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The map label for this gene is upp [H]

Identifier: 94309733

GI number: 94309733

Start: 864347

End: 864997

Strand: Reverse

Name: upp [H]

Synonym: Rmet_0788

Alternate gene names: 94309733

Gene position: 864997-864347 (Counterclockwise)

Preceding gene: 335055503

Following gene: 94309732

Centisome position: 22.02

GC content: 63.75

Gene sequence:

>651_bases
ATGAAACAAGATCCGCGCTTTCCCAATCTCTTCATCCTCGATCACCCGCTGATCCAGCACAAGCTCTCGCACATGCGCGA
CAAGGAAACGTCGACACGCACGTTCCGCGAGTTGCTGCGCGAGATCACGCTGCTGATGGGCTACGAGATCACGCGCAACC
TGCCGCTGACCACGCGCCGCATCGACACGCCGCTGGTGCCGCTGGACGCCCCGGTCATCGCCGGCAAGAAGCTGACGATC
GTGCCCGTGCTGCGCGCCGGCGTCGGCATGAGCGACGGCCTGGTGGAACTGATTCCGTCGGCGCGTATCGGCCATATCGG
CGTATATCGCGACGATCAGCACCGCCCGGTGGAGTATCTGGTGCGCCTGCCGGACGTGGAAGATCGCTCGTTCATCTTGT
GTGACCCGATGGTCGCCACCGGTTATTCGGCTGCCCATGCGGTGGATGTGCTCAAGCGCCGTGGTGTCAAGGACGAATCC
ATCACCTTCGTGGCGCTGGTGGCTGCGCCCGAGGGCGTCGAGGTGTTCCAGAAGGCCCACCCCGGCGTGAAGCTCTACGT
CGCCTCGCTGGACAACCATCTGGACGACCATGCCTATATCGTGCCGGGCCTCGGCGACGCCGGCGACCGTCTCTTCGGCA
CCAAGAACTAA

Upstream 100 bases:

>100_bases
GTGGACTGACCACCGGGCAGGCCCGCGCATCCATTACAATCGCGCTGCACAGGGCCCTCCCGCTCCAGGGGGGGCCTTCC
CGATTTCCGAGCCTGCCGCC

Downstream 100 bases:

>100_bases
GCCCGAACTGAACTGGATTCGTCTGAATGAAATTGAGGCGCTTGATGCGCCTCAAAGTTTTTGTGGGATGACCTTTCCCC
GTGCCTTGTACTGACTACAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKQDPRFPNLFILDHPLIQHKLSHMRDKETSTRTFRELLREITLLMGYEITRNLPLTTRRIDTPLVPLDAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDES
ITFVALVAAPEGVEVFQKAHPGVKLYVASLDNHLDDHAYIVPGLGDAGDRLFGTKN

Sequences:

>Translated_216_residues
MKQDPRFPNLFILDHPLIQHKLSHMRDKETSTRTFRELLREITLLMGYEITRNLPLTTRRIDTPLVPLDAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDES
ITFVALVAAPEGVEVFQKAHPGVKLYVASLDNHLDDHAYIVPGLGDAGDRLFGTKN
>Mature_216_residues
MKQDPRFPNLFILDHPLIQHKLSHMRDKETSTRTFRELLREITLLMGYEITRNLPLTTRRIDTPLVPLDAPVIAGKKLTI
VPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYLVRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDES
ITFVALVAAPEGVEVFQKAHPGVKLYVASLDNHLDDHAYIVPGLGDAGDRLFGTKN

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=33.6787564766839, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=33.6787564766839, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=47.3170731707317, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17539892, Length=222, Percent_Identity=28.8288288288288, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=222, Percent_Identity=28.8288288288288, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=217, Percent_Identity=35.9447004608295, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45550449, Length=222, Percent_Identity=31.981981981982, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573516, Length=222, Percent_Identity=31.981981981982, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573514, Length=222, Percent_Identity=31.981981981982, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573512, Length=222, Percent_Identity=31.981981981982, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005765 [H]

Pfam domain/function: NA

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24073; Mature: 24073

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDPRFPNLFILDHPLIQHKLSHMRDKETSTRTFRELLREITLLMGYEITRNLPLTTRR
CCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEE
IDTPLVPLDAPVIAGKKLTIVPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYL
CCCCCCCCCCCEECCCCEEEEEEHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDESITFVALVAAPEGVEVFQKAH
EECCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHCC
PGVKLYVASLDNHLDDHAYIVPGLGDAGDRLFGTKN
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQDPRFPNLFILDHPLIQHKLSHMRDKETSTRTFRELLREITLLMGYEITRNLPLTTRR
CCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEE
IDTPLVPLDAPVIAGKKLTIVPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYL
CCCCCCCCCCCEECCCCEEEEEEHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHH
VRLPDVEDRSFILCDPMVATGYSAAHAVDVLKRRGVKDESITFVALVAAPEGVEVFQKAH
EECCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHCC
PGVKLYVASLDNHLDDHAYIVPGLGDAGDRLFGTKN
CCEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA