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The map label for this gene is trxA [H]

Identifier: 94311072

GI number: 94311072

Start: 2322741

End: 2323067

Strand: Direct

Name: trxA [H]

Synonym: Rmet_2134

Alternate gene names: 94311072

Gene position: 2322741-2323067 (Clockwise)

Preceding gene: 94311057

Following gene: 94311073

Centisome position: 59.13

GC content: 58.72

Gene sequence:

>327_bases
ATGAGCGAACAAATCAAATATGTGAGCGACGCTTCGTTCGATGCCGACGTGCTCAAGTCCGACAAGCCCGTGCTGCTCGA
CTTCTGGGCCGAATGGTGCGGTCCTTGCAAGATGATCGCCCCGATCCTGGACGAAGTCGCGAAGGACTACGGCGACAAGG
TGCAGGTCGCCAAAATCAACGTGGATGAAAACCAGCAAGTGCCGGCCAAGTTCGGCATTCGCGGCATCCCGACGCTGATC
CTGTTCAAGAACGGCCAAGTGGCCGCGCAGAAGGTTGGCGCGCTGTCGAAGTCGCAGCTGACCGCGTTCCTGGACAGCCA
GCTGTAA

Upstream 100 bases:

>100_bases
CGCGCTGCGAGTCCGCGCAATGTCGTGTAAGGTAGCGGATCGCGCCGACAGCCGTTGTCCGCCTTCAACATAAACTGAGC
GATACCTGAGGTTCCCCGCC

Downstream 100 bases:

>100_bases
TCTGTACCCGCCCGGGGCCGAACGGCTCCGGGAATGCACTACCCGGTCATGCGTGCGTCAGCTCTGGCGCACCGGCCGGA
TTGTGCTATGATGCCACCCA

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKYVSDASFDADVLKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKVQVAKINVDENQQVPAKFGIRGIPTLI
LFKNGQVAAQKVGALSKSQLTAFLDSQL

Sequences:

>Translated_108_residues
MSEQIKYVSDASFDADVLKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKVQVAKINVDENQQVPAKFGIRGIPTLI
LFKNGQVAAQKVGALSKSQLTAFLDSQL
>Mature_107_residues
SEQIKYVSDASFDADVLKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKVQVAKINVDENQQVPAKFGIRGIPTLIL
FKNGQVAAQKVGALSKSQLTAFLDSQL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=40.8602150537634, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=32.3232323232323, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=65.7407407407407, Blast_Score=155, Evalue=5e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=44.5652173913043, Blast_Score=99, Evalue=5e-23,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=43.75, Blast_Score=67, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=39.5833333333333, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=104, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=41.3793103448276, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=40.7894736842105, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=34.6666666666667, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=83, Percent_Identity=37.3493975903614, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=65, Percent_Identity=41.5384615384615, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=87, Percent_Identity=34.4827586206897, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=87, Percent_Identity=34.4827586206897, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=88, Percent_Identity=34.0909090909091, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=41.4893617021277, Blast_Score=77, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=43.6170212765958, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=35.4430379746835, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=47.5, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=33.695652173913, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=42.0454545454545, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=42.0454545454545, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=41.3333333333333, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=31.1827956989247, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17530795, Length=74, Percent_Identity=35.1351351351351, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11859; Mature: 11728

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKYVSDASFDADVLKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKVQVAKIN
CCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VDENQQVPAKFGIRGIPTLILFKNGQVAAQKVGALSKSQLTAFLDSQL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEQIKYVSDASFDADVLKSDKPVLLDFWAEWCGPCKMIAPILDEVAKDYGDKVQVAKIN
CCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
VDENQQVPAKFGIRGIPTLILFKNGQVAAQKVGALSKSQLTAFLDSQL
CCCCCCCCHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496529 [H]