Click here to switch to the map view.

The map label for this gene is garR [H]

Identifier: 94311753

GI number: 94311753

Start: 3069020

End: 3069889

Strand: Direct

Name: garR [H]

Synonym: Rmet_2821

Alternate gene names: 94311753

Gene position: 3069020-3069889 (Clockwise)

Preceding gene: 94311752

Following gene: 94311755

Centisome position: 78.13

GC content: 66.44

Gene sequence:

>870_bases
ATGACCACCGTAGCATTTATTGGCCTTGGCGCGATGGGCGCGCCGATGGTGGGCCACCTGATCCGCGCCGGCCATACCGT
GCGCGCCTTCGTGCGCCGACCCGAAGCAGCCGATGCCGCGCGCCAGTTGGGCGCGGAACCGTTCTTCACGCCCGCGGAAG
CCGCGCAAGGCGCGGCCGTCGTCTTCACTAACGTGACATCGTCCGAGGACGTGCGCGAAGTGCTGCTCGGCCGGAACGGC
GTGGTGGAAGGCGCCGCGCCAGGCACGATCTGCGTCGATCACAGCACCATCTCGCCGATCGTCACGCGCGAGATAGCGCA
AGCGCTGGCAGCGTGCGGCATCGAGGCGCTGGACTGTCCGGTATCGGGCGGCACGGTGGGAGCGCAGGCCGCCACGCTGA
CGATCATGGTCGGCGGCAAGGCCGAGGTGTTGGAAAAGGTGCGTCCGCTGCTGGAGCAGATCGGCAAGACCATCACGCAC
ATTGGCGACAGCGGCGCAGGCCAGGTGGCCAAGCTGTGCAACCAGATCGCTCAGGTGGTCAATATCGAAGGCATCGCCGA
AGCCATGCGCTTTGCCGGCGCGCAGGGCGTGGACACTGCCAAGGTGTTCCAGGCAATGTCCACCGGCATGGCCGGCAGCC
GTATGCTCGACATGCTCGGCCCGAAGATGGTGACGCGCGATTTCTCCGCTGGCATAGAGTCGCGGCTCCACGCCAAGGAT
TTCGGACTCGCGGCGGACATCGCCACCGAGATTGGGCTTGAGTTGCCGGCGATGCGCGCCACGTCGGCGCAACTCGGCGA
GTTGATGGATCAGGGCTGGGGCAAGGACGATACGTCGTCGCTGCTGAAGGTGCTGGAGCTGAAGGGCTGA

Upstream 100 bases:

>100_bases
TCATCAAGGTTTCGACCAGCGTGCCCGCGTGATGGGCGTGGTGCGCAATGGCAAGTTCGCCTACGCAGGCGACAAGTAAG
ACAAGTTCTAGGAAGCATTC

Downstream 100 bases:

>100_bases
CGAAAGTCACCCTGTAGGCGAGCGACTGGCGTCCGCTCGCCCTCGGCCCATCCAGCCGTTCAAAACCCCGCGATCATCCC
CAGCAGCGCGCGCATCATCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTTVAFIGLGAMGAPMVGHLIRAGHTVRAFVRRPEAADAARQLGAEPFFTPAEAAQGAAVVFTNVTSSEDVREVLLGRNG
VVEGAAPGTICVDHSTISPIVTREIAQALAACGIEALDCPVSGGTVGAQAATLTIMVGGKAEVLEKVRPLLEQIGKTITH
IGDSGAGQVAKLCNQIAQVVNIEGIAEAMRFAGAQGVDTAKVFQAMSTGMAGSRMLDMLGPKMVTRDFSAGIESRLHAKD
FGLAADIATEIGLELPAMRATSAQLGELMDQGWGKDDTSSLLKVLELKG

Sequences:

>Translated_289_residues
MTTVAFIGLGAMGAPMVGHLIRAGHTVRAFVRRPEAADAARQLGAEPFFTPAEAAQGAAVVFTNVTSSEDVREVLLGRNG
VVEGAAPGTICVDHSTISPIVTREIAQALAACGIEALDCPVSGGTVGAQAATLTIMVGGKAEVLEKVRPLLEQIGKTITH
IGDSGAGQVAKLCNQIAQVVNIEGIAEAMRFAGAQGVDTAKVFQAMSTGMAGSRMLDMLGPKMVTRDFSAGIESRLHAKD
FGLAADIATEIGLELPAMRATSAQLGELMDQGWGKDDTSSLLKVLELKG
>Mature_288_residues
TTVAFIGLGAMGAPMVGHLIRAGHTVRAFVRRPEAADAARQLGAEPFFTPAEAAQGAAVVFTNVTSSEDVREVLLGRNGV
VEGAAPGTICVDHSTISPIVTREIAQALAACGIEALDCPVSGGTVGAQAATLTIMVGGKAEVLEKVRPLLEQIGKTITHI
GDSGAGQVAKLCNQIAQVVNIEGIAEAMRFAGAQGVDTAKVFQAMSTGMAGSRMLDMLGPKMVTRDFSAGIESRLHAKDF
GLAADIATEIGLELPAMRATSAQLGELMDQGWGKDDTSSLLKVLELKG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=297, Percent_Identity=32.6599326599327, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40556376, Length=253, Percent_Identity=27.6679841897233, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI145693186, Length=278, Percent_Identity=40.2877697841727, Blast_Score=202, Evalue=1e-53,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=40.1408450704225, Blast_Score=200, Evalue=7e-53,
Organism=Escherichia coli, GI1790315, Length=284, Percent_Identity=32.0422535211268, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=29.5138888888889, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=264, Percent_Identity=32.1969696969697, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24655230, Length=301, Percent_Identity=33.8870431893688, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19922568, Length=301, Percent_Identity=33.8870431893688, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.5551601423488, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29795; Mature: 29664

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVAFIGLGAMGAPMVGHLIRAGHTVRAFVRRPEAADAARQLGAEPFFTPAEAAQGAAV
CCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCEE
VFTNVTSSEDVREVLLGRNGVVEGAAPGTICVDHSTISPIVTREIAQALAACGIEALDCP
EEECCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHCCC
VSGGTVGAQAATLTIMVGGKAEVLEKVRPLLEQIGKTITHIGDSGAGQVAKLCNQIAQVV
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
NIEGIAEAMRFAGAQGVDTAKVFQAMSTGMAGSRMLDMLGPKMVTRDFSAGIESRLHAKD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FGLAADIATEIGLELPAMRATSAQLGELMDQGWGKDDTSSLLKVLELKG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTVAFIGLGAMGAPMVGHLIRAGHTVRAFVRRPEAADAARQLGAEPFFTPAEAAQGAAV
CEEEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCEE
VFTNVTSSEDVREVLLGRNGVVEGAAPGTICVDHSTISPIVTREIAQALAACGIEALDCP
EEECCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHCCC
VSGGTVGAQAATLTIMVGGKAEVLEKVRPLLEQIGKTITHIGDSGAGQVAKLCNQIAQVV
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
NIEGIAEAMRFAGAQGVDTAKVFQAMSTGMAGSRMLDMLGPKMVTRDFSAGIESRLHAKD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FGLAADIATEIGLELPAMRATSAQLGELMDQGWGKDDTSSLLKVLELKG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]