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The map label for this gene is dld [H]

Identifier: 94311856

GI number: 94311856

Start: 3179334

End: 3180821

Strand: Direct

Name: dld [H]

Synonym: Rmet_2924

Alternate gene names: 94311856

Gene position: 3179334-3180821 (Clockwise)

Preceding gene: 94311851

Following gene: 94311857

Centisome position: 80.94

GC content: 67.54

Gene sequence:

>1488_bases
GTGGAAGGCGACGTAGAATGGCGGCATTCCCTTGCATACAGAGCTATACGGCCCGAGCCGGAGACCCGCATGAACCACCC
CACACCTGCCACCGCCCTGGCGCGCCGGCCGTTCCCATCGGAACTGGCCGATGCCCTCGCCGCCCGCTTCGGCGACCGCT
TCACCACCTCGGTCGGCGTGCGCGAGCATCATGGGCGCGACGAATCCCCGTTCCCGCCCGAACTGCCGGACGCCGTGGTC
TTTGCCCATAGCACCGAGGAAGTGGCCGAACTGGCGAAGCTCTGCAACACGCATGGCGTGCCGCTGATCCCCTACGGCGC
CGGCTCCTCGCTCGAGGGCCACCTGCTGGCCGTGGCCGGCGGTATCAGCCTCGACCTGTCGCAGATGAACCGGGTGCTGG
CCGTGCACCCCGAGGATCTGACCGTCACCGTCCAGCCCGGCGTCACGCGCAAACAGCTCAACCAGGAGATCAAGGACACG
GGCCTGTTCTTCCCGATCGACCCAGGCGCCGATGCATCGCTGGGTGGCATGTGCGCCACGCGCGCCTCGGGCACCAACGC
GGTCCGCTACGGCACCATGCGCGAGAACGTGCTGGCGCTGACCGTGGTCACGGCCGACGGCCGGGTCATCCGCACCGGCA
CCAATGCGCGCAAGTCGTCGGCGGGCTATGACCTGACGCGCCTGTTTGTCGGCAGCGAAGGCACGCTCGGCATCATCACC
GAAGTTACGGTGCGGCTCTATCCGCAGCCGGAAGCGATCTCCGCGGCCGTCTGCGCCTTCCCGAGCATGGGCGACGCCGT
GCGTGCCACCATCCAGACGATCCAGCTTGGCGTGCCCGTGGCCCGCGTGGAGTTCGTCGACGCCCTGGCAATCCGTGCGA
TCAACCGCCATGACAATCTGACCTTGCCGGAAACGCCCCACCTGTTCTTCGAGTTCCATGGCACTGAGGCCGGCGTGCGC
GAACAGGCCGAGACCGTGCAGGACATCGCCGCCGAGCACGGCGGCCAGGGCTTCGAATGGGCCACACGGCCCGAGGACCG
GTCGCGGCTCTGGAATGCTCGCCACACCGCCTATTTCGCGATGCTCCAGCTGAAGCCGGGCTGCAAATCGGTCACCACCG
ACGTCTGCGTGCCGATCTCTCGGCTGGCCGACTGCGTGACCGAAACCGAGCGCGATCTGAATGCGTCGTCGCTGCCCTGC
CCGATCGTCGGTCACGTCGGGGATGGCAACTTCCACGTGGCGATCCTGGTGGACCCGGACAAGCCCGAGGAAATGGCCGA
GGCCGAGGACATCAACCGCCGCATCGTGCAGCGCGCGCTGGCGATGGGCGGCACCTGCACCGGCGAGCACGGCGTGGGCC
TGCACAAGATGGGATTTCTGGTGCAGGAGCATGGCGAGGATGCGCTCGACCTGATGCGCGCGATCAAGGATGCGCTCGAC
CCGAACCACATCCTGAATCCGGGCAAGATCTTCAGCGCCACGCGCTGA

Upstream 100 bases:

>100_bases
CGATTACCCATGCCGGTCTCCTTGTGGTCAGTGTTTTAGAAGTGGCGCAATTATGGACCCTCCGGGGCCGGGCGGCGCGT
ACCGGGGACGTATGGGAGAC

Downstream 100 bases:

>100_bases
GCACGCGGCCATGGCATCGGTTTTCCATCGCGTCCCACCCCTGCACCTGCTGATCGCGTTCGAAGCGGCTGCCCGGCTGG
GCAGCTTCGCGCGCGCTGCC

Product: D-Lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MEGDVEWRHSLAYRAIRPEPETRMNHPTPATALARRPFPSELADALAARFGDRFTTSVGVREHHGRDESPFPPELPDAVV
FAHSTEEVAELAKLCNTHGVPLIPYGAGSSLEGHLLAVAGGISLDLSQMNRVLAVHPEDLTVTVQPGVTRKQLNQEIKDT
GLFFPIDPGADASLGGMCATRASGTNAVRYGTMRENVLALTVVTADGRVIRTGTNARKSSAGYDLTRLFVGSEGTLGIIT
EVTVRLYPQPEAISAAVCAFPSMGDAVRATIQTIQLGVPVARVEFVDALAIRAINRHDNLTLPETPHLFFEFHGTEAGVR
EQAETVQDIAAEHGGQGFEWATRPEDRSRLWNARHTAYFAMLQLKPGCKSVTTDVCVPISRLADCVTETERDLNASSLPC
PIVGHVGDGNFHVAILVDPDKPEEMAEAEDINRRIVQRALAMGGTCTGEHGVGLHKMGFLVQEHGEDALDLMRAIKDALD
PNHILNPGKIFSATR

Sequences:

>Translated_495_residues
MEGDVEWRHSLAYRAIRPEPETRMNHPTPATALARRPFPSELADALAARFGDRFTTSVGVREHHGRDESPFPPELPDAVV
FAHSTEEVAELAKLCNTHGVPLIPYGAGSSLEGHLLAVAGGISLDLSQMNRVLAVHPEDLTVTVQPGVTRKQLNQEIKDT
GLFFPIDPGADASLGGMCATRASGTNAVRYGTMRENVLALTVVTADGRVIRTGTNARKSSAGYDLTRLFVGSEGTLGIIT
EVTVRLYPQPEAISAAVCAFPSMGDAVRATIQTIQLGVPVARVEFVDALAIRAINRHDNLTLPETPHLFFEFHGTEAGVR
EQAETVQDIAAEHGGQGFEWATRPEDRSRLWNARHTAYFAMLQLKPGCKSVTTDVCVPISRLADCVTETERDLNASSLPC
PIVGHVGDGNFHVAILVDPDKPEEMAEAEDINRRIVQRALAMGGTCTGEHGVGLHKMGFLVQEHGEDALDLMRAIKDALD
PNHILNPGKIFSATR
>Mature_495_residues
MEGDVEWRHSLAYRAIRPEPETRMNHPTPATALARRPFPSELADALAARFGDRFTTSVGVREHHGRDESPFPPELPDAVV
FAHSTEEVAELAKLCNTHGVPLIPYGAGSSLEGHLLAVAGGISLDLSQMNRVLAVHPEDLTVTVQPGVTRKQLNQEIKDT
GLFFPIDPGADASLGGMCATRASGTNAVRYGTMRENVLALTVVTADGRVIRTGTNARKSSAGYDLTRLFVGSEGTLGIIT
EVTVRLYPQPEAISAAVCAFPSMGDAVRATIQTIQLGVPVARVEFVDALAIRAINRHDNLTLPETPHLFFEFHGTEAGVR
EQAETVQDIAAEHGGQGFEWATRPEDRSRLWNARHTAYFAMLQLKPGCKSVTTDVCVPISRLADCVTETERDLNASSLPC
PIVGHVGDGNFHVAILVDPDKPEEMAEAEDINRRIVQRALAMGGTCTGEHGVGLHKMGFLVQEHGEDALDLMRAIKDALD
PNHILNPGKIFSATR

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=462, Percent_Identity=51.9480519480519, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI37595754, Length=467, Percent_Identity=50.321199143469, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI119964728, Length=419, Percent_Identity=32.2195704057279, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4501993, Length=458, Percent_Identity=26.2008733624454, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789351, Length=457, Percent_Identity=31.5098468271335, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1787977, Length=522, Percent_Identity=28.544061302682, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI48994907, Length=227, Percent_Identity=30.8370044052863, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI48994914, Length=189, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=440, Percent_Identity=48.1818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71992381, Length=440, Percent_Identity=47.0454545454545, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71992392, Length=380, Percent_Identity=49.4736842105263, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17534361, Length=423, Percent_Identity=23.8770685579196, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17556096, Length=456, Percent_Identity=25.219298245614, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=433, Percent_Identity=41.5704387990762, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6320764, Length=437, Percent_Identity=28.8329519450801, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320023, Length=455, Percent_Identity=27.4725274725275, Blast_Score=162, Evalue=9e-41,
Organism=Drosophila melanogaster, GI18921117, Length=424, Percent_Identity=27.8301886792453, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24639277, Length=424, Percent_Identity=27.8301886792453, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24639275, Length=424, Percent_Identity=27.8301886792453, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24653753, Length=458, Percent_Identity=27.0742358078603, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 53525; Mature: 53525

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGDVEWRHSLAYRAIRPEPETRMNHPTPATALARRPFPSELADALAARFGDRFTTSVGV
CCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHEEECCC
REHHGRDESPFPPELPDAVVFAHSTEEVAELAKLCNTHGVPLIPYGAGSSLEGHLLAVAG
HHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEC
GISLDLSQMNRVLAVHPEDLTVTVQPGVTRKQLNQEIKDTGLFFPIDPGADASLGGMCAT
CCEEEHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEE
RASGTNAVRYGTMRENVLALTVVTADGRVIRTGTNARKSSAGYDLTRLFVGSEGTLGIIT
CCCCCCEEEECCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEE
EVTVRLYPQPEAISAAVCAFPSMGDAVRATIQTIQLGVPVARVEFVDALAIRAINRHDNL
EEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
TLPETPHLFFEFHGTEAGVREQAETVQDIAAEHGGQGFEWATRPEDRSRLWNARHTAYFA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHEEEEE
MLQLKPGCKSVTTDVCVPISRLADCVTETERDLNASSLPCPIVGHVGDGNFHVAILVDPD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCC
KPEEMAEAEDINRRIVQRALAMGGTCTGEHGVGLHKMGFLVQEHGEDALDLMRAIKDALD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PNHILNPGKIFSATR
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MEGDVEWRHSLAYRAIRPEPETRMNHPTPATALARRPFPSELADALAARFGDRFTTSVGV
CCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCHHEEECCC
REHHGRDESPFPPELPDAVVFAHSTEEVAELAKLCNTHGVPLIPYGAGSSLEGHLLAVAG
HHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEC
GISLDLSQMNRVLAVHPEDLTVTVQPGVTRKQLNQEIKDTGLFFPIDPGADASLGGMCAT
CCEEEHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCEEEE
RASGTNAVRYGTMRENVLALTVVTADGRVIRTGTNARKSSAGYDLTRLFVGSEGTLGIIT
CCCCCCEEEECCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEE
EVTVRLYPQPEAISAAVCAFPSMGDAVRATIQTIQLGVPVARVEFVDALAIRAINRHDNL
EEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
TLPETPHLFFEFHGTEAGVREQAETVQDIAAEHGGQGFEWATRPEDRSRLWNARHTAYFA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHEEEEE
MLQLKPGCKSVTTDVCVPISRLADCVTETERDLNASSLPCPIVGHVGDGNFHVAILVDPD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCC
KPEEMAEAEDINRRIVQRALAMGGTCTGEHGVGLHKMGFLVQEHGEDALDLMRAIKDALD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PNHILNPGKIFSATR
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]