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The map label for this gene is aphA [H]

Identifier: 94310563

GI number: 94310563

Start: 1748372

End: 1749445

Strand: Direct

Name: aphA [H]

Synonym: Rmet_1621

Alternate gene names: 94310563

Gene position: 1748372-1749445 (Clockwise)

Preceding gene: 94310562

Following gene: 94310564

Centisome position: 44.51

GC content: 67.23

Gene sequence:

>1074_bases
ATGCGCGCCTTTTTCTCGGATGACCAGTTGCTGCACCAGCCTCGGCAGTTCATGCGCGCAGGCCGGCTGTGCGAGCCGAC
GGACGTACCGGCTCGCGCCGCCGTGCTCCAGCGGGCGCTCGACGCCCGTGGTATCGAACTCGTCGCGCCGCCCGACTACG
GCCGCGCGCCGCTGGAAACAGTGCATAGCCCGGCGTACCTCGATTTCCTGACCAGCGCGTTCGAGCGCTGGATGGCGCAG
GCAACGCCTACGCTCGAACCGGGCATCGAGGTGCTGCCGAACCTTTCGCCGTATCACAGCGGCAAGATCGACAAGACGCG
GCGTGGCCCGTGTCCATCGGGCAGCGTGATTGCCGAAGCGGGCTACTACCTCGGGGACCTGAGCTGTCCGCTCGGGCCCC
ATAGCTGGCAGTCGATCCTGCGCTCGGCGCATAGCGCGGTGGCGGCGGCGCGGCATGTGTGCGCGCCGCACGACGGCAAT
GGCATGGCCTATGCGCTGTGCCGGCCGTCCGGCCACCACGCCCACGCTGACCGCGCAGGCGGGTTCTGCTACGTCAACAA
CTCGGCGATCGCCGCGCAGACACTGCTGGAGCGCTTCGACAAGGTCGCCGTGCTCGACGTGGACGCCCATCATGGCGATG
GCACGCAGCAGATCTTCTACCAGCGTTCCGACGTGATGACGATTTCGCTGCACGCGGACCCCAGCAGCTACTACCCGTTT
TACACGGGCTACGCCACCGAGCGCGGTCATGGCGCGGGCTATGGCTACAACCTCAATTTCCCGCTGCCGCACGGCACAGG
CGATGCTGGATTCCTGTCGGCGCTGGACAGCGCGCTCGATGCGCTGCGCGACTACCGTCCGCAGGCGCTGGTGCTGGCGC
TTGGCTTCGACACGTACAAGCACGACCCGATCAGCGTGCTGCAGGTGGGGCTGGAAGCCTATCGGGGCGTGGGCGAGCGT
ATCCACGCGCTGGGCGTGCCGACGGTGGTGGTGCAGGAGGGCGGTTACGAAGTGGATGCGATCGGTATCGCGCTGGAAGC
ATTTCTCGCGGGCTTCGTGCCTGCGATGGCATGA

Upstream 100 bases:

>100_bases
GCGTCACGCTCTCCGGCATTCGTGCCGCAGCGCTGGCGCGGCAATCCGCCTGAGCGACGCAACACGACGACAACCGACGG
AACCACCCGTAATTCCCACC

Downstream 100 bases:

>100_bases
ATCAGGAGTACACATGACGACTTTGAACATCGACGGCCAGCGGCTCTGGCAGTCCCTGATGGATCTGGCTGCCATCGGCG
CGACGCCAAAGGGCGGCAAC

Product: putative acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRAFFSDDQLLHQPRQFMRAGRLCEPTDVPARAAVLQRALDARGIELVAPPDYGRAPLETVHSPAYLDFLTSAFERWMAQ
ATPTLEPGIEVLPNLSPYHSGKIDKTRRGPCPSGSVIAEAGYYLGDLSCPLGPHSWQSILRSAHSAVAAARHVCAPHDGN
GMAYALCRPSGHHAHADRAGGFCYVNNSAIAAQTLLERFDKVAVLDVDAHHGDGTQQIFYQRSDVMTISLHADPSSYYPF
YTGYATERGHGAGYGYNLNFPLPHGTGDAGFLSALDSALDALRDYRPQALVLALGFDTYKHDPISVLQVGLEAYRGVGER
IHALGVPTVVVQEGGYEVDAIGIALEAFLAGFVPAMA

Sequences:

>Translated_357_residues
MRAFFSDDQLLHQPRQFMRAGRLCEPTDVPARAAVLQRALDARGIELVAPPDYGRAPLETVHSPAYLDFLTSAFERWMAQ
ATPTLEPGIEVLPNLSPYHSGKIDKTRRGPCPSGSVIAEAGYYLGDLSCPLGPHSWQSILRSAHSAVAAARHVCAPHDGN
GMAYALCRPSGHHAHADRAGGFCYVNNSAIAAQTLLERFDKVAVLDVDAHHGDGTQQIFYQRSDVMTISLHADPSSYYPF
YTGYATERGHGAGYGYNLNFPLPHGTGDAGFLSALDSALDALRDYRPQALVLALGFDTYKHDPISVLQVGLEAYRGVGER
IHALGVPTVVVQEGGYEVDAIGIALEAFLAGFVPAMA
>Mature_357_residues
MRAFFSDDQLLHQPRQFMRAGRLCEPTDVPARAAVLQRALDARGIELVAPPDYGRAPLETVHSPAYLDFLTSAFERWMAQ
ATPTLEPGIEVLPNLSPYHSGKIDKTRRGPCPSGSVIAEAGYYLGDLSCPLGPHSWQSILRSAHSAVAAARHVCAPHDGN
GMAYALCRPSGHHAHADRAGGFCYVNNSAIAAQTLLERFDKVAVLDVDAHHGDGTQQIFYQRSDVMTISLHADPSSYYPF
YTGYATERGHGAGYGYNLNFPLPHGTGDAGFLSALDSALDALRDYRPQALVLALGFDTYKHDPISVLQVGLEAYRGVGER
IHALGVPTVVVQEGGYEVDAIGIALEAFLAGFVPAMA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795202, Length=218, Percent_Identity=31.651376146789, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI30795204, Length=218, Percent_Identity=31.651376146789, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI148539870, Length=231, Percent_Identity=32.9004329004329, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI169234807, Length=231, Percent_Identity=32.9004329004329, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI17158039, Length=218, Percent_Identity=31.651376146789, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI8923769, Length=182, Percent_Identity=32.4175824175824, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI153085395, Length=202, Percent_Identity=34.1584158415842, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13128862, Length=171, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI13128860, Length=171, Percent_Identity=30.9941520467836, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI13128864, Length=192, Percent_Identity=32.8125, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073088, Length=177, Percent_Identity=32.2033898305085, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI62750349, Length=231, Percent_Identity=32.034632034632, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI62750347, Length=231, Percent_Identity=32.034632034632, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI20070354, Length=189, Percent_Identity=32.2751322751323, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI293336691, Length=144, Percent_Identity=34.0277777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073092, Length=114, Percent_Identity=36.8421052631579, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI226529806, Length=188, Percent_Identity=30.3191489361702, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17540332, Length=196, Percent_Identity=33.6734693877551, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193206283, Length=196, Percent_Identity=33.6734693877551, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17540334, Length=196, Percent_Identity=33.6734693877551, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=215, Percent_Identity=30.2325581395349, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17508561, Length=171, Percent_Identity=32.7485380116959, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=212, Percent_Identity=29.7169811320755, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193209491, Length=274, Percent_Identity=28.1021897810219, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537347, Length=194, Percent_Identity=30.9278350515464, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25154020, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=206, Percent_Identity=34.9514563106796, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321244, Length=253, Percent_Identity=28.0632411067194, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=173, Percent_Identity=33.5260115606936, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6325325, Length=321, Percent_Identity=23.6760124610592, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24642142, Length=185, Percent_Identity=37.2972972972973, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24642144, Length=185, Percent_Identity=37.2972972972973, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24642146, Length=185, Percent_Identity=37.2972972972973, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360899, Length=185, Percent_Identity=37.2972972972973, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24641720, Length=190, Percent_Identity=36.3157894736842, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360801, Length=190, Percent_Identity=36.3157894736842, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281360799, Length=190, Percent_Identity=36.3157894736842, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24644244, Length=168, Percent_Identity=36.3095238095238, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24657891, Length=217, Percent_Identity=30.4147465437788, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24649807, Length=187, Percent_Identity=26.2032085561497, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 38502; Mature: 38502

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFFSDDQLLHQPRQFMRAGRLCEPTDVPARAAVLQRALDARGIELVAPPDYGRAPLET
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHH
VHSPAYLDFLTSAFERWMAQATPTLEPGIEVLPNLSPYHSGKIDKTRRGPCPSGSVIAEA
HCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECC
GYYLGDLSCPLGPHSWQSILRSAHSAVAAARHVCAPHDGNGMAYALCRPSGHHAHADRAG
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
GFCYVNNSAIAAQTLLERFDKVAVLDVDAHHGDGTQQIFYQRSDVMTISLHADPSSYYPF
CEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHEEECCCEEEEEEECCCCCCCCE
YTGYATERGHGAGYGYNLNFPLPHGTGDAGFLSALDSALDALRDYRPQALVLALGFDTYK
EECCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
HDPISVLQVGLEAYRGVGERIHALGVPTVVVQEGGYEVDAIGIALEAFLAGFVPAMA
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAFFSDDQLLHQPRQFMRAGRLCEPTDVPARAAVLQRALDARGIELVAPPDYGRAPLET
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCHHH
VHSPAYLDFLTSAFERWMAQATPTLEPGIEVLPNLSPYHSGKIDKTRRGPCPSGSVIAEA
HCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECC
GYYLGDLSCPLGPHSWQSILRSAHSAVAAARHVCAPHDGNGMAYALCRPSGHHAHADRAG
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
GFCYVNNSAIAAQTLLERFDKVAVLDVDAHHGDGTQQIFYQRSDVMTISLHADPSSYYPF
CEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHEEECCCEEEEEEECCCCCCCCE
YTGYATERGHGAGYGYNLNFPLPHGTGDAGFLSALDSALDALRDYRPQALVLALGFDTYK
EECCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
HDPISVLQVGLEAYRGVGERIHALGVPTVVVQEGGYEVDAIGIALEAFLAGFVPAMA
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]