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The map label for this gene is pntAa [H]

Identifier: 94311895

GI number: 94311895

Start: 3220750

End: 3221955

Strand: Direct

Name: pntAa [H]

Synonym: Rmet_2963

Alternate gene names: 94311895

Gene position: 3220750-3221955 (Clockwise)

Preceding gene: 94311889

Following gene: 94311896

Centisome position: 81.99

GC content: 67.5

Gene sequence:

>1206_bases
ATGGTGCGCCGCACGCGGTACACCAAGGGCGAGGACGTCTGCCCGACCAATCAGATACGACGCCATCAAAAGGAGAAATG
GACGATGCATATCGGCATCCCGCTCGAGACGCGGGCAGGTGAGGCGCGAGTCGCCGCCACCCCGGAGACCGTCAAGAAGT
ACGTTGCGCAGGGCCATCAGGTAACGGTGCAAGCCGGCGCCGGTATCCGCGCCAGTATTCCCGACGCAGCGTTCGAAGCG
GCAGGCGCGCGCATCGGCTCCGCGGCCGATGCGCTCGGCGCGGAACTCCTGCTGAAGGTCCGCGCGCCGGACGATGCCGA
ACGTGCCCAGATCAAGCCGGGTGCCGTGCTGGTCGGCATGCTCAATCCCTTCGATATCGAAAACAACGCGCGCATGGCCA
GCGCCGCGATCACGGCGTTCGCGCTCGAAGCCGCGCCGCGTACCACGCGCGCGCAGAGCATGGACGTGCTGTCCTCGCAG
GCCAACATCGCCGGCTACAAGGCCGTGCTGGAGGCCGCGCACCACTACCAGCGCTTCATGCCGATGCTGATGACGGCAGC
GGGCACGGTAAAGGCCGCGCGCGTGCTGATCCTCGGCGCTGGCGTGGCGGGCCTGCAGGCCATCGCCACGGCCAAGCGAC
TGGGCGCCGTGATCGAAGCCTCCGATGTGCGCCCCGCCGTGAAGGAGCAGATCGAATCGCTCGGCGCGAAATTCCTCGAC
GTGCCGTTCCTGACTGACGAAGAGCGCGAGATCGCGCAAGGCGTGGGCGGCTATGCCCGCCCGATGCCCGCCGACTGGAT
GCGGCGCCAGGCCGAACTGGTGCACCAGCGTGCCACGCAGGCCGACATCGTCATCACCACCGCGCTGATCCCGGGCCGCC
GCGCGCCGGTGCTGCTGCAGGAAGAGACTGTCAAGCAGATGAAGCCCGGCTCGGTCGTCGTCGACCTCGCCGCAGCACAG
GGCGGCAACTGCCCGCTGACCGTCGCCGACGAAGTGGTCGAGCGCCACGGCGTCACCCTGATCGGTCACACGAACCTTGC
CGGCATGGTTGCCGCCGATGCGTCCGCGCTGTACGCGCGCAACGTGCTGGACTTCCTCAAGCTGATCATCGACAAGGATG
CCCGCTATACGCTGAATCTCGAGGACGACATCGTTGCCGCCTGCCTGATGTGCAAGGACGGCCAGGTCATCCGCGAGGCA
GCCTGA

Upstream 100 bases:

>100_bases
AAGTCATTTCATGAGGCGCAAGAATGAGTCTCTGTGACGCCACAAATCCCCGACCGGCCAGTCACCACCGAATGTAAGTT
TCGGGTAAGCTGCGCAAAAA

Downstream 100 bases:

>100_bases
TCCGACACCGGCGCCAGGCCATCACGCCCTGGCGCCCGTCCGCCGATGACCTTGCAGCGGCGCGGGGAGCCATCCGCACT
GCAACCCGCCATCGGCGGAC

Product: NAD(P) transhydrogenase (Alpha subunit part 1) oxidoreductase protein

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MVRRTRYTKGEDVCPTNQIRRHQKEKWTMHIGIPLETRAGEARVAATPETVKKYVAQGHQVTVQAGAGIRASIPDAAFEA
AGARIGSAADALGAELLLKVRAPDDAERAQIKPGAVLVGMLNPFDIENNARMASAAITAFALEAAPRTTRAQSMDVLSSQ
ANIAGYKAVLEAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLD
VPFLTDEEREIAQGVGGYARPMPADWMRRQAELVHQRATQADIVITTALIPGRRAPVLLQEETVKQMKPGSVVVDLAAAQ
GGNCPLTVADEVVERHGVTLIGHTNLAGMVAADASALYARNVLDFLKLIIDKDARYTLNLEDDIVAACLMCKDGQVIREA
A

Sequences:

>Translated_401_residues
MVRRTRYTKGEDVCPTNQIRRHQKEKWTMHIGIPLETRAGEARVAATPETVKKYVAQGHQVTVQAGAGIRASIPDAAFEA
AGARIGSAADALGAELLLKVRAPDDAERAQIKPGAVLVGMLNPFDIENNARMASAAITAFALEAAPRTTRAQSMDVLSSQ
ANIAGYKAVLEAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLD
VPFLTDEEREIAQGVGGYARPMPADWMRRQAELVHQRATQADIVITTALIPGRRAPVLLQEETVKQMKPGSVVVDLAAAQ
GGNCPLTVADEVVERHGVTLIGHTNLAGMVAADASALYARNVLDFLKLIIDKDARYTLNLEDDIVAACLMCKDGQVIREA
A
>Mature_401_residues
MVRRTRYTKGEDVCPTNQIRRHQKEKWTMHIGIPLETRAGEARVAATPETVKKYVAQGHQVTVQAGAGIRASIPDAAFEA
AGARIGSAADALGAELLLKVRAPDDAERAQIKPGAVLVGMLNPFDIENNARMASAAITAFALEAAPRTTRAQSMDVLSSQ
ANIAGYKAVLEAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLD
VPFLTDEEREIAQGVGGYARPMPADWMRRQAELVHQRATQADIVITTALIPGRRAPVLLQEETVKQMKPGSVVVDLAAAQ
GGNCPLTVADEVVERHGVTLIGHTNLAGMVAADASALYARNVLDFLKLIIDKDARYTLNLEDDIVAACLMCKDGQVIREA
A

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=415, Percent_Identity=39.0361445783133, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI122939153, Length=415, Percent_Identity=39.0361445783133, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=44.2048517520216, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17550456, Length=375, Percent_Identity=41.6, Blast_Score=288, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 42819; Mature: 42819

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTRYTKGEDVCPTNQIRRHQKEKWTMHIGIPLETRAGEARVAATPETVKKYVAQGHQ
CCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEECEEECCCCCCEEECCHHHHHHHHHCCCE
VTVQAGAGIRASIPDAAFEAAGARIGSAADALGAELLLKVRAPDDAERAQIKPGAVLVGM
EEEEECCCCEECCCHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCHHHCCCCCCEEEEEC
LNPFDIENNARMASAAITAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLEAAHHYQRFM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLD
HHHHHHHCHHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCC
VPFLTDEEREIAQGVGGYARPMPADWMRRQAELVHQRATQADIVITTALIPGRRAPVLLQ
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEC
EETVKQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVTLIGHTNLAGMVAADASALYAR
HHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
NVLDFLKLIIDKDARYTLNLEDDIVAACLMCKDGQVIREAA
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MVRRTRYTKGEDVCPTNQIRRHQKEKWTMHIGIPLETRAGEARVAATPETVKKYVAQGHQ
CCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEECEEECCCCCCEEECCHHHHHHHHHCCCE
VTVQAGAGIRASIPDAAFEAAGARIGSAADALGAELLLKVRAPDDAERAQIKPGAVLVGM
EEEEECCCCEECCCHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCHHHCCCCCCEEEEEC
LNPFDIENNARMASAAITAFALEAAPRTTRAQSMDVLSSQANIAGYKAVLEAAHHYQRFM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
PMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLD
HHHHHHHCHHHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCC
VPFLTDEEREIAQGVGGYARPMPADWMRRQAELVHQRATQADIVITTALIPGRRAPVLLQ
CCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEC
EETVKQMKPGSVVVDLAAAQGGNCPLTVADEVVERHGVTLIGHTNLAGMVAADASALYAR
HHHHHHCCCCCEEEEEECCCCCCCCEEHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
NVLDFLKLIIDKDARYTLNLEDDIVAACLMCKDGQVIREAA
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]