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The map label for this gene is ctpA1 [H]

Identifier: 94311315

GI number: 94311315

Start: 2590243

End: 2592501

Strand: Direct

Name: ctpA1 [H]

Synonym: Rmet_2379

Alternate gene names: 94311315

Gene position: 2590243-2592501 (Clockwise)

Preceding gene: 94311314

Following gene: 94311316

Centisome position: 65.94

GC content: 65.74

Gene sequence:

>2259_bases
ATGCCAAGAGCGGACCGTAGTTCCGGTGGGGATTTCGACTATGAGCAGGCCCGTGTGGCGGGCCGGATGGTGTTTTTCGT
AGACGGGCTTTGGTGCGTGAGCTGTGCGATGGCCTTGCAGCGCGTCCTGCAGCGTGTGCCCGGCGTGGTCTCGGCGACGG
TGAATTTCACCTCCGGTTCGGCGCTGGTGACCTGGGTCCCGGAGTCGATCGACTTCCCCTTGCTGCTGCGAAAGGCCGAG
GGTCTGGGCTACGCACTGTCCCCGTTGAAAGGCAGCGACGAGCTGGAAGCGGCCCTGCAGCGGCAGGCCAGGAAGATCCG
CTTGCAGTTGACCGTCGCGGTCGTCTTCGGGATGTGGAGCATGCTGGGCTCATGGGTGCTTTACCTGAACGCCGACGAGG
CGGCGGCGCTCGTCATCGCCTGGGCCAGCGTCGTAGCAAGCCTTCCCGTCGTCGGATATTCGGCGTGGGATTTCTACCGC
GCCGCCGCCCGTTCGCTGCGCGCCGGGATCGCAGGGATGGACGTCTTTGCCTCTGTTGCTGTCCTTGGCTCCCTCTTTGT
GTCGGTCGGGTCCCTGGCCATGGGGTCCGTGGCGATTTACACCGACGCCGCCACCATGTTGATCACTTTTCTGCTGATCG
GAAGATTGATCGAAATCCATGCCCGGCAGGAGAGCGGACTTGCCGTACAAGCATTGCGCAGCCTTGCGCCGGAAACCGCG
ACGAAGCTGACTTCTGCCGGCGGCGAAAAGGCCGAGAGCACCGTCCTGCTGGCAGAGCTCGCGCCCGGTGATACCGTTTT
GATACGCGCCAACGAGCGCATCGCGGTCGATGGCATCGTCGTAGCGGGACAGTCGGCCGTCGATCTCTCGCTGCTGCAAG
GCGAGTCCGCGCCTCGCAGCGTTCAGCCTGGCGAACGGGTCTTCGCCGGGTCCGTGAACCTGCGCGGACCTCTGACGGTC
CACGTGACCGCCGGTGCGGGGGACCGACGATTGGACGTGCTCGGCCTGCGCATGCTTGAGCTGTTTGGCGCTCGTTCGTC
GTTGTCCGAGACGGCCGAGCGCTTCGTCCGGATACTGCTCCCGGTCGTGGTGACGGCATCTCTGCTCGCCTTCGTCCATT
ACCTGTGGAACGGCTCAAGCGCAGACCAGGCGTTGCTCGGTGCGCTGAGCCTTCTGGTCGCAGCCTGCCCTTGCGCGGTC
GGTCTGGCGATGCCGCTGGCCTACGCCTTTACCTGCCGCGAGGCCGCGCGGCGCGGCGTCCTCCTGAGAGACTCCGCGAG
CGTCGAAGCGCTCGCCAGGGCAAGGATCATGGCGTTCGACAAGACCGGCACATTGACGTGCGGTCAGATGCGTATCGTCA
GCATCCAGACGCGGCACGGGGGGGCCGAACAGGACCTCATCGACCTTGCGGCAAGGGCCGAGGCCGGCGTCGCGCACCCC
ATTGCACACGCGGTGGTCCTCGCGGCCCGGCAGTCTGGAATGAGCAGCGCGTGCGAGCCCGACGGATGCCAGGTGACGGC
GTGCGCGAAAGGCGTGACGATGCATGTCCCCGGCGGCGAGACCGTGTGGGTGGGTGAAAGGCATTGGCTGCTCGCCGCGG
GAGTCGAGGGCATGCCGCCGGAAGATGGCCTGCCAGGGCTGGTACACGTAGCCAATGGCCGGGATTGGCTCGGCTCCTTG
CGTCTGCAGGATGCCCCTCGCGACGACGCCCGTTCGTCACTGCAGCGGTTACGTGCGCAGGGATTGAAACTCTGGTTGCT
GACCGGGGATTCCAGCGCAGCGTCCGAACGCCTGACGGCTGACCTGGGCATAGACTTCGACCGGGTCGAGGCCGATTGCT
CTCCGGAAGAAAAAGCCGACATCGTGGCAAAGAGCCCAGCGCCTGTCGCATTCGTGGGCGACGGCGCCAACGATGGCCTG
GTCCTGGCCCAGGCAGCCTGCGGAATCGCCATCCCAGGATCGAGTTCCGTGGCTGTTTCCGCAGCCGGGGTGGTGATCGC
GCACGGCAGCGTGGGCGCTGTCGTCGAGACCCGTGAGTTGGCTCGCAAGTTTGATCGCATCGTCCGGCAGAATCTCGCAT
TTTCCGTCGTGTACAACCTCGCCGTGATTGTCGTGCTGTTCGAAGCAGGCGTGACGCCCTTTGCCGCCGCGCTCGCCATG
CTGGCCAGCAGCGCGTCGGTGCTCCTGAACACCTGCAGGCTGCTGCAGGGCCGCGTCGTCTGTGACAAGTCGATGCAGGC
CAAGCCGGCTGCGTCCTGA

Upstream 100 bases:

>100_bases
CAGACCGGAACCGTGGCTGAGGCGCTGGAGAAATACCACGAAGGTGAGCAAAGCTACTACGGGAAGGTCGTGGGCGGAAA
ACTGCTTGGGGTTGGAACGG

Downstream 100 bases:

>100_bases
AAGGAGCACTGGAATGCTCAGGCTGTGAGCAGGCTTGCGCGGTGGCGAAATGCCGCGACCTTGGCGTTTGCCGGTAGCGC
ACATGCGTTGACGTTCGCCC

Product: metal transporter ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MPRADRSSGGDFDYEQARVAGRMVFFVDGLWCVSCAMALQRVLQRVPGVVSATVNFTSGSALVTWVPESIDFPLLLRKAE
GLGYALSPLKGSDELEAALQRQARKIRLQLTVAVVFGMWSMLGSWVLYLNADEAAALVIAWASVVASLPVVGYSAWDFYR
AAARSLRAGIAGMDVFASVAVLGSLFVSVGSLAMGSVAIYTDAATMLITFLLIGRLIEIHARQESGLAVQALRSLAPETA
TKLTSAGGEKAESTVLLAELAPGDTVLIRANERIAVDGIVVAGQSAVDLSLLQGESAPRSVQPGERVFAGSVNLRGPLTV
HVTAGAGDRRLDVLGLRMLELFGARSSLSETAERFVRILLPVVVTASLLAFVHYLWNGSSADQALLGALSLLVAACPCAV
GLAMPLAYAFTCREAARRGVLLRDSASVEALARARIMAFDKTGTLTCGQMRIVSIQTRHGGAEQDLIDLAARAEAGVAHP
IAHAVVLAARQSGMSSACEPDGCQVTACAKGVTMHVPGGETVWVGERHWLLAAGVEGMPPEDGLPGLVHVANGRDWLGSL
RLQDAPRDDARSSLQRLRAQGLKLWLLTGDSSAASERLTADLGIDFDRVEADCSPEEKADIVAKSPAPVAFVGDGANDGL
VLAQAACGIAIPGSSSVAVSAAGVVIAHGSVGAVVETRELARKFDRIVRQNLAFSVVYNLAVIVVLFEAGVTPFAAALAM
LASSASVLLNTCRLLQGRVVCDKSMQAKPAAS

Sequences:

>Translated_752_residues
MPRADRSSGGDFDYEQARVAGRMVFFVDGLWCVSCAMALQRVLQRVPGVVSATVNFTSGSALVTWVPESIDFPLLLRKAE
GLGYALSPLKGSDELEAALQRQARKIRLQLTVAVVFGMWSMLGSWVLYLNADEAAALVIAWASVVASLPVVGYSAWDFYR
AAARSLRAGIAGMDVFASVAVLGSLFVSVGSLAMGSVAIYTDAATMLITFLLIGRLIEIHARQESGLAVQALRSLAPETA
TKLTSAGGEKAESTVLLAELAPGDTVLIRANERIAVDGIVVAGQSAVDLSLLQGESAPRSVQPGERVFAGSVNLRGPLTV
HVTAGAGDRRLDVLGLRMLELFGARSSLSETAERFVRILLPVVVTASLLAFVHYLWNGSSADQALLGALSLLVAACPCAV
GLAMPLAYAFTCREAARRGVLLRDSASVEALARARIMAFDKTGTLTCGQMRIVSIQTRHGGAEQDLIDLAARAEAGVAHP
IAHAVVLAARQSGMSSACEPDGCQVTACAKGVTMHVPGGETVWVGERHWLLAAGVEGMPPEDGLPGLVHVANGRDWLGSL
RLQDAPRDDARSSLQRLRAQGLKLWLLTGDSSAASERLTADLGIDFDRVEADCSPEEKADIVAKSPAPVAFVGDGANDGL
VLAQAACGIAIPGSSSVAVSAAGVVIAHGSVGAVVETRELARKFDRIVRQNLAFSVVYNLAVIVVLFEAGVTPFAAALAM
LASSASVLLNTCRLLQGRVVCDKSMQAKPAAS
>Mature_751_residues
PRADRSSGGDFDYEQARVAGRMVFFVDGLWCVSCAMALQRVLQRVPGVVSATVNFTSGSALVTWVPESIDFPLLLRKAEG
LGYALSPLKGSDELEAALQRQARKIRLQLTVAVVFGMWSMLGSWVLYLNADEAAALVIAWASVVASLPVVGYSAWDFYRA
AARSLRAGIAGMDVFASVAVLGSLFVSVGSLAMGSVAIYTDAATMLITFLLIGRLIEIHARQESGLAVQALRSLAPETAT
KLTSAGGEKAESTVLLAELAPGDTVLIRANERIAVDGIVVAGQSAVDLSLLQGESAPRSVQPGERVFAGSVNLRGPLTVH
VTAGAGDRRLDVLGLRMLELFGARSSLSETAERFVRILLPVVVTASLLAFVHYLWNGSSADQALLGALSLLVAACPCAVG
LAMPLAYAFTCREAARRGVLLRDSASVEALARARIMAFDKTGTLTCGQMRIVSIQTRHGGAEQDLIDLAARAEAGVAHPI
AHAVVLAARQSGMSSACEPDGCQVTACAKGVTMHVPGGETVWVGERHWLLAAGVEGMPPEDGLPGLVHVANGRDWLGSLR
LQDAPRDDARSSLQRLRAQGLKLWLLTGDSSAASERLTADLGIDFDRVEADCSPEEKADIVAKSPAPVAFVGDGANDGLV
LAQAACGIAIPGSSSVAVSAAGVVIAHGSVGAVVETRELARKFDRIVRQNLAFSVVYNLAVIVVLFEAGVTPFAAALAML
ASSASVLLNTCRLLQGRVVCDKSMQAKPAAS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=775, Percent_Identity=25.2903225806452, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI55743073, Length=612, Percent_Identity=25.4901960784314, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI115529486, Length=539, Percent_Identity=24.1187384044527, Blast_Score=142, Evalue=2e-33,
Organism=Escherichia coli, GI1786691, Length=751, Percent_Identity=29.693741677763, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1789879, Length=735, Percent_Identity=30.2040816326531, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786914, Length=558, Percent_Identity=26.1648745519713, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17556548, Length=794, Percent_Identity=26.3224181360202, Blast_Score=194, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319772, Length=656, Percent_Identity=27.4390243902439, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320475, Length=634, Percent_Identity=27.2870662460568, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6321430, Length=515, Percent_Identity=24.0776699029126, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221329854, Length=508, Percent_Identity=24.8031496062992, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 78712; Mature: 78581

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRADRSSGGDFDYEQARVAGRMVFFVDGLWCVSCAMALQRVLQRVPGVVSATVNFTSGS
CCCCCCCCCCCCCHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
ALVTWVPESIDFPLLLRKAEGLGYALSPLKGSDELEAALQRQARKIRLQLTVAVVFGMWS
EEEEECCCCCCCHHEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGSWVLYLNADEAAALVIAWASVVASLPVVGYSAWDFYRAAARSLRAGIAGMDVFASVA
HHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
VLGSLFVSVGSLAMGSVAIYTDAATMLITFLLIGRLIEIHARQESGLAVQALRSLAPETA
HHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHH
TKLTSAGGEKAESTVLLAELAPGDTVLIRANERIAVDGIVVAGQSAVDLSLLQGESAPRS
HHHHHCCCCCCCCEEEEEEECCCCEEEEEECCEEEEEEEEEECCCHHHHHHHCCCCCCCC
VQPGERVFAGSVNLRGPLTVHVTAGAGDRRLDVLGLRMLELFGARSSLSETAERFVRILL
CCCCCEEEECCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
PVVVTASLLAFVHYLWNGSSADQALLGALSLLVAACPCAVGLAMPLAYAFTCREAARRGV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LLRDSASVEALARARIMAFDKTGTLTCGQMRIVSIQTRHGGAEQDLIDLAARAEAGVAHP
EEECCCHHHHHHHHHHEEECCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHH
IAHAVVLAARQSGMSSACEPDGCQVTACAKGVTMHVPGGETVWVGERHWLLAAGVEGMPP
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCC
EDGLPGLVHVANGRDWLGSLRLQDAPRDDARSSLQRLRAQGLKLWLLTGDSSAASERLTA
CCCCCCEEEECCCCCHHHCCEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
DLGIDFDRVEADCSPEEKADIVAKSPAPVAFVGDGANDGLVLAQAACGIAIPGSSSVAVS
HCCCCHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEEECCCCEECCCCCCEEEE
AAGVVIAHGSVGAVVETRELARKFDRIVRQNLAFSVVYNLAVIVVLFEAGVTPFAAALAM
ECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LASSASVLLNTCRLLQGRVVCDKSMQAKPAAS
HHCCHHHHHHHHHHHCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
PRADRSSGGDFDYEQARVAGRMVFFVDGLWCVSCAMALQRVLQRVPGVVSATVNFTSGS
CCCCCCCCCCCCHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
ALVTWVPESIDFPLLLRKAEGLGYALSPLKGSDELEAALQRQARKIRLQLTVAVVFGMWS
EEEEECCCCCCCHHEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGSWVLYLNADEAAALVIAWASVVASLPVVGYSAWDFYRAAARSLRAGIAGMDVFASVA
HHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
VLGSLFVSVGSLAMGSVAIYTDAATMLITFLLIGRLIEIHARQESGLAVQALRSLAPETA
HHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHH
TKLTSAGGEKAESTVLLAELAPGDTVLIRANERIAVDGIVVAGQSAVDLSLLQGESAPRS
HHHHHCCCCCCCCEEEEEEECCCCEEEEEECCEEEEEEEEEECCCHHHHHHHCCCCCCCC
VQPGERVFAGSVNLRGPLTVHVTAGAGDRRLDVLGLRMLELFGARSSLSETAERFVRILL
CCCCCEEEECCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
PVVVTASLLAFVHYLWNGSSADQALLGALSLLVAACPCAVGLAMPLAYAFTCREAARRGV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LLRDSASVEALARARIMAFDKTGTLTCGQMRIVSIQTRHGGAEQDLIDLAARAEAGVAHP
EEECCCHHHHHHHHHHEEECCCCCEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHH
IAHAVVLAARQSGMSSACEPDGCQVTACAKGVTMHVPGGETVWVGERHWLLAAGVEGMPP
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEECCCCCEEEECCCEEEEEECCCCCCC
EDGLPGLVHVANGRDWLGSLRLQDAPRDDARSSLQRLRAQGLKLWLLTGDSSAASERLTA
CCCCCCEEEECCCCCHHHCCEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
DLGIDFDRVEADCSPEEKADIVAKSPAPVAFVGDGANDGLVLAQAACGIAIPGSSSVAVS
HCCCCHHHCCCCCCCCCCCCEEECCCCCEEEEECCCCCCEEEEECCCCEECCCCCCEEEE
AAGVVIAHGSVGAVVETRELARKFDRIVRQNLAFSVVYNLAVIVVLFEAGVTPFAAALAM
ECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LASSASVLLNTCRLLQGRVVCDKSMQAKPAAS
HHCCHHHHHHHHHHHCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA