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The map label for this gene is hemF [H]

Identifier: 94309728

GI number: 94309728

Start: 859017

End: 859928

Strand: Reverse

Name: hemF [H]

Synonym: Rmet_0783

Alternate gene names: 94309728

Gene position: 859928-859017 (Counterclockwise)

Preceding gene: 94309729

Following gene: 94309727

Centisome position: 21.89

GC content: 67.11

Gene sequence:

>912_bases
ATGATCGATTCCCAGGCAGTCCGTGACTATCTGCTCGGCCTGCAAGACCGCATCACCGACGCCATCGCCGCTGTCGACGG
CCAGGCGTTCCTGACCGATAACTGGGAGAAGCCCCCCACCGAGCGCCTGCGCGGCAGTGGCCGCACGCGCATCCTGGAGG
GCGGCGCCGTGATGGAGCGGGCTGGCGTGGGGTTCTCGCACGTGCGCGGTGACACGCTGCCGCCGTCGGCCAGCGCCAAC
CGGCCTGAACTGGCCGGCCGCAGCTTCGAGGCGATGGGCGTCTCGCTGGTATTCCATCCGCGCAACCCGTACGTGCCCAC
CGTGCACATGAACGTGCGCTGCTTCATCGCCGTGAAGCCCGACGCGGAACCGGTCTGGTGGTTCGGGGGTGGCATGGATC
TGACGCCGTACTACGGCAACGCCGACGACTGCGCGCACTTCCACCGCACCTGCAAGGATTCGCTGGCCCCGTTCGGCGAC
GACCTGTATCCGCGCTTCAAGCAGTGGTGCGACGAGTATTTTTTCCTCCGCCATCGTGGCGAGGCACGCGGCATCGGCGG
CATCTTCTTCGATGATTTCTCGGCGCTCGGCTTCGACCGCAGCTTCGAGATGCTGCGCTCGGTCGGCGATGCGTTCCTCG
CCGCCTACCTGCCGATCCTCACCGCACGCAAGGACGCCGCCTATGGCGAGCGCGAGCGCGATTTCCAGGCCTATCGCCGC
GGCCGCTACGTCGAATTCAATCTGGTGTTCGACCGTGGCACGCTGTTCGGCCTGCAGTCGGGCGGTCGCACGGAGTCGAT
CCTGATGTCGATGCCACCGCAGGTATCGTGGCGCTACGACTGGCAGCCCGAGCCGGGCACCCCGGAAGCCGCGCTCTATA
CCGATTTCCTGCCGGCGCGGGACTGGGCCTGA

Upstream 100 bases:

>100_bases
CGTGGGGCGAAGCCAGCCGGTACAATCATGACACCGCAATGACAGCCGGAGCGCCCGCCGCCCGGCTGTCCTGCTACCGG
CCTATTCAGACCCACCCATC

Downstream 100 bases:

>100_bases
ATCGATGACCGATAAGAAGCCAGCCACCGCCAACCGACAGCAGCGTCCCTACCGCCTGGGTATCCTCGGCGGCACCTTCG
ACCCTCCGCACCGCGGCCAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIDSQAVRDYLLGLQDRITDAIAAVDGQAFLTDNWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVRGDTLPPSASAN
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDAEPVWWFGGGMDLTPYYGNADDCAHFHRTCKDSLAPFGD
DLYPRFKQWCDEYFFLRHRGEARGIGGIFFDDFSALGFDRSFEMLRSVGDAFLAAYLPILTARKDAAYGERERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPQVSWRYDWQPEPGTPEAALYTDFLPARDWA

Sequences:

>Translated_303_residues
MIDSQAVRDYLLGLQDRITDAIAAVDGQAFLTDNWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVRGDTLPPSASAN
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDAEPVWWFGGGMDLTPYYGNADDCAHFHRTCKDSLAPFGD
DLYPRFKQWCDEYFFLRHRGEARGIGGIFFDDFSALGFDRSFEMLRSVGDAFLAAYLPILTARKDAAYGERERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPQVSWRYDWQPEPGTPEAALYTDFLPARDWA
>Mature_303_residues
MIDSQAVRDYLLGLQDRITDAIAAVDGQAFLTDNWEKPPTERLRGSGRTRILEGGAVMERAGVGFSHVRGDTLPPSASAN
RPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKPDAEPVWWFGGGMDLTPYYGNADDCAHFHRTCKDSLAPFGD
DLYPRFKQWCDEYFFLRHRGEARGIGGIFFDDFSALGFDRSFEMLRSVGDAFLAAYLPILTARKDAAYGERERDFQAYRR
GRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPQVSWRYDWQPEPGTPEAALYTDFLPARDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=44.0397350993377, Blast_Score=250, Evalue=1e-66,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=62.7906976744186, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6320249, Length=307, Percent_Identity=42.9967426710098, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI17864388, Length=303, Percent_Identity=44.2244224422442, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34225; Mature: 34225

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSQAVRDYLLGLQDRITDAIAAVDGQAFLTDNWEKPPTERLRGSGRTRILEGGAVMER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCEEEEECCCHHHH
AGVGFSHVRGDTLPPSASANRPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKP
CCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEEEEEECC
DAEPVWWFGGGMDLTPYYGNADDCAHFHRTCKDSLAPFGDDLYPRFKQWCDEYFFLRHRG
CCCEEEEECCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
EARGIGGIFFDDFSALGFDRSFEMLRSVGDAFLAAYLPILTARKDAAYGERERDFQAYRR
CCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHC
GRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPQVSWRYDWQPEPGTPEAALYTDFLPAR
CCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCCCCHHEEECCCCCC
DWA
CCC
>Mature Secondary Structure
MIDSQAVRDYLLGLQDRITDAIAAVDGQAFLTDNWEKPPTERLRGSGRTRILEGGAVMER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCEEEEECCCHHHH
AGVGFSHVRGDTLPPSASANRPELAGRSFEAMGVSLVFHPRNPYVPTVHMNVRCFIAVKP
CCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEEEEEECC
DAEPVWWFGGGMDLTPYYGNADDCAHFHRTCKDSLAPFGDDLYPRFKQWCDEYFFLRHRG
CCCEEEEECCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
EARGIGGIFFDDFSALGFDRSFEMLRSVGDAFLAAYLPILTARKDAAYGERERDFQAYRR
CCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHC
GRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPQVSWRYDWQPEPGTPEAALYTDFLPAR
CCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCCCCHHEEECCCCCC
DWA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA