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The map label for this gene is lysC [H]

Identifier: 94310034

GI number: 94310034

Start: 1181621

End: 1182871

Strand: Direct

Name: lysC [H]

Synonym: Rmet_1089

Alternate gene names: 94310034

Gene position: 1181621-1182871 (Clockwise)

Preceding gene: 335055515

Following gene: 94310037

Centisome position: 30.08

GC content: 62.03

Gene sequence:

>1251_bases
ATGGCTCTCATCGTTCACAAATACGGCGGCACTTCGATGGGTTCCACGGAACGCATCAAGAATGTCGCCAAGCGCGTGGC
CAAGTGGCACCGCGCCGGTCACCGCGTTGTCGTGGTGCCTTCGGCCATGTCGGGCGAAACCAATCGCCTGCTGGGCCTTG
CCAAGGAAATCTCCGCGCAGCCGGACCCGCGTGAACTCGATATGCTGGCGTCGACCGGCGAGCAGGCCAGCGTGGCCCTG
CTGGCCATCGCGCTGCACGGCGAAGGCATCGACGCGGTCAGCTACACGGGCTGGCAGGTGCCGGTGAAGACGGACTCGTC
CTATACCAAGGCCCGCATCGAATCGATCGATGACGAGCGCATCCTGGGTGACCTCGACGCCGGCAAGGTGGTCGTGGTCA
CGGGTTTCCAGGGCATCGACGGCGACGGCAACATCACGACACTGGGTCGCGGCGGTTCAGATACCTCGGCCGTGGCCATT
GCCGCGGCGATTGAAGCCGACGAGTGCCTGATCTATACCGACGTGGATGGCGTGTACACGACCGATCCGCGCGTGGTCGA
GGACGCCCGCCGCCTGGACCAAATCACCTTCGAGGAAATGCTGGAAATGGCCAGCCTGGGTTCGAAGGTTCTGCAGATCC
GTTCGGTGGAGTTTGCCGGCAAATATCGCGTGAAGACGCGCGTGCTGTCGTCGCTGACCGACCCCCTGATGCCGCTCGAA
CAGGAAATGCATTCGGGCACGCTGATTACTTTTGAGGAAGAGTCTGAAATGGAAGCAGCCGTCATCTCCGGCATCGCCTT
TGCCCGTGACGAAGCCAAGATCACTGTCCTTGGCGTGCCGGACAAGCCGGGCATCGCCTACCAGATCCTGGGCCCGATCG
CCGACGCCAACATCGACGTCGACATGATCATCCAGAACCAGTCCGTGGACGGCAAGACCGACTTCACGTTCACCGTGCCG
CGCGGTGACTACCAGCGTGCGCTGACGATCCTGAACGACAACGTGAAGGGCCATATTGGCGCCGAGAGCGTGTCGGGCGA
TCCGAAGGTGTCGAAGGTCTCGGTGGTGGGCGTGGGTATGCGCTCGCACGTGGGCATCGCCAGCAAGATGTTCCGCACGC
TGTCGGAAGAGGGCATCAACATCCAGATGATCTCCACGTCGGAAATCAAGATCTCGGTGCTGATCGACGAGAAGTACATG
GAGCTCGCCGTGCGCGCGCTGCACAAGGTGTTCGAACTGGATCAGGCGTGA

Upstream 100 bases:

>100_bases
CTGCGGTGTTTTTGCCGGATTTCCCCCCTTTGGCCTTTACGGGCAGCCACTCTTCGTGTAATTTCATTGGCTTTGCACAA
TCGCTGGCGTCGATAAGAAG

Downstream 100 bases:

>100_bases
TCCGGAACTGAAAACGTTCTGGCGAGGGCGTGGCATTTTTTGCTGCGGGTCATCGAATTTTCATTGACCAGTAGCGACAC
CCTCGCTAGAATACGCGCTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVAL
LAIALHGEGIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGKVVVVTGFQGIDGDGNITTLGRGGSDTSAVAI
AAAIEADECLIYTDVDGVYTTDPRVVEDARRLDQITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
QEMHSGTLITFEEESEMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPIADANIDVDMIIQNQSVDGKTDFTFTVP
RGDYQRALTILNDNVKGHIGAESVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKVFELDQA

Sequences:

>Translated_416_residues
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVAL
LAIALHGEGIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGKVVVVTGFQGIDGDGNITTLGRGGSDTSAVAI
AAAIEADECLIYTDVDGVYTTDPRVVEDARRLDQITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
QEMHSGTLITFEEESEMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPIADANIDVDMIIQNQSVDGKTDFTFTVP
RGDYQRALTILNDNVKGHIGAESVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKVFELDQA
>Mature_415_residues
ALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQPDPRELDMLASTGEQASVALL
AIALHGEGIDAVSYTGWQVPVKTDSSYTKARIESIDDERILGDLDAGKVVVVTGFQGIDGDGNITTLGRGGSDTSAVAIA
AAIEADECLIYTDVDGVYTTDPRVVEDARRLDQITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLEQ
EMHSGTLITFEEESEMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPIADANIDVDMIIQNQSVDGKTDFTFTVPR
GDYQRALTILNDNVKGHIGAESVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKVFELDQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=364, Percent_Identity=31.5934065934066, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790455, Length=388, Percent_Identity=29.1237113402062, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790376, Length=90, Percent_Identity=42.2222222222222, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=408, Percent_Identity=27.4509803921569, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44853; Mature: 44722

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQ
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMLASTGEQASVALLAIALHGEGIDAVSYTGWQVPVKTDSSYTKARIESIDDER
CCCHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCC
ILGDLDAGKVVVVTGFQGIDGDGNITTLGRGGSDTSAVAIAAAIEADECLIYTDVDGVYT
EEECCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCEEE
TDPRVVEDARRLDQITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHHHHHHCCCCCHHH
QEMHSGTLITFEEESEMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPIADANIDV
HHHCCCEEEEECCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTDFTFTVPRGDYQRALTILNDNVKGHIGAESVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCCHHHEEEEECCCCCCEECCCCCCCCCCCEEEEEEEECH
RSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKVFELDQA
HHHCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSTERIKNVAKRVAKWHRAGHRVVVVPSAMSGETNRLLGLAKEISAQ
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMLASTGEQASVALLAIALHGEGIDAVSYTGWQVPVKTDSSYTKARIESIDDER
CCCHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCHHHHHHHCCCCCC
ILGDLDAGKVVVVTGFQGIDGDGNITTLGRGGSDTSAVAIAAAIEADECLIYTDVDGVYT
EEECCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCEEEEEECCCEEE
TDPRVVEDARRLDQITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHHHHHHCCCCCHHH
QEMHSGTLITFEEESEMEAAVISGIAFARDEAKITVLGVPDKPGIAYQILGPIADANIDV
HHHCCCEEEEECCCCCHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVDGKTDFTFTVPRGDYQRALTILNDNVKGHIGAESVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCCHHHEEEEECCCCCCEECCCCCCCCCCCEEEEEEEECH
RSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKVFELDQA
HHHCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]