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The map label for this gene is kefC [H]

Identifier: 94312307

GI number: 94312307

Start: 3651343

End: 3653157

Strand: Reverse

Name: kefC [H]

Synonym: Rmet_3376

Alternate gene names: 94312307

Gene position: 3653157-3651343 (Counterclockwise)

Preceding gene: 94312308

Following gene: 94312299

Centisome position: 93.0

GC content: 63.86

Gene sequence:

>1815_bases
ATGAACCAGCACGATTTCATGATTGCGCTGGTCGTCTTCCTGGTGGCGGCAGTGGTGGCCGTGCCGCTGGCGCGGCGATT
CGGGCTTGGCGCCGTGCTCGGATATCTGCTGGCGGGTGCGGCAATCGGGCCCTACGCGCTGAGGCTGGTGACCAACGTCG
AGTCGATTCTCCATTTCTCGGAGTTCGGCGTTGTCCTGATGATGTTCGTGATCGGCCTCGAACTCGAGCCACGCAAGCTG
AAGAACCTGCGCAAGACGATCTTTGGCTACGGCACGGCCCAGCTGGCGGCGTGTGCGCTGGTAGTCGGGGGAGCGGCCGC
ATTGCTGGGTGCGTCGTGGCAGGTTGCGATCGTCATAGGTCTGGGGCTCGCGCTGTCTTCCACCGCCATTGCCTTTGCTA
CCCTGGCCGAGCGGAACCTGATGGGCACGCCTGCTGGTGCGGCCAGCTTCGGCATTCTGCTGTTCCAGGATATCGCTGCG
ATCCCGATGATCGCGCTGCTGCCCTTGCTGGCGATCGATGCCGCCGACATCGCACCCCACGGCCCGCCTCACTGGCAAAC
GGTGGCCAGGGCGGTGGCCGTACTCGGCATCGTGGTGGTCGGTGGCCGGTACCTGGTGCGGCCCGCATTGCGGTTCATCG
CGCGCACGGACATGCGCGAGATGTTCACCGCCTTCGCGCTGCTGCTGGTGGTTGGCATCGCGCTGATGATGGAAGCGGTG
GGCGTGTCGATGGCGCTTGGCACATTCGTCGCCGGCGTGCTGCTGGCGGATTCCGAGTACAAACACGCGCTGGAAGCCGA
CATCGAGCCATTCAAGGGGTTGCTGCTCGGCCTGTTCTTCATGGCCGTCGGCATGTCGATCGACTTCGGCGTGCTCGCCC
AGGCGCCGTGGAAGGTACTTGGGCTGGTTGCCGGATTCGTACTGGTCAAGACACTGGTGCTGGCGGTGCTCGCGCCCCGG
TTCGGGATTGCGCGAGGCCAGTGGTTGCTGTTCGGGCTATTGATTTCGCAAGGCGGCGAGTTCGCGTTCGTGGTGTTTTC
GGTGGCCGACAATGTTGGCCTGCTGACCGAGCATATGCACGCGCTGCTGGTCCTGATCGTGGCGCTGTCGATGGTGGCCA
CGCCGCTGTTGTTGCTTGTCTTCGATCAGCTGATCGCGCCGCGCCTGCACATCCTGATGCGGAAGCCCGACGATGTGATC
CCGCCGCAGCACAACCCGGTAATCATCGCGGGTTTCGGGCGGTATGGTCAGATCATCGGTCGCCTGCTCTATGCGCAGGG
CATCGGTGTGACCGTGCTCGACCATGATCCGGACCAGATCGAGTTTCTGCGCCAGTACGGCTTCAAGATTTTCTACGGCG
ATGCCACGCGGGTGGACCTGCTCGAGGCAGCCGGCGTGGCGGAGGCGAAGATTCTGGTCGTGGCGATCGATGGCATGGAA
GACAGCCTCGCCTTGATCGACCGCGTGCGTGAACGCTGGCCGGAGTTGACGATCTGCGCCCGGGCACGCCATGTATCGCA
CGTCTACCAGCTCAAGGACCGGGGTGTTGGCATCTACGAGCGTGAGATGTTCGAGGGGTCGCTGATGATGGGGCGCCGCG
TGCTGGAAGGCCTCGGCTTCGACCCTGCGGAGGCGCGCAACGTGGCGCTTCGGTTCCGCCGTCACAACATCCAGGGGATC
GACCGGTTCTATCCGTACTACACAGACCAGAAGAAGCTGACGTCCCTGACCAAACAGGCGCGAGACGAGCTCGAGGAAAT
GTTCCGGCAGGATCGTGAGCAGCGGCGCAAGCGCGAGGAGGCCGAGTGGTCCTGA

Upstream 100 bases:

>100_bases
CGCTCCATATCGAGCATGTGGCGCGTCATCTGCCGGCGCTACCGCTACCCCCTGAAACGCAACAGTGGACCGATGCGGAG
CTGGGCGGGGAGGACGCGCC

Downstream 100 bases:

>100_bases
GGGCGGGCGCTGCCGCTGGGGGCAGCGCTATCCGGTGACGCCCGGCCCGCGCGGGGTCAGGCCGCCTTCGAGGAGGTCGA
CCACCATCTCCGCGAACTGG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MNQHDFMIALVVFLVAAVVAVPLARRFGLGAVLGYLLAGAAIGPYALRLVTNVESILHFSEFGVVLMMFVIGLELEPRKL
KNLRKTIFGYGTAQLAACALVVGGAAALLGASWQVAIVIGLGLALSSTAIAFATLAERNLMGTPAGAASFGILLFQDIAA
IPMIALLPLLAIDAADIAPHGPPHWQTVARAVAVLGIVVVGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMEAV
GVSMALGTFVAGVLLADSEYKHALEADIEPFKGLLLGLFFMAVGMSIDFGVLAQAPWKVLGLVAGFVLVKTLVLAVLAPR
FGIARGQWLLFGLLISQGGEFAFVVFSVADNVGLLTEHMHALLVLIVALSMVATPLLLLVFDQLIAPRLHILMRKPDDVI
PPQHNPVIIAGFGRYGQIIGRLLYAQGIGVTVLDHDPDQIEFLRQYGFKIFYGDATRVDLLEAAGVAEAKILVVAIDGME
DSLALIDRVRERWPELTICARARHVSHVYQLKDRGVGIYEREMFEGSLMMGRRVLEGLGFDPAEARNVALRFRRHNIQGI
DRFYPYYTDQKKLTSLTKQARDELEEMFRQDREQRRKREEAEWS

Sequences:

>Translated_604_residues
MNQHDFMIALVVFLVAAVVAVPLARRFGLGAVLGYLLAGAAIGPYALRLVTNVESILHFSEFGVVLMMFVIGLELEPRKL
KNLRKTIFGYGTAQLAACALVVGGAAALLGASWQVAIVIGLGLALSSTAIAFATLAERNLMGTPAGAASFGILLFQDIAA
IPMIALLPLLAIDAADIAPHGPPHWQTVARAVAVLGIVVVGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMEAV
GVSMALGTFVAGVLLADSEYKHALEADIEPFKGLLLGLFFMAVGMSIDFGVLAQAPWKVLGLVAGFVLVKTLVLAVLAPR
FGIARGQWLLFGLLISQGGEFAFVVFSVADNVGLLTEHMHALLVLIVALSMVATPLLLLVFDQLIAPRLHILMRKPDDVI
PPQHNPVIIAGFGRYGQIIGRLLYAQGIGVTVLDHDPDQIEFLRQYGFKIFYGDATRVDLLEAAGVAEAKILVVAIDGME
DSLALIDRVRERWPELTICARARHVSHVYQLKDRGVGIYEREMFEGSLMMGRRVLEGLGFDPAEARNVALRFRRHNIQGI
DRFYPYYTDQKKLTSLTKQARDELEEMFRQDREQRRKREEAEWS
>Mature_604_residues
MNQHDFMIALVVFLVAAVVAVPLARRFGLGAVLGYLLAGAAIGPYALRLVTNVESILHFSEFGVVLMMFVIGLELEPRKL
KNLRKTIFGYGTAQLAACALVVGGAAALLGASWQVAIVIGLGLALSSTAIAFATLAERNLMGTPAGAASFGILLFQDIAA
IPMIALLPLLAIDAADIAPHGPPHWQTVARAVAVLGIVVVGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMEAV
GVSMALGTFVAGVLLADSEYKHALEADIEPFKGLLLGLFFMAVGMSIDFGVLAQAPWKVLGLVAGFVLVKTLVLAVLAPR
FGIARGQWLLFGLLISQGGEFAFVVFSVADNVGLLTEHMHALLVLIVALSMVATPLLLLVFDQLIAPRLHILMRKPDDVI
PPQHNPVIIAGFGRYGQIIGRLLYAQGIGVTVLDHDPDQIEFLRQYGFKIFYGDATRVDLLEAAGVAEAKILVVAIDGME
DSLALIDRVRERWPELTICARARHVSHVYQLKDRGVGIYEREMFEGSLMMGRRVLEGLGFDPAEARNVALRFRRHNIQGI
DRFYPYYTDQKKLTSLTKQARDELEEMFRQDREQRRKREEAEWS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=406, Percent_Identity=25.615763546798, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1786232, Length=594, Percent_Identity=50.1683501683502, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1789749, Length=599, Percent_Identity=45.7429048414023, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786685, Length=542, Percent_Identity=28.4132841328413, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65976; Mature: 65976

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHDFMIALVVFLVAAVVAVPLARRFGLGAVLGYLLAGAAIGPYALRLVTNVESILHFS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPRKLKNLRKTIFGYGTAQLAACALVVGGAAALLGASWQVAIVIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHH
LGLALSSTAIAFATLAERNLMGTPAGAASFGILLFQDIAAIPMIALLPLLAIDAADIAPH
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
GPPHWQTVARAVAVLGIVVVGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMEAV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSMALGTFVAGVLLADSEYKHALEADIEPFKGLLLGLFFMAVGMSIDFGVLAQAPWKVL
HHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GLVAGFVLVKTLVLAVLAPRFGIARGQWLLFGLLISQGGEFAFVVFSVADNVGLLTEHMH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHH
ALLVLIVALSMVATPLLLLVFDQLIAPRLHILMRKPDDVIPPQHNPVIIAGFGRYGQIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHH
RLLYAQGIGVTVLDHDPDQIEFLRQYGFKIFYGDATRVDLLEAAGVAEAKILVVAIDGME
HHHHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
DSLALIDRVRERWPELTICARARHVSHVYQLKDRGVGIYEREMFEGSLMMGRRVLEGLGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
DPAEARNVALRFRRHNIQGIDRFYPYYTDQKKLTSLTKQARDELEEMFRQDREQRRKREE
CHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEWS
CCCC
>Mature Secondary Structure
MNQHDFMIALVVFLVAAVVAVPLARRFGLGAVLGYLLAGAAIGPYALRLVTNVESILHFS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPRKLKNLRKTIFGYGTAQLAACALVVGGAAALLGASWQVAIVIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHH
LGLALSSTAIAFATLAERNLMGTPAGAASFGILLFQDIAAIPMIALLPLLAIDAADIAPH
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
GPPHWQTVARAVAVLGIVVVGGRYLVRPALRFIARTDMREMFTAFALLLVVGIALMMEAV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSMALGTFVAGVLLADSEYKHALEADIEPFKGLLLGLFFMAVGMSIDFGVLAQAPWKVL
HHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GLVAGFVLVKTLVLAVLAPRFGIARGQWLLFGLLISQGGEFAFVVFSVADNVGLLTEHMH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHH
ALLVLIVALSMVATPLLLLVFDQLIAPRLHILMRKPDDVIPPQHNPVIIAGFGRYGQIIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHH
RLLYAQGIGVTVLDHDPDQIEFLRQYGFKIFYGDATRVDLLEAAGVAEAKILVVAIDGME
HHHHHCCCCEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCEEEEEEEECCCC
DSLALIDRVRERWPELTICARARHVSHVYQLKDRGVGIYEREMFEGSLMMGRRVLEGLGF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
DPAEARNVALRFRRHNIQGIDRFYPYYTDQKKLTSLTKQARDELEEMFRQDREQRRKREE
CHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEWS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA