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The map label for this gene is pepA [H]

Identifier: 94311739

GI number: 94311739

Start: 3053924

End: 3055456

Strand: Reverse

Name: pepA [H]

Synonym: Rmet_2807

Alternate gene names: 94311739

Gene position: 3055456-3053924 (Counterclockwise)

Preceding gene: 94311743

Following gene: 94311738

Centisome position: 77.78

GC content: 66.8

Gene sequence:

>1533_bases
ATGGAATTTAGCACAAAAGCCCTGGATCTGAGCAAAGCCGGCCAAAATGGTTTCTTGGCCACGAAGACGGACTGTCTGGT
GGTTGGCCTGTTCGAGGGCCAAAGTCTGGCCGGCGTGGCCAAGGCGCTGGACGTTGCCACCAAGGGGCTGGTGGCGCGTC
TGGTCAAGCAAGGCGACTTCGAAGGCAAGCGCGGCACGCAACTGATGCTGCACGAGGTGGCCGGCGTTGGCGCCGCCCGC
GTGCTGCTGGTGGGCCTGGGCAAGGAAGCCGATTTCAACGACAAGGCCTTTGCCGAAGCCGTGCGCACGGCCACGCGTGC
CCTGGGCGGCACGCGCGCCGCCTCGGCGCTCTGGTGCCTGGTTCAGCAGCCACCGCAGCAGCGCGACGTGGCCTGGGCCA
TCATCACCACGATCACGCTGGTCCGGGAGGCCGGTTATCGCCTGCTGGAGCGCCATCCCGAGCTCAAGCGCGCGCCCCGG
GGCGCCGGCGCCAACGAAAAGGCGTCGCTGCGCAAGATCGTGCTGGCCGTGGACGTGGGCGACGCCAAGGCCGCCTCGCA
GGCCGCCGTGCGTGGCACTGCCATCGCCAACGGCATGGAACTGACCCGCGATCTGGGCAACCTGCCGTCCAACATCTGCA
CGCCGACCTATCTGGCCAATACCGCCCGTGGCATCGCCAAGCGCCACAAGCTCAAGGTGGAGATCCTGGGTCGCAAGCAG
ATCGAGGCGCTCAACATGGGCGCCTTCCTTGCCGTGACCAAGGGCAGCGTCGAGCCGCCGCAGTTCATCGTGCTGCGCTA
TGACGGCGCGAGCGCCAAGCAGGCGCCGGTGGTGCTGGTGGGCAAGGGCATCACGTTCGATACGGGTGGCATCTCGCTGA
AGCCGGGCGAGGGCATGGACGAGATGAAGTACGACATGTGCGGCGCGGCATCGGTGCTGGGCACGATCCAGGCCGTGGCC
GAAATGGGCCTGAAGCAGAACGTGATCGCCGTGGTGCCGACTTGCGAGAACATGCCGAGCGGCATCGCCACCAAGCCGGG
CGACGTAGTGACCAGCATGTCCGGCCAGACCATCGAAATCCTCAATACCGATGCCGAAGGCCGCCTGATCCTGTGCGACG
CGCTGACTTACGTGGAGCGCTTCAAGCCGGCCGCCGTGATCGACGTGGCCACGCTGACCGGTGCCTGCATCATCGCGCTC
GGCCACGTCAACAGCGGCCTGTACGCCCGCAGTGACGCGCTGGCGGACCAGTTGCTGGGTGCCGGCCGCAAGGCCATGGA
TACGGCCTGGCGTCTGCCGCTGGACGATGACTACCAGGACCAGCTCAAGTCGAACTTTGCCGATATGGCCAATATCGGTG
GCCGTCCGGCCGGCAGCGTGACCGCGGCCTGCTTCCTGGCGCGTTATACCGAGAAGTACGACTGGGCCCACCTCGACATC
GCCGGCACAGCGTGGAAGAGCGGCGCGGCCAAGGGCGCCACGGGCCGTCCGGTGCCGTTGCTGACGCAGTTCCTGATGGA
CCGCGCGGCCTAA

Upstream 100 bases:

>100_bases
ACCGCGGGCTGTCAGCTTTCTGGATCGGCGGCGGCGGATCGCGGATGAAAATCGCGGATAATGGGGGTTTCTTTTCGACG
AGCCCCTTGAAGGAAGCGCG

Downstream 100 bases:

>100_bases
TCGGGCGTATCGGGCGGATTTTAGGATCAGGTAAAGGTAGCCGGGATGACGCGCATCGACTTCCATAGCAATGTGCCGGA
CACGCTGACATATGTCTGCC

Product: multifunctional aminopeptidase A

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MEFSTKALDLSKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVARLVKQGDFEGKRGTQLMLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTATRALGGTRAASALWCLVQQPPQQRDVAWAIITTITLVREAGYRLLERHPELKRAPR
GAGANEKASLRKIVLAVDVGDAKAASQAAVRGTAIANGMELTRDLGNLPSNICTPTYLANTARGIAKRHKLKVEILGRKQ
IEALNMGAFLAVTKGSVEPPQFIVLRYDGASAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTIQAVA
EMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVIDVATLTGACIIAL
GHVNSGLYARSDALADQLLGAGRKAMDTAWRLPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLARYTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA

Sequences:

>Translated_510_residues
MEFSTKALDLSKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVARLVKQGDFEGKRGTQLMLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTATRALGGTRAASALWCLVQQPPQQRDVAWAIITTITLVREAGYRLLERHPELKRAPR
GAGANEKASLRKIVLAVDVGDAKAASQAAVRGTAIANGMELTRDLGNLPSNICTPTYLANTARGIAKRHKLKVEILGRKQ
IEALNMGAFLAVTKGSVEPPQFIVLRYDGASAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTIQAVA
EMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVIDVATLTGACIIAL
GHVNSGLYARSDALADQLLGAGRKAMDTAWRLPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLARYTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
>Mature_510_residues
MEFSTKALDLSKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVARLVKQGDFEGKRGTQLMLHEVAGVGAAR
VLLVGLGKEADFNDKAFAEAVRTATRALGGTRAASALWCLVQQPPQQRDVAWAIITTITLVREAGYRLLERHPELKRAPR
GAGANEKASLRKIVLAVDVGDAKAASQAAVRGTAIANGMELTRDLGNLPSNICTPTYLANTARGIAKRHKLKVEILGRKQ
IEALNMGAFLAVTKGSVEPPQFIVLRYDGASAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTIQAVA
EMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVIDVATLTGACIIAL
GHVNSGLYARSDALADQLLGAGRKAMDTAWRLPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLARYTEKYDWAHLDI
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=329, Percent_Identity=44.6808510638298, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI47155554, Length=314, Percent_Identity=35.031847133758, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1790710, Length=513, Percent_Identity=48.9278752436647, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=37.9310344827586, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=33.6391437308869, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=212, Percent_Identity=33.0188679245283, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129969, Length=503, Percent_Identity=30.8151093439364, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161077148, Length=337, Percent_Identity=36.4985163204748, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20130057, Length=337, Percent_Identity=36.4985163204748, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=36.7601246105919, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=37.0820668693009, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=36.7601246105919, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355645, Length=333, Percent_Identity=35.7357357357357, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24662223, Length=333, Percent_Identity=35.7357357357357, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI20129963, Length=510, Percent_Identity=30.9803921568627, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19922386, Length=332, Percent_Identity=36.144578313253, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21357381, Length=311, Percent_Identity=33.4405144694534, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221379063, Length=311, Percent_Identity=33.4405144694534, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI221379062, Length=311, Percent_Identity=33.4405144694534, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646701, Length=370, Percent_Identity=27.2972972972973, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646703, Length=370, Percent_Identity=27.2972972972973, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21358201, Length=370, Percent_Identity=27.2972972972973, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53737; Mature: 53737

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTKALDLSKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVARLVKQGDF
CCCCCCHHHHHCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EGKRGTQLMLHEVAGVGAARVLLVGLGKEADFNDKAFAEAVRTATRALGGTRAASALWCL
CCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
VQQPPQQRDVAWAIITTITLVREAGYRLLERHPELKRAPRGAGANEKASLRKIVLAVDVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHCEEEEEEEEECC
DAKAASQAAVRGTAIANGMELTRDLGNLPSNICTPTYLANTARGIAKRHKLKVEILGRKQ
CCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHEEEEEEECCHH
IEALNMGAFLAVTKGSVEPPQFIVLRYDGASAKQAPVVLVGKGITFDTGGISLKPGEGMD
HHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHH
EMKYDMCGAASVLGTIQAVAEMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEE
LNTDAEGRLILCDALTYVERFKPAAVIDVATLTGACIIALGHVNSGLYARSDALADQLLG
EECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHH
AGRKAMDTAWRLPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLARYTEKYDWAHLDI
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFSTKALDLSKAGQNGFLATKTDCLVVGLFEGQSLAGVAKALDVATKGLVARLVKQGDF
CCCCCCHHHHHCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EGKRGTQLMLHEVAGVGAARVLLVGLGKEADFNDKAFAEAVRTATRALGGTRAASALWCL
CCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
VQQPPQQRDVAWAIITTITLVREAGYRLLERHPELKRAPRGAGANEKASLRKIVLAVDVG
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHCEEEEEEEEECC
DAKAASQAAVRGTAIANGMELTRDLGNLPSNICTPTYLANTARGIAKRHKLKVEILGRKQ
CCHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHEEEEEEECCHH
IEALNMGAFLAVTKGSVEPPQFIVLRYDGASAKQAPVVLVGKGITFDTGGISLKPGEGMD
HHHHCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHH
EMKYDMCGAASVLGTIQAVAEMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEE
LNTDAEGRLILCDALTYVERFKPAAVIDVATLTGACIIALGHVNSGLYARSDALADQLLG
EECCCCCCEEEEHHHHHHHHCCCCCEEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHH
AGRKAMDTAWRLPLDDDYQDQLKSNFADMANIGGRPAGSVTAACFLARYTEKYDWAHLDI
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
AGTAWKSGAAKGATGRPVPLLTQFLMDRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA