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The map label for this gene is purC

Identifier: 94309449

GI number: 94309449

Start: 535064

End: 535972

Strand: Direct

Name: purC

Synonym: Rmet_0504

Alternate gene names: 94309449

Gene position: 535064-535972 (Clockwise)

Preceding gene: 94309448

Following gene: 94309450

Centisome position: 13.62

GC content: 64.91

Gene sequence:

>909_bases
ATGTCCGACGCCCTCTACGAATCCTCCATCCAGTCCCTGCCGCTGCTCGGCAAAGGCAAGGTCCGCGATAACTACGCTGT
CGGCGACGACAAGCTGCTGATCGTGACCACCGACCGTCTGTCGGCCTTCGACGTGATCCTGGGCGAGCCGATTCCGGCCA
AGGGCCGCGTGCTGAACCAGATGGCCAACTTCTGGTTCAAGAAGCTCGCGCACATCGTGCCGAACCATGAGACCGACGTG
ACCGCTGAGTCCGTGGTGGCGCCGAACGAGGTGGAGCAGGTGAAGGGCCGTGCCGTGGTGGTCAAGCGCCTGAAGCCGAT
CCTGGTGGAAGCGGTGGTGCGCGGCTACCTCGCCGGCAGCGGCTGGAAGGACTACCAGGCCACGGGCAAGGTGTGCGGCA
TCGCCCTGCCGGCCGGCCTGCAGAACGCGCAGAAGCTGCCCGAGCCGATCTTCACGCCGGCGGCCAAGGCCGAGATGGGC
GAGCACGACGAGAACATCTCGTTCGATGAAGTCGAGGCCCGCATCGGCAAGGAACTGGCCGCGAAGATGCGTGACATCTC
GATCCGTCTGTACAAGGAAGCCGCCGACTACGCCGCCACGCGCGGCATCATCATCGCCGACACAAAGTTCGAGTTCGGTC
TGGACGAAAACGGCACGCTGACGCTGATGGACGAAGTGCTGACGGCCGACTCGTCGCGCTTCTGGCCGGCCGATTCGTAT
CAGGTGGGCACCAACCCGCCGTCGTTCGACAAGCAGTTCGTGCGTGACTGGCTCGAAGCCGTACGCATCGACGGCAAGCC
GTGGCCGAAGACCGCGCCGGCGCCGAAGCTGCCGGAAGACGTGGTGCAGAAGACCGCCGACAAGTACAAGGAAGCGCTGA
CCCGCCTGACCGGCGAAGCGCTGCAGTAA

Upstream 100 bases:

>100_bases
TGTGTCGTTGCCCCGCCTGGTGCGGGGCTTTGCTTCTTCATGGGGCTTCGCATCGCGCTCGAAGCCCCGCTTGTTTTTCA
GCCGCAGCCGTTTTCACACC

Downstream 100 bases:

>100_bases
GGGCAGGAAAGGTAATTGACGATGAGCAACGAATCGAAGCCTGTGGTTGGCGTGGTAATGGGCAGCAGTTCCGATTGGGA
CGTGATGCAGCACGCCGTGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSDALYESSIQSLPLLGKGKVRDNYAVGDDKLLIVTTDRLSAFDVILGEPIPAKGRVLNQMANFWFKKLAHIVPNHETDV
TAESVVAPNEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIALPAGLQNAQKLPEPIFTPAAKAEMG
EHDENISFDEVEARIGKELAAKMRDISIRLYKEAADYAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPEDVVQKTADKYKEALTRLTGEALQ

Sequences:

>Translated_302_residues
MSDALYESSIQSLPLLGKGKVRDNYAVGDDKLLIVTTDRLSAFDVILGEPIPAKGRVLNQMANFWFKKLAHIVPNHETDV
TAESVVAPNEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIALPAGLQNAQKLPEPIFTPAAKAEMG
EHDENISFDEVEARIGKELAAKMRDISIRLYKEAADYAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPEDVVQKTADKYKEALTRLTGEALQ
>Mature_301_residues
SDALYESSIQSLPLLGKGKVRDNYAVGDDKLLIVTTDRLSAFDVILGEPIPAKGRVLNQMANFWFKKLAHIVPNHETDVT
AESVVAPNEVEQVKGRAVVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGIALPAGLQNAQKLPEPIFTPAAKAEMGE
HDENISFDEVEARIGKELAAKMRDISIRLYKEAADYAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSYQ
VGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPEDVVQKTADKYKEALTRLTGEALQ

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=46.2837837837838, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_RALME (Q1LR36)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582659.1
- ProteinModelPortal:   Q1LR36
- SMR:   Q1LR36
- STRING:   Q1LR36
- GeneID:   4037293
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0504
- eggNOG:   COG0152
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- PhylomeDB:   Q1LR36
- ProtClustDB:   PRK13961
- BioCyc:   RMET266264:RMET_0504-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33240; Mature: 33109

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDALYESSIQSLPLLGKGKVRDNYAVGDDKLLIVTTDRLSAFDVILGEPIPAKGRVLNQ
CCCHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHH
MANFWFKKLAHIVPNHETDVTAESVVAPNEVEQVKGRAVVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGIALPAGLQNAQKLPEPIFTPAAKAEMGEHDENISFDEVEARIGKELA
CCCCHHHCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHH
AKMRDISIRLYKEAADYAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEHHHHHHCCCCCCCCCCCC
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPEDVVQKTADKYKEALTRLTGEA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQ
CC
>Mature Secondary Structure 
SDALYESSIQSLPLLGKGKVRDNYAVGDDKLLIVTTDRLSAFDVILGEPIPAKGRVLNQ
CCHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHH
MANFWFKKLAHIVPNHETDVTAESVVAPNEVEQVKGRAVVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGIALPAGLQNAQKLPEPIFTPAAKAEMGEHDENISFDEVEARIGKELA
CCCCHHHCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHH
AKMRDISIRLYKEAADYAATRGIIIADTKFEFGLDENGTLTLMDEVLTADSSRFWPADSY
HHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCCCEEEHHHHHHCCCCCCCCCCCC
QVGTNPPSFDKQFVRDWLEAVRIDGKPWPKTAPAPKLPEDVVQKTADKYKEALTRLTGEA
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA