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The map label for this gene is ycgO [H]

Identifier: 94309320

GI number: 94309320

Start: 400416

End: 401852

Strand: Direct

Name: ycgO [H]

Synonym: Rmet_0375

Alternate gene names: 94309320

Gene position: 400416-401852 (Clockwise)

Preceding gene: 335055487

Following gene: 94309321

Centisome position: 10.19

GC content: 62.14

Gene sequence:

>1437_bases
ATGCTGATCTGGTTCGTCATCATCTATTGGATCATCTCGGTCGGTATCGGCCTGTGGGCGGCGCTTCGCGTCAAGGGAAC
CGCCGACTTCGCCGTGGCCGGCCGCAGCCTGCCGTTCTATATCGTCACCGCCACGGTCTTTGCCACCTGGTTTGGCTCTG
AAACCGTGCTCGGCATCCCGGCCGTGTTCCTCAAGGAAGGCCTGTCCGGGGTGGTTTCGGATCCCTTCGGTTCCTCGCTC
TGCCTGATCCTGGTTGGCCTGTTCTTCGCCCGGCCGCTGTACCGGATGAACCTGCTGACGATCGGCGACTACTATCACAA
CCGCTATGGCCGGCTGGCCGAAGTGCTGACCACGCTATGTATCGTGGTCTCGTATCTGGGCTGGGTGGCTGCGCAGATCA
AGGCGCTGGGGCTGGTGTTCTATACGGTGTCGGACGGCGCGCTGTCCCAGGATGCCGGGATGATGATCGGCGCGGCCAGC
GTGCTGGTCTATACGCTGTTCGGCGGCATGTGGTCGGTGGCCGTGACCGACTTCATCCAGATGATCATCATCGTGATCGG
CATGCTCTATATCGGTTACGAAGTCAGCGGCCAGGCGGGTGGCGTGACGGCCGTGGTGTCACACGCGGCGGCGGCCGGCA
AGTTCGAGTTCCTGCCGTCGCTGGACCTGGTGCAGATCATCGGGTTTGCCGCGGCGCTGTTCACGATGATGCTCGGCTCG
ATTCCCCAGCAGGACGTGTTCCAGCGGGTCACCTCCTCGCGCACCGAGCAGATCGCCGGTCGTGCGTCGGTGCTGGGTGG
TGTGCTGTATTTTTTCTTCGCCTTCATTCCGATGTTCCTGGCCTATTCGGCCACACTGATCGACCCGGCGATGGTCGAGA
AGTACATCAACTCGGATTCGCAACTGATTCTTCCGCAGCTGATCCTGACGCACGCGCCGATGTTCGCCCAGGTGATGTTC
TTCGGTGCGCTGCTTTCCGCCATCAAGAGCTGCGCCTCGGCCACGCTGCTGGCGCCGTCGGTAACCTTCGCCGAGAACAT
CCTGCGCCCGTACTTCCGCCATCTCGCGGACAAGCAGTTCCTGCGCGTGATGCAGGTGGTGGTGCTCGTCTTCACGTCGC
TGGTCACGCTGTTCGCGCTGAACTCGCACCTGTCGATCTTCCACATGGTCGAGAACGCCTACAAGGTGACGCTGGTGTCG
TCGTTCGTGCCGCTGGCCTTCGGCATGTTCTGGAAGCCGGCCACCCGCCAGGGCGGTCTGGCCGCGATCCTGCTTGGCCT
GGCCTCGTGGCTGACCTGCGAGATCGCCTTTGCCGATGCCACGGTGCCACCGCAAATGGTAGGGTTGCTGTTCTCGATCA
GCGGGATGGTATTCGGGTCGCTGCTGCCTCAATGGATCAGCGATCGGCCGCCCGTTCGTGAAGTGCATATTGCATAA

Upstream 100 bases:

>100_bases
AACCCTTGACCCGGTCAAGGGCGTCAGGTGCCCCGCCGGCATTCGGTTTTTCGCCGCCAGGGCACATCAATTCTGGCCAT
TCTGGGATAAGGGCAGCGGT

Downstream 100 bases:

>100_bases
CTTTATGCCTTCAAGGCCTTATCCGGGCTGCTTGTGGACGTTTGCGGCCCCGAATGTCCCCTTTTCCGGTCGGTAGCCGG
TCCGGCAACGGTTTATAATC

Product: putative Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MLIWFVIIYWIISVGIGLWAALRVKGTADFAVAGRSLPFYIVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIIGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPAMVEKYINSDSQLILPQLILTHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLADKQFLRVMQVVVLVFTSLVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLAAILLGLASWLTCEIAFADATVPPQMVGLLFSISGMVFGSLLPQWISDRPPVREVHIA

Sequences:

>Translated_478_residues
MLIWFVIIYWIISVGIGLWAALRVKGTADFAVAGRSLPFYIVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIIGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPAMVEKYINSDSQLILPQLILTHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLADKQFLRVMQVVVLVFTSLVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLAAILLGLASWLTCEIAFADATVPPQMVGLLFSISGMVFGSLLPQWISDRPPVREVHIA
>Mature_478_residues
MLIWFVIIYWIISVGIGLWAALRVKGTADFAVAGRSLPFYIVTATVFATWFGSETVLGIPAVFLKEGLSGVVSDPFGSSL
CLILVGLFFARPLYRMNLLTIGDYYHNRYGRLAEVLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGALSQDAGMMIGAAS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGYEVSGQAGGVTAVVSHAAAAGKFEFLPSLDLVQIIGFAAALFTMMLGS
IPQQDVFQRVTSSRTEQIAGRASVLGGVLYFFFAFIPMFLAYSATLIDPAMVEKYINSDSQLILPQLILTHAPMFAQVMF
FGALLSAIKSCASATLLAPSVTFAENILRPYFRHLADKQFLRVMQVVVLVFTSLVTLFALNSHLSIFHMVENAYKVTLVS
SFVPLAFGMFWKPATRQGGLAAILLGLASWLTCEIAFADATVPPQMVGLLFSISGMVFGSLLPQWISDRPPVREVHIA

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=404, Percent_Identity=29.7029702970297, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI14140236, Length=528, Percent_Identity=23.1060606060606, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4507035, Length=394, Percent_Identity=25.6345177664975, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI87082237, Length=436, Percent_Identity=23.8532110091743, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787251, Length=446, Percent_Identity=24.4394618834081, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=400, Percent_Identity=23.75, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648033, Length=439, Percent_Identity=25.9681093394077, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356865, Length=439, Percent_Identity=25.9681093394077, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51924; Mature: 51924

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]