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The map label for this gene is surA

Identifier: 94309382

GI number: 94309382

Start: 463255

End: 464736

Strand: Direct

Name: surA

Synonym: Rmet_0437

Alternate gene names: 94309382

Gene position: 463255-464736 (Clockwise)

Preceding gene: 94309381

Following gene: 94309383

Centisome position: 11.79

GC content: 66.73

Gene sequence:

>1482_bases
ATGAAACGTCAAGCCTTCTCCCTGTTGTCCCGCCTGAACCCCTGGCAGCAGCTGCTGCTGTCGGCCGTGCTCGTGACGCT
GGCCGCGCCGGCAGCTGCGCAACTGCGCGCGCCCGGCACGCGTACGCAGGGCATCTTCACGCAGCAGGGCAGCCAATCGG
CCAGCCAGGGCAGCACCGTGGCGCCGAGCCAGCCGATGATGGGCGTGCCGCAGCCTTCGTCCCAGCCGCGCTCGCAGTTG
GTGGACGAGGTGGTGGCTGTCGTCAACAACAGCGTGATCACGCGCCGGGAACTGCTTGACCGCGCCGACGAGATCGAAAG
CCAGCTTCGCGCCGCCAAGCGTGAGGTGCCACCGCGGCCTGACTTGCTAGGCGAAGTGCTGGAACGCCTCGTGATGGAGC
GCGTGCAGACGCAGGCCGCGCAGGAAGCCGGGATCAAGGTGACCGATCAGGAAGTCGATCGGGCGATCGAATCGGTGGCG
CAACAGAACAAGATGTCTGCGACGGAGTTGCGCAGCCGCGTGGAAGCCAGCGGCATGTCGTGGACCAAGTACCGCGACGA
ACTGCGCAAGCAGGTCCAGGTGATCCGCCTGCGCGAACGCGAGGTGGACTCGAAGGTGCAGGTCTACGACGGCGAGATCG
ACAACTATCTGGCTGCGCGTAATGGTGGCCAGGCGGCAGCCTCGGGCCCGACTGAGTTCAATGTGGCGCAGATCCTCGTG
CGCGTGCCCGAAGATGCGTCCGATGCACAGAAGGCCCAGCTCAAGACGAAAGCGGAAGGCCTGCTGAAGCAGGTGCAGGG
CGGGGCGGACTTTGCCGAACTGGCCAAGGCCAACTCCGAGGCGCCGGAAGCCTCGCAAGGCGGCTCGCTGGGTTTCCGCG
AGATTGGCCGGCTGCCTGCCGTGTTCGCCAATGCCGTGGTCGACCTGCAGCCGGGCGCGGTGGTGCCCGAGGTTCTGGAA
TCGGCCAATGGTTTCCACGTGGTCAAGCTTGTGTCCAAGCGCACGGCCGCCGCGCAGCCGGCAGCGAGCGACCGCATCGC
GCAGACGCAGGTGCGCCATATCCTGATCCGCACCGGCCCGAACATGCCCGAGGCCGAAGCCAAGCGTCAGATGGCGACGA
TCCGCGACCGGATCACGCACGGCGTAGATTTCGCCGATGCCGCGCGTCGCTACTCGCAGGACGGCTCGGCGTCGCAAGGC
GGCGAACTCGGCTGGGTGTCGCCGGGCGAACTAGTGCCCGAGTTCGAGCAGGCCATGAACCGCCTGCGCCCGGGCGAGAT
CTCCGACCCGGTAGTCACGCAGTTCGGTGTGCACCTGATCCAGGTGGAAAATCGCCGCGAGACCGAAGTGTCGCCCGAGA
AGCAGCGTGACTTCGCACGTGCCGAAGTTCGCGAGCAGAAGCTGCGCGCCGCCTATGATGACTGGGTGCGCCAGCTCCGC
AGCGCGGCGTATGTCGAATACCGGATCAACCGCCAGCGCTGA

Upstream 100 bases:

>100_bases
CCCGCTGGACATGTTGCGCCTGAACGTGCCGGGCTACGAGCCCGTGACGGCACGGCCGGTGCCGACAACCCCGTACGATC
ACTATGAATGACGGACCAAG

Downstream 100 bases:

>100_bases
TGCGCTGGCCCGAACCATGCCCGACCCCGCGCCACTCGACCTAGCGATCACGACCGGAGAACCGGCCGGCATCGGTCCCG
ATATCACGATCGGTGCCCTG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MKRQAFSLLSRLNPWQQLLLSAVLVTLAAPAAAQLRAPGTRTQGIFTQQGSQSASQGSTVAPSQPMMGVPQPSSQPRSQL
VDEVVAVVNNSVITRRELLDRADEIESQLRAAKREVPPRPDLLGEVLERLVMERVQTQAAQEAGIKVTDQEVDRAIESVA
QQNKMSATELRSRVEASGMSWTKYRDELRKQVQVIRLREREVDSKVQVYDGEIDNYLAARNGGQAAASGPTEFNVAQILV
RVPEDASDAQKAQLKTKAEGLLKQVQGGADFAELAKANSEAPEASQGGSLGFREIGRLPAVFANAVVDLQPGAVVPEVLE
SANGFHVVKLVSKRTAAAQPAASDRIAQTQVRHILIRTGPNMPEAEAKRQMATIRDRITHGVDFADAARRYSQDGSASQG
GELGWVSPGELVPEFEQAMNRLRPGEISDPVVTQFGVHLIQVENRRETEVSPEKQRDFARAEVREQKLRAAYDDWVRQLR
SAAYVEYRINRQR

Sequences:

>Translated_493_residues
MKRQAFSLLSRLNPWQQLLLSAVLVTLAAPAAAQLRAPGTRTQGIFTQQGSQSASQGSTVAPSQPMMGVPQPSSQPRSQL
VDEVVAVVNNSVITRRELLDRADEIESQLRAAKREVPPRPDLLGEVLERLVMERVQTQAAQEAGIKVTDQEVDRAIESVA
QQNKMSATELRSRVEASGMSWTKYRDELRKQVQVIRLREREVDSKVQVYDGEIDNYLAARNGGQAAASGPTEFNVAQILV
RVPEDASDAQKAQLKTKAEGLLKQVQGGADFAELAKANSEAPEASQGGSLGFREIGRLPAVFANAVVDLQPGAVVPEVLE
SANGFHVVKLVSKRTAAAQPAASDRIAQTQVRHILIRTGPNMPEAEAKRQMATIRDRITHGVDFADAARRYSQDGSASQG
GELGWVSPGELVPEFEQAMNRLRPGEISDPVVTQFGVHLIQVENRRETEVSPEKQRDFARAEVREQKLRAAYDDWVRQLR
SAAYVEYRINRQR
>Mature_493_residues
MKRQAFSLLSRLNPWQQLLLSAVLVTLAAPAAAQLRAPGTRTQGIFTQQGSQSASQGSTVAPSQPMMGVPQPSSQPRSQL
VDEVVAVVNNSVITRRELLDRADEIESQLRAAKREVPPRPDLLGEVLERLVMERVQTQAAQEAGIKVTDQEVDRAIESVA
QQNKMSATELRSRVEASGMSWTKYRDELRKQVQVIRLREREVDSKVQVYDGEIDNYLAARNGGQAAASGPTEFNVAQILV
RVPEDASDAQKAQLKTKAEGLLKQVQGGADFAELAKANSEAPEASQGGSLGFREIGRLPAVFANAVVDLQPGAVVPEVLE
SANGFHVVKLVSKRTAAAQPAASDRIAQTQVRHILIRTGPNMPEAEAKRQMATIRDRITHGVDFADAARRYSQDGSASQG
GELGWVSPGELVPEFEQAMNRLRPGEISDPVVTQFGVHLIQVENRRETEVSPEKQRDFARAEVREQKLRAAYDDWVRQLR
SAAYVEYRINRQR

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains

Homologues:

Organism=Escherichia coli, GI1786238, Length=416, Percent_Identity=33.4134615384615, Blast_Score=224, Evalue=7e-60,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): SURA_RALME (Q1LRA3)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582592.1
- ProteinModelPortal:   Q1LRA3
- SMR:   Q1LRA3
- STRING:   Q1LRA3
- GeneID:   4037225
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0437
- eggNOG:   COG0760
- HOGENOM:   HBG391483
- OMA:   RHILIKT
- ProtClustDB:   CLSK896579
- BioCyc:   RMET266264:RMET_0437-MONOMER
- HAMAP:   MF_01183
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 54231; Mature: 54231

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQAFSLLSRLNPWQQLLLSAVLVTLAAPAAAQLRAPGTRTQGIFTQQGSQSASQGSTV
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEECCCCCCCCCCCCC
APSQPMMGVPQPSSQPRSQLVDEVVAVVNNSVITRRELLDRADEIESQLRAAKREVPPRP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLGEVLERLVMERVQTQAAQEAGIKVTDQEVDRAIESVAQQNKMSATELRSRVEASGMS
HHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
WTKYRDELRKQVQVIRLREREVDSKVQVYDGEIDNYLAARNGGQAAASGPTEFNVAQILV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RVPEDASDAQKAQLKTKAEGLLKQVQGGADFAELAKANSEAPEASQGGSLGFREIGRLPA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
VFANAVVDLQPGAVVPEVLESANGFHVVKLVSKRTAAAQPAASDRIAQTQVRHILIRTGP
HHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NMPEAEAKRQMATIRDRITHGVDFADAARRYSQDGSASQGGELGWVSPGELVPEFEQAMN
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RLRPGEISDPVVTQFGVHLIQVENRRETEVSPEKQRDFARAEVREQKLRAAYDDWVRQLR
HCCCCCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAYVEYRINRQR
HHHHHHHCCCCCC
>Mature Secondary Structure
MKRQAFSLLSRLNPWQQLLLSAVLVTLAAPAAAQLRAPGTRTQGIFTQQGSQSASQGSTV
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCEECCCCCCCCCCCCC
APSQPMMGVPQPSSQPRSQLVDEVVAVVNNSVITRRELLDRADEIESQLRAAKREVPPRP
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLGEVLERLVMERVQTQAAQEAGIKVTDQEVDRAIESVAQQNKMSATELRSRVEASGMS
HHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
WTKYRDELRKQVQVIRLREREVDSKVQVYDGEIDNYLAARNGGQAAASGPTEFNVAQILV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHH
RVPEDASDAQKAQLKTKAEGLLKQVQGGADFAELAKANSEAPEASQGGSLGFREIGRLPA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
VFANAVVDLQPGAVVPEVLESANGFHVVKLVSKRTAAAQPAASDRIAQTQVRHILIRTGP
HHHHHHHCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
NMPEAEAKRQMATIRDRITHGVDFADAARRYSQDGSASQGGELGWVSPGELVPEFEQAMN
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RLRPGEISDPVVTQFGVHLIQVENRRETEVSPEKQRDFARAEVREQKLRAAYDDWVRQLR
HCCCCCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAYVEYRINRQR
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA