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The map label for this gene is adk

Identifier: 94309477

GI number: 94309477

Start: 567475

End: 568140

Strand: Reverse

Name: adk

Synonym: Rmet_0532

Alternate gene names: 94309477

Gene position: 568140-567475 (Counterclockwise)

Preceding gene: 94309478

Following gene: 94309476

Centisome position: 14.46

GC content: 62.01

Gene sequence:

>666_bases
ATGCGTTTGATCCTGTTGGGCGCACCTGGCGCCGGCAAAGGCACGCAAGCCAAGTTCATCTGCGAGAAGTTCGGCATTCC
GCAAATCTCCACGGGCGACATGCTGCGCGCCGCGGTGAAGGCGGGCACGCCGCTGGGCATCGAAGCCAAGAAGGTGATGG
ACGCGGGCGGACTGGTGTCGGATGACATCATTATCGGCCTGGTGAAAGACCGTCTTAAGCAGCCTGATTGCGAAAAGGGC
TACCTGTTCGATGGTTTCCCGCGCACGATTCCGCAGGCCGAGGCAATGAAGGAAGCCGGCGTGGCGATCGACTACGTGCT
GGAAATCGACGTGCCGTTCGACGCCATCATCGAGCGCATGAGCGGCCGCCGCGTGCATGTGGCGTCGGGCCGGACATACC
ACGTCAAGTTCAACCCGCCGAAGGCCGACATGGTCGACGACGAAACGGGCGAAGCACTGATCCAGCGCGACGACGACAAG
GAAGAGACGGTGCGCAAGCGCCTGGACGTGTACTCGCAGCAAACCCGTCCGCTGGTCGACTACTACTCGAACTGGGCCGC
CAACGGCGATGCCTCGGCGAAGGTATCGCCGCCGAAGTACCGCAAGATCGCGGGTCTTGGCGAAGTCGACAAGATCACGG
CAAGCGTGTTCGACGCGCTGAAGTAA

Upstream 100 bases:

>100_bases
ACAGTCTGGCCTGACCGCGTAAGTCCTGCGTCAAGTTGCGGCGGTACCCTCCTTCCATCCCTCCCGCCAGACCGAATTCA
AATACCTTGAGGACCCGTAA

Downstream 100 bases:

>100_bases
GTCGCGAAGCGCTTTCAGCATCAAGAAGAAGCGGCCCTGGGCAACCGGGCCGCTTTTTTATTTGCCGATCGGTTCGCGCG
GTTCGTACAATAGCCTCCAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLKQPDCEKG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKFNPPKADMVDDETGEALIQRDDDK
EETVRKRLDVYSQQTRPLVDYYSNWAANGDASAKVSPPKYRKIAGLGEVDKITASVFDALK

Sequences:

>Translated_221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLKQPDCEKG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKFNPPKADMVDDETGEALIQRDDDK
EETVRKRLDVYSQQTRPLVDYYSNWAANGDASAKVSPPKYRKIAGLGEVDKITASVFDALK
>Mature_221_residues
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVSDDIIIGLVKDRLKQPDCEKG
YLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHVKFNPPKADMVDDETGEALIQRDDDK
EETVRKRLDVYSQQTRPLVDYYSNWAANGDASAKVSPPKYRKIAGLGEVDKITASVFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=201, Percent_Identity=46.2686567164179, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI4502013, Length=201, Percent_Identity=46.2686567164179, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI19923437, Length=204, Percent_Identity=44.1176470588235, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI310110345, Length=204, Percent_Identity=37.2549019607843, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832003, Length=204, Percent_Identity=37.2549019607843, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI8051579, Length=204, Percent_Identity=37.2549019607843, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832001, Length=204, Percent_Identity=37.2549019607843, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI22749187, Length=191, Percent_Identity=31.413612565445, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4502011, Length=223, Percent_Identity=28.2511210762332, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=188, Percent_Identity=30.8510638297872, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI28144897, Length=196, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI28144899, Length=196, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=62.037037037037, Blast_Score=271, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17552384, Length=192, Percent_Identity=47.3958333333333, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=220, Percent_Identity=30.4545454545455, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=51.5463917525773, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=206, Percent_Identity=41.747572815534, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=51.3661202185792, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=42.8571428571429, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=42.8571428571429, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=31.8435754189944, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=31.8435754189944, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=26.046511627907, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=26.046511627907, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_RALME (Q1LR08)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582687.1
- ProteinModelPortal:   Q1LR08
- SMR:   Q1LR08
- STRING:   Q1LR08
- GeneID:   4037321
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0532
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q1LR08
- ProtClustDB:   PRK00279
- BioCyc:   RMET266264:RMET_0532-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24144; Mature: 24144

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIIIGLVKDRLKQPDCEKGYLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERM
CHHHEEEHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKFNPPKADMVDDETGEALIQRDDDKEETVRKRLDVYSQQTRPLVD
CCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
YYSNWAANGDASAKVSPPKYRKIAGLGEVDKITASVFDALK
HHHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGIEAKKVMDAGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIIIGLVKDRLKQPDCEKGYLFDGFPRTIPQAEAMKEAGVAIDYVLEIDVPFDAIIERM
CHHHEEEHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRVHVASGRTYHVKFNPPKADMVDDETGEALIQRDDDKEETVRKRLDVYSQQTRPLVD
CCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHH
YYSNWAANGDASAKVSPPKYRKIAGLGEVDKITASVFDALK
HHHCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA