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The map label for this gene is corC [H]

Identifier: 94309395

GI number: 94309395

Start: 477549

End: 478436

Strand: Reverse

Name: corC [H]

Synonym: Rmet_0450

Alternate gene names: 94309395

Gene position: 478436-477549 (Counterclockwise)

Preceding gene: 94309396

Following gene: 94309394

Centisome position: 12.18

GC content: 62.27

Gene sequence:

>888_bases
ATGAACGACCCCTATCCCAGTTCGAAACCTGCCAATCACAAGCAGACGGATCGCCCACGATCCCTACTCGAACGCCTTTC
GGACTTCATCTCTCCTGAGCCCGATACCCGCGCCGAATTACTGGAAGTGCTGCAGGACGCGCACGAGCGTAACCTGATTG
ACGCCGACTCGTTGTCGATGATCGAAGGCGTGTTCCAGGTGTCTGAACTCACCGCGCGCGACATCATGGTGCCCCGGGCG
CAGATGGACACGGTCAACATCGCGGACGCGCCGGAGACCTTCATCCCGTACATGCAGCAGACCGCGCACTCGCGGTTTCC
GGTCTACGAAGGCAACCGTGACAACATCATCGGTATCCTGCTGGCCAAGGACCTGCTGCGCTATTACACGGACCCGAACT
TCGACCTGCGCGAAACGCTGCGCCCGGCCGTGTTCATCCCCGAGTCAAAGCGGCTGAACATTCTGCTGCGCGAGTTCCGT
ATCAATCGCAATCACATCGCGATCGTCGTCGACGAGTACGGCGGCGTGGCCGGTCTGGTCACGATCGAGGACGTGCTCGA
GCAGATCGTGGGTGACATCGAGGACGAGTTCGACCTCGACGAGGACCATGACAACATCCTGCCTACCGCCGACGGCGCCT
GGCGCGTGCATGGCCTGACCGAGATCGAGCAGTTCAACGAGACCTTCGGCACGGCATTTCCCGATGACGACGTCGATACG
GTCGGCGGCCTGCTCACGAACCATGTGGGGCATGTGCCGCATCGTGGCGAGATCATCACGCTGCCGCCGATGCAGTTTGA
AGTCCTGCGCGCGGATGCCCGCCAGGTGCACCTGCTGCTGGTGCGCCGCGAGGCGCCCGCCGAACCGGCTCTCGTCGCCG
AAGCATGA

Upstream 100 bases:

>100_bases
CGAAAAGCCACCCGGACAGCCACCCCACCCGGCCCTGTCACGGGCCCGCAAGGCTTTTAGTGTATGCTTCAGACGATCTC
CACCACGCGCTAGCCGCGAC

Downstream 100 bases:

>100_bases
CGCGCGTCGGCACGCCCGGCGCCGTGGGCACCCCTCGGGCCGGTTCGGCCGACTCACCAATGGGCGGCACGCCGCCCTCC
CCTTTTCAGACTATGCAAGT

Product: magnesium and cobalt efflux protein CorC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNDPYPSSKPANHKQTDRPRSLLERLSDFISPEPDTRAELLEVLQDAHERNLIDADSLSMIEGVFQVSELTARDIMVPRA
QMDTVNIADAPETFIPYMQQTAHSRFPVYEGNRDNIIGILLAKDLLRYYTDPNFDLRETLRPAVFIPESKRLNILLREFR
INRNHIAIVVDEYGGVAGLVTIEDVLEQIVGDIEDEFDLDEDHDNILPTADGAWRVHGLTEIEQFNETFGTAFPDDDVDT
VGGLLTNHVGHVPHRGEIITLPPMQFEVLRADARQVHLLLVRREAPAEPALVAEA

Sequences:

>Translated_295_residues
MNDPYPSSKPANHKQTDRPRSLLERLSDFISPEPDTRAELLEVLQDAHERNLIDADSLSMIEGVFQVSELTARDIMVPRA
QMDTVNIADAPETFIPYMQQTAHSRFPVYEGNRDNIIGILLAKDLLRYYTDPNFDLRETLRPAVFIPESKRLNILLREFR
INRNHIAIVVDEYGGVAGLVTIEDVLEQIVGDIEDEFDLDEDHDNILPTADGAWRVHGLTEIEQFNETFGTAFPDDDVDT
VGGLLTNHVGHVPHRGEIITLPPMQFEVLRADARQVHLLLVRREAPAEPALVAEA
>Mature_295_residues
MNDPYPSSKPANHKQTDRPRSLLERLSDFISPEPDTRAELLEVLQDAHERNLIDADSLSMIEGVFQVSELTARDIMVPRA
QMDTVNIADAPETFIPYMQQTAHSRFPVYEGNRDNIIGILLAKDLLRYYTDPNFDLRETLRPAVFIPESKRLNILLREFR
INRNHIAIVVDEYGGVAGLVTIEDVLEQIVGDIEDEFDLDEDHDNILPTADGAWRVHGLTEIEQFNETFGTAFPDDDVDT
VGGLLTNHVGHVPHRGEIITLPPMQFEVLRADARQVHLLLVRREAPAEPALVAEA

Specific function: Plays a role in the transport of magnesium and cobalt ions [H]

COG id: COG4535

COG function: function code P; Putative Mg2+ and Co2+ transporter CorC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=209, Percent_Identity=32.0574162679426, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI40068055, Length=182, Percent_Identity=30.2197802197802, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40068053, Length=182, Percent_Identity=30.2197802197802, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI94681046, Length=182, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1786879, Length=258, Percent_Identity=44.9612403100775, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693175, Length=273, Percent_Identity=27.1062271062271, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788119, Length=231, Percent_Identity=32.4675324675325, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082033, Length=273, Percent_Identity=27.1062271062271, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790664, Length=237, Percent_Identity=25.7383966244726, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 33331; Mature: 33331

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPYPSSKPANHKQTDRPRSLLERLSDFISPEPDTRAELLEVLQDAHERNLIDADSLSM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
IEGVFQVSELTARDIMVPRAQMDTVNIADAPETFIPYMQQTAHSRFPVYEGNRDNIIGIL
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCEEHHH
LAKDLLRYYTDPNFDLRETLRPAVFIPESKRLNILLREFRINRNHIAIVVDEYGGVAGLV
HHHHHHHHHCCCCCCHHHHCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEH
TIEDVLEQIVGDIEDEFDLDEDHDNILPTADGAWRVHGLTEIEQFNETFGTAFPDDDVDT
HHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCHHH
VGGLLTNHVGHVPHRGEIITLPPMQFEVLRADARQVHLLLVRREAPAEPALVAEA
HHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHEEEEEEEECCCCCCCCEECCC
>Mature Secondary Structure
MNDPYPSSKPANHKQTDRPRSLLERLSDFISPEPDTRAELLEVLQDAHERNLIDADSLSM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
IEGVFQVSELTARDIMVPRAQMDTVNIADAPETFIPYMQQTAHSRFPVYEGNRDNIIGIL
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCEEHHH
LAKDLLRYYTDPNFDLRETLRPAVFIPESKRLNILLREFRINRNHIAIVVDEYGGVAGLV
HHHHHHHHHCCCCCCHHHHCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEEEH
TIEDVLEQIVGDIEDEFDLDEDHDNILPTADGAWRVHGLTEIEQFNETFGTAFPDDDVDT
HHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCHHH
VGGLLTNHVGHVPHRGEIITLPPMQFEVLRADARQVHLLLVRREAPAEPALVAEA
HHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHEEEEEEEECCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]