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The map label for this gene is ilvD [H]

Identifier: 94311736

GI number: 94311736

Start: 3051158

End: 3052831

Strand: Direct

Name: ilvD [H]

Synonym: Rmet_2804

Alternate gene names: 94311736

Gene position: 3051158-3052831 (Clockwise)

Preceding gene: 94311733

Following gene: 94311740

Centisome position: 77.68

GC content: 65.05

Gene sequence:

>1674_bases
ATGGCTTACAACAAACGTTCCCAGCACATCACGCAAGGCGTGGCGCGCTCCCCCAACCGTTCGATGTACTACGCGCTCGG
CTACAAGAAGGAAGACTTCGACAAGCCGATGGTGGGTATCGCCAACGGCCACTCGACGATCACCCCCTGCAACGCCGGCC
TGCAGCGCCTGGCGGACGCGGCCGTGGATGCGATCAAGGCCTCGGACGCCAACCCGCAGATCTTCGGCACGCCGACGATC
TCCGACGGCATGTCGATGGGCACCGAGGGCATGAAGTACTCGCTGATCTCGCGTGAAGTCATTGCCGACTGCATCGAAAC
CGCTGCCCAGGGCCAGTGGATGGACGGCGTGGTCGTGATCGGCGGCTGCGACAAGAACATGCCCGGCGGCATGATCGCAC
TGGCGCGCACCAACGTGCCGGGCATCTACGTCTACGGCGGCACCATCCGCCCGGGTAACTGGAAGGGCAAGGACCTGACC
ATCGTGTCGTCGTTCGAGGCCGTGGGCGAATTCACCGCCGGCCGCATGAGCGAGGAAGACTTCGAGGGCGTGGAGAAGAA
CGCCTGCCCGAGCACCGGCTCGTGCGGTGGCATGTACACCGCCAACACAATGAGCTCGTCGTTCGAGGCGCTGGGCATGT
CGCTGCTGAATTCGTCGACGATGGCCAACCCGGACCAGGAAAAGGTGGACAGCGCCGCCGAATCGGCCCGCGTGCTGGTG
GAAGCCATCAAGAAGGACATCAAGCCGCGCGACATCATCACGCGCAAATCGATCGAGAACGCCGTGACGCTGATCATGGC
CACGGGCGGTTCCACCAACGCGGTACTGCATTACCTGGCCATCGCCCACTCGGCCGAAGTGGAATGGACCATCGACGATT
TCGAGCGCATCCGCCGCCGCGTGCCGGTGATCTGCAACCTGAAGCCGTCGGGCGCCTACGTGGCCACCGACCTGCACCGC
GCCGGTGGCATTCCGCAAGTGATGAAGATCCTGCTGAACGCCGGTCTGCTGCATGGCGACTGCCTGACGATCACGGGCCG
CACGCTGGCCGAGGAGCTCGAGCACGTTCCCAATGAGCCGCGTACCGACCAGGACGTGATCCTGCCGATCTCGCAGGCCC
TGTACAAGCAAGGCCACCTGGCCATCCTGAAGGGCAACCTCGCCGAGGAAGGCGCAGTGGCCAAAATCACCGGCCTGAAG
AACCCGGTCATCACCGGCCCGGCCCGCGTGTTCGAGGACGAACAGAGCGCCATGGAAGCGATCCTGGCGGACAAGATCAA
CGCTGGCGACATCCTGGTGCTGCGCTACCTTGGCCCGAAGGGCGGCCCGGGCATGCCTGAAATGCTGGCGCCGACTTCGG
CGATCATCGGCAAGGGTCTCGGCGAATCGGTTGGTTTCATCACCGACGGCCGCTTCTCGGGGGGCACCTGGGGCATGGTG
GTTGGCCACGTTGCGCCGGAAGCCCATGTGGGCGGTACGATTGCACTGGTTCAGGAAGGCGACTCGATCACGATCGACGC
GCACCAGCTGCTGCTGCAACTGAATGTGGCCGACGACGAGCTGGCCCGCCGCCGCGCTGCCTGGAAACAGCCGGCGCCGC
GCTACACGCGCGGCGTACTGGCGAAGTTCGCGAGGCTGGCCTCCACGGCCAGCAAGGGCGCCGTGACGGACTGA

Upstream 100 bases:

>100_bases
AAAGGTCGAATCATATATTTGACACGATAAAACGCAAGCGCCATTCTTCTGACCACAACACGGCCACCCCGCCACCAGCC
CCCCCCCGGAGACACCCGCC

Downstream 100 bases:

>100_bases
TCCGGCGAAAGTAGCCCCCTGCAATGCAAAAGGCCTGCGAGTCCATCGCAGGCCTTTTTGCTTGGGTGCCGATACCGGCG
CGGGCCGGTAGCAAGGCCCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MAYNKRSQHITQGVARSPNRSMYYALGYKKEDFDKPMVGIANGHSTITPCNAGLQRLADAAVDAIKASDANPQIFGTPTI
SDGMSMGTEGMKYSLISREVIADCIETAAQGQWMDGVVVIGGCDKNMPGGMIALARTNVPGIYVYGGTIRPGNWKGKDLT
IVSSFEAVGEFTAGRMSEEDFEGVEKNACPSTGSCGGMYTANTMSSSFEALGMSLLNSSTMANPDQEKVDSAAESARVLV
EAIKKDIKPRDIITRKSIENAVTLIMATGGSTNAVLHYLAIAHSAEVEWTIDDFERIRRRVPVICNLKPSGAYVATDLHR
AGGIPQVMKILLNAGLLHGDCLTITGRTLAEELEHVPNEPRTDQDVILPISQALYKQGHLAILKGNLAEEGAVAKITGLK
NPVITGPARVFEDEQSAMEAILADKINAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAHVGGTIALVQEGDSITIDAHQLLLQLNVADDELARRRAAWKQPAPRYTRGVLAKFARLASTASKGAVTD

Sequences:

>Translated_557_residues
MAYNKRSQHITQGVARSPNRSMYYALGYKKEDFDKPMVGIANGHSTITPCNAGLQRLADAAVDAIKASDANPQIFGTPTI
SDGMSMGTEGMKYSLISREVIADCIETAAQGQWMDGVVVIGGCDKNMPGGMIALARTNVPGIYVYGGTIRPGNWKGKDLT
IVSSFEAVGEFTAGRMSEEDFEGVEKNACPSTGSCGGMYTANTMSSSFEALGMSLLNSSTMANPDQEKVDSAAESARVLV
EAIKKDIKPRDIITRKSIENAVTLIMATGGSTNAVLHYLAIAHSAEVEWTIDDFERIRRRVPVICNLKPSGAYVATDLHR
AGGIPQVMKILLNAGLLHGDCLTITGRTLAEELEHVPNEPRTDQDVILPISQALYKQGHLAILKGNLAEEGAVAKITGLK
NPVITGPARVFEDEQSAMEAILADKINAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAHVGGTIALVQEGDSITIDAHQLLLQLNVADDELARRRAAWKQPAPRYTRGVLAKFARLASTASKGAVTD
>Mature_556_residues
AYNKRSQHITQGVARSPNRSMYYALGYKKEDFDKPMVGIANGHSTITPCNAGLQRLADAAVDAIKASDANPQIFGTPTIS
DGMSMGTEGMKYSLISREVIADCIETAAQGQWMDGVVVIGGCDKNMPGGMIALARTNVPGIYVYGGTIRPGNWKGKDLTI
VSSFEAVGEFTAGRMSEEDFEGVEKNACPSTGSCGGMYTANTMSSSFEALGMSLLNSSTMANPDQEKVDSAAESARVLVE
AIKKDIKPRDIITRKSIENAVTLIMATGGSTNAVLHYLAIAHSAEVEWTIDDFERIRRRVPVICNLKPSGAYVATDLHRA
GGIPQVMKILLNAGLLHGDCLTITGRTLAEELEHVPNEPRTDQDVILPISQALYKQGHLAILKGNLAEEGAVAKITGLKN
PVITGPARVFEDEQSAMEAILADKINAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMVV
GHVAPEAHVGGTIALVQEGDSITIDAHQLLLQLNVADDELARRRAAWKQPAPRYTRGVLAKFARLASTASKGAVTD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=37.6237623762376, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI2367371, Length=507, Percent_Identity=35.5029585798817, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786464, Length=493, Percent_Identity=35.9026369168357, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788157, Length=469, Percent_Identity=31.9829424307036, Blast_Score=194, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=46.9750889679715, Blast_Score=513, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59181; Mature: 59050

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNKRSQHITQGVARSPNRSMYYALGYKKEDFDKPMVGIANGHSTITPCNAGLQRLADA
CCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
AVDAIKASDANPQIFGTPTISDGMSMGTEGMKYSLISREVIADCIETAAQGQWMDGVVVI
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARTNVPGIYVYGGTIRPGNWKGKDLTIVSSFEAVGEFTAGRMSEED
ECCCCCCCCCEEEEEECCCCEEEEECCEECCCCCCCCEEEEEECHHHHHHHHCCCCCCHH
FEGVEKNACPSTGSCGGMYTANTMSSSFEALGMSLLNSSTMANPDQEKVDSAAESARVLV
HCCCHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EAIKKDIKPRDIITRKSIENAVTLIMATGGSTNAVLHYLAIAHSAEVEWTIDDFERIRRR
HHHHHCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHC
VPVICNLKPSGAYVATDLHRAGGIPQVMKILLNAGLLHGDCLTITGRTLAEELEHVPNEP
CCEEEEECCCCCEEEECHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RTDQDVILPISQALYKQGHLAILKGNLAEEGAVAKITGLKNPVITGPARVFEDEQSAMEA
CCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHHCCHHHHHHH
ILADKINAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHHCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCCEEE
VGHVAPEAHVGGTIALVQEGDSITIDAHQLLLQLNVADDELARRRAAWKQPAPRYTRGVL
EECCCCCCCCCCEEEEEECCCEEEEEHHHEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKFARLASTASKGAVTD
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AYNKRSQHITQGVARSPNRSMYYALGYKKEDFDKPMVGIANGHSTITPCNAGLQRLADA
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
AVDAIKASDANPQIFGTPTISDGMSMGTEGMKYSLISREVIADCIETAAQGQWMDGVVVI
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARTNVPGIYVYGGTIRPGNWKGKDLTIVSSFEAVGEFTAGRMSEED
ECCCCCCCCCEEEEEECCCCEEEEECCEECCCCCCCCEEEEEECHHHHHHHHCCCCCCHH
FEGVEKNACPSTGSCGGMYTANTMSSSFEALGMSLLNSSTMANPDQEKVDSAAESARVLV
HCCCHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EAIKKDIKPRDIITRKSIENAVTLIMATGGSTNAVLHYLAIAHSAEVEWTIDDFERIRRR
HHHHHCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHC
VPVICNLKPSGAYVATDLHRAGGIPQVMKILLNAGLLHGDCLTITGRTLAEELEHVPNEP
CCEEEEECCCCCEEEECHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RTDQDVILPISQALYKQGHLAILKGNLAEEGAVAKITGLKNPVITGPARVFEDEQSAMEA
CCCCCEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHHCCHHHHHHH
ILADKINAGDILVLRYLGPKGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHHCCCCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCCEEE
VGHVAPEAHVGGTIALVQEGDSITIDAHQLLLQLNVADDELARRRAAWKQPAPRYTRGVL
EECCCCCCCCCCEEEEEECCCEEEEEHHHEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKFARLASTASKGAVTD
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA