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The map label for this gene is frlR [H]

Identifier: 94311424

GI number: 94311424

Start: 2700495

End: 2701349

Strand: Reverse

Name: frlR [H]

Synonym: Rmet_2488

Alternate gene names: 94311424

Gene position: 2701349-2700495 (Counterclockwise)

Preceding gene: 94311431

Following gene: 94311422

Centisome position: 68.77

GC content: 64.09

Gene sequence:

>855_bases
ATGTCATCCCTGCCTACGTCCCTGCCCGCAGCCGCCGCCAATGGCGCGCCGGAATCGGGCGCCCCCCAAAGCGGCGCCGG
GACGCAGCCGTCCACGAACGCGCCGGGCGCTGCAGTCGCCCCCGCGACGGCCGCGCCGTCGCCGACTTTCAGCCCACTTT
ACCAGCAGATCAAGGCCCTGATCATGCAAAGCCTGCAGACGGGCGAGTGGAAGCCGGGCGAAATGATTCCGAGCGAGATG
GATCTGGCTGCCCGCTACAAGGTGAGCCAAGGCACCGTGCGCAAGGCCATCGACGAACTGGCCGCCGAGAATCTGGTGGC
GCGTCGTCAGGGCAAGGGCACGTTCGTGACTACCCATTATGAGGACGTGGTTAAATTCCGCTTCCTCCGCCTGGTACCCG
ACGAGGGTGAGCCCCATTACGGCTCCAGCCGCGTGCTCGAATGCAAGCGGTTGCGCGCGCCTGCCGAGATCGCCCGCCTG
CTCGATATTCGCACTGGCGATAGCGTGGTGCAGATCCGCCGCGTGCTGACTTTCTCGAATGAAGCCACGGTGCTGGACGA
GATCTGGCTACTGGGCGCCAACTTCAAGGGCCTGACGGCCGAAAAGCTCAACGAGTGGAAGGGCCCGATGTACGCGCTCT
TCGAGGGCGAGTTCGGTACGCGGATGATCCGCGCCACGGAGAAGATCCGTGCGGTGGTTGCCGATGATACGGCGGCGGAA
TTGCTGTCGGTGGCACCGGGCTCACCGCTGCTATCGGTGGAGCGTGTCTCATTCACATATGGTGACCGCCCGGTGGAAGT
CCGCCGCGGTCTGTATGTCACGACGCGGCACTATTACCAAAACGACTTGAGTTAA

Upstream 100 bases:

>100_bases
GTGAGCCCTGATTGATGTCAATTCATATGTCTTATATAAGACATAAGACATTTCATAGCGTGCTGGACGTGATTCTCGCT
TTTGTGGTTGAATCCGGGCT

Downstream 100 bases:

>100_bases
TGCGCGATGGCGATGGGGGAGCGGTCCAGGGCGTCGATTATTGTGGCGCGTGTATGGGACCTGCTTCAACCATTGTTGAG
CGTGAATGGAATGGCCAGAT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSSLPTSLPAAAANGAPESGAPQSGAGTQPSTNAPGAAVAPATAAPSPTFSPLYQQIKALIMQSLQTGEWKPGEMIPSEM
DLAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHYEDVVKFRFLRLVPDEGEPHYGSSRVLECKRLRAPAEIARL
LDIRTGDSVVQIRRVLTFSNEATVLDEIWLLGANFKGLTAEKLNEWKGPMYALFEGEFGTRMIRATEKIRAVVADDTAAE
LLSVAPGSPLLSVERVSFTYGDRPVEVRRGLYVTTRHYYQNDLS

Sequences:

>Translated_284_residues
MSSLPTSLPAAAANGAPESGAPQSGAGTQPSTNAPGAAVAPATAAPSPTFSPLYQQIKALIMQSLQTGEWKPGEMIPSEM
DLAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHYEDVVKFRFLRLVPDEGEPHYGSSRVLECKRLRAPAEIARL
LDIRTGDSVVQIRRVLTFSNEATVLDEIWLLGANFKGLTAEKLNEWKGPMYALFEGEFGTRMIRATEKIRAVVADDTAAE
LLSVAPGSPLLSVERVSFTYGDRPVEVRRGLYVTTRHYYQNDLS
>Mature_283_residues
SSLPTSLPAAAANGAPESGAPQSGAGTQPSTNAPGAAVAPATAAPSPTFSPLYQQIKALIMQSLQTGEWKPGEMIPSEMD
LAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHYEDVVKFRFLRLVPDEGEPHYGSSRVLECKRLRAPAEIARLL
DIRTGDSVVQIRRVLTFSNEATVLDEIWLLGANFKGLTAEKLNEWKGPMYALFEGEFGTRMIRATEKIRAVVADDTAAEL
LSVAPGSPLLSVERVSFTYGDRPVEVRRGLYVTTRHYYQNDLS

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=222, Percent_Identity=27.4774774774775, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790540, Length=223, Percent_Identity=28.6995515695067, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786950, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790118, Length=212, Percent_Identity=27.3584905660377, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788418, Length=233, Percent_Identity=24.8927038626609, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 30911; Mature: 30780

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPTSLPAAAANGAPESGAPQSGAGTQPSTNAPGAAVAPATAAPSPTFSPLYQQIKAL
CCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
IMQSLQTGEWKPGEMIPSEMDLAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHY
HHHHHHCCCCCCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
EDVVKFRFLRLVPDEGEPHYGSSRVLECKRLRAPAEIARLLDIRTGDSVVQIRRVLTFSN
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
EATVLDEIWLLGANFKGLTAEKLNEWKGPMYALFEGEFGTRMIRATEKIRAVVADDTAAE
CCHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHH
LLSVAPGSPLLSVERVSFTYGDRPVEVRRGLYVTTRHYYQNDLS
HHHCCCCCCCEEEEEEEEECCCCCHHHHCCEEEEEHHHHHCCCC
>Mature Secondary Structure 
SSLPTSLPAAAANGAPESGAPQSGAGTQPSTNAPGAAVAPATAAPSPTFSPLYQQIKAL
CCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
IMQSLQTGEWKPGEMIPSEMDLAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHY
HHHHHHCCCCCCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHH
EDVVKFRFLRLVPDEGEPHYGSSRVLECKRLRAPAEIARLLDIRTGDSVVQIRRVLTFSN
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCC
EATVLDEIWLLGANFKGLTAEKLNEWKGPMYALFEGEFGTRMIRATEKIRAVVADDTAAE
CCHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHH
LLSVAPGSPLLSVERVSFTYGDRPVEVRRGLYVTTRHYYQNDLS
HHHCCCCCCCEEEEEEEEECCCCCHHHHCCEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]