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The map label for this gene is asd [H]

Identifier: 94311407

GI number: 94311407

Start: 2684226

End: 2685362

Strand: Reverse

Name: asd [H]

Synonym: Rmet_2471

Alternate gene names: 94311407

Gene position: 2685362-2684226 (Counterclockwise)

Preceding gene: 94311408

Following gene: 94311406

Centisome position: 68.36

GC content: 63.32

Gene sequence:

>1137_bases
ATGATTGTAGGTCTCGTCGGTTGGCGAGGAATGGTCGGCAGCGTCCTGATGCAGCGCATGCAGGAAGAAGGTGATTTCGA
CCACTTCGAACCCATTTTCTTCAGCACGTCCAACGCGGGTGGCAAGGCTCCGGCCATGGCCAAGAATGAAACCACGCTGA
AGGACGCGAATGACATCGAAGCGCTGAAGAAGTGCGACGTGGTGCTCACCGCCCAGGGCGGCGACTACACCAACGACGTC
TTCCCGCGACTGCGCGCAGCCGGCTGGAATGGCTACTGGATCGACGCCGCATCGTCGCTTCGCATGAAGGACGACGCGAT
CATCGTGCTCGATCCGGTGAACATGGGTGTGATCAAGGACGCGCTGAAGAAGGGCGTCAAGAATTTCATCGGTGGCAATT
GCACCGTGAGTTGCATGCTGATGGGTCTGGGTGGCCTGTTCGAGCATGACTTGGTCGAGTGGATGACCTCGATGACGTAC
CAGGCCGCTTCGGGCGGTGGCGCCCAGCATATGCGCGAGCTGCTGACCCAGTTCGGCACGCTGAACGCCGCGGTCAAGCC
GCTGCTGGACAACCCGGCCTCGGCCATCCTGGAGATCGACCGTCAGATCCTGTCGACCCAGCACGGCCTGTCTGCCGACG
AAACCAAGCAGTTCGGCGTGCCGCTGGCCGGGAACCTGATCCCCTGGATCGACAAGGACCTCGGTAACGGCGTGTCGCGC
GAGGAATGGAAGGGCGGCGCCGAGACCAACAAGATTCTGGGTCGTGGCGAAGGCTTCCTGGGCGCCACCGGCGCCAGCCC
GATCGCCGTGGATGGCCTGTGCGTGCGGATCGGCGCGATGCGCTGCCACTCGCAGGCACTGACGATCAAGCTCCGCAAGG
ACGTGCCGCTGGACGAGATCGAAGGCATGCTGGCCGCCAACAACCAATGGGCCAAGGTGGTGCCGAATACGCGTGAGGCC
AGCATGAAGGACCTGACGCCGGCCGCCGTGACCGGCACGCTGACGATTCCGGTCGGTCGCCTGCGCAAGATGCAGATGGG
CGGCGAATACCTCTCGGCGTTCACCGTTGGCGACCAGTTGCTCTGGGGCGCCGCCGAGCCGCTGCGTCGTATGCTGCGCA
TTCTGATCGAGGGTTGA

Upstream 100 bases:

>100_bases
CGATCCCCTAGATCGTTCGTCGTGCCTGCCCGTCTTCCCCGCGCAGCCACGCCGGGCGAGGAAAATGGCGGGGAAGTTCA
CATCACATCCGAGGTAAGTC

Downstream 100 bases:

>100_bases
TTCCCGAACTTGCCTCGCCGCATCGTTGCAGCGAGGCAACAGAATCTGCTGCTTTGCCTGCAACGCCGCGCCACAGCGCG
GCGTTGTTGCATCCGGGTGG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MIVGLVGWRGMVGSVLMQRMQEEGDFDHFEPIFFSTSNAGGKAPAMAKNETTLKDANDIEALKKCDVVLTAQGGDYTNDV
FPRLRAAGWNGYWIDAASSLRMKDDAIIVLDPVNMGVIKDALKKGVKNFIGGNCTVSCMLMGLGGLFEHDLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNAAVKPLLDNPASAILEIDRQILSTQHGLSADETKQFGVPLAGNLIPWIDKDLGNGVSR
EEWKGGAETNKILGRGEGFLGATGASPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAANNQWAKVVPNTREA
SMKDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIEG

Sequences:

>Translated_378_residues
MIVGLVGWRGMVGSVLMQRMQEEGDFDHFEPIFFSTSNAGGKAPAMAKNETTLKDANDIEALKKCDVVLTAQGGDYTNDV
FPRLRAAGWNGYWIDAASSLRMKDDAIIVLDPVNMGVIKDALKKGVKNFIGGNCTVSCMLMGLGGLFEHDLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNAAVKPLLDNPASAILEIDRQILSTQHGLSADETKQFGVPLAGNLIPWIDKDLGNGVSR
EEWKGGAETNKILGRGEGFLGATGASPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAANNQWAKVVPNTREA
SMKDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIEG
>Mature_378_residues
MIVGLVGWRGMVGSVLMQRMQEEGDFDHFEPIFFSTSNAGGKAPAMAKNETTLKDANDIEALKKCDVVLTAQGGDYTNDV
FPRLRAAGWNGYWIDAASSLRMKDDAIIVLDPVNMGVIKDALKKGVKNFIGGNCTVSCMLMGLGGLFEHDLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNAAVKPLLDNPASAILEIDRQILSTQHGLSADETKQFGVPLAGNLIPWIDKDLGNGVSR
EEWKGGAETNKILGRGEGFLGATGASPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAANNQWAKVVPNTREA
SMKDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIEG

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=375, Percent_Identity=66.4, Blast_Score=501, Evalue=1e-143,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40737; Mature: 40737

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGLVGWRGMVGSVLMQRMQEEGDFDHFEPIFFSTSNAGGKAPAMAKNETTLKDANDIE
CEEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
ALKKCDVVLTAQGGDYTNDVFPRLRAAGWNGYWIDAASSLRMKDDAIIVLDPVNMGVIKD
HHHHCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCHHHHHH
ALKKGVKNFIGGNCTVSCMLMGLGGLFEHDLVEWMTSMTYQAASGGGAQHMRELLTQFGT
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
LNAAVKPLLDNPASAILEIDRQILSTQHGLSADETKQFGVPLAGNLIPWIDKDLGNGVSR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHCCCCCH
EEWKGGAETNKILGRGEGFLGATGASPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEI
HHCCCCCCHHHHHCCCCCCEECCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHH
EGMLAANNQWAKVVPNTREASMKDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQL
CCHHHCCCCCEEECCCCCCCHHHCCCCHHEEEEEEECHHHHHHHHHCCHHHHHHHHHHHH
LWGAAEPLRRMLRILIEG
HHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVGLVGWRGMVGSVLMQRMQEEGDFDHFEPIFFSTSNAGGKAPAMAKNETTLKDANDIE
CEEEEECHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
ALKKCDVVLTAQGGDYTNDVFPRLRAAGWNGYWIDAASSLRMKDDAIIVLDPVNMGVIKD
HHHHCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCHHHHHH
ALKKGVKNFIGGNCTVSCMLMGLGGLFEHDLVEWMTSMTYQAASGGGAQHMRELLTQFGT
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
LNAAVKPLLDNPASAILEIDRQILSTQHGLSADETKQFGVPLAGNLIPWIDKDLGNGVSR
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHCCCCCH
EEWKGGAETNKILGRGEGFLGATGASPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEI
HHCCCCCCHHHHHCCCCCCEECCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHH
EGMLAANNQWAKVVPNTREASMKDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQL
CCHHHCCCCCEEECCCCCCCHHHCCCCHHEEEEEEECHHHHHHHHHCCHHHHHHHHHHHH
LWGAAEPLRRMLRILIEG
HHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]