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The map label for this gene is adh [H]

Identifier: 94310038

GI number: 94310038

Start: 1189387

End: 1190415

Strand: Direct

Name: adh [H]

Synonym: Rmet_1093

Alternate gene names: 94310038

Gene position: 1189387-1190415 (Clockwise)

Preceding gene: 94310037

Following gene: 94310039

Centisome position: 30.28

GC content: 62.29

Gene sequence:

>1029_bases
ATGCCAGCCATGATGAAAGCCGCAGTCGTGCGCGCGTTCGGCGCACCTCTGACTATCGACGAGGTGCCCGTGCCGCAGCC
TGGCCCTGGCCAGATCCAGGTCAAGATCGAAGCGTCCGGCGTTTGCCACACCGATCTGCATGCGGCGCAGGGCGACTGGC
CGGTCAAGCCGTCGCTGCCATTCATTCCCGGCCATGAAGGCGTGGGATTCGTGTCGGCAGTTGGTGCCAATGTCAAACGC
GTGAAGGAAGGGGATCGCGTCGGCGTGCCGTGGCTCTACAGCGCCTGCGGTTACTGCGAACACTGCCTCCAGGGCTGGGA
AACGCTGTGTGAGAAGCAGCAGAACACCGGCTACTCCGTCAACGGTGGCTACGGCGAGTTCGTGGTGGCCGATCCGAACT
ATGTCGGTCTGCTGCCGAAGAATGTCGACTTCATCGAAATCGCGCCGATCCTGTGCGCTGGGGTGACGGTCTACAAGGGT
CTCAAGGTCACCGACACACGGCCGGGGCAGTGGGTGGTGATCTCGGGAATCGGTGGTCTGGGCCACGTGGCCGTACAGTA
TGCGAGGGCAATGGGCCTGCGCGTGGCCGCCGTCGACATTGACGACGCGAAGCTCGCTTTCGCGCGCAAGCTCGGTGCCG
AAGTTGCAATCAATGCTCGCACTACCGACCCTGCTGCTTTCTTGCAGAAGGAAATTGGCGGCGCGCACGGTGTATTGGTC
ACCGCAGTCTCGCCGCAGGCGTTCTCGCAGGCTATCGGCATGGTGCGACGCGGTGGCACGATCTCGCTGAACGGCCTGCC
TCCGGGAGACTTCCCCACCCCGATCTTCGACGTGGTGCTGAAGGCCATCACTATCCGTGGCTCCATTGTCGGCACGCGTA
GCGATCTGCAGGAAGCGCTCGAATTTGCCGCCAGCGGTGTGGTGAAAGCCACGGTATCCACGGAAAAACTGGACTCGATC
AATAGTATCTTCGACCGCATGAAGGCCGGCCAGATCGAAGGCCGCATTGTGCTGGACTTCAGCCGCTGA

Upstream 100 bases:

>100_bases
TCCGGATCCTGATTCATATCATGACTCTGGCGTCCGACGCCGCGTGACTATGGCATGTTTCCCGCTGTTGACGACGCGCC
ACCTGTAGAAGGAGCCACAT

Downstream 100 bases:

>100_bases
CAAAAGCCACTCGCGCTACTGGTGCCGGGGACGTCGGGTTTCGCGTTCTGTCGTTCTGTCAGACGATATTCACCCGACGT
CTTGTGCTGCGTGCAACGTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQIQVKIEASGVCHTDLHAAQGDWPVKPSLPFIPGHEGVGFVSAVGANVKR
VKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEFVVADPNYVGLLPKNVDFIEIAPILCAGVTVYKG
LKVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLAFARKLGAEVAINARTTDPAAFLQKEIGGAHGVLV
TAVSPQAFSQAIGMVRRGGTISLNGLPPGDFPTPIFDVVLKAITIRGSIVGTRSDLQEALEFAASGVVKATVSTEKLDSI
NSIFDRMKAGQIEGRIVLDFSR

Sequences:

>Translated_342_residues
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQIQVKIEASGVCHTDLHAAQGDWPVKPSLPFIPGHEGVGFVSAVGANVKR
VKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEFVVADPNYVGLLPKNVDFIEIAPILCAGVTVYKG
LKVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLAFARKLGAEVAINARTTDPAAFLQKEIGGAHGVLV
TAVSPQAFSQAIGMVRRGGTISLNGLPPGDFPTPIFDVVLKAITIRGSIVGTRSDLQEALEFAASGVVKATVSTEKLDSI
NSIFDRMKAGQIEGRIVLDFSR
>Mature_341_residues
PAMMKAAVVRAFGAPLTIDEVPVPQPGPGQIQVKIEASGVCHTDLHAAQGDWPVKPSLPFIPGHEGVGFVSAVGANVKRV
KEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSVNGGYGEFVVADPNYVGLLPKNVDFIEIAPILCAGVTVYKGL
KVTDTRPGQWVVISGIGGLGHVAVQYARAMGLRVAAVDIDDAKLAFARKLGAEVAINARTTDPAAFLQKEIGGAHGVLVT
AVSPQAFSQAIGMVRRGGTISLNGLPPGDFPTPIFDVVLKAITIRGSIVGTRSDLQEALEFAASGVVKATVSTEKLDSIN
SIFDRMKAGQIEGRIVLDFSR

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=27.9569892473118, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=236, Percent_Identity=32.6271186440678, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI71565154, Length=238, Percent_Identity=31.5126050420168, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4501929, Length=236, Percent_Identity=32.2033898305085, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=254, Percent_Identity=27.5590551181102, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI71743840, Length=254, Percent_Identity=27.5590551181102, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI156627571, Length=287, Percent_Identity=27.8745644599303, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=24.6684350132626, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI156523966, Length=235, Percent_Identity=28.0851063829787, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501939, Length=235, Percent_Identity=28.0851063829787, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=45.8333333333333, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=33.9080459770115, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=30.0578034682081, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788073, Length=269, Percent_Identity=33.8289962825279, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=29.2168674698795, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI87082125, Length=220, Percent_Identity=33.1818181818182, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788075, Length=318, Percent_Identity=31.7610062893082, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=31.129476584022, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI226510992, Length=297, Percent_Identity=28.956228956229, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788407, Length=274, Percent_Identity=29.5620437956204, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787863, Length=320, Percent_Identity=27.8125, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786825, Length=355, Percent_Identity=27.0422535211268, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790718, Length=286, Percent_Identity=23.4265734265734, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=345, Percent_Identity=40, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=41.2103746397695, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI71988145, Length=343, Percent_Identity=36.734693877551, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=32.5301204819277, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=30.7228915662651, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=25.6613756613757, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=380, Percent_Identity=25.2631578947368, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507255, Length=270, Percent_Identity=25.5555555555556, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=221, Percent_Identity=27.1493212669683, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=42.1965317919075, Blast_Score=275, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=41.907514450867, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=41.6184971098266, Blast_Score=268, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6324486, Length=346, Percent_Identity=41.3294797687861, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319949, Length=336, Percent_Identity=30.952380952381, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=30.0940438871473, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=246, Percent_Identity=31.7073170731707, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=312, Percent_Identity=29.4871794871795, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=328, Percent_Identity=29.2682926829268, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=26.3975155279503, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=224, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=309, Percent_Identity=27.1844660194175, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737895, Length=240, Percent_Identity=27.9166666666667, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17737897, Length=207, Percent_Identity=28.9855072463768, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36061; Mature: 35930

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMMKAAVVRAFGAPLTIDEVPVPQPGPGQIQVKIEASGVCHTDLHAAQGDWPVKPSLP
CCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVSAVGANVKRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV
CCCCCCCCCHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGYGEFVVADPNYVGLLPKNVDFIEIAPILCAGVTVYKGLKVTDTRPGQWVVISGIGGL
CCCCCEEEEECCCEEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYARAMGLRVAAVDIDDAKLAFARKLGAEVAINARTTDPAAFLQKEIGGAHGVLV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
TAVSPQAFSQAIGMVRRGGTISLNGLPPGDFPTPIFDVVLKAITIRGSIVGTRSDLQEAL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECHHHHHHHH
EFAASGVVKATVSTEKLDSINSIFDRMKAGQIEGRIVLDFSR
HHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
PAMMKAAVVRAFGAPLTIDEVPVPQPGPGQIQVKIEASGVCHTDLHAAQGDWPVKPSLP
CHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVSAVGANVKRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNTGYSV
CCCCCCCCCHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGYGEFVVADPNYVGLLPKNVDFIEIAPILCAGVTVYKGLKVTDTRPGQWVVISGIGGL
CCCCCEEEEECCCEEEECCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHVAVQYARAMGLRVAAVDIDDAKLAFARKLGAEVAINARTTDPAAFLQKEIGGAHGVLV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
TAVSPQAFSQAIGMVRRGGTISLNGLPPGDFPTPIFDVVLKAITIRGSIVGTRSDLQEAL
EEECHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECHHHHHHHH
EFAASGVVKATVSTEKLDSINSIFDRMKAGQIEGRIVLDFSR
HHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]