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The map label for this gene is ptpA [C]

Identifier: 94309967

GI number: 94309967

Start: 1112013

End: 1112492

Strand: Direct

Name: ptpA [C]

Synonym: Rmet_1022

Alternate gene names: 94309967

Gene position: 1112013-1112492 (Clockwise)

Preceding gene: 94309966

Following gene: 94309968

Centisome position: 28.31

GC content: 65.0

Gene sequence:

>480_bases
ATGAAAAAGTACGCCATTTTGATGTGTTGCATGGGCAATATCTGCCGTTCCCCGACGGCGGAGGGTGTCCTGCGCGCCAA
GCTCGAGGCCGCCGGCCTTGCCGATCTGGTCGAACTCGATTCGGCCGGCACGCATGACTATCACGTGGGCAGGGCGCCCG
ACGCGCGCAGCCAGCGCCATGCGCTGCGACGCGGCTACGACTTGTCCGCACTGCGTGCCCGGCAGGTGGTCGTGGCGGAC
TTCAGCCGCTTCGACCTGGTGCTTGCGATGGACCAGGCCAACCTTTCGGCGCTGCACGCGCTCCATGCCGATGCCGGCGC
CGACAAGCTGCGCCTGCTGATGAGCTTTGCCACGCAGCACAACGCCGAGGAAGTGCCCGACCCGTACTACGGCGAGGGCG
ATGGTTTCGAGCGCGTGCTGGACTATATCGAGGATGCCTGTGACGGCGTGATCGAGATGTTGCGGAAGCGGCTGACCTGA

Upstream 100 bases:

>100_bases
GCCGAGGCGGCCGGATTCGCACGTGGCAAGGCGATCGCCGAGCAACTCTGACCGGGCGAAGTCGTTTCGGCGTCAGTCGG
CAGGCGGTAGAATCGCGCCG

Downstream 100 bases:

>100_bases
TGCTGCGTTCCCTGTTTCGAAAGTGGCGCGAGTCACGCAATGCCAGCCTGCAGCTGGATGCCATCCTGGCCGCGGCCGAC
CCCGATGCGCTGCTCGCCGA

Product: protein-tyrosine-phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKKYAILMCCMGNICRSPTAEGVLRAKLEAAGLADLVELDSAGTHDYHVGRAPDARSQRHALRRGYDLSALRARQVVVAD
FSRFDLVLAMDQANLSALHALHADAGADKLRLLMSFATQHNAEEVPDPYYGEGDGFERVLDYIEDACDGVIEMLRKRLT

Sequences:

>Translated_159_residues
MKKYAILMCCMGNICRSPTAEGVLRAKLEAAGLADLVELDSAGTHDYHVGRAPDARSQRHALRRGYDLSALRARQVVVAD
FSRFDLVLAMDQANLSALHALHADAGADKLRLLMSFATQHNAEEVPDPYYGEGDGFERVLDYIEDACDGVIEMLRKRLT
>Mature_159_residues
MKKYAILMCCMGNICRSPTAEGVLRAKLEAAGLADLVELDSAGTHDYHVGRAPDARSQRHALRRGYDLSALRARQVVVAD
FSRFDLVLAMDQANLSALHALHADAGADKLRLLMSFATQHNAEEVPDPYYGEGDGFERVLDYIEDACDGVIEMLRKRLT

Specific function: Unknown

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=150, Percent_Identity=36, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI6005988, Length=150, Percent_Identity=35.3333333333333, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI87081812, Length=148, Percent_Identity=31.0810810810811, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=138, Percent_Identity=29.7101449275362, Blast_Score=90, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78706770, Length=155, Percent_Identity=34.8387096774194, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI78706772, Length=155, Percent_Identity=34.8387096774194, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI78706766, Length=147, Percent_Identity=38.0952380952381, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI78706768, Length=147, Percent_Identity=38.0952380952381, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI78706764, Length=125, Percent_Identity=38.4, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI78711846, Length=151, Percent_Identity=33.112582781457, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17551; Mature: 17551

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYAILMCCMGNICRSPTAEGVLRAKLEAAGLADLVELDSAGTHDYHVGRAPDARSQRH
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
ALRRGYDLSALRARQVVVADFSRFDLVLAMDQANLSALHALHADAGADKLRLLMSFATQH
HHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHC
NAEEVPDPYYGEGDGFERVLDYIEDACDGVIEMLRKRLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKYAILMCCMGNICRSPTAEGVLRAKLEAAGLADLVELDSAGTHDYHVGRAPDARSQRH
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
ALRRGYDLSALRARQVVVADFSRFDLVLAMDQANLSALHALHADAGADKLRLLMSFATQH
HHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHC
NAEEVPDPYYGEGDGFERVLDYIEDACDGVIEMLRKRLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]