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The map label for this gene is fdhC [H]

Identifier: 94311690

GI number: 94311690

Start: 2998940

End: 3000133

Strand: Reverse

Name: fdhC [H]

Synonym: Rmet_2758

Alternate gene names: 94311690

Gene position: 3000133-2998940 (Counterclockwise)

Preceding gene: 94311691

Following gene: 94311689

Centisome position: 76.38

GC content: 66.0

Gene sequence:

>1194_bases
ATGACGCGGCTTTCACGTACAGGACGGTGGCTAGCCGGCGCGCTGATGACGCTGGCGATGGCCGGCGCGTTCGCGCAGGC
GCCAGCTTCGGCACCGCAGGCGCAACAGTCCGCCACGCAGTCCGCCACACAGTCCGATAACGCAAACAACCCGGCCACGC
ACCCCGCGCAGCCGTTCGCGGGCATTGCGAGCGAGAACATCTTCAATGTGCCGCGCCGCGACATGGCCGCCGAGGCGCGT
GCGCAGCAGGAGCGTTCGCAGACGCAGCCGGGCAACAATGCGCCGGTCTGGCGCGAGGCGAACTCCGACCAGCCGAACTA
CAGCAGCCTGCCGGCCAAGGAAGCTGGTGTGCTGATCCAGCGCACGGGTCAGAAGTGGCGTCTGTTCCGCAATGGCGTGA
TCACGGTGTGGGGTGGCTGGCTGGTGTTGATCGTGCCGCTGGCGATCCTGGCGTTCTTCGCCTGGCGGGGCACGATTCCG
CTCAAGACACCGCGCACGGGCCGCATGATCGAACGCTTCACGCCGCTGGAACGCATCGTGCACTGGACCATGGCGATCTC
GTTCTCGATCCTGGCGATCTCGGGCCTCGTGATCCTGTTTGGCAAGCACGTCCTGCTGCCGATCTTCGGCCATACGCTGT
TCGGATGGCTCACGTACATCCTCAAGAACCTGCATAACCTGAGCGGGCCGGTGTTCACGGTTGCGATCGTCGTTGCCTTC
GTGCTCTTCGTGCGCGACAACCTGCCCAGCCGCGACGACCTGACGTGGATCGCGCGGGCAGGGGGGCTGCTCACGGGCAG
CCACGTGCCGAGTCACCGTTTCAACGCCGGCGAAAAGCTCTGGTTCTGGGTCGGACTGGTCTTTTTTGGGCTGATCCTGT
CTGCGTCGGGGTGGGTGCTCGACATGATCGTGCCGGGCCTGGAGTACTACCGCGCCACGATGCAGATCGCCAACGTCATC
CACGCGATCGCCGCGGTGCTGATGATCGCGCTGGCCTGCGGCCATATCTACATGGGCACGATCGGCATGGAAGGCGCCTA
CCGCGCCATGCGCGATGGCTACGTGGACGAGGCCTGGGCCCAGGAGCACCACGAGCACTGGTACGACGATATCAAGGCCG
GCAAGATCCCCGCGCAGCGTTCCACACCGCCGGAGGACGCGGGCCGTAGCCGCCAGCGTCCGGGGCAGGCTTGA

Upstream 100 bases:

>100_bases
ACGCCGGGTGACAGGGATAGCTGGGTGCGCCAGATCCATGAGCGCAACCAGTACCAGAACGAGTACAACAAGACGCCGTG
AGCGCCGGCAAGGAGGGCTT

Downstream 100 bases:

>100_bases
TCATGTGCATTGGCACGGCGTTGCAGTTTGCGGCAGTCGTATGTGCAGGTCAGGCGTACAATCGCCCGGGCTTTTAACCG
CAAGAGGAGGGCTCGGCATG

Product: Formate dehydrogenase subunit C

Products: CO2; NADH

Alternate protein names: Aerobic formate dehydrogenase cytochrome b556 subunit; FDH-Z subunit gamma; Formate dehydrogenase-O subunit gamma [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTRLSRTGRWLAGALMTLAMAGAFAQAPASAPQAQQSATQSATQSDNANNPATHPAQPFAGIASENIFNVPRRDMAAEAR
AQQERSQTQPGNNAPVWREANSDQPNYSSLPAKEAGVLIQRTGQKWRLFRNGVITVWGGWLVLIVPLAILAFFAWRGTIP
LKTPRTGRMIERFTPLERIVHWTMAISFSILAISGLVILFGKHVLLPIFGHTLFGWLTYILKNLHNLSGPVFTVAIVVAF
VLFVRDNLPSRDDLTWIARAGGLLTGSHVPSHRFNAGEKLWFWVGLVFFGLILSASGWVLDMIVPGLEYYRATMQIANVI
HAIAAVLMIALACGHIYMGTIGMEGAYRAMRDGYVDEAWAQEHHEHWYDDIKAGKIPAQRSTPPEDAGRSRQRPGQA

Sequences:

>Translated_397_residues
MTRLSRTGRWLAGALMTLAMAGAFAQAPASAPQAQQSATQSATQSDNANNPATHPAQPFAGIASENIFNVPRRDMAAEAR
AQQERSQTQPGNNAPVWREANSDQPNYSSLPAKEAGVLIQRTGQKWRLFRNGVITVWGGWLVLIVPLAILAFFAWRGTIP
LKTPRTGRMIERFTPLERIVHWTMAISFSILAISGLVILFGKHVLLPIFGHTLFGWLTYILKNLHNLSGPVFTVAIVVAF
VLFVRDNLPSRDDLTWIARAGGLLTGSHVPSHRFNAGEKLWFWVGLVFFGLILSASGWVLDMIVPGLEYYRATMQIANVI
HAIAAVLMIALACGHIYMGTIGMEGAYRAMRDGYVDEAWAQEHHEHWYDDIKAGKIPAQRSTPPEDAGRSRQRPGQA
>Mature_396_residues
TRLSRTGRWLAGALMTLAMAGAFAQAPASAPQAQQSATQSATQSDNANNPATHPAQPFAGIASENIFNVPRRDMAAEARA
QQERSQTQPGNNAPVWREANSDQPNYSSLPAKEAGVLIQRTGQKWRLFRNGVITVWGGWLVLIVPLAILAFFAWRGTIPL
KTPRTGRMIERFTPLERIVHWTMAISFSILAISGLVILFGKHVLLPIFGHTLFGWLTYILKNLHNLSGPVFTVAIVVAFV
LFVRDNLPSRDDLTWIARAGGLLTGSHVPSHRFNAGEKLWFWVGLVFFGLILSASGWVLDMIVPGLEYYRATMQIANVIH
AIAAVLMIALACGHIYMGTIGMEGAYRAMRDGYVDEAWAQEHHEHWYDDIKAGKIPAQRSTPPEDAGRSRQRPGQA

Specific function: Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase [H]

COG id: COG2864

COG function: function code C; Cytochrome b subunit of formate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate dehydrogenase gamma subunit family [H]

Homologues:

Organism=Escherichia coli, GI1790325, Length=210, Percent_Identity=30.4761904761905, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787750, Length=218, Percent_Identity=29.3577981651376, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005797
- InterPro:   IPR016174
- InterPro:   IPR006471 [H]

Pfam domain/function: PF00033 Cytochrom_B_N [H]

EC number: 1.2.1.2

Molecular weight: Translated: 43783; Mature: 43652

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLSRTGRWLAGALMTLAMAGAFAQAPASAPQAQQSATQSATQSDNANNPATHPAQPFA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
GIASENIFNVPRRDMAAEARAQQERSQTQPGNNAPVWREANSDQPNYSSLPAKEAGVLIQ
HHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHHCHHHH
RTGQKWRLFRNGVITVWGGWLVLIVPLAILAFFAWRGTIPLKTPRTGRMIERFTPLERIV
HCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
HWTMAISFSILAISGLVILFGKHVLLPIFGHTLFGWLTYILKNLHNLSGPVFTVAIVVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLFVRDNLPSRDDLTWIARAGGLLTGSHVPSHRFNAGEKLWFWVGLVFFGLILSASGWVL
HHHHHCCCCCCCCHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
DMIVPGLEYYRATMQIANVIHAIAAVLMIALACGHIYMGTIGMEGAYRAMRDGYVDEAWA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHH
QEHHEHWYDDIKAGKIPAQRSTPPEDAGRSRQRPGQA
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TRLSRTGRWLAGALMTLAMAGAFAQAPASAPQAQQSATQSATQSDNANNPATHPAQPFA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHH
GIASENIFNVPRRDMAAEARAQQERSQTQPGNNAPVWREANSDQPNYSSLPAKEAGVLIQ
HHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHHCHHHH
RTGQKWRLFRNGVITVWGGWLVLIVPLAILAFFAWRGTIPLKTPRTGRMIERFTPLERIV
HCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
HWTMAISFSILAISGLVILFGKHVLLPIFGHTLFGWLTYILKNLHNLSGPVFTVAIVVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VLFVRDNLPSRDDLTWIARAGGLLTGSHVPSHRFNAGEKLWFWVGLVFFGLILSASGWVL
HHHHHCCCCCCCCHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHH
DMIVPGLEYYRATMQIANVIHAIAAVLMIALACGHIYMGTIGMEGAYRAMRDGYVDEAWA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHH
QEHHEHWYDDIKAGKIPAQRSTPPEDAGRSRQRPGQA
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate; NAD+

Specific reaction: formate + NAD+ = CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]