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The map label for this gene is msrA [H]

Identifier: 94310114

GI number: 94310114

Start: 1279575

End: 1280306

Strand: Reverse

Name: msrA [H]

Synonym: Rmet_1169

Alternate gene names: 94310114

Gene position: 1280306-1279575 (Counterclockwise)

Preceding gene: 94310115

Following gene: 94310101

Centisome position: 32.59

GC content: 61.2

Gene sequence:

>732_bases
ATGGATGCCATGACAACACTGCAACGCTGGACCCGCCCCACCGCGCTGAAGCTCGCAAGCTTGGCCGTGCTGATGGTGGC
GGCCGCAATGTGGGAGCTACCCGCGATCTCGGCCGAGGCCGCCGTGAAGATCCCCGCGCCGGCCGTCGACGAAAAAGCCG
GCACGAGCCATACCGAGACCGCGGTATTCGCCGGTGGATGCTTCTGGGGCGTGCAAGGCGTGTTCCAACATGTCCGCGGC
GTTACACGGGTAACGTCCGGTTACTCTGGCGGCTCGGCCAGCAACGCCCAATACGAGATGGTGGGCACCGGCATGACCGG
ACACGCGGAGTCGGTCGAAATCCGCTACGACCCCACCCAGATCAGCTACGGCAAGCTGCTGCAGATCTTCTTCTCGGTCG
CGCACAATCCTACGCAACTGAACTATCAGGGGCCCGATCACGGTACGCAGTACCGCTCGGCGATCTTCCCGCGCTCGCCG
GTGCAACGCTCGATTGCCGAGGCGTATATCACCCAGCTCGACACGTCGAAAGCGTACCGCGCGCCGATCGTCACGCGCGT
CGAGGATTACAAGGGGTTCTTTCCGGCCGAGAACTATCACCAGGATTTTCTCGTCAAGAATCCGAGCTATCCGTACATCG
TCATCAATGACCTGCCGAAGATCGGCAATCTGAAAACGATGTTCCCGGACGTGTATCGGAATGATGCGGTGCTGGTATCG
AAGGGAGGTTGA

Upstream 100 bases:

>100_bases
CGTCGCCGATCGCACGTTCGCCATCGAATTCCTCGACCCCGGCGTGCAGGCCTATGCGTTCACGTTCGGCTGATCTACGC
TTCCTTCAAGGAGTCTGACC

Downstream 100 bases:

>100_bases
AGCGATCGGTGAGAGATGGCGCCAGGGTCAACCCAGCACCTTGACCGCTATCGTCAGGAACCAGCCGGCAGCCAGGCAAG
CCCCCACCCATCCAAAACCA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MDAMTTLQRWTRPTALKLASLAVLMVAAAMWELPAISAEAAVKIPAPAVDEKAGTSHTETAVFAGGCFWGVQGVFQHVRG
VTRVTSGYSGGSASNAQYEMVGTGMTGHAESVEIRYDPTQISYGKLLQIFFSVAHNPTQLNYQGPDHGTQYRSAIFPRSP
VQRSIAEAYITQLDTSKAYRAPIVTRVEDYKGFFPAENYHQDFLVKNPSYPYIVINDLPKIGNLKTMFPDVYRNDAVLVS
KGG

Sequences:

>Translated_243_residues
MDAMTTLQRWTRPTALKLASLAVLMVAAAMWELPAISAEAAVKIPAPAVDEKAGTSHTETAVFAGGCFWGVQGVFQHVRG
VTRVTSGYSGGSASNAQYEMVGTGMTGHAESVEIRYDPTQISYGKLLQIFFSVAHNPTQLNYQGPDHGTQYRSAIFPRSP
VQRSIAEAYITQLDTSKAYRAPIVTRVEDYKGFFPAENYHQDFLVKNPSYPYIVINDLPKIGNLKTMFPDVYRNDAVLVS
KGG
>Mature_243_residues
MDAMTTLQRWTRPTALKLASLAVLMVAAAMWELPAISAEAAVKIPAPAVDEKAGTSHTETAVFAGGCFWGVQGVFQHVRG
VTRVTSGYSGGSASNAQYEMVGTGMTGHAESVEIRYDPTQISYGKLLQIFFSVAHNPTQLNYQGPDHGTQYRSAIFPRSP
VQRSIAEAYITQLDTSKAYRAPIVTRVEDYKGFFPAENYHQDFLVKNPSYPYIVINDLPKIGNLKTMFPDVYRNDAVLVS
KGG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=43.5897435897436, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=43.5897435897436, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=45.3703703703704, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=45.0980392156863, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533973, Length=163, Percent_Identity=31.2883435582822, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=34.8387096774194, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=35.3658536585366, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=35.3658536585366, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=34.8101265822785, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26603; Mature: 26603

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAMTTLQRWTRPTALKLASLAVLMVAAAMWELPAISAEAAVKIPAPAVDEKAGTSHTET
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCC
AVFAGGCFWGVQGVFQHVRGVTRVTSGYSGGSASNAQYEMVGTGMTGHAESVEIRYDPTQ
EEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCC
ISYGKLLQIFFSVAHNPTQLNYQGPDHGTQYRSAIFPRSPVQRSIAEAYITQLDTSKAYR
CCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHC
APIVTRVEDYKGFFPAENYHQDFLVKNPSYPYIVINDLPKIGNLKTMFPDVYRNDAVLVS
CCHHEEHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHCHHHHCCCEEEEE
KGG
CCC
>Mature Secondary Structure
MDAMTTLQRWTRPTALKLASLAVLMVAAAMWELPAISAEAAVKIPAPAVDEKAGTSHTET
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCC
AVFAGGCFWGVQGVFQHVRGVTRVTSGYSGGSASNAQYEMVGTGMTGHAESVEIRYDPTQ
EEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCC
ISYGKLLQIFFSVAHNPTQLNYQGPDHGTQYRSAIFPRSPVQRSIAEAYITQLDTSKAYR
CCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHC
APIVTRVEDYKGFFPAENYHQDFLVKNPSYPYIVINDLPKIGNLKTMFPDVYRNDAVLVS
CCHHEEHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHCHHHHCCCEEEEE
KGG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]