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The map label for this gene is blh [H]

Identifier: 94311308

GI number: 94311308

Start: 2582975

End: 2583934

Strand: Direct

Name: blh [H]

Synonym: Rmet_2372

Alternate gene names: 94311308

Gene position: 2582975-2583934 (Clockwise)

Preceding gene: 94311307

Following gene: 94311309

Centisome position: 65.76

GC content: 64.79

Gene sequence:

>960_bases
GTGAGAACGACCCACAAACATCCGATCAAGGGAGCTTGGGCGACAACAGACGGGTCATACATTCAGCGAGGCAAAGACAC
CGTGAAGATCGAACCCTTCTTTGACGAGGACACCAGCACCTTCAGCTACATCGTGCTGGACACGAAAAGCGGTCAGTGCG
CCATCATCGACAGCGTGCTCGGCTACGATCCTAAATCCGGCCGCACCTCGCGCGCCGGCGCGGACCGCATGGCCGAGCGC
GTGCGGGAACTGGGGGCGAGCGTCCAGTGGATTCTGGAGACGCATGTGCACGCAGATCACCTGAGCGCCGCGCCGTATCT
CCATTCGTGCCTGGGCGGCCGAACCGGCATTGGGGCGAACATCCGTACCGTACAGCAGGTGTTCGGCCAGCTCTTCAACG
CCGAGCCGGCCTTCGCGCGTGACGGCCGGCAGTTTGATCGTCTGTTCGACGACGGCGAGACCTTCATGCTCGGCACGCTG
CAGGTGCGGGCCATGCATACCCCCGGCCATACGCCCGCTTGCATGACCTATCTGGTCCAGGACAACGCCACACCTGAAGC
GCCTGCCGCAGCCTTCGTGGGCGACACGCTGTTCATGCCCGACTATGGCACGGCGCGTTGCGACTTTCCGGGTGGCGACG
CGCGCACACTGTTCCGCTCGATCGGCCGCGTGCTGTCGCTGCCGCCGGAGACCGTGCTCTACATGTGCCACGACTACCGC
CCCGGGGGGCGCGAGCTTCAATGGAAGACCACCGTGGCCGAGGAGCGTGCGCACAACATCCATGTGCGTGACGGCATCAG
CGAGGATGACTTCGCGGCCACGCGCGAGCAGCGCGACGCCACGCTGGCGATGCCCGTGCTTCTGCTGCCCTCCGTGCAGG
TGAACATGCGGGCCGGCGAGTTGCCGCCTGCCGAATCCAACGGCGTCCACTACCTCAAGATTCCCATCGATGCCCTCTGA

Upstream 100 bases:

>100_bases
GGGTGGGGAAGCGATTTCTTCACTCGGCCGCCGGTCGGCAAGAACATGCGACGGCAAGTTTTTAATTTTGAGTTAATTCG
ACCCGGACACCATCTGGCAT

Downstream 100 bases:

>100_bases
GAGCGGCACCGACCGGCTGAAAGGACAATTTCCGGGCAGGAGACCCTCATGGACATCAAAGCCTTGGACCAGGGACTGGC
CGTCAGCGGCCAGATCGCTG

Product: putative hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRTTHKHPIKGAWATTDGSYIQRGKDTVKIEPFFDEDTSTFSYIVLDTKSGQCAIIDSVLGYDPKSGRTSRAGADRMAER
VRELGASVQWILETHVHADHLSAAPYLHSCLGGRTGIGANIRTVQQVFGQLFNAEPAFARDGRQFDRLFDDGETFMLGTL
QVRAMHTPGHTPACMTYLVQDNATPEAPAAAFVGDTLFMPDYGTARCDFPGGDARTLFRSIGRVLSLPPETVLYMCHDYR
PGGRELQWKTTVAEERAHNIHVRDGISEDDFAATREQRDATLAMPVLLLPSVQVNMRAGELPPAESNGVHYLKIPIDAL

Sequences:

>Translated_319_residues
MRTTHKHPIKGAWATTDGSYIQRGKDTVKIEPFFDEDTSTFSYIVLDTKSGQCAIIDSVLGYDPKSGRTSRAGADRMAER
VRELGASVQWILETHVHADHLSAAPYLHSCLGGRTGIGANIRTVQQVFGQLFNAEPAFARDGRQFDRLFDDGETFMLGTL
QVRAMHTPGHTPACMTYLVQDNATPEAPAAAFVGDTLFMPDYGTARCDFPGGDARTLFRSIGRVLSLPPETVLYMCHDYR
PGGRELQWKTTVAEERAHNIHVRDGISEDDFAATREQRDATLAMPVLLLPSVQVNMRAGELPPAESNGVHYLKIPIDAL
>Mature_319_residues
MRTTHKHPIKGAWATTDGSYIQRGKDTVKIEPFFDEDTSTFSYIVLDTKSGQCAIIDSVLGYDPKSGRTSRAGADRMAER
VRELGASVQWILETHVHADHLSAAPYLHSCLGGRTGIGANIRTVQQVFGQLFNAEPAFARDGRQFDRLFDDGETFMLGTL
QVRAMHTPGHTPACMTYLVQDNATPEAPAAAFVGDTLFMPDYGTARCDFPGGDARTLFRSIGRVLSLPPETVLYMCHDYR
PGGRELQWKTTVAEERAHNIHVRDGISEDDFAATREQRDATLAMPVLLLPSVQVNMRAGELPPAESNGVHYLKIPIDAL

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=285, Percent_Identity=29.1228070175439, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI14150041, Length=252, Percent_Identity=25.7936507936508, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI46361987, Length=240, Percent_Identity=25.8333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538952, Length=279, Percent_Identity=27.5985663082437, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330176, Length=268, Percent_Identity=29.8507462686567, Blast_Score=114, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 35164; Mature: 35164

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTTHKHPIKGAWATTDGSYIQRGKDTVKIEPFFDEDTSTFSYIVLDTKSGQCAIIDSVL
CCCCCCCCCCCCEECCCCHHHHCCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEHHHH
GYDPKSGRTSRAGADRMAERVRELGASVQWILETHVHADHLSAAPYLHSCLGGRTGIGAN
CCCCCCCCCCCCCHHHHHHHHHHHCCHHEEHHHHHCCHHHHCCCHHHHHHHCCCCCCCCC
IRTVQQVFGQLFNAEPAFARDGRQFDRLFDDGETFMLGTLQVRAMHTPGHTPACMTYLVQ
HHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCEEEEEEEEEEEEECCCCCHHHEEEEEE
DNATPEAPAAAFVGDTLFMPDYGTARCDFPGGDARTLFRSIGRVLSLPPETVLYMCHDYR
CCCCCCCCCHHHHCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCC
PGGRELQWKTTVAEERAHNIHVRDGISEDDFAATREQRDATLAMPVLLLPSVQVNMRAGE
CCCCEEEEEHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCEEEEHHHCCCCCEEEEECCC
LPPAESNGVHYLKIPIDAL
CCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRTTHKHPIKGAWATTDGSYIQRGKDTVKIEPFFDEDTSTFSYIVLDTKSGQCAIIDSVL
CCCCCCCCCCCCEECCCCHHHHCCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEEHHHH
GYDPKSGRTSRAGADRMAERVRELGASVQWILETHVHADHLSAAPYLHSCLGGRTGIGAN
CCCCCCCCCCCCCHHHHHHHHHHHCCHHEEHHHHHCCHHHHCCCHHHHHHHCCCCCCCCC
IRTVQQVFGQLFNAEPAFARDGRQFDRLFDDGETFMLGTLQVRAMHTPGHTPACMTYLVQ
HHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCCCEEEEEEEEEEEEECCCCCHHHEEEEEE
DNATPEAPAAAFVGDTLFMPDYGTARCDFPGGDARTLFRSIGRVLSLPPETVLYMCHDYR
CCCCCCCCCHHHHCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCC
PGGRELQWKTTVAEERAHNIHVRDGISEDDFAATREQRDATLAMPVLLLPSVQVNMRAGE
CCCCEEEEEHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCEEEEHHHCCCCCEEEEECCC
LPPAESNGVHYLKIPIDAL
CCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]