9166666666667, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081978, Length=159, Percent_Identity=35.2201257861635, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786508, Length=171, Percent_Identity=25.7309941520468, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082132, Length=189, Percent_Identity=26.4550264550265, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35732; Mature: 35600

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAWRRTAIGSKTGLLSSSLATPIVTTMLLRHVRYFLAVADAGNFTRAAEALHVSQPTL
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
SQQIRQLEESLGAPLFDRSGRTVRLTDAGEAYYVHARRALQDLEAGRRAIHDVGELTRGN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
LRLAITPTFTPYLVAPLIVAFNSAYPNITLSLREMPQERVEPLLADDEVDIGIAFDDIHL
EEEEECCCCCHHHHHHHHHHHCCCCCCEEEEHHHCCHHHCCCCCCCCCCEEEEEECCCCC
PDLDATPLMEEPLAYMVGATHALARRRTALRADVLAAQSMAMLTREFATRGYIARYFGAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIEPRITFEANSVSAVLDAVRSGRHATVLPAAIAAGHPDLCVLKLELPLPPRRAALLQRR
CCCCEEEEECCHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHC
GAYRTAAARAFVAFALDEVNRRGSPAHG
CCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
APAWRRTAIGSKTGLLSSSLATPIVTTMLLRHVRYFLAVADAGNFTRAAEALHVSQPTL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
SQQIRQLEESLGAPLFDRSGRTVRLTDAGEAYYVHARRALQDLEAGRRAIHDVGELTRGN
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
LRLAITPTFTPYLVAPLIVAFNSAYPNITLSLREMPQERVEPLLADDEVDIGIAFDDIHL
EEEEECCCCCHHHHHHHHHHHCCCCCCEEEEHHHCCHHHCCCCCCCCCCEEEEEECCCCC
PDLDATPLMEEPLAYMVGATHALARRRTALRADVLAAQSMAMLTREFATRGYIARYFGAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIEPRITFEANSVSAVLDAVRSGRHATVLPAAIAAGHPDLCVLKLELPLPPRRAALLQRR
CCCCEEEEECCHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHC
GAYRTAAARAFVAFALDEVNRRGSPAHG
CCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]