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The map label for this gene is gcp

Identifier: 94311548

GI number: 94311548

Start: 2841236

End: 2841961

Strand: Direct

Name: gcp

Synonym: Rmet_2612

Alternate gene names: 94311548

Gene position: 2841236-2841961 (Clockwise)

Preceding gene: 94311547

Following gene: 94311549

Centisome position: 72.33

GC content: 66.12

Gene sequence:

>726_bases
ATGATCGGCGTGCACCATCTGGAAGGCCATCTGCTCTCGCCACTGCTGACGAGTGCCCCGCCGCCGTTCCCGTTCGTGGC
GCTGCTGGTGTCTGGTGGGCACACCCAGCTCATGGAAGTAAAGGGCATCGGCGACTACAAGCTACTCGGCGAAACGCTCG
ACGACGCCGCCGGCGAAGCATTCGACAAGACCGCCAAGCTGCTGGGCCTCGGGTATCCGGGCGGCCCGGAAGTGTCGCGG
CTGGCCGAATTCGGCAACCCCGGCGCCTTCGAACTGCCCCGGCCGATGCTGCATTCTGGCAATCTCGATTTCTCGTTCGC
TGGCCTCAAGACCGCCGTGCTGACGCAGACACGCAAGCTCAGCAATGCCTGCGAGCAGGACCGCGCCAATCTGGCGCGCG
CGTTCGTCGATGCGATCGTCGACGTACTGGCCGCCAAGTCGTTCGCCGCGCTCAAGCAGACCGGCGACAAGCGTCTCGTG
GTTGCGGGCGGCGTGGGCGCGAATCGGCAACTGCGCGAACGGCTCAATGAGATGGGCAAGCGCCGCAAGGTCGAGGTGTT
CTACCCCGATCTGGCGTTCTGCACCGACAATGGCGCGATGATCGCGTTCGCCGGCGCGATGCGCCTGAAGGCCGCGCCAG
AGCTTGCCCGGCACGGCTACGACTATGGCGTGACGCCACGGTGGGATCTGGCCGATATCCGCCTGCCCGAGGCCCGGACT
TCGTAG

Upstream 100 bases:

>100_bases
CATCGACGCCATCGCTTACACGCAGGGCCCCGGACTTGCCGGCGCGCTGCTGGTGGGCGCATCGGTGGCCAATGCGCTGG
GCTTCGCGCTCGGTGTGCCG

Downstream 100 bases:

>100_bases
AAAAGCGCTAATCGAGCTGACATCCAGACACATGGCGGTCACGGGACCACCGAACAATTTGCGATTCCTGCATCACATAA
CAAGGAAGGGAACGCAAAGT

Product: O-sialoglycoprotein endopeptidase (fragment)

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEAFDKTAKLLGLGYPGGPEVSR
LAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKLSNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLV
VAGGVGANRQLRERLNEMGKRRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEART
S

Sequences:

>Translated_241_residues
MIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEAFDKTAKLLGLGYPGGPEVSR
LAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKLSNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLV
VAGGVGANRQLRERLNEMGKRRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEART
S
>Mature_241_residues
MIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEAFDKTAKLLGLGYPGGPEVSR
LAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKLSNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLV
VAGGVGANRQLRERLNEMGKRRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEART
S

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=232, Percent_Identity=32.7586206896552, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI8923380, Length=243, Percent_Identity=29.2181069958848, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1789445, Length=232, Percent_Identity=60.3448275862069, Blast_Score=264, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI71995670, Length=216, Percent_Identity=32.4074074074074, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557464, Length=223, Percent_Identity=28.2511210762332, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320099, Length=263, Percent_Identity=31.9391634980989, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322891, Length=230, Percent_Identity=26.9565217391304, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129063, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357207, Length=229, Percent_Identity=28.82096069869, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_RALME (Q1LK37)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584758.1
- ProteinModelPortal:   Q1LK37
- SMR:   Q1LK37
- STRING:   Q1LK37
- MEROPS:   M22.001
- GeneID:   4039438
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2612
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- BioCyc:   RMET266264:RMET_2612-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 25928; Mature: 25928

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEA
CCCCCCCCCHHHHHHHHCCCCCCCEEHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
FDKTAKLLGLGYPGGPEVSRLAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKL
HHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHH
SNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLVVAGGVGANRQLRERLNEMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
RRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEART
HCEEEEEECCEEEEECCCCEEEEECHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
S
C
>Mature Secondary Structure
MIGVHHLEGHLLSPLLTSAPPPFPFVALLVSGGHTQLMEVKGIGDYKLLGETLDDAAGEA
CCCCCCCCCHHHHHHHHCCCCCCCEEHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
FDKTAKLLGLGYPGGPEVSRLAEFGNPGAFELPRPMLHSGNLDFSFAGLKTAVLTQTRKL
HHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHH
SNACEQDRANLARAFVDAIVDVLAAKSFAALKQTGDKRLVVAGGVGANRQLRERLNEMGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
RRKVEVFYPDLAFCTDNGAMIAFAGAMRLKAAPELARHGYDYGVTPRWDLADIRLPEART
HCEEEEEECCEEEEECCCCEEEEECHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA