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The map label for this gene is prpR [H]

Identifier: 94310530

GI number: 94310530

Start: 1711364

End: 1713265

Strand: Direct

Name: prpR [H]

Synonym: Rmet_1588

Alternate gene names: 94310530

Gene position: 1711364-1713265 (Clockwise)

Preceding gene: 94310524

Following gene: 94310536

Centisome position: 43.57

GC content: 67.35

Gene sequence:

>1902_bases
ATGGGCATCAGCCGTCTCTCTCGCGCCTTTGCCGAACTGATTCCGGCCTACGCGGGCCGGGCGGAATTCCGGATCGTTGG
CCGGGCCTTCGAAGCCGCGGCCAGCGCCATCAACCGGGAGGCACGGGAGAACCGCGTCGATGTGGTGGTGGCGGGCGGAT
CGAACGGCGCCTACCTGCGCCAGCATGTCGACGTGCCGGTGGTGCTGGTCAAGGTGACCGGCTTCGACGTCATGAGCGCG
TTAGCCACCGCCCGGCGCATTTCGCCGAAGGTGGCGCTGGTGACGCATGCCTCCACCTACGCCGAGGTCGACGAGTTTGT
ACGGGCCTTCTCGCTCGATATCCCGCGCTACACCTATCTGACTGAAGACGATGCGACCGCACGTGTACGGGCGCTCAAGG
AGGAGGGCGTGCGCGTGGTGGTCGGCCCGGGCCTGGTGACAGACATGGCCGACAAGTACGGGCTCGTCGGCGTGTTTCTC
TACTCGGGCAATGCCGTGCGGCTGGCGCTGGAGGATGCAATCGAGGCCGCGCGGTTGCGTCGTATCGAATCCACGCGACG
CGAATACGTGAACACGATTCTTGCCCACCTGAACGAAGGCGTGGCTGCGGTAGACGGCGAGGGGCGGGTGCAGGCGTTCA
ATCCGGCGATGGAGCGATTCCTCGGCACGCCTGCCGGGGTTGCGGTGGGTCGCAAGCTATCCACGCTGGCGCCCGGACTG
TCCCTCGACGGCGTGATGCAGAGCGGCGCGCGCGAGCTCGAAGCAATCCATCGGTTGGGCGACAAGATGGTGGTCGTCAA
CCGGATTCCGATCATGAGCGAGGCCGGCACGACAGGCGCCGTGCTGACGATCCAGGACGCCAACGCGATTCACCGCGCGG
ACCGCAACCTGCGCTCGCGCACACGCGCCCGGGCGGCGGGCGTGCGTTACAGCCTGGACGACCTGGCGGGCGATTCGCCG
GCGATGAGCGATCTGCGTGCGCTGGCGCGGCGCTATGCGATGGTCGATTCGACCGTTCTGGTCAGCGGCGAAAGCGGTAC
CGGCAAGGAAGTGCTGGCGCAGGGGATGCACGACGCGAGTCCGCGCCGCGCCTTTCCCTTCGTGGCGGTCAACTGCGCGG
CCTTCCCCGAGACGCTGCTCGAGTCCGAGCTGTTCGGCTACGAGGAAGGGGCGTTCACGGGCGCCCGGCGTGGCGGCAAG
GCCGGCCTGTTCGAGTCGGCGCATAACGGCACGCTGTTTCTCGACGAGATCGGCGATATGCCGCCGGCGCTGCAAACGCG
CCTGCTGCGTGTGCTGCAGGAGAAACAGGTGCTGCCAATCGGCGCGATCGAGGCCGTGCCGGTCAATGTGCGCGTGATCG
CCGCCACGCACCGCGACCTGGCCGCGCTCGTGCGCGATGGGGCATTCCGCCAGGATCTCTACTACCGCCTGAACATCCTC
CGCATCGAGATGCCGCCTTTGCGCGACCGCGCGGGAGACCTGCCCGTGCTGGCGGAACTGCTCTACCGGCGTGCGCAGGA
ACGGCTTGGCATGTCGGATGGGGAACCGCTACCCGCGATCGTGCGGGCACGCCTGGCGCGTTACGTGTGGCCGGGGAATA
TTCGCGAACTCGAAAACGTGACCGAGCGGATTGCAGTGCTTGTGGCCGGCGCGAACCTGACACCTGTGGCGCTGCAGCGG
GAGTTGCAGGCGGCGGTGCCGGAACTGTTTTCTGGTGATCACGGGACGGCCATCGAAATGTCCGACGGCGTGCCCGCGCA
ATCGCTGGCAGGGGTGGCCAAGGCAAGCCAGGCCGAGCATATCCGCCGTGTGCTGGCCGATTGCGGCGGTAACCGCGCGG
CGGCCTGCGCGCAGCTAGGCATCAGTCCGACAACACTTTGGAGACGGTTGCGCGAGGAGTGA

Upstream 100 bases:

>100_bases
AAGCTGTTCCATGACACCGTCGCACCCTACTGTTCCTCAGCCGATTTCCCTCAACCCCGCTGGCCCCGTCGCCCCTGGCG
CCCGCCCGAGGATCTGGGCC

Downstream 100 bases:

>100_bases
TCGATATCCGGTCCTTCATGAAGTCCGTTATTTCGCAATTAACGGCCAGAATTATTCGCCACCAATAATTTGGGCTAAAA
GTCCAAGGCCTTGAAAGACC

Product: propionate catabolism activator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MGISRLSRAFAELIPAYAGRAEFRIVGRAFEAAASAINREARENRVDVVVAGGSNGAYLRQHVDVPVVLVKVTGFDVMSA
LATARRISPKVALVTHASTYAEVDEFVRAFSLDIPRYTYLTEDDATARVRALKEEGVRVVVGPGLVTDMADKYGLVGVFL
YSGNAVRLALEDAIEAARLRRIESTRREYVNTILAHLNEGVAAVDGEGRVQAFNPAMERFLGTPAGVAVGRKLSTLAPGL
SLDGVMQSGARELEAIHRLGDKMVVVNRIPIMSEAGTTGAVLTIQDANAIHRADRNLRSRTRARAAGVRYSLDDLAGDSP
AMSDLRALARRYAMVDSTVLVSGESGTGKEVLAQGMHDASPRRAFPFVAVNCAAFPETLLESELFGYEEGAFTGARRGGK
AGLFESAHNGTLFLDEIGDMPPALQTRLLRVLQEKQVLPIGAIEAVPVNVRVIAATHRDLAALVRDGAFRQDLYYRLNIL
RIEMPPLRDRAGDLPVLAELLYRRAQERLGMSDGEPLPAIVRARLARYVWPGNIRELENVTERIAVLVAGANLTPVALQR
ELQAAVPELFSGDHGTAIEMSDGVPAQSLAGVAKASQAEHIRRVLADCGGNRAAACAQLGISPTTLWRRLREE

Sequences:

>Translated_633_residues
MGISRLSRAFAELIPAYAGRAEFRIVGRAFEAAASAINREARENRVDVVVAGGSNGAYLRQHVDVPVVLVKVTGFDVMSA
LATARRISPKVALVTHASTYAEVDEFVRAFSLDIPRYTYLTEDDATARVRALKEEGVRVVVGPGLVTDMADKYGLVGVFL
YSGNAVRLALEDAIEAARLRRIESTRREYVNTILAHLNEGVAAVDGEGRVQAFNPAMERFLGTPAGVAVGRKLSTLAPGL
SLDGVMQSGARELEAIHRLGDKMVVVNRIPIMSEAGTTGAVLTIQDANAIHRADRNLRSRTRARAAGVRYSLDDLAGDSP
AMSDLRALARRYAMVDSTVLVSGESGTGKEVLAQGMHDASPRRAFPFVAVNCAAFPETLLESELFGYEEGAFTGARRGGK
AGLFESAHNGTLFLDEIGDMPPALQTRLLRVLQEKQVLPIGAIEAVPVNVRVIAATHRDLAALVRDGAFRQDLYYRLNIL
RIEMPPLRDRAGDLPVLAELLYRRAQERLGMSDGEPLPAIVRARLARYVWPGNIRELENVTERIAVLVAGANLTPVALQR
ELQAAVPELFSGDHGTAIEMSDGVPAQSLAGVAKASQAEHIRRVLADCGGNRAAACAQLGISPTTLWRRLREE
>Mature_632_residues
GISRLSRAFAELIPAYAGRAEFRIVGRAFEAAASAINREARENRVDVVVAGGSNGAYLRQHVDVPVVLVKVTGFDVMSAL
ATARRISPKVALVTHASTYAEVDEFVRAFSLDIPRYTYLTEDDATARVRALKEEGVRVVVGPGLVTDMADKYGLVGVFLY
SGNAVRLALEDAIEAARLRRIESTRREYVNTILAHLNEGVAAVDGEGRVQAFNPAMERFLGTPAGVAVGRKLSTLAPGLS
LDGVMQSGARELEAIHRLGDKMVVVNRIPIMSEAGTTGAVLTIQDANAIHRADRNLRSRTRARAAGVRYSLDDLAGDSPA
MSDLRALARRYAMVDSTVLVSGESGTGKEVLAQGMHDASPRRAFPFVAVNCAAFPETLLESELFGYEEGAFTGARRGGKA
GLFESAHNGTLFLDEIGDMPPALQTRLLRVLQEKQVLPIGAIEAVPVNVRVIAATHRDLAALVRDGAFRQDLYYRLNILR
IEMPPLRDRAGDLPVLAELLYRRAQERLGMSDGEPLPAIVRARLARYVWPGNIRELENVTERIAVLVAGANLTPVALQRE
LQAAVPELFSGDHGTAIEMSDGVPAQSLAGVAKASQAEHIRRVLADCGGNRAAACAQLGISPTTLWRRLREE

Specific function: Involved In The Transcriptional Regulation Of The Propionate Catabolism Operon. [C]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=382, Percent_Identity=44.5026178010471, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1789233, Length=446, Percent_Identity=35.2017937219731, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1788550, Length=355, Percent_Identity=40.5633802816901, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1790437, Length=318, Percent_Identity=46.5408805031447, Blast_Score=243, Evalue=4e-65,
Organism=Escherichia coli, GI87082117, Length=242, Percent_Identity=51.6528925619835, Blast_Score=241, Evalue=2e-64,
Organism=Escherichia coli, GI1788905, Length=252, Percent_Identity=48.8095238095238, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1790299, Length=353, Percent_Identity=39.6600566572238, Blast_Score=229, Evalue=6e-61,
Organism=Escherichia coli, GI1789087, Length=348, Percent_Identity=40.5172413793103, Blast_Score=224, Evalue=2e-59,
Organism=Escherichia coli, GI87082152, Length=307, Percent_Identity=42.671009771987, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI1787583, Length=366, Percent_Identity=33.879781420765, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=41.991341991342, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87081858, Length=482, Percent_Identity=28.8381742738589, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1789828, Length=235, Percent_Identity=36.1702127659575, Blast_Score=122, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00989 PAS; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 68362; Mature: 68231

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGISRLSRAFAELIPAYAGRAEFRIVGRAFEAAASAINREARENRVDVVVAGGSNGAYLR
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
QHVDVPVVLVKVTGFDVMSALATARRISPKVALVTHASTYAEVDEFVRAFSLDIPRYTYL
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEE
TEDDATARVRALKEEGVRVVVGPGLVTDMADKYGLVGVFLYSGNAVRLALEDAIEAARLR
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHH
RIESTRREYVNTILAHLNEGVAAVDGEGRVQAFNPAMERFLGTPAGVAVGRKLSTLAPGL
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCHHHHHHCCCCCHHHHCCHHHHHCCCC
SLDGVMQSGARELEAIHRLGDKMVVVNRIPIMSEAGTTGAVLTIQDANAIHRADRNLRSR
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCEEEEEECCHHHHHHHHHHHHH
TRARAAGVRYSLDDLAGDSPAMSDLRALARRYAMVDSTVLVSGESGTGKEVLAQGMHDAS
HHHHHHCCCEEHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCC
PRRAFPFVAVNCAAFPETLLESELFGYEEGAFTGARRGGKAGLFESAHNGTLFLDEIGDM
CCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCC
PPALQTRLLRVLQEKQVLPIGAIEAVPVNVRVIAATHRDLAALVRDGAFRQDLYYRLNIL
CHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEEEECHHHHHHHHHCCCHHHHHHEEEEEE
RIEMPPLRDRAGDLPVLAELLYRRAQERLGMSDGEPLPAIVRARLARYVWPGNIRELENV
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
TERIAVLVAGANLTPVALQRELQAAVPELFSGDHGTAIEMSDGVPAQSLAGVAKASQAEH
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
IRRVLADCGGNRAAACAQLGISPTTLWRRLREE
HHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GISRLSRAFAELIPAYAGRAEFRIVGRAFEAAASAINREARENRVDVVVAGGSNGAYLR
CHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
QHVDVPVVLVKVTGFDVMSALATARRISPKVALVTHASTYAEVDEFVRAFSLDIPRYTYL
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEE
TEDDATARVRALKEEGVRVVVGPGLVTDMADKYGLVGVFLYSGNAVRLALEDAIEAARLR
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHCCEEEEEEECCCEEEEEHHHHHHHHHHH
RIESTRREYVNTILAHLNEGVAAVDGEGRVQAFNPAMERFLGTPAGVAVGRKLSTLAPGL
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCHHHHHHCCCCCHHHHCCHHHHHCCCC
SLDGVMQSGARELEAIHRLGDKMVVVNRIPIMSEAGTTGAVLTIQDANAIHRADRNLRSR
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCEEEEEECCHHHHHHHHHHHHH
TRARAAGVRYSLDDLAGDSPAMSDLRALARRYAMVDSTVLVSGESGTGKEVLAQGMHDAS
HHHHHHCCCEEHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCC
PRRAFPFVAVNCAAFPETLLESELFGYEEGAFTGARRGGKAGLFESAHNGTLFLDEIGDM
CCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCC
PPALQTRLLRVLQEKQVLPIGAIEAVPVNVRVIAATHRDLAALVRDGAFRQDLYYRLNIL
CHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEEEECHHHHHHHHHCCCHHHHHHEEEEEE
RIEMPPLRDRAGDLPVLAELLYRRAQERLGMSDGEPLPAIVRARLARYVWPGNIRELENV
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
TERIAVLVAGANLTPVALQRELQAAVPELFSGDHGTAIEMSDGVPAQSLAGVAKASQAEH
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHH
IRRVLADCGGNRAAACAQLGISPTTLWRRLREE
HHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA