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The map label for this gene is moeA [H]

Identifier: 94310902

GI number: 94310902

Start: 2138931

End: 2140166

Strand: Reverse

Name: moeA [H]

Synonym: Rmet_1964

Alternate gene names: 94310902

Gene position: 2140166-2138931 (Counterclockwise)

Preceding gene: 94310903

Following gene: 94310901

Centisome position: 54.48

GC content: 68.12

Gene sequence:

>1236_bases
ATGACCCAGACTGCTGCGCGCCCTCCGATGCTGACGATGGCCCAGGCGCTCGATGCCCTGATGGCCGGCGTTCGCCCGAT
CACCGATTCCGAAACCGTCGATACGCTGCAGGCCAACGGCCGGGTGCTGGCGGCCGGGGTCACCAGCGCGTTGCGCGTGC
CGCCGGCCGATAACACGTCGATGGACGGCTATGTGATGCGTGCCGCCGATGTGCCCGCGCCGGGCACGCGGCTGCCAGTC
TCGCAACGGATACCGGCGGGCCACGTGGGTACCGAACTGGCCCCGGGTACCGCCGCGCGCATCTTCACCGGCGGCCTGAT
TCCGCCTGGCGCCGATGCGGTGGTGATGCAGGAGCAGTGCCAGGCCGATGGCGACGCGGTGATCGTCAATCATGCACCGG
CATCGGGCGAGTGGATTCGCCGTGCCGGCGAGGATATCGAGGCCGGCAGCGAGATCCTGCCCGCCGGCACGCGCCTGTCG
CCGCAAGCGCTGGGCCTGGCCGCGTCGGTGGGACAGGCAAAGCTCGACGTGGTCCGCCGCGTGCGCGTGGCCGTGTTCTT
TACCGGCGACGAACTGGCAATGCCCGGCGAGCCGCTCAAGCCCGGCGCGATCTACAACTCGAACCGGTTCACGCTGCGCG
GTCTGCTGGAGAACCTCGGCTGCGAAGTGACTGACTTCGGTATCGTCCCGGACACGCTGGCAGCCACGCGCGACACGTTG
CGCCGCGCCGCCGAGGGCAACGACCTGATCATCACGTCGGGCGGCGTATCGGTAGGCGAGGAAGACCATATCCGTCCGGC
CGTCACGGCGGAAGGTCGGCTGGACCTCTGGCAGATTGCGATCAAGCCGGGCAAGCCGCTGGCCTTCGGGCAGGTGGCCA
ACGGCACCGAGCTGCCCGCGTTTTTCCTGGGCCTGCCGGGCAATCCCGTGTCGAGCTTCGTCACATTCCTGCTGTTCGTG
CGCCCGTTCATCCTGCGTCTGCAGGGCGTCGCGGATGTGACGCCGCGTCGTCTGCCGCTGCGTGCGGATTTCGATCTGCC
GCGCGGCGACCGCCGCAACGAATTCCTGCGCGCGCGCATCAACGATGCTGGCGGCCTCGACTTGTTTCCGAACCAGAGCT
CGGGCGTGCTGACGTCCACCGTGTGGGGCGATGGCCTGATCGACAATCCGCCGAACCAGACCATCCAGCGCGGCGACGTT
GTGCAGTTCATTCCATTTGCCAGTTTGCTGGCCTGA

Upstream 100 bases:

>100_bases
CGCTACAATCGGGTTTGCCGGGCTCCGCTGCCACGGCCCCCAGGCTTCCCGGCCCGGGGGCTGTTTCATTTGGAGCCAAC
CTGAATCCCACACGCATCCC

Downstream 100 bases:

>100_bases
TCATGCAACTAGAACTCCGATACTTCGCCAGCGTGCGCGAACAGGTGGGGCAGGGCGCCGAACGCGCCGAGGTGCCCGCC
GAGGTTCGCACGGTTGGCGA

Product: molybdopterin biosynthesis protein (MoeA-like, domain I and II)

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTQTAARPPMLTMAQALDALMAGVRPITDSETVDTLQANGRVLAAGVTSALRVPPADNTSMDGYVMRAADVPAPGTRLPV
SQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCQADGDAVIVNHAPASGEWIRRAGEDIEAGSEILPAGTRLS
PQALGLAASVGQAKLDVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVTDFGIVPDTLAATRDTL
RRAAEGNDLIITSGGVSVGEEDHIRPAVTAEGRLDLWQIAIKPGKPLAFGQVANGTELPAFFLGLPGNPVSSFVTFLLFV
RPFILRLQGVADVTPRRLPLRADFDLPRGDRRNEFLRARINDAGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQTIQRGDV
VQFIPFASLLA

Sequences:

>Translated_411_residues
MTQTAARPPMLTMAQALDALMAGVRPITDSETVDTLQANGRVLAAGVTSALRVPPADNTSMDGYVMRAADVPAPGTRLPV
SQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCQADGDAVIVNHAPASGEWIRRAGEDIEAGSEILPAGTRLS
PQALGLAASVGQAKLDVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVTDFGIVPDTLAATRDTL
RRAAEGNDLIITSGGVSVGEEDHIRPAVTAEGRLDLWQIAIKPGKPLAFGQVANGTELPAFFLGLPGNPVSSFVTFLLFV
RPFILRLQGVADVTPRRLPLRADFDLPRGDRRNEFLRARINDAGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQTIQRGDV
VQFIPFASLLA
>Mature_410_residues
TQTAARPPMLTMAQALDALMAGVRPITDSETVDTLQANGRVLAAGVTSALRVPPADNTSMDGYVMRAADVPAPGTRLPVS
QRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQCQADGDAVIVNHAPASGEWIRRAGEDIEAGSEILPAGTRLSP
QALGLAASVGQAKLDVVRRVRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVTDFGIVPDTLAATRDTLR
RAAEGNDLIITSGGVSVGEEDHIRPAVTAEGRLDLWQIAIKPGKPLAFGQVANGTELPAFFLGLPGNPVSSFVTFLLFVR
PFILRLQGVADVTPRRLPLRADFDLPRGDRRNEFLRARINDAGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQTIQRGDVV
QFIPFASLLA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=424, Percent_Identity=32.311320754717, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI10880983, Length=424, Percent_Identity=32.311320754717, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=41.9270833333333, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25147659, Length=351, Percent_Identity=31.9088319088319, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=400, Percent_Identity=25.5, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17136978, Length=403, Percent_Identity=31.2655086848635, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24638841, Length=403, Percent_Identity=31.2655086848635, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43398; Mature: 43267

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAARPPMLTMAQALDALMAGVRPITDSETVDTLQANGRVLAAGVTSALRVPPADNTS
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCHHEECCCCCCCC
MDGYVMRAADVPAPGTRLPVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQC
CCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCEEEHHHH
QADGDAVIVNHAPASGEWIRRAGEDIEAGSEILPAGTRLSPQALGLAASVGQAKLDVVRR
CCCCCEEEEECCCCCCHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHE
VRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVTDFGIVPDTLAATRDTL
EEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
RRAAEGNDLIITSGGVSVGEEDHIRPAVTAEGRLDLWQIAIKPGKPLAFGQVANGTELPA
HHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCEEECCCCCCCCCCE
FFLGLPGNPVSSFVTFLLFVRPFILRLQGVADVTPRRLPLRADFDLPRGDRRNEFLRARI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCHHHHEEE
NDAGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQTIQRGDVVQFIPFASLLA
CCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCHHCCCCEEEEHHHHHHHC
>Mature Secondary Structure 
TQTAARPPMLTMAQALDALMAGVRPITDSETVDTLQANGRVLAAGVTSALRVPPADNTS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCHHEECCCCCCCC
MDGYVMRAADVPAPGTRLPVSQRIPAGHVGTELAPGTAARIFTGGLIPPGADAVVMQEQC
CCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCEEEHHHH
QADGDAVIVNHAPASGEWIRRAGEDIEAGSEILPAGTRLSPQALGLAASVGQAKLDVVRR
CCCCCEEEEECCCCCCHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHE
VRVAVFFTGDELAMPGEPLKPGAIYNSNRFTLRGLLENLGCEVTDFGIVPDTLAATRDTL
EEEEEEECCCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
RRAAEGNDLIITSGGVSVGEEDHIRPAVTAEGRLDLWQIAIKPGKPLAFGQVANGTELPA
HHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCEEEEEEECCCCCEEECCCCCCCCCCE
FFLGLPGNPVSSFVTFLLFVRPFILRLQGVADVTPRRLPLRADFDLPRGDRRNEFLRARI
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCHHHHEEE
NDAGGLDLFPNQSSGVLTSTVWGDGLIDNPPNQTIQRGDVVQFIPFASLLA
CCCCCCEECCCCCCCEEEEEECCCCCCCCCCCCHHCCCCEEEEHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]