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The map label for this gene is hoxA [H]

Identifier: 94310484

GI number: 94310484

Start: 1663625

End: 1664554

Strand: Direct

Name: hoxA [H]

Synonym: Rmet_1542

Alternate gene names: 94310484

Gene position: 1663625-1664554 (Clockwise)

Preceding gene: 94310483

Following gene: 94310486

Centisome position: 42.35

GC content: 66.67

Gene sequence:

>930_bases
ATGACGACAAAAACCAGGTTGCCCACCGTGCTGGTGGTGGATGACGAGGTGCGCTCCCAAGAGGCGCTGCGCCGCACGCT
GGAGGAGGAATTCGAGGTGCTCACCGCCTCCGGCGCGGGGGAGGCGCGAGGCATCATGGAGCGCGACTTCGTGCAGCTGC
TGCTCTGCGACCAGCGCATGCCCGGCATGTCCGGCGTGGAGTTCCTCAAGCAGGTGCGCAGCCAGTGGCCGGACGTGGTG
CGGATGATCATCTCCGGCTACACGGACTCCAAAGACATCATTGCCGGCATCAATGACGCTGGCATCTACCAGTACATCCT
CAAGCCGTGGCAGCCGGAGCAGCTACTGCTCACCCTGCACAACGCCGCCGAGCTTTACCGGCTGCAGAGCGAGAACCAGC
GCCTGGCGCTGGAGCTGCGCACCAGCGAGCCGGTGCTGAAGAAGCGCGTCCACGTTGGCGCGGCTGGTGGTGGTGACAAT
GGCCGTTTTCAGGCCGGCGGCCTTCGCTTCGCCCAGCTGGCGCGCCACGCCGGGACGAATCTCCACGAGGCCGGCGATCA
CGGCCTCGGTGTAGCGGCGCGTCTTGTCCTTGTGCAGGGCAGCGACGAACCCGTCCACGTCGCGTGCGGCGAGCAGGTCC
GGGTGGTCCTCGGCCAGGAAACGCCGGATGCGCTCCTTGCCGCCGGAGACCTTGAGCAGAACGCGATAACGCTCCAGGCT
CCAGTGCCCCAGGTTTGCACAGCCCCCGGCTCGGGAATCCCACCCGAGCCGTTCCACGAGGGGGCCAGGTCGTTCTTGGG
ACGGTCCGGCGAACGACTTGCCGGGCCCATCGCGGCGAAGGTGGCATTGAACGCCTGGCGGTGTAGCTGCTCGGTTTCGG
CGAGGGTGCCGTCCACGTCAAAAAGCAGCGCCTTGAGCGTCATGACGTGA

Upstream 100 bases:

>100_bases
ATCATTTCGTGCGCCGCACGCCGCACTCGTGGACGCCGCGGCATCTGGCCGCACACCGCGACATCGATTGGGGGACAGGC
CGCCTGAAGGCCGTGAAGCC

Downstream 100 bases:

>100_bases
CGCCTTCGGTGACCGGAGCGCACGACAGCGGCAGCGTCGAGGCGCCGGTGACCCGGTCGGCGACGCGGAAATCGCTGGTC
AGGCGGTCCGCCGCCGCCGG

Product: hydrogenase transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTTKTRLPTVLVVDDEVRSQEALRRTLEEEFEVLTASGAGEARGIMERDFVQLLLCDQRMPGMSGVEFLKQVRSQWPDVV
RMIISGYTDSKDIIAGINDAGIYQYILKPWQPEQLLLTLHNAAELYRLQSENQRLALELRTSEPVLKKRVHVGAAGGGDN
GRFQAGGLRFAQLARHAGTNLHEAGDHGLGVAARLVLVQGSDEPVHVACGEQVRVVLGQETPDALLAAGDLEQNAITLQA
PVPQVCTAPGSGIPPEPFHEGARSFLGRSGERLAGPIAAKVALNAWRCSCSVSARVPSTSKSSALSVMT

Sequences:

>Translated_309_residues
MTTKTRLPTVLVVDDEVRSQEALRRTLEEEFEVLTASGAGEARGIMERDFVQLLLCDQRMPGMSGVEFLKQVRSQWPDVV
RMIISGYTDSKDIIAGINDAGIYQYILKPWQPEQLLLTLHNAAELYRLQSENQRLALELRTSEPVLKKRVHVGAAGGGDN
GRFQAGGLRFAQLARHAGTNLHEAGDHGLGVAARLVLVQGSDEPVHVACGEQVRVVLGQETPDALLAAGDLEQNAITLQA
PVPQVCTAPGSGIPPEPFHEGARSFLGRSGERLAGPIAAKVALNAWRCSCSVSARVPSTSKSSALSVMT
>Mature_308_residues
TTKTRLPTVLVVDDEVRSQEALRRTLEEEFEVLTASGAGEARGIMERDFVQLLLCDQRMPGMSGVEFLKQVRSQWPDVVR
MIISGYTDSKDIIAGINDAGIYQYILKPWQPEQLLLTLHNAAELYRLQSENQRLALELRTSEPVLKKRVHVGAAGGGDNG
RFQAGGLRFAQLARHAGTNLHEAGDHGLGVAARLVLVQGSDEPVHVACGEQVRVVLGQETPDALLAAGDLEQNAITLQAP
VPQVCTAPGSGIPPEPFHEGARSFLGRSGERLAGPIAAKVALNAWRCSCSVSARVPSTSKSSALSVMT

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG3437

COG function: function code KT; Response regulator containing a CheY-like receiver domain and an HD-GYP domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

None

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 33276; Mature: 33145

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKTRLPTVLVVDDEVRSQEALRRTLEEEFEVLTASGAGEARGIMERDFVQLLLCDQRM
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCC
PGMSGVEFLKQVRSQWPDVVRMIISGYTDSKDIIAGINDAGIYQYILKPWQPEQLLLTLH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHCCCCCHHHHHHHH
NAAELYRLQSENQRLALELRTSEPVLKKRVHVGAAGGGDNGRFQAGGLRFAQLARHAGTN
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHEEECCCCCCCCCEECCCHHHHHHHHHHCCC
LHEAGDHGLGVAARLVLVQGSDEPVHVACGEQVRVVLGQETPDALLAAGDLEQNAITLQA
CHHCCCCCCCEEEEEEEEECCCCCEEEECCCEEEEEECCCCCHHHEEECCCCCCEEEEEC
PVPQVCTAPGSGIPPEPFHEGARSFLGRSGERLAGPIAAKVALNAWRCSCSVSARVPSTS
CCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHCHHHHHHHHHHEEEEEEEEECCCCCC
KSSALSVMT
CCCEEEECC
>Mature Secondary Structure 
TTKTRLPTVLVVDDEVRSQEALRRTLEEEFEVLTASGAGEARGIMERDFVQLLLCDQRM
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCC
PGMSGVEFLKQVRSQWPDVVRMIISGYTDSKDIIAGINDAGIYQYILKPWQPEQLLLTLH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCHHHHHHHCCCCCHHHHHHHH
NAAELYRLQSENQRLALELRTSEPVLKKRVHVGAAGGGDNGRFQAGGLRFAQLARHAGTN
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHEEECCCCCCCCCEECCCHHHHHHHHHHCCC
LHEAGDHGLGVAARLVLVQGSDEPVHVACGEQVRVVLGQETPDALLAAGDLEQNAITLQA
CHHCCCCCCCEEEEEEEEECCCCCEEEECCCEEEEEECCCCCHHHEEECCCCCCEEEEEC
PVPQVCTAPGSGIPPEPFHEGARSFLGRSGERLAGPIAAKVALNAWRCSCSVSARVPSTS
CCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHCHHHHHHHHHHEEEEEEEEECCCCCC
KSSALSVMT
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488 [H]