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The map label for this gene is clpP [H]

Identifier: 94310823

GI number: 94310823

Start: 2051060

End: 2051710

Strand: Reverse

Name: clpP [H]

Synonym: Rmet_1885

Alternate gene names: 94310823

Gene position: 2051710-2051060 (Counterclockwise)

Preceding gene: 94310824

Following gene: 94310822

Centisome position: 52.23

GC content: 58.99

Gene sequence:

>651_bases
ATGACCCGCAATGATTTGCTTGATCGTCTCGCCACCACGCAGGCTTCTGCTCTGGAGACCCAGGGTCTTGGTCTGGTGCC
GATGGTCGTCGAGCAGTCCGGCCGGGGCGAGCGCGCGTACGACATCTACTCGCGCCTGCTCAAGGAACGTGTCGTCTTCA
TGGTCGGCGAAGTGAACGACCAGACTGCCAACCTGGTGGTGGCTCAGCTTCTGTTCCTCGAAAGCGAGAATCCTGATAAG
GACGTGTCGCTGTACATCAATTCGCCCGGTGGTTCGGTTTCGGCCGGTCTGGCGATCTATGACACGATGCAGTTCATCAA
GCCCGATGTGCAAACACTGTGCATGGGCATGGCTGCCAGCATGGGTGCATTCCTGCTCGCAGCAGGCGCCAAGGGTAAGC
GCAGCGCGCTGCCAAACTCGCGAATCATGATTCACCAGCCGTTGGGCGGTGCGCGTGGTCAGGCTTCGGACATCGAAATC
CAGGCACGCGAGATCCTGTATCTGCGCGAACGCCTGAACAGCATCCTTTCTGAGGTGACCGGCCAGCCCGTGGAGAAGAT
CGCGCGCGATACTGACCGCGATAACTTCATGAGCGGCGATCAGGCTGTGGATTACGGTCTGATCGATAAGGTGATTACCC
GTCGCAGTTGA

Upstream 100 bases:

>100_bases
TAAGCCGGAAGCCGCGCGAGTATGGCGCGGCGCTGGCTTGCGTCAATCGGCCTCGCGCGCTGGCCGATTGACGCCATTCC
TGAATATCTGGAGAACCTGC

Downstream 100 bases:

>100_bases
GACGGATCGGCCGGTTTGCCGGTAGGCCATTCCGGGTGCGATCCAGAAAGGATTGCCCCGGGTGGCGCCCGGTAACGCCG
GGCGTAGGCTGTACGAATCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFMVGEVNDQTANLVVAQLLFLESENPDK
DVSLYINSPGGSVSAGLAIYDTMQFIKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVITRRS

Sequences:

>Translated_216_residues
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFMVGEVNDQTANLVVAQLLFLESENPDK
DVSLYINSPGGSVSAGLAIYDTMQFIKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEI
QAREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVITRRS
>Mature_215_residues
TRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFMVGEVNDQTANLVVAQLLFLESENPDKD
VSLYINSPGGSVSAGLAIYDTMQFIKPDVQTLCMGMAASMGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQ
AREILYLRERLNSILSEVTGQPVEKIARDTDRDNFMSGDQAVDYGLIDKVITRRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=57.5757575757576, Blast_Score=240, Evalue=8e-64,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=67.0103092783505, Blast_Score=295, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=54.4973544973545, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=56.3157894736842, Blast_Score=233, Evalue=8e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23582; Mature: 23451

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFMVGEVND
CCHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QTANLVVAQLLFLESENPDKDVSLYINSPGGSVSAGLAIYDTMQFIKPDVQTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNSILSEVT
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVEKIARDTDRDNFMSGDQAVDYGLIDKVITRRS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRNDLLDRLATTQASALETQGLGLVPMVVEQSGRGERAYDIYSRLLKERVVFMVGEVND
CHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QTANLVVAQLLFLESENPDKDVSLYINSPGGSVSAGLAIYDTMQFIKPDVQTLCMGMAAS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHH
MGAFLLAAGAKGKRSALPNSRIMIHQPLGGARGQASDIEIQAREILYLRERLNSILSEVT
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GQPVEKIARDTDRDNFMSGDQAVDYGLIDKVITRRS
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]