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The map label for this gene is accB [H]

Identifier: 94309554

GI number: 94309554

Start: 661976

End: 663583

Strand: Reverse

Name: accB [H]

Synonym: Rmet_0609

Alternate gene names: 94309554

Gene position: 663583-661976 (Counterclockwise)

Preceding gene: 94309555

Following gene: 94309553

Centisome position: 16.89

GC content: 66.23

Gene sequence:

>1608_bases
ATGCCAACCATAGAAACCAAACTCAACGCCCGCTCCGAGTCGTTCAAGGCCAATGCGGAGACGATGCAGGCGCTCGTGGC
CGATCTCCGGCAGAAGATCACAAAGCTGGCCGAAGGCGGTGGCGAGGCCGCGCGCGACAAGCACCTGTCGCGCGGCAAGC
TGCTGCCGCGCGACCGCGTGCAGCAACTGCTCGACCCGGGTACGCCGTTCCTGGAACTGTCGCAACTGGCTGCGTACGGC
ATGTACGACGATGCGGCGCCCGGCGCGGGCATCATCACCGGCATCGGTCGCGTGGCCGGCCAGGAATGCGTGATCGTCTG
CAACGACGCCACGGTCAAGGGCGGCACGTACTACCCGATGACGGTCAAGAAACACGTGCGCGCGCAGGAGATCGCCGAGC
AGAACAACCTGCCATGCATCTATCTGGTGGATTCCGGCGGCGCGAACCTGCCGAACCAGGACGAGGTGTTCCCTGACCGC
GACCACTTTGGCCGCATCTTCTACAACCAGGCCAACCTGTCGGCGCAAGGCATTCCGCAGATCGCCGTGGTGATGGGCTC
GTGCACGGCCGGCGGCGCGTATGTGCCGGCGATGAGCGACGAGTCGATCATCGTCAAGAACCAGGGCACGATCTTCCTGG
GCGGCCCGCCGCTGGTGAAGGCAGCCACCGGCGAGGAAGTGACCGCCGAGGACCTGGGCGGCGCCGACGTGCACACGCGC
CTCTCGGGCGTGGCGGACTACTTCGCGCAGAACGATCATCACGCGCTCTCGCTGGCGCGCAATATCGTGCAGCACCTGAA
CCGCCGCAAGCCGGATCAGATCCGCCTGCACGAGCCGGCCGAGCCGCTGTATCCGCCCGAAGAACTGTACGGCGTGATCC
CGACCGACACGCGCAAGCCGTACGACGTGCGCGAGGTCATCGCCCGCATCGTCGACGGCTCCGAGTTCGACGAATTCAAG
GCCCGCTACGGCACCACGCTGGTCTGCGGCTTCGCGCGGATCTGGGGCTACCCGGTCGGTATCGTCGCCAACAACGGCAT
CCTGTTCTCGGAGTCGGCGCTGAAGGGTTCACACTTCATCGAGCTGTGCTGCCAGCGCAAGATCCCGCTGGTGTTCCTGC
AGAACATCACCGGCTTCATGGTCGGCCGCAAGTACGAGAACGAGGGCATCGCGCGCAATGGCGCCAAGATGGTGACGGCG
GTGGCCACGGCACAGGTGCCGAAGTTCACGGTGATCATCGGCGGCTCGTTCGGCGCGGGCAACTACGGCATGTGCGGACG
CGCGTACTCGCCGCGCTTCCTGTGGATGTGGCCGAACGCGCGGATCTCCGTGATGGGCGGCGAGCAGGCCGCCAGCGTGC
TGGCAACGGTCCGCCGCGATGGCATCGAGGCCAAGGGCGGCGAGTGGAGCCCGCAGGAGGAAGAAGCCTTCAAGGCACCG
ATCCGCGACCAGTACGAACTGCAGGGACATCCGTACTACGCCAGCGCGCGGCTCTGGGACGATGGCGTCATCGATCCCGC
GCAGACGCGCACCGTGCTCGGCCTGGGCCTGTCCGCCAGCCTCAACGCCCCGATCGGCGACATGAAGTTCGGCGTGTTCC
GCATGTAA

Upstream 100 bases:

>100_bases
GACGAGATGCCCATGACGATCACCGGCAAGGTGCAGAAGTTCGTCATGCGGGACCAGATGACCCAGGAACTCGGAATCAG
CCCCAAGGCCAAGTGAAGCC

Downstream 100 bases:

>100_bases
GGGGAAAACAATAATGTTCACGAAGATCCTGATTGCGAACCGTGGCGAGATCGCCTGCCGTGTGGCGGCCACCTGCCGCC
GCCTCGGCATCCGCACCGTG

Product: acetyl/propionyl-CoA carboxylase,carboxyltransferase subunit

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPTIETKLNARSESFKANAETMQALVADLRQKITKLAEGGGEAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYG
MYDDAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQANLSAQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPAEPLYPPEELYGVIPTDTRKPYDVREVIARIVDGSEFDEFK
ARYGTTLVCGFARIWGYPVGIVANNGILFSESALKGSHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGEWSPQEEEAFKAP
IRDQYELQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIGDMKFGVFRM

Sequences:

>Translated_535_residues
MPTIETKLNARSESFKANAETMQALVADLRQKITKLAEGGGEAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYG
MYDDAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQANLSAQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPAEPLYPPEELYGVIPTDTRKPYDVREVIARIVDGSEFDEFK
ARYGTTLVCGFARIWGYPVGIVANNGILFSESALKGSHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTA
VATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGEWSPQEEEAFKAP
IRDQYELQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIGDMKFGVFRM
>Mature_534_residues
PTIETKLNARSESFKANAETMQALVADLRQKITKLAEGGGEAARDKHLSRGKLLPRDRVQQLLDPGTPFLELSQLAAYGM
YDDAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPMTVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQANLSAQGIPQIAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTRL
SGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPAEPLYPPEELYGVIPTDTRKPYDVREVIARIVDGSEFDEFKA
RYGTTLVCGFARIWGYPVGIVANNGILFSESALKGSHFIELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATAQVPKFTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGEWSPQEEEAFKAPI
RDQYELQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIGDMKFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=534, Percent_Identity=66.8539325842697, Blast_Score=734, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=526, Percent_Identity=33.2699619771863, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI295821216, Length=546, Percent_Identity=32.0512820512821, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI310133460, Length=144, Percent_Identity=58.3333333333333, Blast_Score=155, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.9774859287054, Blast_Score=727, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=35.1239669421488, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=35.1239669421488, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=64.6098003629764, Blast_Score=737, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58142; Mature: 58011

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIETKLNARSESFKANAETMQALVADLRQKITKLAEGGGEAARDKHLSRGKLLPRDRV
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
QQLLDPGTPFLELSQLAAYGMYDDAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCEECCC
TVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQANLSAQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCHHHHH
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPAEPLYPPEELYGVIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVIARIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIVANNGILFSESALKGSHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCHHEEEHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGEWSPQEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCC
IRDQYELQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIGDMKFGVFRM
CCCCEEECCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
PTIETKLNARSESFKANAETMQALVADLRQKITKLAEGGGEAARDKHLSRGKLLPRDRV
CCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
QQLLDPGTPFLELSQLAAYGMYDDAAPGAGIITGIGRVAGQECVIVCNDATVKGGTYYPM
HHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCEECCC
TVKKHVRAQEIAEQNNLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQANLSAQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCE
IAVVMGSCTAGGAYVPAMSDESIIVKNQGTIFLGGPPLVKAATGEEVTAEDLGGADVHTR
EEEEEECCCCCCEEECCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCHHHHH
LSGVADYFAQNDHHALSLARNIVQHLNRRKPDQIRLHEPAEPLYPPEELYGVIPTDTRKP
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVIARIVDGSEFDEFKARYGTTLVCGFARIWGYPVGIVANNGILFSESALKGSHFI
CCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCEEEECCCCCCHHHH
ELCCQRKIPLVFLQNITGFMVGRKYENEGIARNGAKMVTAVATAQVPKFTVIIGGSFGAG
HHHHCCCCCEEEECCCHHHHCCCEECCCCCCCCCCHHEEEHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDGIEAKGGEWSPQEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCC
IRDQYELQGHPYYASARLWDDGVIDPAQTRTVLGLGLSASLNAPIGDMKFGVFRM
CCCCEEECCCCEEEEEEECCCCCCCCHHHCEEEEECCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]