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The map label for this gene is ddc [H]

Identifier: 94309405

GI number: 94309405

Start: 488468

End: 490126

Strand: Direct

Name: ddc [H]

Synonym: Rmet_0460

Alternate gene names: 94309405

Gene position: 488468-490126 (Clockwise)

Preceding gene: 94309404

Following gene: 335055493

Centisome position: 12.44

GC content: 64.44

Gene sequence:

>1659_bases
ATGAAGGCGCGCAAGGCGGGGAGGTCAGACAACGCTCGCGAGGCAACCGGCAACGACGCGGAAATGGGCGAGGGCTGTCC
GCTGCACTGGTTCGATGCGGACCTTGGCGCGTTCGACGACCTGGAGCGGCGCGTTGCCGAGCATCCCGCGGACTTCTTTG
CCGGCCAGGACTTCGATCCGGTTGGTGCCTGCGCGACGCGCGAGGCGTCCTTTGCCTCGGTCCAGATACCGGAAGATCCG
ACCGCGCCGCAGCAACACGCGGATCATCTGCTCAACGATGTGTTCCGGCATGTGATGCCCGTGGCGTCGCCAACGTTCGT
CGGTCACATGACGTCGTCGCTGCCATCGTTCATGCCGTCGCTGGCCAAGATCGTGGCGGCGCTGAACCAGAACGTGGTCA
AGCTTGAAACGTCGGGTGCATTGACGGGACTGGAGCGTCAGGTAATCGGGATGCTGCATCACCTGGTCTTTGCGCGGGAC
GACGCGTTCTACGCGCAATGGCTGCACAATGCCGAGCATTCTCTCGGAGCATTCTGCTCGGGCGGCACCACGGCCAATCT
CACCGCGCTCTGGGCCAGCCGCAACAACACGCTGCGCGCGCGCGACGGCTTCGCGGGCATCAACCAGGCGGGGCTGGTAG
CGGCGTTGCGGCACTACGGATACGCAGGGCTGGCGATCGTCGTGTCGGAGCGCGGCCATTATTCGCTGCGAAAGGCGGCG
GATATCCTCGGTATCGGCCGCGAGAATCTGGTGCCGGTAGGCGTCGATGAAGACGGGCGGATGCGCGTCGACCTGTTGCG
CGACACATTACGCGATCTTCAACAACGCAACATCCGGACAGTGGCGATTGTCGGTATCGCTGGCACCACTGAGACTGGTG
CGGTGGACCCGCTCGATGCCATTGCCGATGTGGCGCAGGAGATCGGCTGCCACTTTCATGTGGACGCCGCGTGGGGGGGT
GCCACACTGCTCTCCGCACGCGAGCGCGCGCGCTTTGCCGGGATCGAGCGCGCGGATTCGGTCGTCATCGACGCGCACAA
GCAGTTCTATGTGCCGATGGGCGCCGGCATGGTGTTGTTCCGCGATCCGGCGTGGACGCAGGACATCATCCAGCACGCAA
ACTACATCGTGCGGAAGGGCTCGGTGGACCTGGGGCGCCATACGCTCGAAGGGTCCCGCGGTTCGGCGGCCGTCATGCTC
TATGCGAACCTGCACCTGCTTGGCCGCAAGGGGCTGGCGAAGCTGATCGATACGGGCATCGACAACGCGAAGTACTTCGC
GTCGTTGATCGAACAGCAGCCCGACTTCGAACTGGACAGCCGGCCGCAGCTTTGCATCCTCACCTATCGCTACGTGCCGG
CGCCGGTGCGAGCGGCGTTGCTTTCGGCCTCGCCCGAACAGCGCGAACAACTGCTCGAGGCGCTCGACGCGCTGACCATC
AACATCCAGGAAATGCAGCGCGACGCAGGCCGCTCGTTCGTGTCGCGGACGCAGTTGACGTCCTCCCAGTGGGGCGGGCG
TCCGATCGCGGTGTTTCGTGTGGTGCTGGCGAATCCCGATACGACGCACGAGATCCTGCAGAGCCTTCTGGAAGAGCAGC
GTGGGCTGGCAAAACAGAGTCCGATGCTGCCTGCGTTGATGGCGATGGTTGGCGGTTAA

Upstream 100 bases:

>100_bases
GTGGGCGTGCAGCGCCGGCCTCGGCTTATCCGGCATAATCCCAGCGATTCGCCGCCGCTGCAGCGGCGGCACCACACTGG
ACTGGGACTGGAATAGGCAC

Downstream 100 bases:

>100_bases
GAGGCGCGATCAACATGATTCTGGCGTCGTTGCGCAGCCTTGCCGTGCCACTTGTACTGTCTGCGGCCGCGCGTCTAGCC
AGAACCGTTTCGCTTCATTT

Product: Pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MKARKAGRSDNAREATGNDAEMGEGCPLHWFDADLGAFDDLERRVAEHPADFFAGQDFDPVGACATREASFASVQIPEDP
TAPQQHADHLLNDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKIVAALNQNVVKLETSGALTGLERQVIGMLHHLVFARD
DAFYAQWLHNAEHSLGAFCSGGTTANLTALWASRNNTLRARDGFAGINQAGLVAALRHYGYAGLAIVVSERGHYSLRKAA
DILGIGRENLVPVGVDEDGRMRVDLLRDTLRDLQQRNIRTVAIVGIAGTTETGAVDPLDAIADVAQEIGCHFHVDAAWGG
ATLLSARERARFAGIERADSVVIDAHKQFYVPMGAGMVLFRDPAWTQDIIQHANYIVRKGSVDLGRHTLEGSRGSAAVML
YANLHLLGRKGLAKLIDTGIDNAKYFASLIEQQPDFELDSRPQLCILTYRYVPAPVRAALLSASPEQREQLLEALDALTI
NIQEMQRDAGRSFVSRTQLTSSQWGGRPIAVFRVVLANPDTTHEILQSLLEEQRGLAKQSPMLPALMAMVGG

Sequences:

>Translated_552_residues
MKARKAGRSDNAREATGNDAEMGEGCPLHWFDADLGAFDDLERRVAEHPADFFAGQDFDPVGACATREASFASVQIPEDP
TAPQQHADHLLNDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKIVAALNQNVVKLETSGALTGLERQVIGMLHHLVFARD
DAFYAQWLHNAEHSLGAFCSGGTTANLTALWASRNNTLRARDGFAGINQAGLVAALRHYGYAGLAIVVSERGHYSLRKAA
DILGIGRENLVPVGVDEDGRMRVDLLRDTLRDLQQRNIRTVAIVGIAGTTETGAVDPLDAIADVAQEIGCHFHVDAAWGG
ATLLSARERARFAGIERADSVVIDAHKQFYVPMGAGMVLFRDPAWTQDIIQHANYIVRKGSVDLGRHTLEGSRGSAAVML
YANLHLLGRKGLAKLIDTGIDNAKYFASLIEQQPDFELDSRPQLCILTYRYVPAPVRAALLSASPEQREQLLEALDALTI
NIQEMQRDAGRSFVSRTQLTSSQWGGRPIAVFRVVLANPDTTHEILQSLLEEQRGLAKQSPMLPALMAMVGG
>Mature_552_residues
MKARKAGRSDNAREATGNDAEMGEGCPLHWFDADLGAFDDLERRVAEHPADFFAGQDFDPVGACATREASFASVQIPEDP
TAPQQHADHLLNDVFRHVMPVASPTFVGHMTSSLPSFMPSLAKIVAALNQNVVKLETSGALTGLERQVIGMLHHLVFARD
DAFYAQWLHNAEHSLGAFCSGGTTANLTALWASRNNTLRARDGFAGINQAGLVAALRHYGYAGLAIVVSERGHYSLRKAA
DILGIGRENLVPVGVDEDGRMRVDLLRDTLRDLQQRNIRTVAIVGIAGTTETGAVDPLDAIADVAQEIGCHFHVDAAWGG
ATLLSARERARFAGIERADSVVIDAHKQFYVPMGAGMVLFRDPAWTQDIIQHANYIVRKGSVDLGRHTLEGSRGSAAVML
YANLHLLGRKGLAKLIDTGIDNAKYFASLIEQQPDFELDSRPQLCILTYRYVPAPVRAALLSASPEQREQLLEALDALTI
NIQEMQRDAGRSFVSRTQLTSSQWGGRPIAVFRVVLANPDTTHEILQSLLEEQRGLAKQSPMLPALMAMVGG

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=365, Percent_Identity=29.041095890411, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4503875, Length=365, Percent_Identity=29.041095890411, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI197383062, Length=475, Percent_Identity=25.2631578947368, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI58331246, Length=448, Percent_Identity=23.8839285714286, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI194294551, Length=456, Percent_Identity=26.7543859649123, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI92110055, Length=386, Percent_Identity=25.6476683937824, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4503281, Length=397, Percent_Identity=23.4256926952141, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI132814448, Length=397, Percent_Identity=23.4256926952141, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555682, Length=466, Percent_Identity=26.8240343347639, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71993062, Length=447, Percent_Identity=27.0693512304251, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71993058, Length=371, Percent_Identity=27.4932614555256, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136594, Length=529, Percent_Identity=24.5746691871456, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356415, Length=470, Percent_Identity=23.6170212765957, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24657193, Length=383, Percent_Identity=24.8041775456919, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24657185, Length=383, Percent_Identity=24.8041775456919, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24657188, Length=383, Percent_Identity=24.8041775456919, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24652373, Length=389, Percent_Identity=28.0205655526992, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573972, Length=430, Percent_Identity=22.3255813953488, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221476190, Length=254, Percent_Identity=26.3779527559055, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585143, Length=254, Percent_Identity=26.3779527559055, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585139, Length=254, Percent_Identity=26.3779527559055, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136190, Length=399, Percent_Identity=25.062656641604, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 60006; Mature: 60006

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARKAGRSDNAREATGNDAEMGEGCPLHWFDADLGAFDDLERRVAEHPADFFAGQDFDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCCC
VGACATREASFASVQIPEDPTAPQQHADHLLNDVFRHVMPVASPTFVGHMTSSLPSFMPS
CCCHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LAKIVAALNQNVVKLETSGALTGLERQVIGMLHHLVFARDDAFYAQWLHNAEHSLGAFCS
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCEEC
GGTTANLTALWASRNNTLRARDGFAGINQAGLVAALRHYGYAGLAIVVSERGHYSLRKAA
CCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
DILGIGRENLVPVGVDEDGRMRVDLLRDTLRDLQQRNIRTVAIVGIAGTTETGAVDPLDA
HHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHH
IADVAQEIGCHFHVDAAWGGATLLSARERARFAGIERADSVVIDAHKQFYVPMGAGMVLF
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEE
RDPAWTQDIIQHANYIVRKGSVDLGRHTLEGSRGSAAVMLYANLHLLGRKGLAKLIDTGI
ECCCCHHHHHHHHHHEEECCCCCCCCHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCC
DNAKYFASLIEQQPDFELDSRPQLCILTYRYVPAPVRAALLSASPEQREQLLEALDALTI
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
NIQEMQRDAGRSFVSRTQLTSSQWGGRPIAVFRVVLANPDTTHEILQSLLEEQRGLAKQS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHCCHHCC
PMLPALMAMVGG
CHHHHHHHHHCC
>Mature Secondary Structure
MKARKAGRSDNAREATGNDAEMGEGCPLHWFDADLGAFDDLERRVAEHPADFFAGQDFDP
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCHHHHCCCCCCC
VGACATREASFASVQIPEDPTAPQQHADHLLNDVFRHVMPVASPTFVGHMTSSLPSFMPS
CCCHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LAKIVAALNQNVVKLETSGALTGLERQVIGMLHHLVFARDDAFYAQWLHNAEHSLGAFCS
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCEEC
GGTTANLTALWASRNNTLRARDGFAGINQAGLVAALRHYGYAGLAIVVSERGHYSLRKAA
CCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHH
DILGIGRENLVPVGVDEDGRMRVDLLRDTLRDLQQRNIRTVAIVGIAGTTETGAVDPLDA
HHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHH
IADVAQEIGCHFHVDAAWGGATLLSARERARFAGIERADSVVIDAHKQFYVPMGAGMVLF
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEE
RDPAWTQDIIQHANYIVRKGSVDLGRHTLEGSRGSAAVMLYANLHLLGRKGLAKLIDTGI
ECCCCHHHHHHHHHHEEECCCCCCCCHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCC
DNAKYFASLIEQQPDFELDSRPQLCILTYRYVPAPVRAALLSASPEQREQLLEALDALTI
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
NIQEMQRDAGRSFVSRTQLTSSQWGGRPIAVFRVVLANPDTTHEILQSLLEEQRGLAKQS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHCCHHCC
PMLPALMAMVGG
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]