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The map label for this gene is glpR [H]

Identifier: 94311173

GI number: 94311173

Start: 2450563

End: 2451342

Strand: Direct

Name: glpR [H]

Synonym: Rmet_2235

Alternate gene names: 94311173

Gene position: 2450563-2451342 (Clockwise)

Preceding gene: 335055586

Following gene: 94311176

Centisome position: 62.39

GC content: 63.97

Gene sequence:

>780_bases
ATGCCGGACATGACGCTCAATCCACGCCAGACCGCACTCCTCGAGGAAGTCCGCACGCAGGGCTTTGCCTCTATCGACGA
ACTCGCGCGCAAGTTCGGCGTGACCCTGCAAACGGTGCGCCGGGACGTCAACCTGCTGGCCGAGAACGGCATGCTGGCCC
GATTTCATGGCGGGGTACGGGTAGAGGGATCGACCACCGAGAACATTGCCTACCGGCAACGCCAGGTGCTGAACGCGGAG
GGTAAGGCGCGCATCGCGCGCGCGGTGGCGGCTGCCGTGCCGGAAGGCTGCTCGCTGATCCTGAACATCGGCACCACGGT
GGAGGAAGTGGCGCGCGCGCTGATCCATCACCGGGGCTTGCGGGTAATCACGAACAACCTGAACGTGGCCAATATCCTGG
CCGACAACCCCGACTGCGAGGTCATCGTCGCCGGTGGCGTGCTGCGTTCACGCGACCGCGGCATCGTTGGCGAGGCTACG
GTGGAATTTATCCGGCAGTTCAAGGTGGATATCGGCCTGATCGGCATCTCGGGCATCGAGGCCGACGGCACGCTGCGCGA
CTATGATTTTCGCGAGGTCAAGGTGTCTCGCACGATCATGGAACACTCGCGCGAAATCTGGCTGGCGGCCGACGCCAGCA
AGTTCAACCGGCGAGCCATGGTGGAACTGGCGCCGCTCGCGAGCATCGACCGGCTATTCACGGACGAGCCGTTACCCGCG
CCTTTCGACACGATGCTGCAGGAAAGCGGGGTGGAATGTGTGGTCGCGGATCAGGAGTGA

Upstream 100 bases:

>100_bases
TGAGGCGCACTTTTCATAGCAACCCGCTCGTTTTAGCTCAAAAACGAACACAAAACAATACTGCGCCGCATCATTTGTTT
TCGTTTCTGTTTGAACTAGA

Downstream 100 bases:

>100_bases
GGTGGGCTCACGTCTCGCGCTCCCTTCTCACGCTTGTGGGAAAGGGGTTCTGGGAGAAGGCATTGGGGTAGCAGCAATCA
GCACAGGTCGCAATTTGAGC

Product: DNA-binding transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPDMTLNPRQTALLEEVRTQGFASIDELARKFGVTLQTVRRDVNLLAENGMLARFHGGVRVEGSTTENIAYRQRQVLNAE
GKARIARAVAAAVPEGCSLILNIGTTVEEVARALIHHRGLRVITNNLNVANILADNPDCEVIVAGGVLRSRDRGIVGEAT
VEFIRQFKVDIGLIGISGIEADGTLRDYDFREVKVSRTIMEHSREIWLAADASKFNRRAMVELAPLASIDRLFTDEPLPA
PFDTMLQESGVECVVADQE

Sequences:

>Translated_259_residues
MPDMTLNPRQTALLEEVRTQGFASIDELARKFGVTLQTVRRDVNLLAENGMLARFHGGVRVEGSTTENIAYRQRQVLNAE
GKARIARAVAAAVPEGCSLILNIGTTVEEVARALIHHRGLRVITNNLNVANILADNPDCEVIVAGGVLRSRDRGIVGEAT
VEFIRQFKVDIGLIGISGIEADGTLRDYDFREVKVSRTIMEHSREIWLAADASKFNRRAMVELAPLASIDRLFTDEPLPA
PFDTMLQESGVECVVADQE
>Mature_258_residues
PDMTLNPRQTALLEEVRTQGFASIDELARKFGVTLQTVRRDVNLLAENGMLARFHGGVRVEGSTTENIAYRQRQVLNAEG
KARIARAVAAAVPEGCSLILNIGTTVEEVARALIHHRGLRVITNNLNVANILADNPDCEVIVAGGVLRSRDRGIVGEATV
EFIRQFKVDIGLIGISGIEADGTLRDYDFREVKVSRTIMEHSREIWLAADASKFNRRAMVELAPLASIDRLFTDEPLPAP
FDTMLQESGVECVVADQE

Specific function: Repressor of the glycerol-3-phosphate regulon [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=250, Percent_Identity=44.8, Blast_Score=233, Evalue=7e-63,
Organism=Escherichia coli, GI87082344, Length=259, Percent_Identity=42.8571428571429, Blast_Score=220, Evalue=7e-59,
Organism=Escherichia coli, GI226510968, Length=251, Percent_Identity=31.4741035856574, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789519, Length=251, Percent_Identity=27.4900398406374, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789059, Length=249, Percent_Identity=30.1204819277108, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788069, Length=252, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787540, Length=254, Percent_Identity=28.740157480315, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1790753, Length=224, Percent_Identity=28.125, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789170, Length=230, Percent_Identity=23.4782608695652, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790635, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28477; Mature: 28346

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMTLNPRQTALLEEVRTQGFASIDELARKFGVTLQTVRRDVNLLAENGMLARFHGGVR
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCEE
VEGSTTENIAYRQRQVLNAEGKARIARAVAAAVPEGCSLILNIGTTVEEVARALIHHRGL
EECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCC
RVITNNLNVANILADNPDCEVIVAGGVLRSRDRGIVGEATVEFIRQFKVDIGLIGISGIE
EEEECCCCEEEEEECCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCC
ADGTLRDYDFREVKVSRTIMEHSREIWLAADASKFNRRAMVELAPLASIDRLFTDEPLPA
CCCCEECCCHHHHHHHHHHHHCCCEEEEEECCHHCCCHHHEEEHHHHHHHHHHCCCCCCC
PFDTMLQESGVECVVADQE
CHHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
PDMTLNPRQTALLEEVRTQGFASIDELARKFGVTLQTVRRDVNLLAENGMLARFHGGVR
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCEE
VEGSTTENIAYRQRQVLNAEGKARIARAVAAAVPEGCSLILNIGTTVEEVARALIHHRGL
EECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCC
RVITNNLNVANILADNPDCEVIVAGGVLRSRDRGIVGEATVEFIRQFKVDIGLIGISGIE
EEEECCCCEEEEEECCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCC
ADGTLRDYDFREVKVSRTIMEHSREIWLAADASKFNRRAMVELAPLASIDRLFTDEPLPA
CCCCEECCCHHHHHHHHHHHHCCCEEEEEECCHHCCCHHHEEEHHHHHHHHHHCCCCCCC
PFDTMLQESGVECVVADQE
CHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8752340; 10984043 [H]