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The map label for this gene is lpxK

Identifier: 94309480

GI number: 94309480

Start: 569492

End: 570610

Strand: Reverse

Name: lpxK

Synonym: Rmet_0535

Alternate gene names: 94309480

Gene position: 570610-569492 (Counterclockwise)

Preceding gene: 94309481

Following gene: 94309479

Centisome position: 14.53

GC content: 66.85

Gene sequence:

>1119_bases
ATGGCCGCTCCCCAACACACCCTCGCCGACTTCGTCACCGACCAGTGGCAGCGCCGTAGCTGGTTTACCTGGCTCATGTG
GCCGCTGTCGCTGCTGTTCGGCCTGATCGCGCGCATTCGCCGGTACGGCTATCAACAGGGATGGTTCAAGTCGACCCGTC
TGCCGATGCCGGTCATCGTGGTTGGCAACGTGACCGTGGGCGGCACCGGCAAGACCCCGGCCGTGATCGCGCTGGCCCAT
GCGCTGGCGGAAGCCGGCCTGCGCCCGGGCGTGGTTTCGCGTGGCTACGGCGTGAAGCTGAACCACCCGCGCCGCGTCAA
GCCGACCTCGAAGGCCGCCGACGTCGGCGACGAGCCGCTGCTGATCGCACGCGCCGCGGACGTCCCGGTGTGGGTCTTCC
CGGACCGCGCCCTGTGCACGCAGGCCATGCTCGTCTCGCATCCCGGCGTCAACGTACTACTGCTCGATGATGGCCTGCAG
CACTACAAGCTCCAGCGGGACTTCGAGATCGTAATGTTCGACACGCGCATGGGCGGCAACGGCATGATGCTGCCGGCCGG
CCCGCTACGCGAACCGCTGACCCGGCCACGCGACGCCACGCTGATCAACGATCCGAATTTCCGCGCCACGCCAGACAAAC
CCGACGTCTACGGCATGCGCCTGGAGCTCGACGAAGCCTGGCAACTCAACGATCCGACGATGTCGTGCGACGTGTCCAAG
TTCGCGGACAAGCGGGTGCTGGCGGCAGCCGGCATCGGCCACCCGGAACGCTTCTTCGCCAGCCTGCGTCAGGCGGGGCT
ATCCCCCGCCACGCTGCCGCTGCCGGACCATTACGATTTCGTGCAGGACCCGTTCGCGGACAATCCTGCCGCGCTCGAAG
CCGACGTGATCCTGATCACCGAGAAGGATGCCGTAAAATGCGAGCGCTTCGACGACCCGCGTATCTGGGTCGTCCCCACC
ACGCCCGTGATCGACGCGGGCCTGATCGATAAAATCCGCCGCGTCGTGCAGGCGCGCAACCCGGCCATCGCCACACCCGT
CACCGTGGGGCAATCCACCGCCACCGGGATGGCCGACGGTCTCGACAAGGAACACCAAGATGGACAACCGGCTGCTTGA

Upstream 100 bases:

>100_bases
AACGGCAGGCTTGCGACAAGCGTCGGGCAATGCCCATAATGTCTGCATTCGCCCGGCGCCACCCTAGCGGTGGCGCCGCC
CGCTCCCGTCCCCGATCTTC

Downstream 100 bases:

>100_bases
AATCCTCGTTTGCCCGCTGTGCAAGGGCAAACTGGAATACGATCGCGCCGCCCAGGAACTGATCTGCCACGCCGACAAGC
TGGCCTACCCGATCCGTGAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MAAPQHTLADFVTDQWQRRSWFTWLMWPLSLLFGLIARIRRYGYQQGWFKSTRLPMPVIVVGNVTVGGTGKTPAVIALAH
ALAEAGLRPGVVSRGYGVKLNHPRRVKPTSKAADVGDEPLLIARAADVPVWVFPDRALCTQAMLVSHPGVNVLLLDDGLQ
HYKLQRDFEIVMFDTRMGGNGMMLPAGPLREPLTRPRDATLINDPNFRATPDKPDVYGMRLELDEAWQLNDPTMSCDVSK
FADKRVLAAAGIGHPERFFASLRQAGLSPATLPLPDHYDFVQDPFADNPAALEADVILITEKDAVKCERFDDPRIWVVPT
TPVIDAGLIDKIRRVVQARNPAIATPVTVGQSTATGMADGLDKEHQDGQPAA

Sequences:

>Translated_372_residues
MAAPQHTLADFVTDQWQRRSWFTWLMWPLSLLFGLIARIRRYGYQQGWFKSTRLPMPVIVVGNVTVGGTGKTPAVIALAH
ALAEAGLRPGVVSRGYGVKLNHPRRVKPTSKAADVGDEPLLIARAADVPVWVFPDRALCTQAMLVSHPGVNVLLLDDGLQ
HYKLQRDFEIVMFDTRMGGNGMMLPAGPLREPLTRPRDATLINDPNFRATPDKPDVYGMRLELDEAWQLNDPTMSCDVSK
FADKRVLAAAGIGHPERFFASLRQAGLSPATLPLPDHYDFVQDPFADNPAALEADVILITEKDAVKCERFDDPRIWVVPT
TPVIDAGLIDKIRRVVQARNPAIATPVTVGQSTATGMADGLDKEHQDGQPAA
>Mature_371_residues
AAPQHTLADFVTDQWQRRSWFTWLMWPLSLLFGLIARIRRYGYQQGWFKSTRLPMPVIVVGNVTVGGTGKTPAVIALAHA
LAEAGLRPGVVSRGYGVKLNHPRRVKPTSKAADVGDEPLLIARAADVPVWVFPDRALCTQAMLVSHPGVNVLLLDDGLQH
YKLQRDFEIVMFDTRMGGNGMMLPAGPLREPLTRPRDATLINDPNFRATPDKPDVYGMRLELDEAWQLNDPTMSCDVSKF
ADKRVLAAAGIGHPERFFASLRQAGLSPATLPLPDHYDFVQDPFADNPAALEADVILITEKDAVKCERFDDPRIWVVPTT
PVIDAGLIDKIRRVVQARNPAIATPVTVGQSTATGMADGLDKEHQDGQPAA

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=316, Percent_Identity=41.4556962025316, Blast_Score=207, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_RALME (Q1LR05)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582690.1
- STRING:   Q1LR05
- GeneID:   4037324
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0535
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   TPHVEYL
- PhylomeDB:   Q1LR05
- ProtClustDB:   PRK01906
- BioCyc:   RMET266264:RMET_0535-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 40905; Mature: 40774

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPQHTLADFVTDQWQRRSWFTWLMWPLSLLFGLIARIRRYGYQQGWFKSTRLPMPVIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
VGNVTVGGTGKTPAVIALAHALAEAGLRPGVVSRGYGVKLNHPRRVKPTSKAADVGDEPL
EECEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCE
LIARAADVPVWVFPDRALCTQAMLVSHPGVNVLLLDDGLQHYKLQRDFEIVMFDTRMGGN
EEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCEEEEEEEEEECCC
GMMLPAGPLREPLTRPRDATLINDPNFRATPDKPDVYGMRLELDEAWQLNDPTMSCDVSK
EEECCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCHHH
FADKRVLAAAGIGHPERFFASLRQAGLSPATLPLPDHYDFVQDPFADNPAALEADVILIT
HHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEEEEE
EKDAVKCERFDDPRIWVVPTTPVIDAGLIDKIRRVVQARNPAIATPVTVGQSTATGMADG
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCEECCCCCCCCHHHC
LDKEHQDGQPAA
CCCCCCCCCCCC
>Mature Secondary Structure 
AAPQHTLADFVTDQWQRRSWFTWLMWPLSLLFGLIARIRRYGYQQGWFKSTRLPMPVIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
VGNVTVGGTGKTPAVIALAHALAEAGLRPGVVSRGYGVKLNHPRRVKPTSKAADVGDEPL
EECEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCE
LIARAADVPVWVFPDRALCTQAMLVSHPGVNVLLLDDGLQHYKLQRDFEIVMFDTRMGGN
EEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCEEEEEEEEEECCC
GMMLPAGPLREPLTRPRDATLINDPNFRATPDKPDVYGMRLELDEAWQLNDPTMSCDVSK
EEECCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCHHH
FADKRVLAAAGIGHPERFFASLRQAGLSPATLPLPDHYDFVQDPFADNPAALEADVILIT
HHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEEEEE
EKDAVKCERFDDPRIWVVPTTPVIDAGLIDKIRRVVQARNPAIATPVTVGQSTATGMADG
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCEECCCCCCCCHHHC
LDKEHQDGQPAA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA