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The map label for this gene is purE [H]

Identifier: 94309450

GI number: 94309450

Start: 535994

End: 536491

Strand: Direct

Name: purE [H]

Synonym: Rmet_0505

Alternate gene names: 94309450

Gene position: 535994-536491 (Clockwise)

Preceding gene: 94309449

Following gene: 94309451

Centisome position: 13.65

GC content: 68.27

Gene sequence:

>498_bases
ATGAGCAACGAATCGAAGCCTGTGGTTGGCGTGGTAATGGGCAGCAGTTCCGATTGGGACGTGATGCAGCACGCCGTGGC
CATGCTCAAGGATTTCAACGTGCCGTTCGAAGCGCAGGTGGTGTCGGCGCACCGGATGGCCGATGACATGTTCCGCTATG
CCGAAGCGGCGCGCGGCCGTGGCATCCGCGCGATCATCGCCGGCGCCGGCGGTGCCGCGCACCTGCCGGGCATGATCGCC
GCCAAGACCATCGTGCCGGTGTTCGGCGTGCCGGTGCCGTCGAAGTACCTGCGCGGCGAGGACTCGCTGCTGTCGATCGT
GCAGATGCCGAAGGGTGTGCCCGTGGCCACCTTCGCCATCGGCGAGGCCGGCGCCGCCAACGCGGCGCTGCACGCGATCG
CCACGCTGGCCACCACTGACGACGCGCTGGCCAGCGCGCTGGAAGCGTTCCGCGCAAAGCAGACCGAAGCCGCGCGCGCG
ATGACGCTGCCCGTATAA

Upstream 100 bases:

>100_bases
GCCGGAAGACGTGGTGCAGAAGACCGCCGACAAGTACAAGGAAGCGCTGACCCGCCTGACCGGCGAAGCGCTGCAGTAAG
GGCAGGAAAGGTAATTGACG

Downstream 100 bases:

>100_bases
CTTTCTGAAGTCTCACCGTAGCCTGAGCCATGCCGACCGATATCCATCCCCACCTGTCCGAAGCGCATACCCCCGAGTCG
CGCGCCGAGTTCGGCGTGAA

Product: N5-carboxyaminoimidazole ribonucleotide mutase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSNESKPVVGVVMGSSSDWDVMQHAVAMLKDFNVPFEAQVVSAHRMADDMFRYAEAARGRGIRAIIAGAGGAAHLPGMIA
AKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRAKQTEAARA
MTLPV

Sequences:

>Translated_165_residues
MSNESKPVVGVVMGSSSDWDVMQHAVAMLKDFNVPFEAQVVSAHRMADDMFRYAEAARGRGIRAIIAGAGGAAHLPGMIA
AKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRAKQTEAARA
MTLPV
>Mature_164_residues
SNESKPVVGVVMGSSSDWDVMQHAVAMLKDFNVPFEAQVVSAHRMADDMFRYAEAARGRGIRAIIAGAGGAAHLPGMIAA
KTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAIGEAGAANAALHAIATLATTDDALASALEAFRAKQTEAARAM
TLPV

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=58.5987261146497, Blast_Score=147, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=57.6158940397351, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17103; Mature: 16972

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNESKPVVGVVMGSSSDWDVMQHAVAMLKDFNVPFEAQVVSAHRMADDMFRYAEAARGR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GIRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAI
CEEEEEECCCCCHHCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEEC
GEAGAANAALHAIATLATTDDALASALEAFRAKQTEAARAMTLPV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
SNESKPVVGVVMGSSSDWDVMQHAVAMLKDFNVPFEAQVVSAHRMADDMFRYAEAARGR
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GIRAIIAGAGGAAHLPGMIAAKTIVPVFGVPVPSKYLRGEDSLLSIVQMPKGVPVATFAI
CEEEEEECCCCCHHCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEEC
GEAGAANAALHAIATLATTDDALASALEAFRAKQTEAARAMTLPV
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]