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The map label for this gene is mucD [H]

Identifier: 94311358

GI number: 94311358

Start: 2631803

End: 2633308

Strand: Reverse

Name: mucD [H]

Synonym: Rmet_2422

Alternate gene names: 94311358

Gene position: 2633308-2631803 (Counterclockwise)

Preceding gene: 335055597

Following gene: 94311357

Centisome position: 67.04

GC content: 64.21

Gene sequence:

>1506_bases
ATGATTTCCAGATCTCCAGCCCTGGCAAGGGTCGTGGTCATGGTGGCCATGCTCGTGTTCGGTCCGGCTGTTTCCGAATT
GGGGCACGCTCAGGCGGCGGCCCAGAACTACAACCTGCCCGACTTTACCGACTTGGTCGAGAAGGTGAGCCCGGCGGTTG
TGAATATCCGCACGACAGAGCGCGTGCGCTCGCGTGGCGGCAATTCCCCCGATGACGACGAAATGGCGGAGTTCTTCCGT
CGCTTCTTCGGCGTGCCAATGCCCGGAACGCCGGGACAGCCGCGCCGTGGCCAGCCTCCGCAAGGACAGGGCCAAAGTCA
GGGGCAGGGCGAAGAGATGAGCCGGGGCGTGGGTTCCGGTTTCATCATCAGCCAGGATGGCTACGTGATGACGAACGCCC
ACGTGGTGGCAGAGGCTGACACGATCTACGTGACGCTGCCTGACAAGCGCGAATTCAAGGCCAAGCTGATTGGTGCGGAC
AAGCGTACCGACGTGGCGCTGCTCAAGATCGATGCAACGGGTCTGCCACGCCTGCCACTCGGGGATTCGGACAAGGTCCG
CACTGGCGAGTGGGTATTGGCCATTGGTTCGCCGTTCGGCCTGGACAGCAGCGTGACCGCCGGTATCGTATCGGCTAAGG
CGCGCGACACCGGCGACTACCTGCCGCTTATCCAGACTGACGTGGCGGTGAACCCTGGTAATTCGGGTGGCCCGCTGATC
AACCTGCGCGGCGAAGTCATCGGCATTAATTCGCAGATCTACAGCCGCAGCGGCGGTTATATGGGCATTTCGTTCGCGAC
CCCGATCGACGAAGCGATGCGTGTGACCGAGCAACTGAAGGCGACTGGCAAGGTGACGCGTGGGCGGATCGCCGTGGCGA
TCGGTGATGTGACCAAGGAAGTGGCGGACTCGCTGGGCCTTGGGCGCACTCGCGGCGCGCTGGTTGGTAGCGTCGAGCCG
GGCGGTCCTGCCGAAAAGGCCGGTATCGAGGCGGGCGACATCATCCTGAAGTACAACGGCCGGGATATTGAGAAGGCTGC
GGATCTGCCGCGGATGGTCGGTGACACCAAGCCGGGTACGCGCGTGCCGATGCAGGTGTGGCGCAAGGGGCAGACCCGCG
AGGTAATGATCACGGTGGCGGAGCTTGAGCCCGACACCCCTCGCGCCACGCCGCGCCGCGGCGACAAGCGCGGCGGAGGT
AACGAAGAGGCACCCGCGCCGAAGCCGAATGCACTGGGCCTGATCGTCAACGACATCCCCGAGGCGCGGATGCGCGAGCT
CAAGCTGAAGTCAGGGGTGGAGGTCGACACGGTTGATGGTCCGGCCGCTCGCGCCGGGATCCGTCCGGGCGACATCATCC
TGCGACTCGGTGATACCGACGTGACCAGTGCGAGGCAGTTCAACGATCTCGTCAAGGGACTGGACAAGAACAAGATGGCT
GCCGTGTTCGTGCGCCGCGGCGATGCTACCCAGGTGCTGACGCTGCGTCCCAATCAGACGCGCTGA

Upstream 100 bases:

>100_bases
CAGTCCCGCAACACCGCCAGGCAGTACGCTTTGCAGGCGTCCCCCGGCCTTATGCGCTGTGAAGCATCCGTTTCTCGCTG
ATCTCCCGGGAGTTTTGTCG

Downstream 100 bases:

>100_bases
CCAGGCCCTGGATCGAGCCTTCAAACAATCGCGCCGGACAAGTTCCGGCGCGATTGTTTCGTGGTGGGTGCGTCAAACGT
CATTTTGGCGCACCGCGCCC

Product: Trypsin-like serine protease, typically periplasmic, contains C-terminal PDZ domain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MISRSPALARVVVMVAMLVFGPAVSELGHAQAAAQNYNLPDFTDLVEKVSPAVVNIRTTERVRSRGGNSPDDDEMAEFFR
RFFGVPMPGTPGQPRRGQPPQGQGQSQGQGEEMSRGVGSGFIISQDGYVMTNAHVVAEADTIYVTLPDKREFKAKLIGAD
KRTDVALLKIDATGLPRLPLGDSDKVRTGEWVLAIGSPFGLDSSVTAGIVSAKARDTGDYLPLIQTDVAVNPGNSGGPLI
NLRGEVIGINSQIYSRSGGYMGISFATPIDEAMRVTEQLKATGKVTRGRIAVAIGDVTKEVADSLGLGRTRGALVGSVEP
GGPAEKAGIEAGDIILKYNGRDIEKAADLPRMVGDTKPGTRVPMQVWRKGQTREVMITVAELEPDTPRATPRRGDKRGGG
NEEAPAPKPNALGLIVNDIPEARMRELKLKSGVEVDTVDGPAARAGIRPGDIILRLGDTDVTSARQFNDLVKGLDKNKMA
AVFVRRGDATQVLTLRPNQTR

Sequences:

>Translated_501_residues
MISRSPALARVVVMVAMLVFGPAVSELGHAQAAAQNYNLPDFTDLVEKVSPAVVNIRTTERVRSRGGNSPDDDEMAEFFR
RFFGVPMPGTPGQPRRGQPPQGQGQSQGQGEEMSRGVGSGFIISQDGYVMTNAHVVAEADTIYVTLPDKREFKAKLIGAD
KRTDVALLKIDATGLPRLPLGDSDKVRTGEWVLAIGSPFGLDSSVTAGIVSAKARDTGDYLPLIQTDVAVNPGNSGGPLI
NLRGEVIGINSQIYSRSGGYMGISFATPIDEAMRVTEQLKATGKVTRGRIAVAIGDVTKEVADSLGLGRTRGALVGSVEP
GGPAEKAGIEAGDIILKYNGRDIEKAADLPRMVGDTKPGTRVPMQVWRKGQTREVMITVAELEPDTPRATPRRGDKRGGG
NEEAPAPKPNALGLIVNDIPEARMRELKLKSGVEVDTVDGPAARAGIRPGDIILRLGDTDVTSARQFNDLVKGLDKNKMA
AVFVRRGDATQVLTLRPNQTR
>Mature_501_residues
MISRSPALARVVVMVAMLVFGPAVSELGHAQAAAQNYNLPDFTDLVEKVSPAVVNIRTTERVRSRGGNSPDDDEMAEFFR
RFFGVPMPGTPGQPRRGQPPQGQGQSQGQGEEMSRGVGSGFIISQDGYVMTNAHVVAEADTIYVTLPDKREFKAKLIGAD
KRTDVALLKIDATGLPRLPLGDSDKVRTGEWVLAIGSPFGLDSSVTAGIVSAKARDTGDYLPLIQTDVAVNPGNSGGPLI
NLRGEVIGINSQIYSRSGGYMGISFATPIDEAMRVTEQLKATGKVTRGRIAVAIGDVTKEVADSLGLGRTRGALVGSVEP
GGPAEKAGIEAGDIILKYNGRDIEKAADLPRMVGDTKPGTRVPMQVWRKGQTREVMITVAELEPDTPRATPRRGDKRGGG
NEEAPAPKPNALGLIVNDIPEARMRELKLKSGVEVDTVDGPAARAGIRPGDIILRLGDTDVTSARQFNDLVKGLDKNKMA
AVFVRRGDATQVLTLRPNQTR

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=370, Percent_Identity=34.8648648648649, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI22129776, Length=355, Percent_Identity=33.8028169014084, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=35.2, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7019477, Length=288, Percent_Identity=35.7638888888889, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1789629, Length=475, Percent_Identity=34.1052631578947, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1786356, Length=483, Percent_Identity=34.7826086956522, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789630, Length=275, Percent_Identity=37.8181818181818, Blast_Score=176, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646839, Length=270, Percent_Identity=35.1851851851852, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53358; Mature: 53358

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRSPALARVVVMVAMLVFGPAVSELGHAQAAAQNYNLPDFTDLVEKVSPAVVNIRTTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECHH
RVRSRGGNSPDDDEMAEFFRRFFGVPMPGTPGQPRRGQPPQGQGQSQGQGEEMSRGVGSG
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FIISQDGYVMTNAHVVAEADTIYVTLPDKREFKAKLIGADKRTDVALLKIDATGLPRLPL
EEECCCCEEEECCEEEEECCEEEEECCCCCCCHHEEECCCCCCCEEEEEEECCCCCCCCC
GDSDKVRTGEWVLAIGSPFGLDSSVTAGIVSAKARDTGDYLPLIQTDVAVNPGNSGGPLI
CCCCCEECCCEEEEECCCCCCCCCHHHHHEECCCCCCCCCCCEEEECEEECCCCCCCCEE
NLRGEVIGINSQIYSRSGGYMGISFATPIDEAMRVTEQLKATGKVTRGRIAVAIGDVTKE
EECCCEEEECHHHEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHH
VADSLGLGRTRGALVGSVEPGGPAEKAGIEAGDIILKYNGRDIEKAADLPRMVGDTKPGT
HHHHCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECCCCHHHHHCCHHHHCCCCCCC
RVPMQVWRKGQTREVMITVAELEPDTPRATPRRGDKRGGGNEEAPAPKPNALGLIVNDIP
CCCHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
EARMRELKLKSGVEVDTVDGPAARAGIRPGDIILRLGDTDVTSARQFNDLVKGLDKNKMA
HHHHHHHHHHCCCEEECCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEE
AVFVRRGDATQVLTLRPNQTR
EEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure
MISRSPALARVVVMVAMLVFGPAVSELGHAQAAAQNYNLPDFTDLVEKVSPAVVNIRTTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECHH
RVRSRGGNSPDDDEMAEFFRRFFGVPMPGTPGQPRRGQPPQGQGQSQGQGEEMSRGVGSG
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FIISQDGYVMTNAHVVAEADTIYVTLPDKREFKAKLIGADKRTDVALLKIDATGLPRLPL
EEECCCCEEEECCEEEEECCEEEEECCCCCCCHHEEECCCCCCCEEEEEEECCCCCCCCC
GDSDKVRTGEWVLAIGSPFGLDSSVTAGIVSAKARDTGDYLPLIQTDVAVNPGNSGGPLI
CCCCCEECCCEEEEECCCCCCCCCHHHHHEECCCCCCCCCCCEEEECEEECCCCCCCCEE
NLRGEVIGINSQIYSRSGGYMGISFATPIDEAMRVTEQLKATGKVTRGRIAVAIGDVTKE
EECCCEEEECHHHEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHH
VADSLGLGRTRGALVGSVEPGGPAEKAGIEAGDIILKYNGRDIEKAADLPRMVGDTKPGT
HHHHCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECCCCHHHHHCCHHHHCCCCCCC
RVPMQVWRKGQTREVMITVAELEPDTPRATPRRGDKRGGGNEEAPAPKPNALGLIVNDIP
CCCHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
EARMRELKLKSGVEVDTVDGPAARAGIRPGDIILRLGDTDVTSARQFNDLVKGLDKNKMA
HHHHHHHHHHCCCEEECCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEE
AVFVRRGDATQVLTLRPNQTR
EEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]