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The map label for this gene is yccK [H]

Identifier: 94312459

GI number: 94312459

Start: 3820513

End: 3821511

Strand: Reverse

Name: yccK [H]

Synonym: Rmet_3528

Alternate gene names: 94312459

Gene position: 3821511-3820513 (Counterclockwise)

Preceding gene: 94312460

Following gene: 94312458

Centisome position: 97.29

GC content: 64.96

Gene sequence:

>999_bases
ATGACCACACCGCGCAAGCTGGGCCGTAACGGCCCCGAGGTATTTCCCATCGGTCTGGGCTGCATGGGCATGAGCGAGTT
CTATGGCGCGCATGACGATGCCGAATCTATCCGAACGATTCACCATGCGCTCGACCACGGCGTGAATCTGCTCGACACCG
CCGACATCTATGGTCCGCACACGAACGAGCAACTCGTGGGGCGCGCGCTTGCCGGTGGCCGGCGTGACAAAGTGGTGCTG
GCGACCAAGTTCGGCATCGTGCGCGATCCGTCGAATCCGACGGCGCGCGGCGTCAATGGTCGTCCTGAATATGTGCGCGC
CGCCTGCGATGCGAGTTTGAAGCGGCTCGGTGTCGACCATATCGATCTGTACTACCAGCACCGCATCGATCCCGATACGC
CGATCGAGGACACCGTTGGCGCAATGGCCGATCTGGTCAAGGCGGGCAAGGTGCGGTGGATCGGCCTTTCTGAGGCCGGC
GTCGAGACAATCGAGCGGGCGCACGCGGTGCATCCGGTCACGGCGCTACAGACCGAGTATTCGCTCTGGACGCGTGACGT
CGACGAGAACGGCATCATGGCTACCTGCGAGCGGCTTGGCATCGGCTTCGTGCCGTATAGCCCGCTGGGCCGTGGGTTCC
TGACCGGCGCGATCCGCACGCCCGACGATTTCGAAGCGGACGACTATCGACGTACCAATCCGCGCTTCATGGGCGAGAAC
TTCGCGCGCAACCTGCAACTGGTCGATGCCGTGCGAGCGTTGGCGAGCGAGAAGGGATGCTCGCCGGCGCAACTGGCGCT
GGCCTGGGTGCTGACGCGCGGTGAACACGTGGTGCCGATTCCCGGCACGCGGCGCGTGGCCAATCTCGACGACAACCTGG
GCGCGCTCGGCGTGACGTTGAGCGCGCAGGATCTGGCCCGCATCGACGCGATTTTCCCGCTGGGCGCAGCGGCGGGTACG
CGCTATGCGGCAGCGATGATGCAGTTCCTGTCGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCCACGGAAGACGCCTGCGGGGCCGGTCCGGCAATAGCCGCACGACGCGCGTATCATCGCGGGGTTCGCTGAAGTAC
CTATCCTGAGGAGCTTCCAG

Downstream 100 bases:

>100_bases
TCGGAACCGAGTCATCGGCGCGGCGTACTTCCGGCGACTCTCGGCGACTCTCGGCGACAATGGCGGTCTCGTTTGCCAAA
CCGCCTTGTTGCCGATGACC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTTPRKLGRNGPEVFPIGLGCMGMSEFYGAHDDAESIRTIHHALDHGVNLLDTADIYGPHTNEQLVGRALAGGRRDKVVL
ATKFGIVRDPSNPTARGVNGRPEYVRAACDASLKRLGVDHIDLYYQHRIDPDTPIEDTVGAMADLVKAGKVRWIGLSEAG
VETIERAHAVHPVTALQTEYSLWTRDVDENGIMATCERLGIGFVPYSPLGRGFLTGAIRTPDDFEADDYRRTNPRFMGEN
FARNLQLVDAVRALASEKGCSPAQLALAWVLTRGEHVVPIPGTRRVANLDDNLGALGVTLSAQDLARIDAIFPLGAAAGT
RYAAAMMQFLSR

Sequences:

>Translated_332_residues
MTTPRKLGRNGPEVFPIGLGCMGMSEFYGAHDDAESIRTIHHALDHGVNLLDTADIYGPHTNEQLVGRALAGGRRDKVVL
ATKFGIVRDPSNPTARGVNGRPEYVRAACDASLKRLGVDHIDLYYQHRIDPDTPIEDTVGAMADLVKAGKVRWIGLSEAG
VETIERAHAVHPVTALQTEYSLWTRDVDENGIMATCERLGIGFVPYSPLGRGFLTGAIRTPDDFEADDYRRTNPRFMGEN
FARNLQLVDAVRALASEKGCSPAQLALAWVLTRGEHVVPIPGTRRVANLDDNLGALGVTLSAQDLARIDAIFPLGAAAGT
RYAAAMMQFLSR
>Mature_331_residues
TTPRKLGRNGPEVFPIGLGCMGMSEFYGAHDDAESIRTIHHALDHGVNLLDTADIYGPHTNEQLVGRALAGGRRDKVVLA
TKFGIVRDPSNPTARGVNGRPEYVRAACDASLKRLGVDHIDLYYQHRIDPDTPIEDTVGAMADLVKAGKVRWIGLSEAGV
ETIERAHAVHPVTALQTEYSLWTRDVDENGIMATCERLGIGFVPYSPLGRGFLTGAIRTPDDFEADDYRRTNPRFMGENF
ARNLQLVDAVRALASEKGCSPAQLALAWVLTRGEHVVPIPGTRRVANLDDNLGALGVTLSAQDLARIDAIFPLGAAAGTR
YAAAMMQFLSR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI4504825, Length=323, Percent_Identity=28.7925696594427, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI27436969, Length=323, Percent_Identity=28.7925696594427, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI27436971, Length=323, Percent_Identity=30.030959752322, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI27436966, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI27436962, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI27436964, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI223718702, Length=320, Percent_Identity=30, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI41327764, Length=278, Percent_Identity=29.4964028776978, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI41152114, Length=317, Percent_Identity=26.1829652996845, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081735, Length=328, Percent_Identity=32.6219512195122, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789375, Length=307, Percent_Identity=31.5960912052117, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=32.2683706070287, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789199, Length=339, Percent_Identity=29.7935103244838, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787674, Length=304, Percent_Identity=27.6315789473684, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788081, Length=304, Percent_Identity=27.3026315789474, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994888, Length=279, Percent_Identity=26.5232974910394, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325169, Length=340, Percent_Identity=28.2352941176471, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6325384, Length=299, Percent_Identity=28.4280936454849, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323998, Length=336, Percent_Identity=25.297619047619, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319958, Length=312, Percent_Identity=22.7564102564103, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322615, Length=261, Percent_Identity=24.5210727969349, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319951, Length=325, Percent_Identity=23.3846153846154, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24657054, Length=328, Percent_Identity=26.8292682926829, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640980, Length=339, Percent_Identity=25.0737463126844, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45549126, Length=339, Percent_Identity=25.0737463126844, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24663317, Length=360, Percent_Identity=26.3888888888889, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646155, Length=157, Percent_Identity=33.7579617834395, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129731, Length=345, Percent_Identity=26.3768115942029, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646159, Length=226, Percent_Identity=28.7610619469027, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36054; Mature: 35923

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPRKLGRNGPEVFPIGLGCMGMSEFYGAHDDAESIRTIHHALDHGVNLLDTADIYGPH
CCCCHHHCCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEHHHCCCCC
TNEQLVGRALAGGRRDKVVLATKFGIVRDPSNPTARGVNGRPEYVRAACDASLKRLGVDH
CCHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
IDLYYQHRIDPDTPIEDTVGAMADLVKAGKVRWIGLSEAGVETIERAHAVHPVTALQTEY
HHHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHH
SLWTRDVDENGIMATCERLGIGFVPYSPLGRGFLTGAIRTPDDFEADDYRRTNPRFMGEN
HHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHCHH
FARNLQLVDAVRALASEKGCSPAQLALAWVLTRGEHVVPIPGTRRVANLDDNLGALGVTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCEEEEEE
SAQDLARIDAIFPLGAAAGTRYAAAMMQFLSR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTPRKLGRNGPEVFPIGLGCMGMSEFYGAHDDAESIRTIHHALDHGVNLLDTADIYGPH
CCCHHHCCCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEHHHCCCCC
TNEQLVGRALAGGRRDKVVLATKFGIVRDPSNPTARGVNGRPEYVRAACDASLKRLGVDH
CCHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
IDLYYQHRIDPDTPIEDTVGAMADLVKAGKVRWIGLSEAGVETIERAHAVHPVTALQTEY
HHHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHH
SLWTRDVDENGIMATCERLGIGFVPYSPLGRGFLTGAIRTPDDFEADDYRRTNPRFMGEN
HHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHCHH
FARNLQLVDAVRALASEKGCSPAQLALAWVLTRGEHVVPIPGTRRVANLDDNLGALGVTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCEEEEEE
SAQDLARIDAIFPLGAAAGTRYAAAMMQFLSR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]