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The map label for this gene is dapE [H]

Identifier: 94310552

GI number: 94310552

Start: 1737099

End: 1738442

Strand: Direct

Name: dapE [H]

Synonym: Rmet_1610

Alternate gene names: 94310552

Gene position: 1737099-1738442 (Clockwise)

Preceding gene: 94310549

Following gene: 94310557

Centisome position: 44.22

GC content: 63.69

Gene sequence:

>1344_bases
ATGCCGAATGCAGCCACCGTTGCGTCTCCTGAATCGACAACGCTCACCACGCAGGCGATTGCCGATGCCGTGCGCGCACT
CACGCCGTACATGGTGAAAACCCTGAGTGACTTCGTGGCGGCAGAGAGCCCGTCGGGTGCGGAGCAGCCCGCGGTGGACT
TCATGGACGATGCGCTGCGCGAGCTTGGACTGGAGTCGGAACGCATCGTCCTGAACACGGCGCAGCTGAAAGACATGCCG
CTGTTCTCCACGCCGTGCTGTCCCGATGGTGGACGCTACAACCTGCTGGCCACCCATCGTCCGCGCGAACGCGGTGGCCG
CTCGGTACTGTTCAATGGTCACCTCGACGTGGTGCCAACCGGCCCCGATTCGATGTGGCGCGAGTCACCGTTCAAGTCGT
ATGTCGAGGATGGTTGGCTCTATGGTCGCGGCGCAGGTGACATGAAGGCGGGCATCGTCTGCGCGCTGGCCGCGTTCAAG
GCACTGAAGGAACTGGGTGTACAGCCTGCCGGCAACGTCGGATTCAACGGCGTGCTGGAAGAAGAGAGCACCGGCAACGG
CGCGCTGGCGACGGTGGCTTCGCTGCGTAGCGCCGTGGGCGCTGGCAAGCTCGCTTCGTTCGATACAGTGCTGATCCCCG
AGCCGCTGGGTGAAGCCCTGATGAGCGCGCAGATGGGTGTGTTCTGGATGTATGTGGAACTGACGGGCCGCCCCGCCCAC
GCCGCGTATATGACTACTGGCGTCAATCCCGTGGAGGCCGGCATCGCGGTGATGGATGACCTGCGCCGTCTCGAAGCCGA
ATGGAACCTGCCGGAGAACCGGCCCGCCGCCTATCGCGACCACGCACATCCGATCAACTTCAACCTGGGCCAGATCCACG
GTGGCGAATGGAACTCATCCGTGCCGTGTACCTGCACGCTTGGTATCCGCATCGGCTTCTATCCGCAGATGGATGTCAAC
GATGCCAAGGCCATCGTTGCCCAGCGCGTTCGTGATGCGCTGGCGCGTCTGGGTAGCACGCTTGACCTGAACATCCGCTA
CGAAGGCTTTCACGCGCCGGGCTGCGAGTTCGATCTCGATAATGCGCCGATGCTGGCGCTGGCCGAGGCGCACCGCAAGG
CCCACGGCAATGCGCTGAAGCGTCAGGCCACCACGGCTACCACCGACGCCCGTCACTTCCGCATCACGCTCGATACACCC
GTCACCTGCTACGGCCCCGAAGCTCGCAACATCCACGGCATCGACGAATCGGTGTCGATCGAAAGCATGGTGCGCGTGGC
GACCACGTTCGCACAGTTCATGCACGACTGGTGCGGTGTAGAGCCAGCCGCCGACCAGACCTAG

Upstream 100 bases:

>100_bases
CAAAAAACAGGATATGGACCTACCGATGGTACCAACCATCGGATAATTTTCCATCCGTGCTGATGCTGTTTTTTTTCGAT
GTCCCCATCGCGGAGCCCCC

Downstream 100 bases:

>100_bases
AAACCGGTTTTCCCTCGTTGCTGTACCGCCTGGGCAAATGCGCCACCACGTGGTGGGGCGTTGCCCGTTGCCCTCGCTTG
TCCCAAAAATAGGAAACGAC

Product: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase

Products: acetate; L-ornithine

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MPNAATVASPESTTLTTQAIADAVRALTPYMVKTLSDFVAAESPSGAEQPAVDFMDDALRELGLESERIVLNTAQLKDMP
LFSTPCCPDGGRYNLLATHRPRERGGRSVLFNGHLDVVPTGPDSMWRESPFKSYVEDGWLYGRGAGDMKAGIVCALAAFK
ALKELGVQPAGNVGFNGVLEEESTGNGALATVASLRSAVGAGKLASFDTVLIPEPLGEALMSAQMGVFWMYVELTGRPAH
AAYMTTGVNPVEAGIAVMDDLRRLEAEWNLPENRPAAYRDHAHPINFNLGQIHGGEWNSSVPCTCTLGIRIGFYPQMDVN
DAKAIVAQRVRDALARLGSTLDLNIRYEGFHAPGCEFDLDNAPMLALAEAHRKAHGNALKRQATTATTDARHFRITLDTP
VTCYGPEARNIHGIDESVSIESMVRVATTFAQFMHDWCGVEPAADQT

Sequences:

>Translated_447_residues
MPNAATVASPESTTLTTQAIADAVRALTPYMVKTLSDFVAAESPSGAEQPAVDFMDDALRELGLESERIVLNTAQLKDMP
LFSTPCCPDGGRYNLLATHRPRERGGRSVLFNGHLDVVPTGPDSMWRESPFKSYVEDGWLYGRGAGDMKAGIVCALAAFK
ALKELGVQPAGNVGFNGVLEEESTGNGALATVASLRSAVGAGKLASFDTVLIPEPLGEALMSAQMGVFWMYVELTGRPAH
AAYMTTGVNPVEAGIAVMDDLRRLEAEWNLPENRPAAYRDHAHPINFNLGQIHGGEWNSSVPCTCTLGIRIGFYPQMDVN
DAKAIVAQRVRDALARLGSTLDLNIRYEGFHAPGCEFDLDNAPMLALAEAHRKAHGNALKRQATTATTDARHFRITLDTP
VTCYGPEARNIHGIDESVSIESMVRVATTFAQFMHDWCGVEPAADQT
>Mature_446_residues
PNAATVASPESTTLTTQAIADAVRALTPYMVKTLSDFVAAESPSGAEQPAVDFMDDALRELGLESERIVLNTAQLKDMPL
FSTPCCPDGGRYNLLATHRPRERGGRSVLFNGHLDVVPTGPDSMWRESPFKSYVEDGWLYGRGAGDMKAGIVCALAAFKA
LKELGVQPAGNVGFNGVLEEESTGNGALATVASLRSAVGAGKLASFDTVLIPEPLGEALMSAQMGVFWMYVELTGRPAHA
AYMTTGVNPVEAGIAVMDDLRRLEAEWNLPENRPAAYRDHAHPINFNLGQIHGGEWNSSVPCTCTLGIRIGFYPQMDVND
AKAIVAQRVRDALARLGSTLDLNIRYEGFHAPGCEFDLDNAPMLALAEAHRKAHGNALKRQATTATTDARHFRITLDTPV
TCYGPEARNIHGIDESVSIESMVRVATTFAQFMHDWCGVEPAADQT

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=331, Percent_Identity=22.6586102719033, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790395, Length=351, Percent_Identity=24.5014245014245, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788816, Length=339, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356353, Length=339, Percent_Identity=22.7138643067847, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16

Molecular weight: Translated: 48176; Mature: 48045

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAATVASPESTTLTTQAIADAVRALTPYMVKTLSDFVAAESPSGAEQPAVDFMDDALR
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ELGLESERIVLNTAQLKDMPLFSTPCCPDGGRYNLLATHRPRERGGRSVLFNGHLDVVPT
HHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCEEEEECCEEEEEC
GPDSMWRESPFKSYVEDGWLYGRGAGDMKAGIVCALAAFKALKELGVQPAGNVGFNGVLE
CCHHHHHCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEC
EESTGNGALATVASLRSAVGAGKLASFDTVLIPEPLGEALMSAQMGVFWMYVELTGRPAH
CCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEECCCCCC
AAYMTTGVNPVEAGIAVMDDLRRLEAEWNLPENRPAAYRDHAHPINFNLGQIHGGEWNSS
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCC
VPCTCTLGIRIGFYPQMDVNDAKAIVAQRVRDALARLGSTLDLNIRYEGFHAPGCEFDLD
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCC
NAPMLALAEAHRKAHGNALKRQATTATTDARHFRITLDTPVTCYGPEARNIHGIDESVSI
CCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCH
ESMVRVATTFAQFMHDWCGVEPAADQT
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PNAATVASPESTTLTTQAIADAVRALTPYMVKTLSDFVAAESPSGAEQPAVDFMDDALR
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ELGLESERIVLNTAQLKDMPLFSTPCCPDGGRYNLLATHRPRERGGRSVLFNGHLDVVPT
HHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCHHCCCCEEEEECCEEEEEC
GPDSMWRESPFKSYVEDGWLYGRGAGDMKAGIVCALAAFKALKELGVQPAGNVGFNGVLE
CCHHHHHCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEC
EESTGNGALATVASLRSAVGAGKLASFDTVLIPEPLGEALMSAQMGVFWMYVELTGRPAH
CCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEECCCCCC
AAYMTTGVNPVEAGIAVMDDLRRLEAEWNLPENRPAAYRDHAHPINFNLGQIHGGEWNSS
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCC
VPCTCTLGIRIGFYPQMDVNDAKAIVAQRVRDALARLGSTLDLNIRYEGFHAPGCEFDLD
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCC
NAPMLALAEAHRKAHGNALKRQATTATTDARHFRITLDTPVTCYGPEARNIHGIDESVSI
CCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCH
ESMVRVATTFAQFMHDWCGVEPAADQT
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-acetyl-L-ornithine; H2O

Specific reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]