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The map label for this gene is dapA [H]

Identifier: 94310013

GI number: 94310013

Start: 1160386

End: 1161270

Strand: Direct

Name: dapA [H]

Synonym: Rmet_1068

Alternate gene names: 94310013

Gene position: 1160386-1161270 (Clockwise)

Preceding gene: 94310012

Following gene: 94310014

Centisome position: 29.54

GC content: 63.62

Gene sequence:

>885_bases
ATGACACAGATTACCGGCAGCATCGTGGCCATCGTCACCCCGATGCACGAGGATGGCAGCCTGGACTTTCCCGCGCTGCG
CGCCCTCATCGACTGGCACGCGGCGGAAGGCACCGATGGCATCGTGATCGTGGGTACCACGGGCGAATCGCCGACCGTCA
ACGTCGACGAGCATTGCGAACTGATTCGCGTGGCCGTCGAGCAATCCGCGGGCCGTGTACCGATCATCGCGGGCACGGGC
GGCAACTCCACCAGCGAGGCGATTGAGCTGACCGCCTTCGCCAAGAAGGTGGGCGCCAACGCATCGCTGCAGGTCGTGCC
CTACTACAACAAGCCGACGCAAGAAGGCATGTACCGCCATTTCCGCACGATCGCGGAAGCGGTGGATCTGCCGGTGGTGC
TCTACAACGTGCCCGGCCGTACCGTGGCGGACATGAACAACGATACGATCCTGCGCCTGGCGCAGGTACCCGGTATCGTC
GGCGTAAAGGAAGCGACTGGTAATATCGACCGTGCCGCGCAACTGATCAATGGCGCGCCGGAAGGCTTCGCCATCTACAG
TGGCGACGATCCCACGGCCGTGGCGCTGATCCTGCTGGGCGGCCATGGAAATATCTCGGTGACCGCTAACGTGGCACCGC
GCAAGATGCATGAGATGTGTGTTGCCGCGCTCAAGGGCGATGTGGTGACGGCGCGTCGTCTGCATATGGAGCTGATTGAC
CTCAATCGCGCAATGTTCGTGGAGGCCAATCCGATCCCCGTGAAGTGGGCGCTCCAGCAAATGGGCAAGATGGAAGGCGG
TATCCGCCTGCCGCTGACCCCGCTGGCCGAAGGTCAGCATGAAACCGTGCGCCGCGCGCTCGCCGCCGCCGGCCTGCTTG
GCTAA

Upstream 100 bases:

>100_bases
ACGTTACGCCCGCTAACGTTTTCCCTCATTCCGTGGGTGTCCGGAGGGCCTGACGGTTCCGGTACAATCGCGGATGTTCG
AATTTCCGAATTCCTGAGCT

Downstream 100 bases:

>100_bases
GACTTACCGGCCCACATGCGGCGATGTGCCGACTCTTGAAACCAGGATTACGTGTCAATGAAACAGAAGCTTAACCGTCG
CGGCGCGACGCAAGTCCGCC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTQITGSIVAIVTPMHEDGSLDFPALRALIDWHAAEGTDGIVIVGTTGESPTVNVDEHCELIRVAVEQSAGRVPIIAGTG
GNSTSEAIELTAFAKKVGANASLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVVLYNVPGRTVADMNNDTILRLAQVPGIV
GVKEATGNIDRAAQLINGAPEGFAIYSGDDPTAVALILLGGHGNISVTANVAPRKMHEMCVAALKGDVVTARRLHMELID
LNRAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLAEGQHETVRRALAAAGLLG

Sequences:

>Translated_294_residues
MTQITGSIVAIVTPMHEDGSLDFPALRALIDWHAAEGTDGIVIVGTTGESPTVNVDEHCELIRVAVEQSAGRVPIIAGTG
GNSTSEAIELTAFAKKVGANASLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVVLYNVPGRTVADMNNDTILRLAQVPGIV
GVKEATGNIDRAAQLINGAPEGFAIYSGDDPTAVALILLGGHGNISVTANVAPRKMHEMCVAALKGDVVTARRLHMELID
LNRAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLAEGQHETVRRALAAAGLLG
>Mature_293_residues
TQITGSIVAIVTPMHEDGSLDFPALRALIDWHAAEGTDGIVIVGTTGESPTVNVDEHCELIRVAVEQSAGRVPIIAGTGG
NSTSEAIELTAFAKKVGANASLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVVLYNVPGRTVADMNNDTILRLAQVPGIVG
VKEATGNIDRAAQLINGAPEGFAIYSGDDPTAVALILLGGHGNISVTANVAPRKMHEMCVAALKGDVVTARRLHMELIDL
NRAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLAEGQHETVRRALAAAGLLG

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=294, Percent_Identity=26.8707482993197, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=51.2027491408935, Blast_Score=297, Evalue=5e-82,
Organism=Escherichia coli, GI87082415, Length=300, Percent_Identity=32.3333333333333, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=34.2857142857143, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789620, Length=244, Percent_Identity=30.327868852459, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31107; Mature: 30976

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQITGSIVAIVTPMHEDGSLDFPALRALIDWHAAEGTDGIVIVGTTGESPTVNVDEHCE
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECHHHHHH
LIRVAVEQSAGRVPIIAGTGGNSTSEAIELTAFAKKVGANASLQVVPYYNKPTQEGMYRH
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
FRTIAEAVDLPVVLYNVPGRTVADMNNDTILRLAQVPGIVGVKEATGNIDRAAQLINGAP
HHHHHHHHCCCEEEEECCCCEEECCCCCEEEEEECCCCCEEEHHCCCCHHHHHHHHCCCC
EGFAIYSGDDPTAVALILLGGHGNISVTANVAPRKMHEMCVAALKGDVVTARRLHMELID
CCEEEECCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHEE
LNRAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLAEGQHETVRRALAAAGLLG
CCCEEEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQITGSIVAIVTPMHEDGSLDFPALRALIDWHAAEGTDGIVIVGTTGESPTVNVDEHCE
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECHHHHHH
LIRVAVEQSAGRVPIIAGTGGNSTSEAIELTAFAKKVGANASLQVVPYYNKPTQEGMYRH
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
FRTIAEAVDLPVVLYNVPGRTVADMNNDTILRLAQVPGIVGVKEATGNIDRAAQLINGAP
HHHHHHHHCCCEEEEECCCCEEECCCCCEEEEEECCCCCEEEHHCCCCHHHHHHHHCCCC
EGFAIYSGDDPTAVALILLGGHGNISVTANVAPRKMHEMCVAALKGDVVTARRLHMELID
CCEEEECCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHEE
LNRAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLAEGQHETVRRALAAAGLLG
CCCEEEEECCCCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]