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The map label for this gene is purK [H]

Identifier: 94309451

GI number: 94309451

Start: 536521

End: 537765

Strand: Direct

Name: purK [H]

Synonym: Rmet_0506

Alternate gene names: 94309451

Gene position: 536521-537765 (Clockwise)

Preceding gene: 94309450

Following gene: 94309452

Centisome position: 13.66

GC content: 67.79

Gene sequence:

>1245_bases
ATGCCGACCGATATCCATCCCCACCTGTCCGAAGCGCATACCCCCGAGTCGCGCGCCGAGTTCGGCGTGAACAGTCCGAA
CTCGCCGATCCTGCCGGGCGCCTGGCTCGGCATGCTCGGCGGCGGCCAGCTCGGCCGCATGTTCACGCACGCGGCGCAGT
CGATGGGGTACCGCGTTTGCGTGCTCGATCCGGACCAGGACAGCCCGGCCGGCTCCGTGGCTGACCGGCACATCTGCGCG
GCATACACCGACGATGCGGCGCTGGCCGAACTGTCCAGCCTGTGCGAGGCGGTGAGCACCGAGTTCGAGAACGTGCCGTC
GATCTCGCTCGAGCGTCTGGAGGAAGCCGGCGTGTTCGTCGCGCCGCGCGGCTACTGCGTGTCGATCGCGCAGAACCGCA
TCGGCGAAAAGAAGTTCTTCGCCTCCTGTGCGGACCGTACCGGCGTGCCGCCGGCCCCGCACTGGGTGATCCAGCACGAT
GCCGATGTGGACCGGCTGCCTGACGAAGTGCTGCCGGGCATCCTGAAAACCGCGCGGATGGGCTACGACGGCAAGGGCCA
GGCGCGCGTGAAGTCGCGCGACGACGTGCGCGCCGCATGGAAGGCCATGCAGCATGTACCGTGCGTGCTCGAGCGGATGC
TGCCGCTGGCGTACGAGGTGTCGGTGCTGGCCGCGCGTGCCGCCGATGGCTCCACCGCCACGTGGCCGCTGGCCGAGAAC
GTGCACCGCGATGGCATCCTGTTTTCGACGACGATGCCTTCGACGAGCGTGTCGGACGATATTTCCCAACGCGCCCGCAA
CGCCGCGGCGACGATTGCTTCGGAAATGGGCTACGTCGGCGTGCTTTGCATCGAATTCTTCGTGCTGACCGATGGCACGC
TGGTGGCCAATGAAATGGCGCCGCGCCCGCATAACTCGGGGCACATCACGATGGATGCCTGCGAGACCAGCCAGTTCGAG
CAACAGGTCCGCGCGATGGCTCGCCTGCCGCTGGGCAGCACCCGCCAGCATTCGGCCGGCAAGATGCTGAACCTGCTTGG
CGACTGCTGGTTCGAGTTCGGCCTGGAGCGTACGCCCGCGTGGGATGAGGTGCTGGCGCAGCCCGGCGCCAAGCTGCACC
TCTACGGCAAGAACGATGCGCGCCCGTCGCGCAAGATGGGGCACGTGAACTGCGTTGGCGACCACGCCGAAGCGGCCGAC
CGCACGTTCGATGCCGCCGCCAAGGCGCTGCACATCCCCAGCTGA

Upstream 100 bases:

>100_bases
TGGCCAGCGCGCTGGAAGCGTTCCGCGCAAAGCAGACCGAAGCCGCGCGCGCGATGACGCTGCCCGTATAACTTTCTGAA
GTCTCACCGTAGCCTGAGCC

Downstream 100 bases:

>100_bases
AACCGGTAGTTCGCGATGTCTTCACGTATGCCCACCGCCGCGGAGCTGGACGAAGCCGTCCGCCTGCTCGAAGCCGGCGA
GCTGGTGGCCTTCCCGACCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPTDIHPHLSEAHTPESRAEFGVNSPNSPILPGAWLGMLGGGQLGRMFTHAAQSMGYRVCVLDPDQDSPAGSVADRHICA
AYTDDAALAELSSLCEAVSTEFENVPSISLERLEEAGVFVAPRGYCVSIAQNRIGEKKFFASCADRTGVPPAPHWVIQHD
ADVDRLPDEVLPGILKTARMGYDGKGQARVKSRDDVRAAWKAMQHVPCVLERMLPLAYEVSVLAARAADGSTATWPLAEN
VHRDGILFSTTMPSTSVSDDISQRARNAAATIASEMGYVGVLCIEFFVLTDGTLVANEMAPRPHNSGHITMDACETSQFE
QQVRAMARLPLGSTRQHSAGKMLNLLGDCWFEFGLERTPAWDEVLAQPGAKLHLYGKNDARPSRKMGHVNCVGDHAEAAD
RTFDAAAKALHIPS

Sequences:

>Translated_414_residues
MPTDIHPHLSEAHTPESRAEFGVNSPNSPILPGAWLGMLGGGQLGRMFTHAAQSMGYRVCVLDPDQDSPAGSVADRHICA
AYTDDAALAELSSLCEAVSTEFENVPSISLERLEEAGVFVAPRGYCVSIAQNRIGEKKFFASCADRTGVPPAPHWVIQHD
ADVDRLPDEVLPGILKTARMGYDGKGQARVKSRDDVRAAWKAMQHVPCVLERMLPLAYEVSVLAARAADGSTATWPLAEN
VHRDGILFSTTMPSTSVSDDISQRARNAAATIASEMGYVGVLCIEFFVLTDGTLVANEMAPRPHNSGHITMDACETSQFE
QQVRAMARLPLGSTRQHSAGKMLNLLGDCWFEFGLERTPAWDEVLAQPGAKLHLYGKNDARPSRKMGHVNCVGDHAEAAD
RTFDAAAKALHIPS
>Mature_413_residues
PTDIHPHLSEAHTPESRAEFGVNSPNSPILPGAWLGMLGGGQLGRMFTHAAQSMGYRVCVLDPDQDSPAGSVADRHICAA
YTDDAALAELSSLCEAVSTEFENVPSISLERLEEAGVFVAPRGYCVSIAQNRIGEKKFFASCADRTGVPPAPHWVIQHDA
DVDRLPDEVLPGILKTARMGYDGKGQARVKSRDDVRAAWKAMQHVPCVLERMLPLAYEVSVLAARAADGSTATWPLAENV
HRDGILFSTTMPSTSVSDDISQRARNAAATIASEMGYVGVLCIEFFVLTDGTLVANEMAPRPHNSGHITMDACETSQFEQ
QVRAMARLPLGSTRQHSAGKMLNLLGDCWFEFGLERTPAWDEVLAQPGAKLHLYGKNDARPSRKMGHVNCVGDHAEAADR
TFDAAAKALHIPS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=379, Percent_Identity=31.3984168865435, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788155, Length=365, Percent_Identity=27.1232876712329, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324702, Length=390, Percent_Identity=27.9487179487179, Blast_Score=188, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 44724; Mature: 44593

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDIHPHLSEAHTPESRAEFGVNSPNSPILPGAWLGMLGGGQLGRMFTHAAQSMGYRVC
CCCCCCCCCHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEE
VLDPDQDSPAGSVADRHICAAYTDDAALAELSSLCEAVSTEFENVPSISLERLEEAGVFV
EECCCCCCCCCCHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEE
APRGYCVSIAQNRIGEKKFFASCADRTGVPPAPHWVIQHDADVDRLPDEVLPGILKTARM
CCCCCEEHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHHC
GYDGKGQARVKSRDDVRAAWKAMQHVPCVLERMLPLAYEVSVLAARAADGSTATWPLAEN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
VHRDGILFSTTMPSTSVSDDISQRARNAAATIASEMGYVGVLCIEFFVLTDGTLVANEMA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCC
PRPHNSGHITMDACETSQFEQQVRAMARLPLGSTRQHSAGKMLNLLGDCWFEFGLERTPA
CCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WDEVLAQPGAKLHLYGKNDARPSRKMGHVNCVGDHAEAADRTFDAAAKALHIPS
HHHHHHCCCCEEEEEECCCCCCCHHCCCEEEECCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PTDIHPHLSEAHTPESRAEFGVNSPNSPILPGAWLGMLGGGQLGRMFTHAAQSMGYRVC
CCCCCCCCHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEE
VLDPDQDSPAGSVADRHICAAYTDDAALAELSSLCEAVSTEFENVPSISLERLEEAGVFV
EECCCCCCCCCCHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEE
APRGYCVSIAQNRIGEKKFFASCADRTGVPPAPHWVIQHDADVDRLPDEVLPGILKTARM
CCCCCEEHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHCCHHHHHHHHHHHHC
GYDGKGQARVKSRDDVRAAWKAMQHVPCVLERMLPLAYEVSVLAARAADGSTATWPLAEN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
VHRDGILFSTTMPSTSVSDDISQRARNAAATIASEMGYVGVLCIEFFVLTDGTLVANEMA
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCC
PRPHNSGHITMDACETSQFEQQVRAMARLPLGSTRQHSAGKMLNLLGDCWFEFGLERTPA
CCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
WDEVLAQPGAKLHLYGKNDARPSRKMGHVNCVGDHAEAADRTFDAAAKALHIPS
HHHHHHCCCCEEEEEECCCCCCCHHCCCEEEECCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]