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The map label for this gene is cbbA2 [H]

Identifier: 94310460

GI number: 94310460

Start: 1639908

End: 1640945

Strand: Direct

Name: cbbA2 [H]

Synonym: Rmet_1518

Alternate gene names: 94310460

Gene position: 1639908-1640945 (Clockwise)

Preceding gene: 94310459

Following gene: 94310461

Centisome position: 41.75

GC content: 66.57

Gene sequence:

>1038_bases
ATGGCCCTCATCTCACTGCGCCAAGTGCTCGATCACGCTGCCGAATACGGCTACGGCGTGCCCGCTTTCAATGTCAACAA
CCTGGAGCAGGTCCACGCCATCATGGAGGCGGCGCAGGAAACGCAGTCGCCGGTGATTTTGCAAGCCTCGGCCGGCGCCC
GCAAGTATGCCGGCGAGCCCTACCTGCGCCACCTGGTGCTGGCGGCCGTGGAGATGCACCCCGACATCCCGGTCGTGCTG
CACCAGGACCACGGCGCCTCGCCGGCGGTGTGCCAGCAGTCGATCCGCTCGGGCTTCACCAGCGTGATGATGGACGGCTC
CCTGCTCGAAGACGCGAAGACGCCCGCGAGCTACGATTACAACGTCGACGTCACGCGCAAGGTCTGCGAAATGGCGCATT
CAATCGGCGTCTCGGTCGAGGGTGAACTGGGCTGCCTGGGTTCGCTCGAAACGGGCGAGGCCGGCGAAGAAGACGGCGTC
GGTGCCGTGGGCAAGCTCACGCACGACATGATGCTCACCAATCCCGAGGAGGCCAAGGACTTCGTGGCCCGCACTGGCGT
GGATGCGCTGGCTATTGCCATCGGCACCAGCCACGGCGCCTACAAGTTCACCCGCAAGCCCACCGGCGACATCCTGGCCA
TCGAGCGCATCGCGCAGATCCACGCCGCGGTGCCGAACACGCACCTGGTGATGCACGGCTCCTCCAGTGTGCCGCAGGAG
TGGCTGGCGATCATCCGCAAGTACGGCGGCGACATCAAGGAGACCTACGGCGTGCCGGTCGAGGAGATCCAGCGCGGGAT
CAAGAGCGGTGTGCGCAAGATCAACATCGATACCGACATCCGCTTGGCGATGACCGCGGCGATGCGCCAAGTGTTCGCCG
AGCAGCCCAGCGAGTTCGACCCGCGCAAGGCGCTGCAGGCGGCCACTAAGGCCGCGCGCAGCGTGGTCAAGGCGCGCTTC
GAGGCCTTCGGCTGCGCCGGGCAGGGGGCCCGCATCAAGCCGCTCCCGCTCGAAGTCATGGCGGCACGCTACGCGTGA

Upstream 100 bases:

>100_bases
ACTGGTTTGCGCAACGGGACACGATCTGCGACTACCCGTAGCGCACTTGCACTCGATCCAACGACTTCCTGAACCTTCAA
CGACTTACGGAGAATCCTTC

Downstream 100 bases:

>100_bases
AGGCCCGCCACACCATGCGCCGCAACCGCAACGCCAAGATCGTCGCCACGCTCGGCCCGTCCAGTTCCGACAAGGACACC
ATCCGCCGGCTGTTCGCCGC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MALISLRQVLDHAAEYGYGVPAFNVNNLEQVHAIMEAAQETQSPVILQASAGARKYAGEPYLRHLVLAAVEMHPDIPVVL
HQDHGASPAVCQQSIRSGFTSVMMDGSLLEDAKTPASYDYNVDVTRKVCEMAHSIGVSVEGELGCLGSLETGEAGEEDGV
GAVGKLTHDMMLTNPEEAKDFVARTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIAQIHAAVPNTHLVMHGSSSVPQE
WLAIIRKYGGDIKETYGVPVEEIQRGIKSGVRKINIDTDIRLAMTAAMRQVFAEQPSEFDPRKALQAATKAARSVVKARF
EAFGCAGQGARIKPLPLEVMAARYA

Sequences:

>Translated_345_residues
MALISLRQVLDHAAEYGYGVPAFNVNNLEQVHAIMEAAQETQSPVILQASAGARKYAGEPYLRHLVLAAVEMHPDIPVVL
HQDHGASPAVCQQSIRSGFTSVMMDGSLLEDAKTPASYDYNVDVTRKVCEMAHSIGVSVEGELGCLGSLETGEAGEEDGV
GAVGKLTHDMMLTNPEEAKDFVARTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIAQIHAAVPNTHLVMHGSSSVPQE
WLAIIRKYGGDIKETYGVPVEEIQRGIKSGVRKINIDTDIRLAMTAAMRQVFAEQPSEFDPRKALQAATKAARSVVKARF
EAFGCAGQGARIKPLPLEVMAARYA
>Mature_344_residues
ALISLRQVLDHAAEYGYGVPAFNVNNLEQVHAIMEAAQETQSPVILQASAGARKYAGEPYLRHLVLAAVEMHPDIPVVLH
QDHGASPAVCQQSIRSGFTSVMMDGSLLEDAKTPASYDYNVDVTRKVCEMAHSIGVSVEGELGCLGSLETGEAGEEDGVG
AVGKLTHDMMLTNPEEAKDFVARTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIAQIHAAVPNTHLVMHGSSSVPQEW
LAIIRKYGGDIKETYGVPVEEIQRGIKSGVRKINIDTDIRLAMTAAMRQVFAEQPSEFDPRKALQAATKAARSVVKARFE
AFGCAGQGARIKPLPLEVMAARYA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=34.6504559270517, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789526, Length=328, Percent_Identity=33.5365853658537, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788072, Length=326, Percent_Identity=27.3006134969325, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789293, Length=372, Percent_Identity=24.4623655913978, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=364, Percent_Identity=24.1758241758242, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37058; Mature: 36927

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISLRQVLDHAAEYGYGVPAFNVNNLEQVHAIMEAAQETQSPVILQASAGARKYAGEP
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCH
YLRHLVLAAVEMHPDIPVVLHQDHGASPAVCQQSIRSGFTSVMMDGSLLEDAKTPASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
NVDVTRKVCEMAHSIGVSVEGELGCLGSLETGEAGEEDGVGAVGKLTHDMMLTNPEEAKD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
FVARTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIAQIHAAVPNTHLVMHGSSSVPQE
HHHHCCCHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
WLAIIRKYGGDIKETYGVPVEEIQRGIKSGVRKINIDTDIRLAMTAAMRQVFAEQPSEFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCCC
PRKALQAATKAARSVVKARFEAFGCAGQGARIKPLPLEVMAARYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
ALISLRQVLDHAAEYGYGVPAFNVNNLEQVHAIMEAAQETQSPVILQASAGARKYAGEP
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCH
YLRHLVLAAVEMHPDIPVVLHQDHGASPAVCQQSIRSGFTSVMMDGSLLEDAKTPASYDY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
NVDVTRKVCEMAHSIGVSVEGELGCLGSLETGEAGEEDGVGAVGKLTHDMMLTNPEEAKD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHH
FVARTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIAQIHAAVPNTHLVMHGSSSVPQE
HHHHCCCHHEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
WLAIIRKYGGDIKETYGVPVEEIQRGIKSGVRKINIDTDIRLAMTAAMRQVFAEQPSEFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCCC
PRKALQAATKAARSVVKARFEAFGCAGQGARIKPLPLEVMAARYA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7763137 [H]