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The map label for this gene is yngG [H]

Identifier: 94311062

GI number: 94311062

Start: 2305777

End: 2306757

Strand: Reverse

Name: yngG [H]

Synonym: Rmet_2124

Alternate gene names: 94311062

Gene position: 2306757-2305777 (Counterclockwise)

Preceding gene: 94311063

Following gene: 94311061

Centisome position: 58.72

GC content: 67.28

Gene sequence:

>981_bases
ATGAGTGCCAAGATGAGTGCTGCTACGTATCCGCTGTCAGGCCCGGCGAAGGTCGAGATCAACGAAGTCGCCCCGCGCGA
CGGGCTGCAGATCGAACCGTTCATCGTTCCCACCGAGGGCAAGGTCGCTTTCGTCAATGCGCTGGCCCGCTGCGGTTTCG
CGCGTATCGAAGCTACGTCGTTCACGTCGGCCCGCGCCATTCCCGCGCTGGCAGATGCGGAGGCCGTGATGCATCAGGTC
GAGCGCGTCGCCGGCGTTGGGCTGACCGTGCTGGTGCCGAACCTGCGCGGGCTGGAGCGCGCACTGTCGTGTCGCCCCGA
CGAGGTCAATCTGGTGATGTCGTCCAGCGAGACGCACAATCGCGCCAATCTGCGCATGACGCGCGAGCAGTCGCAGGCCC
AGTTGCTGGCGATGATCGCGGAAGCGGGCAAGGCCGGCGTGCCTGTCAACGTGTCGCTGTCGACCGTGTTCGGCTGCCCG
TTCGAGGGCGACGTCAGCGAAGCTGAGGTCATGCGCCTGGCGAAGGCGTTTGCCGATGCCGGCGCGGCGGGTATCACCCT
GTGCGATACCACGGGCATGGCCTATCCCAACCAGGTGGCCGCGCTCTGCGAGACGTTCCAGCGCGCCTTGCCGAAGACTG
GCCTGACGATTCACCTGCACAACACCCGAGGCATGGGCCTGGCGAACGCGATCGCCGCGTGGCAGACCGGCGTGACGCGG
TTCGACGCCGCGGCCGGTGGGTTGGGTGGGTGCCCCTACGCGCCCGGCGCGAGCGGCAACGTCAGCACCGAGGAACTTGT
GCACATGTTCGCGTCGATGGGCGTGGATACGGGTGTCGAACTGGGCGCGCTGCTCGACGTGGTCGCTGGCGTCTCCGATC
TGGTGCAGCGCGACGTGTCCAGCCAACTCCTGCGCGCCGGCCCGCGCCTGCGCACGCATCAGCCGCCTGCGTGGATGGAA
GAGTTTTTCGCCAAGGCTTGA

Upstream 100 bases:

>100_bases
ATCGCGCGCCGACGCTGGGCGAGCATACCGATTCCGTGCTGGCCGATGCCGGCTTCGACGCGGCGGCCATTGCCGACCTG
CGTAATCGCGGAGTGATTGC

Downstream 100 bases:

>100_bases
TGGCAGGCATCAACCGACAGATTTTTTGAGTCCCCCAATAAAACATACGGAGACAACCATGAAACGCACACTGATTGGTG
CCGGCACACTGCTGGCTGCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSAKMSAATYPLSGPAKVEINEVAPRDGLQIEPFIVPTEGKVAFVNALARCGFARIEATSFTSARAIPALADAEAVMHQV
ERVAGVGLTVLVPNLRGLERALSCRPDEVNLVMSSSETHNRANLRMTREQSQAQLLAMIAEAGKAGVPVNVSLSTVFGCP
FEGDVSEAEVMRLAKAFADAGAAGITLCDTTGMAYPNQVAALCETFQRALPKTGLTIHLHNTRGMGLANAIAAWQTGVTR
FDAAAGGLGGCPYAPGASGNVSTEELVHMFASMGVDTGVELGALLDVVAGVSDLVQRDVSSQLLRAGPRLRTHQPPAWME
EFFAKA

Sequences:

>Translated_326_residues
MSAKMSAATYPLSGPAKVEINEVAPRDGLQIEPFIVPTEGKVAFVNALARCGFARIEATSFTSARAIPALADAEAVMHQV
ERVAGVGLTVLVPNLRGLERALSCRPDEVNLVMSSSETHNRANLRMTREQSQAQLLAMIAEAGKAGVPVNVSLSTVFGCP
FEGDVSEAEVMRLAKAFADAGAAGITLCDTTGMAYPNQVAALCETFQRALPKTGLTIHLHNTRGMGLANAIAAWQTGVTR
FDAAAGGLGGCPYAPGASGNVSTEELVHMFASMGVDTGVELGALLDVVAGVSDLVQRDVSSQLLRAGPRLRTHQPPAWME
EFFAKA
>Mature_325_residues
SAKMSAATYPLSGPAKVEINEVAPRDGLQIEPFIVPTEGKVAFVNALARCGFARIEATSFTSARAIPALADAEAVMHQVE
RVAGVGLTVLVPNLRGLERALSCRPDEVNLVMSSSETHNRANLRMTREQSQAQLLAMIAEAGKAGVPVNVSLSTVFGCPF
EGDVSEAEVMRLAKAFADAGAAGITLCDTTGMAYPNQVAALCETFQRALPKTGLTIHLHNTRGMGLANAIAAWQTGVTRF
DAAAGGLGGCPYAPGASGNVSTEELVHMFASMGVDTGVELGALLDVVAGVSDLVQRDVSSQLLRAGPRLRTHQPPAWMEE
FFAKA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=299, Percent_Identity=36.7892976588629, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI109150427, Length=299, Percent_Identity=36.7892976588629, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=36.8243243243243, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI260654708, Length=138, Percent_Identity=38.4057971014493, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17510563, Length=271, Percent_Identity=35.0553505535055, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24582381, Length=313, Percent_Identity=36.4217252396166, Blast_Score=208, Evalue=3e-54,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34163; Mature: 34032

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKMSAATYPLSGPAKVEINEVAPRDGLQIEPFIVPTEGKVAFVNALARCGFARIEATS
CCCCCCCCCCCCCCCCEEEECCCCCCCCCEECEEEECCCCCHHHHHHHHHCCHHHEEECC
FTSARAIPALADAEAVMHQVERVAGVGLTVLVPNLRGLERALSCRPDEVNLVMSSSETHN
CCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCC
RANLRMTREQSQAQLLAMIAEAGKAGVPVNVSLSTVFGCPFEGDVSEAEVMRLAKAFADA
CCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEHHHEECCCCCCCCCHHHHHHHHHHHHCC
GAAGITLCDTTGMAYPNQVAALCETFQRALPKTGLTIHLHNTRGMGLANAIAAWQTGVTR
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCHH
FDAAAGGLGGCPYAPGASGNVSTEELVHMFASMGVDTGVELGALLDVVAGVSDLVQRDVS
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLRAGPRLRTHQPPAWMEEFFAKA
HHHHHCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAKMSAATYPLSGPAKVEINEVAPRDGLQIEPFIVPTEGKVAFVNALARCGFARIEATS
CCCCCCCCCCCCCCCEEEECCCCCCCCCEECEEEECCCCCHHHHHHHHHCCHHHEEECC
FTSARAIPALADAEAVMHQVERVAGVGLTVLVPNLRGLERALSCRPDEVNLVMSSSETHN
CCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCC
RANLRMTREQSQAQLLAMIAEAGKAGVPVNVSLSTVFGCPFEGDVSEAEVMRLAKAFADA
CCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEHHHEECCCCCCCCCHHHHHHHHHHHHCC
GAAGITLCDTTGMAYPNQVAALCETFQRALPKTGLTIHLHNTRGMGLANAIAAWQTGVTR
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCHH
FDAAAGGLGGCPYAPGASGNVSTEELVHMFASMGVDTGVELGALLDVVAGVSDLVQRDVS
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SQLLRAGPRLRTHQPPAWMEEFFAKA
HHHHHCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]