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The map label for this gene is thrB

Identifier: 94311563

GI number: 94311563

Start: 2860222

End: 2861208

Strand: Direct

Name: thrB

Synonym: Rmet_2627

Alternate gene names: 94311563

Gene position: 2860222-2861208 (Clockwise)

Preceding gene: 94311562

Following gene: 94311564

Centisome position: 72.81

GC content: 64.34

Gene sequence:

>987_bases
ATGGCCGTTTTCACCACGGTCTCGCAGGACGAGATCGCCCGCTGGCTGCTTGACTATGACCTTGGCGAAGTGCGCGCGCT
GCGCGGCATTGCCTCGGGCATCGAGAACAGCAACTTTTTCCTGACCATGGAGCAGGATGGCGTCACACGTGAGTACGTAC
TGACGATCTTTGAACGGCTGCAATTCGACCAGCTGCCGTATTACCTGCACCTGATGGACCATCTGGCACGACACGGCATC
TGCGTGCCGGCGCCGATGCCAGCCCGCGACGGCGAGATCCTGCGCGAACTGAAGGGCAAGCCGGCGACCATCGTCACGCG
CCTGCCCGGCGCCTCGCAACTTGCGCCGCAGCCCGACCATTGCGCCGAAGTCGGTGCAATGCTGGCGCGCATGCATATCG
CCGGCCAGGACTATCCACGCAAGCAGCCGAATCTGCGCAGCCTGGCATGGTGGCAGCAAACCACCCCGGAAATCACACCT
TTCCTCGATGCCGCGCAGCGCAAGCTGCTGACCGAGGAAATCGCGCACCAGACCGCGTTTTTCGGCAGCGGTGACTACGC
CGCGCTGCAGGGTGGCCCTTGCCACTGCGACCTGTTCCGCGACAACGCGCTGTTCGACACTGACAGCGCCGGCAACCACC
GGCTCGGCGGCTTCTTCGATTTCTACTTTGCCGGCGACGACAAATGGCTGTTCGACCTGGCCGTCACCGTCAACGACTGG
TGCATCGACCTCGCGACCGGCACCATCGACATGGAACGTGCGCAGGCCATGCTGCGGGCTTATCATGCGGTCAGGCCCCT
GACGGCAGTGGAGGCGGCGCACTGGCAAGATATGCTGCGCGCTGGCGCACTGCGCTTCTGGGTATCGCGCCTGTGGGATT
TCTACCTGCCGCGCGAGGCCGATATGCTCCAGCCGCACGATCCGACCCACTTCGAACGCATCCTGCGCCGCCGCATCGAC
GACGCCGCAGCGCTCCCCTGGATCTGA

Upstream 100 bases:

>100_bases
GAAGGTCGCGCCGGCCCTCCGGCAGTGATGCCGCGGCGGCGAACCGCCATTGCCATCCGCCCTCGGTTCGTCGCGTCCCG
AATTGCACCAACAGAACAGT

Downstream 100 bases:

>100_bases
TTCGCCATGCAACTACTGGAAGTTTCCGCCAAGGAAGGCTACGTCTGGTTCCGCCAGGGCATCTGGCTGTTCCGCAAGAA
CCCGCTGGCATTCCTGATGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAVFTTVSQDEIARWLLDYDLGEVRALRGIASGIENSNFFLTMEQDGVTREYVLTIFERLQFDQLPYYLHLMDHLARHGI
CVPAPMPARDGEILRELKGKPATIVTRLPGASQLAPQPDHCAEVGAMLARMHIAGQDYPRKQPNLRSLAWWQQTTPEITP
FLDAAQRKLLTEEIAHQTAFFGSGDYAALQGGPCHCDLFRDNALFDTDSAGNHRLGGFFDFYFAGDDKWLFDLAVTVNDW
CIDLATGTIDMERAQAMLRAYHAVRPLTAVEAAHWQDMLRAGALRFWVSRLWDFYLPREADMLQPHDPTHFERILRRRID
DAAALPWI

Sequences:

>Translated_328_residues
MAVFTTVSQDEIARWLLDYDLGEVRALRGIASGIENSNFFLTMEQDGVTREYVLTIFERLQFDQLPYYLHLMDHLARHGI
CVPAPMPARDGEILRELKGKPATIVTRLPGASQLAPQPDHCAEVGAMLARMHIAGQDYPRKQPNLRSLAWWQQTTPEITP
FLDAAQRKLLTEEIAHQTAFFGSGDYAALQGGPCHCDLFRDNALFDTDSAGNHRLGGFFDFYFAGDDKWLFDLAVTVNDW
CIDLATGTIDMERAQAMLRAYHAVRPLTAVEAAHWQDMLRAGALRFWVSRLWDFYLPREADMLQPHDPTHFERILRRRID
DAAALPWI
>Mature_327_residues
AVFTTVSQDEIARWLLDYDLGEVRALRGIASGIENSNFFLTMEQDGVTREYVLTIFERLQFDQLPYYLHLMDHLARHGIC
VPAPMPARDGEILRELKGKPATIVTRLPGASQLAPQPDHCAEVGAMLARMHIAGQDYPRKQPNLRSLAWWQQTTPEITPF
LDAAQRKLLTEEIAHQTAFFGSGDYAALQGGPCHCDLFRDNALFDTDSAGNHRLGGFFDFYFAGDDKWLFDLAVTVNDWC
IDLATGTIDMERAQAMLRAYHAVRPLTAVEAAHWQDMLRAGALRFWVSRLWDFYLPREADMLQPHDPTHFERILRRRIDD
AAALPWI

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_RALME (Q1LK22)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584773.1
- ProteinModelPortal:   Q1LK22
- SMR:   Q1LK22
- STRING:   Q1LK22
- GeneID:   4039453
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2627
- eggNOG:   COG2334
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   PRK05231
- BioCyc:   RMET266264:RMET_2627-MONOMER
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 37361; Mature: 37230

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFTTVSQDEIARWLLDYDLGEVRALRGIASGIENSNFFLTMEQDGVTREYVLTIFERL
CCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
QFDQLPYYLHLMDHLARHGICVPAPMPARDGEILRELKGKPATIVTRLPGASQLAPQPDH
HHHCCCHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
CAEVGAMLARMHIAGQDYPRKQPNLRSLAWWQQTTPEITPFLDAAQRKLLTEEIAHQTAF
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
FGSGDYAALQGGPCHCDLFRDNALFDTDSAGNHRLGGFFDFYFAGDDKWLFDLAVTVNDW
CCCCCEEEECCCCCEEEEECCCCEECCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCE
CIDLATGTIDMERAQAMLRAYHAVRPLTAVEAAHWQDMLRAGALRFWVSRLWDFYLPREA
EEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DMLQPHDPTHFERILRRRIDDAAALPWI
CCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVFTTVSQDEIARWLLDYDLGEVRALRGIASGIENSNFFLTMEQDGVTREYVLTIFERL
CEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
QFDQLPYYLHLMDHLARHGICVPAPMPARDGEILRELKGKPATIVTRLPGASQLAPQPDH
HHHCCCHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
CAEVGAMLARMHIAGQDYPRKQPNLRSLAWWQQTTPEITPFLDAAQRKLLTEEIAHQTAF
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
FGSGDYAALQGGPCHCDLFRDNALFDTDSAGNHRLGGFFDFYFAGDDKWLFDLAVTVNDW
CCCCCEEEECCCCCEEEEECCCCEECCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCE
CIDLATGTIDMERAQAMLRAYHAVRPLTAVEAAHWQDMLRAGALRFWVSRLWDFYLPREA
EEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DMLQPHDPTHFERILRRRIDDAAALPWI
CCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA