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The map label for this gene is trxB [H]

Identifier: 94310860

GI number: 94310860

Start: 2088455

End: 2090107

Strand: Reverse

Name: trxB [H]

Synonym: Rmet_1922

Alternate gene names: 94310860

Gene position: 2090107-2088455 (Counterclockwise)

Preceding gene: 94310861

Following gene: 94310859

Centisome position: 53.21

GC content: 63.04

Gene sequence:

>1653_bases
ATGATCCAGCAGAATACAGGCGGTGTCGGGTCGCGCAGACATCAGATGTTTCCCGTTCTGACGCCGATTCAGGTTGAGGC
GGCTAGCCGATTCGCAAGCGGTCCGCCGCGCGTGTTCGCATCGGGTGAGACTGTCTTTGCCACGGGGGACAGGAACGTAC
CGGTTTGGCTCGTGCTGGATGGTTCCATTGATGTTCTGCGCCGCAATGGCCTGGACGAGAGCGCGCCCATCACTACCCAT
CGCGCGGGGCAGTTTACCGGAGAGGTCAGTCAGATCGATGGCCGTGCGTCGCTTGCGCTGGCGCAGGCGGGTCCGGACGG
CGCCACGCTGCTGCCATTCGATCCACCGCACTTGCGCGCGCTGATGATCGGATCGGCGGAGGTTGGCGAAATCGTCATGC
GCGCATTGATCTTGCGGCGCGTCAGCCTGATCGAGCATGGTGGCTCGGGTACGATTTTGATTGGTGCGTCAGATGATTTG
CACCTTCTGCGCCTGCAGGGATTTCTGACCCGTGGCGGCTACCCCAATCACATCATGGACCCTCGGGTCGACGGTGATGG
GCGTAGCTTCGTCGAGCGGATGGCGCTTCTTCCTACCGACATGCCGCTGGTGGTCTGCCCCGGTGGCGCAGTATTGAAGC
GGCCGGACGAGCGTGAACTGGCGGCCTGCCTCGGCATTCTCCCCAAGATCGAGCAGCGGAAAACCTACGACGTTGCCGTT
GTGGGTGCGGGTCCGGCCGGGTTGGCGGCTGCGGTCTATGGCGCTTCGGAGGGCCTCTCGGTGATCGTTCTTGACGAGCG
CACCATGGGCGGGCAGGCCGGAGCGTCGGCGCGAATCGAAAACTATCTTGGCTTTCCGACCGGCATCTCGGGGCAGGCGC
TCGCAGGCCGCGCATTCACCCAGGCCCTGAAGTTCGGGGCCGAGGTGGCCATCCCCGTGAGTGTGGGGCGGCTGGATCGC
GATGGGGATCGGCTGACGCTGGGGCTCTCCGATGACTCGACAGTGGCAGCGCGCACTGTCGTGATCGCTTCAGGTGCTGC
CTACCGGCAACCAGACATCGCCGGCCTCAGGCATTTCGAAGGCGCTGGGGTCTCCTATTGGGCATCTCCGATCGAAGCGC
GCTTGTGTGCAGGCAAGGAAATCGCCCTTGTCGGCGGCGGCAATTCGGCGGGCCAGGCGATCGTGTTTCTTGCTCCGCAC
GTGAAGCGGCTTCACGTATTCGTGCGGCGAGAGCTTTCGGAGACGATGTCGCGCTACCTCATCAATCGTATTTCTGCGTT
ACCCAACGTCGACATTCATGTCGGCACGGATCTGATCGGACTCGCACCCCATGGTGAGACGCTTGCCAGCGCCACAGTTC
GCGATCGCGCCAGCGCGGCGTTGACGCAGTACGAAATCTGCCATCTCTTCCTGTTCATCGGCGCGACACCGCATACCTGC
TGGCTCAACGGTTCATTAGCGATGGACGACAAGGGCTTCATCTTGACTGGTGGATCGACGTCTTCGCTCGAGACCAGCAT
GCCCGGAGTCTTTGCCATCGGCGACGTCCGAGCGGGCTCGACCAAGCGGGTGGCCGCCGCAGTCGGCGATGGGGCTGCCG
CCATTTCACAGATCCACAATTACCTCAGCAAGCAGGCCAAGGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
GGCTTGACGTCGACGTGTTTCAGGCAGGCCGCCTTCAGGCATTCCCGAGCTGGCTGGCAACGAACCCGCCGGACGCTGGG
CGGAAGAGGAGAGCGCTCAT

Downstream 100 bases:

>100_bases
AAACTTGTGACCATGCGGATACGATCCGTGACGTCGTACCAAGCGCCCGGGGTTGCGAAGAATGTCTGAACGTGGGCAGC
ACGTGGGTGCATCTTCGGTT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MIQQNTGGVGSRRHQMFPVLTPIQVEAASRFASGPPRVFASGETVFATGDRNVPVWLVLDGSIDVLRRNGLDESAPITTH
RAGQFTGEVSQIDGRASLALAQAGPDGATLLPFDPPHLRALMIGSAEVGEIVMRALILRRVSLIEHGGSGTILIGASDDL
HLLRLQGFLTRGGYPNHIMDPRVDGDGRSFVERMALLPTDMPLVVCPGGAVLKRPDERELAACLGILPKIEQRKTYDVAV
VGAGPAGLAAAVYGASEGLSVIVLDERTMGGQAGASARIENYLGFPTGISGQALAGRAFTQALKFGAEVAIPVSVGRLDR
DGDRLTLGLSDDSTVAARTVVIASGAAYRQPDIAGLRHFEGAGVSYWASPIEARLCAGKEIALVGGGNSAGQAIVFLAPH
VKRLHVFVRRELSETMSRYLINRISALPNVDIHVGTDLIGLAPHGETLASATVRDRASAALTQYEICHLFLFIGATPHTC
WLNGSLAMDDKGFILTGGSTSSLETSMPGVFAIGDVRAGSTKRVAAAVGDGAAAISQIHNYLSKQAKEAA

Sequences:

>Translated_550_residues
MIQQNTGGVGSRRHQMFPVLTPIQVEAASRFASGPPRVFASGETVFATGDRNVPVWLVLDGSIDVLRRNGLDESAPITTH
RAGQFTGEVSQIDGRASLALAQAGPDGATLLPFDPPHLRALMIGSAEVGEIVMRALILRRVSLIEHGGSGTILIGASDDL
HLLRLQGFLTRGGYPNHIMDPRVDGDGRSFVERMALLPTDMPLVVCPGGAVLKRPDERELAACLGILPKIEQRKTYDVAV
VGAGPAGLAAAVYGASEGLSVIVLDERTMGGQAGASARIENYLGFPTGISGQALAGRAFTQALKFGAEVAIPVSVGRLDR
DGDRLTLGLSDDSTVAARTVVIASGAAYRQPDIAGLRHFEGAGVSYWASPIEARLCAGKEIALVGGGNSAGQAIVFLAPH
VKRLHVFVRRELSETMSRYLINRISALPNVDIHVGTDLIGLAPHGETLASATVRDRASAALTQYEICHLFLFIGATPHTC
WLNGSLAMDDKGFILTGGSTSSLETSMPGVFAIGDVRAGSTKRVAAAVGDGAAAISQIHNYLSKQAKEAA
>Mature_550_residues
MIQQNTGGVGSRRHQMFPVLTPIQVEAASRFASGPPRVFASGETVFATGDRNVPVWLVLDGSIDVLRRNGLDESAPITTH
RAGQFTGEVSQIDGRASLALAQAGPDGATLLPFDPPHLRALMIGSAEVGEIVMRALILRRVSLIEHGGSGTILIGASDDL
HLLRLQGFLTRGGYPNHIMDPRVDGDGRSFVERMALLPTDMPLVVCPGGAVLKRPDERELAACLGILPKIEQRKTYDVAV
VGAGPAGLAAAVYGASEGLSVIVLDERTMGGQAGASARIENYLGFPTGISGQALAGRAFTQALKFGAEVAIPVSVGRLDR
DGDRLTLGLSDDSTVAARTVVIASGAAYRQPDIAGLRHFEGAGVSYWASPIEARLCAGKEIALVGGGNSAGQAIVFLAPH
VKRLHVFVRRELSETMSRYLINRISALPNVDIHVGTDLIGLAPHGETLASATVRDRASAALTQYEICHLFLFIGATPHTC
WLNGSLAMDDKGFILTGGSTSSLETSMPGVFAIGDVRAGSTKRVAAAVGDGAAAISQIHNYLSKQAKEAA

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=319, Percent_Identity=30.7210031347962, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787114, Length=315, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321898, Length=330, Percent_Identity=29.0909090909091, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320560, Length=323, Percent_Identity=28.4829721362229, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 57653; Mature: 57653

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQNTGGVGSRRHQMFPVLTPIQVEAASRFASGPPRVFASGETVFATGDRNVPVWLVLD
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCEEECCCEEEEECCCCCEEEEEEC
GSIDVLRRNGLDESAPITTHRAGQFTGEVSQIDGRASLALAQAGPDGATLLPFDPPHLRA
CCCHHHHHCCCCCCCCCCEECCCCCCCCHHHCCCCEEEEEEECCCCCCEECCCCCCCEEE
LMIGSAEVGEIVMRALILRRVSLIEHGGSGTILIGASDDLHLLRLQGFLTRGGYPNHIMD
EEECCCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCEEEEEEEHHHHCCCCCCCCCC
PRVDGDGRSFVERMALLPTDMPLVVCPGGAVLKRPDERELAACLGILPKIEQRKTYDVAV
CCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCHHHHHHHHHHCCCCCCCCEEEEEE
VGAGPAGLAAAVYGASEGLSVIVLDERTMGGQAGASARIENYLGFPTGISGQALAGRAFT
EECCCHHHHHHEECCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH
QALKFGAEVAIPVSVGRLDRDGDRLTLGLSDDSTVAARTVVIASGAAYRQPDIAGLRHFE
HHHHCCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCCHHHHHHCC
GAGVSYWASPIEARLCAGKEIALVGGGNSAGQAIVFLAPHVKRLHVFVRRELSETMSRYL
CCCCHHHCCCHHHHHCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
INRISALPNVDIHVGTDLIGLAPHGETLASATVRDRASAALTQYEICHLFLFIGATPHTC
HHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
WLNGSLAMDDKGFILTGGSTSSLETSMPGVFAIGDVRAGSTKRVAAAVGDGAAAISQIHN
EECCEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHH
YLSKQAKEAA
HHHHHHHHCC
>Mature Secondary Structure
MIQQNTGGVGSRRHQMFPVLTPIQVEAASRFASGPPRVFASGETVFATGDRNVPVWLVLD
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCCEEECCCEEEEECCCCCEEEEEEC
GSIDVLRRNGLDESAPITTHRAGQFTGEVSQIDGRASLALAQAGPDGATLLPFDPPHLRA
CCCHHHHHCCCCCCCCCCEECCCCCCCCHHHCCCCEEEEEEECCCCCCEECCCCCCCEEE
LMIGSAEVGEIVMRALILRRVSLIEHGGSGTILIGASDDLHLLRLQGFLTRGGYPNHIMD
EEECCCHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCEEEEEEEHHHHCCCCCCCCCC
PRVDGDGRSFVERMALLPTDMPLVVCPGGAVLKRPDERELAACLGILPKIEQRKTYDVAV
CCCCCCHHHHHHHHHHCCCCCCEEECCCCCEECCCCHHHHHHHHHHCCCCCCCCEEEEEE
VGAGPAGLAAAVYGASEGLSVIVLDERTMGGQAGASARIENYLGFPTGISGQALAGRAFT
EECCCHHHHHHEECCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHH
QALKFGAEVAIPVSVGRLDRDGDRLTLGLSDDSTVAARTVVIASGAAYRQPDIAGLRHFE
HHHHCCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCCCHHHHHHCC
GAGVSYWASPIEARLCAGKEIALVGGGNSAGQAIVFLAPHVKRLHVFVRRELSETMSRYL
CCCCHHHCCCHHHHHCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
INRISALPNVDIHVGTDLIGLAPHGETLASATVRDRASAALTQYEICHLFLFIGATPHTC
HHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEE
WLNGSLAMDDKGFILTGGSTSSLETSMPGVFAIGDVRAGSTKRVAAAVGDGAAAISQIHN
EECCEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHH
YLSKQAKEAA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]