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The map label for this gene is ccmA

Identifier: 94311321

GI number: 94311321

Start: 2597603

End: 2598226

Strand: Direct

Name: ccmA

Synonym: Rmet_2385

Alternate gene names: 94311321

Gene position: 2597603-2598226 (Clockwise)

Preceding gene: 94311318

Following gene: 94311322

Centisome position: 66.13

GC content: 59.94

Gene sequence:

>624_bases
ATGACCCGGCCCATGCTTGAAGCTCTCGATCTCGCGGGCGTTCGCGGGGAGCGCCGCCTGTTTGACCATTTGACTTTCCG
GATCGTGCCGGGCGAGTGCCTGTCGGTGCACGGCGAGAACGGCAGCGGGAAGACCACGCTATTGCGAACGCTTGCAGGGT
TCGCTACGCCTGCTGCTGGCAGAGTCTTGTGGAAAGGAAAGCCGCTGCGCAACCAGTGGAGTGAATACCAACGCGAACTG
GTTTACAACGGCCATGGCATTGGACTCAAAGAAGACCTGAATGCCTTGGACAACCTGCTTGCCGCGGCCGCCATCGCTGG
TGAGCCGGTCACCACGGAATGCGTGGAATCAGCGTTGGACGAAGTTGGCTTGGCCGAGCACAGGCACTTGCCGTTCCGGA
TGTTGTCACAAGGCCAAAAGCGTCGTGCAAGCCTGGCTCGATTGCTCCTCTACAGGAGGAAGTTGTGGATTCTCGATGAG
CCCTCCACAGCGCTGGACCAATTCGGTGCGCGATGGCTTGGTGAACTGATCCATCGGCACCAGTCACGCGGCGGCATGGT
CGTTCTGACGAGTCACCAGGAGCTGGCCTTGAAAACTTCTCAGACCGTCCGGATGGGGGCATGA

Upstream 100 bases:

>100_bases
ACGCAAGTTCCCGCTAATTCTCAGTTAATCGGGAGAAGACATGATTTTGAAGATTGCCCCTTGAGGGCGCACCTTCCAGG
GATGCCCATGTGCATGAACT

Downstream 100 bases:

>100_bases
GCCGGCCCCTCGTTGCCAATCCGGTATTTGTCGTGATGCGCCGGGACTTGAAGCTCGCCTTGCTCCGAAGGTCAGACGCG
CTGATACCTCTTTGCTTCTT

Product: heme exporter subunit ; ATP-binding component of ABC superfamily

Products: NA

Alternate protein names: Heme exporter protein A 1

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTRPMLEALDLAGVRGERRLFDHLTFRIVPGECLSVHGENGSGKTTLLRTLAGFATPAAGRVLWKGKPLRNQWSEYQREL
VYNGHGIGLKEDLNALDNLLAAAAIAGEPVTTECVESALDEVGLAEHRHLPFRMLSQGQKRRASLARLLLYRRKLWILDE
PSTALDQFGARWLGELIHRHQSRGGMVVLTSHQELALKTSQTVRMGA

Sequences:

>Translated_207_residues
MTRPMLEALDLAGVRGERRLFDHLTFRIVPGECLSVHGENGSGKTTLLRTLAGFATPAAGRVLWKGKPLRNQWSEYQREL
VYNGHGIGLKEDLNALDNLLAAAAIAGEPVTTECVESALDEVGLAEHRHLPFRMLSQGQKRRASLARLLLYRRKLWILDE
PSTALDQFGARWLGELIHRHQSRGGMVVLTSHQELALKTSQTVRMGA
>Mature_206_residues
TRPMLEALDLAGVRGERRLFDHLTFRIVPGECLSVHGENGSGKTTLLRTLAGFATPAAGRVLWKGKPLRNQWSEYQRELV
YNGHGIGLKEDLNALDNLLAAAAIAGEPVTTECVESALDEVGLAEHRHLPFRMLSQGQKRRASLARLLLYRRKLWILDEP
STALDQFGARWLGELIHRHQSRGGMVVLTSHQELALKTSQTVRMGA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI31657092, Length=182, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI27881501, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI30795238, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=29.7435897435897, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=29.7435897435897, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI105990541, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI116734710, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21536376, Length=183, Percent_Identity=29.5081967213115, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=201, Percent_Identity=44.7761194029851, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI87081834, Length=199, Percent_Identity=34.1708542713568, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081791, Length=196, Percent_Identity=30.6122448979592, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1789873, Length=200, Percent_Identity=28.5, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786698, Length=188, Percent_Identity=27.1276595744681, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787712, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786703, Length=185, Percent_Identity=31.3513513513514, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI48994997, Length=178, Percent_Identity=28.6516853932584, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788225, Length=189, Percent_Identity=29.1005291005291, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1789864, Length=216, Percent_Identity=24.537037037037, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1786563, Length=193, Percent_Identity=32.6424870466321, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081782, Length=190, Percent_Identity=25.7894736842105, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787500, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081709, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787164, Length=177, Percent_Identity=34.4632768361582, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1789991, Length=199, Percent_Identity=25.6281407035176, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786345, Length=189, Percent_Identity=30.1587301587302, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787029, Length=197, Percent_Identity=25.3807106598985, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994943, Length=164, Percent_Identity=28.0487804878049, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786803, Length=159, Percent_Identity=30.8176100628931, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790544, Length=195, Percent_Identity=28.7179487179487, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=182, Percent_Identity=29.1208791208791, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17565586, Length=183, Percent_Identity=28.9617486338798, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=177, Percent_Identity=30.5084745762712, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=191, Percent_Identity=25.130890052356, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24666092, Length=193, Percent_Identity=33.160621761658, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28574533, Length=188, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574150, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007328, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580930, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574744, Length=180, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648314, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17136592, Length=180, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA1_RALME (Q1LKR4)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584531.1
- ProteinModelPortal:   Q1LKR4
- SMR:   Q1LKR4
- STRING:   Q1LKR4
- GeneID:   4039205
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2385
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- PhylomeDB:   Q1LKR4
- BioCyc:   RMET266264:RMET_2385-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23024; Mature: 22893

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPMLEALDLAGVRGERRLFDHLTFRIVPGECLSVHGENGSGKTTLLRTLAGFATPAAG
CCCHHHHHHHHHCCCCHHHHHHHHHEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
RVLWKGKPLRNQWSEYQRELVYNGHGIGLKEDLNALDNLLAAAAIAGEPVTTECVESALD
EEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EVGLAEHRHLPFRMLSQGQKRRASLARLLLYRRKLWILDEPSTALDQFGARWLGELIHRH
HCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHH
QSRGGMVVLTSHQELALKTSQTVRMGA
HCCCCEEEEECCHHHHHHHCCHHCCCC
>Mature Secondary Structure 
TRPMLEALDLAGVRGERRLFDHLTFRIVPGECLSVHGENGSGKTTLLRTLAGFATPAAG
CCHHHHHHHHHCCCCHHHHHHHHHEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
RVLWKGKPLRNQWSEYQRELVYNGHGIGLKEDLNALDNLLAAAAIAGEPVTTECVESALD
EEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EVGLAEHRHLPFRMLSQGQKRRASLARLLLYRRKLWILDEPSTALDQFGARWLGELIHRH
HCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHH
QSRGGMVVLTSHQELALKTSQTVRMGA
HCCCCEEEEECCHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA