Click here to switch to the map view.

The map label for this gene is mdtA [H]

Identifier: 94309546

GI number: 94309546

Start: 650067

End: 651446

Strand: Reverse

Name: mdtA [H]

Synonym: Rmet_0601

Alternate gene names: 94309546

Gene position: 651446-650067 (Counterclockwise)

Preceding gene: 94309550

Following gene: 94309545

Centisome position: 16.58

GC content: 67.61

Gene sequence:

>1380_bases
ATGGAGGCCCACGCAAGGGCCCGAGGCTTGACGCGCGAGTCACATCGTGAGCCTGAAATAATCAGTAATAAGGCGGTCAT
ATCTCACATGACAGCCACGGACTATGCTTGTCGAGTCAAGCGACCAATGTCACGCATGTCTGCTTCGCCTCCCCCCCGCC
GGCGGCCATTGGCCATAGCCCTGTACGTCGTCATCGCCATCGTGGTGGTCTGGCTGGTTGCCAGGCCACTGGGACGATGG
CTGTTCCCGCCCAAGGCCCCGCAGGCGAACCCGGCCATCGTGGTTACCACGGCCGCGGCGCAAGGCGAGGACGTGGACAT
TGGCCTGACCGGCGTCGGCACAGTCCAGGCCATGCAGACTGTGACGGTCAAGCCACGCGTGGACGGGCAGCTCGAGCGCG
TTGGCTTCGTCGAAGGCCAGGACGTCAAGGAAGGCCAGGTGCTGGCGCAGATCGACCCACGCACGTTCCAGGCGCAACTG
CAGCAGGCGCAGGCCACCAAGGCGCGCGACGAGGCGCAGCTTGCCAACGCTCGCCTGGACCTGAAACGCTACGAAGAACT
GATCAAGGTCGACTCGACCACGCGCCAGACACTCGACACCCAACGCGCGCTGGTCGACCAGCTTGCCGCCGCCGTGCGCA
ATGACGAAGCGCAGATCGCGCTGGACAAGGTGCAGCTCGATTTCACGACCATCACGGCGCCGCTCTCCGGCCGCGTCGGC
GCCCGGCTGGTCGACCCCGGCAATATCGTCCATGCCACCGACACCACCGGCCTCGTCGTGATCCGCCAGATCGACCCGAT
CGACGTCGTCTTCACGCTGCCCGACGACGCCTTCGGCCGCATCAACCGCGCGATGCAAGCCAGCCAGTCGCCACTGGTGG
TGTTCGCCCACGAGCGCGGCACCGACGCCGACCTCGGGCACGGCGGCCTGATCCTGCTGAACAACACGATCGACACCACC
AGCGGCACCATCCAGCTCAAGGCGCGCTTTCCGAATCCGAAGCACCTGCTGTGGCCGGGCCAGTACGTCAACGCCCGGCT
CGTGCTGGGCCAGCGTGACCGCGCGGTGGTCATTCCGGCGTCCGCGGTGCAACGTAACGATGCCGGTACCTATGTCTATG
CGGTGCAGGCGGACCAGACCGTGAAGCTGCAGCCGGTGGAGGTAGCGGAACTCCAGGGCGCGCGGGCCGTGATCGCCAAG
GGCGTCCAGGCCGGGGAGCGCGTGGTGGCCGATGGCCAGTACAAGCTCAAGCCCGGCTCGCTGATTGCCGAGGCGCCCGC
GCGGCCAGGCACCGCACCGACTGGCGGGGCGGCCGCCGAGTCCACTGCCGCCACCTCCCCTGCTGTCGCCGCCAGCGCCA
CGGCCGCCGTACGCCAGTGA

Upstream 100 bases:

>100_bases
CCTCTAACCCTTTCGTTGTTGTGTCAGGCCGCGGGCCACGAATTGCGGCCTCCCGCCTATCTTCTACGCTGCACATCGTG
GCAGCGCAATAGGAGAATGG

Downstream 100 bases:

>100_bases
GCCTTCCGATGAGCCACCCATGAGTATTTCGGCCACCTTCATCAAGCGGCCGATCGGCACATCGCTGCTGGCGCTCGCGT
TGCTGCTCGTTGGCCTGGCC

Product: multidrug resistance protein MdtA

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MEAHARARGLTRESHREPEIISNKAVISHMTATDYACRVKRPMSRMSASPPPRRRPLAIALYVVIAIVVVWLVARPLGRW
LFPPKAPQANPAIVVTTAAAQGEDVDIGLTGVGTVQAMQTVTVKPRVDGQLERVGFVEGQDVKEGQVLAQIDPRTFQAQL
QQAQATKARDEAQLANARLDLKRYEELIKVDSTTRQTLDTQRALVDQLAAAVRNDEAQIALDKVQLDFTTITAPLSGRVG
ARLVDPGNIVHATDTTGLVVIRQIDPIDVVFTLPDDAFGRINRAMQASQSPLVVFAHERGTDADLGHGGLILLNNTIDTT
SGTIQLKARFPNPKHLLWPGQYVNARLVLGQRDRAVVIPASAVQRNDAGTYVYAVQADQTVKLQPVEVAELQGARAVIAK
GVQAGERVVADGQYKLKPGSLIAEAPARPGTAPTGGAAAESTAATSPAVAASATAAVRQ

Sequences:

>Translated_459_residues
MEAHARARGLTRESHREPEIISNKAVISHMTATDYACRVKRPMSRMSASPPPRRRPLAIALYVVIAIVVVWLVARPLGRW
LFPPKAPQANPAIVVTTAAAQGEDVDIGLTGVGTVQAMQTVTVKPRVDGQLERVGFVEGQDVKEGQVLAQIDPRTFQAQL
QQAQATKARDEAQLANARLDLKRYEELIKVDSTTRQTLDTQRALVDQLAAAVRNDEAQIALDKVQLDFTTITAPLSGRVG
ARLVDPGNIVHATDTTGLVVIRQIDPIDVVFTLPDDAFGRINRAMQASQSPLVVFAHERGTDADLGHGGLILLNNTIDTT
SGTIQLKARFPNPKHLLWPGQYVNARLVLGQRDRAVVIPASAVQRNDAGTYVYAVQADQTVKLQPVEVAELQGARAVIAK
GVQAGERVVADGQYKLKPGSLIAEAPARPGTAPTGGAAAESTAATSPAVAASATAAVRQ
>Mature_459_residues
MEAHARARGLTRESHREPEIISNKAVISHMTATDYACRVKRPMSRMSASPPPRRRPLAIALYVVIAIVVVWLVARPLGRW
LFPPKAPQANPAIVVTTAAAQGEDVDIGLTGVGTVQAMQTVTVKPRVDGQLERVGFVEGQDVKEGQVLAQIDPRTFQAQL
QQAQATKARDEAQLANARLDLKRYEELIKVDSTTRQTLDTQRALVDQLAAAVRNDEAQIALDKVQLDFTTITAPLSGRVG
ARLVDPGNIVHATDTTGLVVIRQIDPIDVVFTLPDDAFGRINRAMQASQSPLVVFAHERGTDADLGHGGLILLNNTIDTT
SGTIQLKARFPNPKHLLWPGQYVNARLVLGQRDRAVVIPASAVQRNDAGTYVYAVQADQTVKLQPVEVAELQGARAVIAK
GVQAGERVVADGQYKLKPGSLIAEAPARPGTAPTGGAAAESTAATSPAVAASATAAVRQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=325, Percent_Identity=45.2307692307692, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1789665, Length=317, Percent_Identity=33.4384858044164, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789929, Length=304, Percent_Identity=30.9210526315789, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786668, Length=314, Percent_Identity=32.8025477707006, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081796, Length=407, Percent_Identity=25.7985257985258, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 49078; Mature: 49078

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAHARARGLTRESHREPEIISNKAVISHMTATDYACRVKRPMSRMSASPPPRRRPLAIA
CCCCHHHCCCCHHHCCCCCHHCCCHHEEECCCCCHHHHHHCCHHHHCCCCCCCCCCHHHH
LYVVIAIVVVWLVARPLGRWLFPPKAPQANPAIVVTTAAAQGEDVDIGLTGVGTVQAMQT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEE
VTVKPRVDGQLERVGFVEGQDVKEGQVLAQIDPRTFQAQLQQAQATKARDEAQLANARLD
EEECCCCCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKRYEELIKVDSTTRQTLDTQRALVDQLAAAVRNDEAQIALDKVQLDFTTITAPLSGRVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEECCCCCCC
ARLVDPGNIVHATDTTGLVVIRQIDPIDVVFTLPDDAFGRINRAMQASQSPLVVFAHERG
EEEECCCCEEEECCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCC
TDADLGHGGLILLNNTIDTTSGTIQLKARFPNPKHLLWPGQYVNARLVLGQRDRAVVIPA
CCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEECCCCCEEEEEH
SAVQRNDAGTYVYAVQADQTVKLQPVEVAELQGARAVIAKGVQAGERVVADGQYKLKPGS
HHHCCCCCCCEEEEEECCCEEEECCCHHHHHCCCHHHHHHHHHCCCEEEECCEEEECCCC
LIAEAPARPGTAPTGGAAAESTAATSPAVAASATAAVRQ
EEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEAHARARGLTRESHREPEIISNKAVISHMTATDYACRVKRPMSRMSASPPPRRRPLAIA
CCCCHHHCCCCHHHCCCCCHHCCCHHEEECCCCCHHHHHHCCHHHHCCCCCCCCCCHHHH
LYVVIAIVVVWLVARPLGRWLFPPKAPQANPAIVVTTAAAQGEDVDIGLTGVGTVQAMQT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEE
VTVKPRVDGQLERVGFVEGQDVKEGQVLAQIDPRTFQAQLQQAQATKARDEAQLANARLD
EEECCCCCCCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LKRYEELIKVDSTTRQTLDTQRALVDQLAAAVRNDEAQIALDKVQLDFTTITAPLSGRVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEEEECCCCCCC
ARLVDPGNIVHATDTTGLVVIRQIDPIDVVFTLPDDAFGRINRAMQASQSPLVVFAHERG
EEEECCCCEEEECCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCC
TDADLGHGGLILLNNTIDTTSGTIQLKARFPNPKHLLWPGQYVNARLVLGQRDRAVVIPA
CCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEECCCCCEEEEEH
SAVQRNDAGTYVYAVQADQTVKLQPVEVAELQGARAVIAKGVQAGERVVADGQYKLKPGS
HHHCCCCCCCEEEEEECCCEEEECCCHHHHHCCCHHHHHHHHHCCCEEEECCEEEECCCC
LIAEAPARPGTAPTGGAAAESTAATSPAVAASATAAVRQ
EEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA