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The map label for this gene is bioC [H]

Identifier: 94309204

GI number: 94309204

Start: 276652

End: 277554

Strand: Direct

Name: bioC [H]

Synonym: Rmet_0259

Alternate gene names: 94309204

Gene position: 276652-277554 (Clockwise)

Preceding gene: 94309201

Following gene: 94309205

Centisome position: 7.04

GC content: 66.45

Gene sequence:

>903_bases
TTGCCGCCCGCGCGCCTGACCCGGCTTGCCTTTGACCGCCGCAGTCCCAGCTTCGGCCAGCTCGATTTTCTGCTGGGCGA
AATCGGCCAGCGGATGCACGAGCGCATGGACGTGGTCAAGCTGACGCCGCGCCGGGCCATCGATATCGGCTGCGGCCACG
GGCAGGGCCTGGCGGGATTGCGCGCGCGCTTTCCCGATGCGCAGATTGCCGGTCTCGATATTTCCGGCGCTATGCTGCAG
CAAGCGGGACAGCGCGATCCGCAGCGGCGCCCCGGCTGGATCGGACGCCTGCTCGGCAAGCGGCCGATGTTCGACCTGGT
GCAGGGCGATCTTGCCACACTGCCATTCGGCGCGGCCAGCTTCGATCTGTTGTGGTCGAACCTCGCCTTGCACTGGCATC
CGGAGCCGCATCGCGTGTTTCCGGAATGGCATCGCGTGACCGGCGACGAAGGGCTCGTGATGTTCTCGCTGTTCGGCCCC
GACACGCTGAAGGAACTGCGCGCGGCGTTTGCCGATGTCGATCTCGACGCGCACACGATGCGCTTCGTCGACATGCACGA
TATCGGCGACATGCTCGTGCACAGCGGCTGGTCCACCCCGGTGATGGACATGGAAACGCTGACGGTCACCTACGAGTCGC
CAGAGAACCTGTTGCGCGAAGTGCAATCGTTCGGCGGCTTCCGTCGTCCGGGGGCGGTCGGGCTGCGTGGCAGGCGGTGG
TATCGGGCCGTGCTGGCCGCGCTCGAACGTCAACGTAACGCCGATGGCGTGATCCCATTGACGTTCGAAATTGTCTACGG
CCATGCATGGAAGCTGGCGCCGCGTGGCAGGCAGGCAACCGACGATCAGGGCCGCGCAGTTGTGCCGGTCGACAGCATCG
GACGCGCCAGGCCGCGACCGTGA

Upstream 100 bases:

>100_bases
CATGCCGAGGTGCGACACGCTGTTGCGCCGCCCGCCGATTCCACTGATTCCGTTCCGTCTCTCCGTGTCCCTGCATGCTG
CTGATTCCCCCGATGCCTGG

Downstream 100 bases:

>100_bases
AAGCGGCGTCGCGCATGGTTGCGCGACAATGCGCGCGCGCCGATTGTGTTGACTATCGGGGGCGATGCGGCCATGCACAA
AAACTAGATGAGCGCAAGCA

Product: putative methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPPARLTRLAFDRRSPSFGQLDFLLGEIGQRMHERMDVVKLTPRRAIDIGCGHGQGLAGLRARFPDAQIAGLDISGAMLQ
QAGQRDPQRRPGWIGRLLGKRPMFDLVQGDLATLPFGAASFDLLWSNLALHWHPEPHRVFPEWHRVTGDEGLVMFSLFGP
DTLKELRAAFADVDLDAHTMRFVDMHDIGDMLVHSGWSTPVMDMETLTVTYESPENLLREVQSFGGFRRPGAVGLRGRRW
YRAVLAALERQRNADGVIPLTFEIVYGHAWKLAPRGRQATDDQGRAVVPVDSIGRARPRP

Sequences:

>Translated_300_residues
MPPARLTRLAFDRRSPSFGQLDFLLGEIGQRMHERMDVVKLTPRRAIDIGCGHGQGLAGLRARFPDAQIAGLDISGAMLQ
QAGQRDPQRRPGWIGRLLGKRPMFDLVQGDLATLPFGAASFDLLWSNLALHWHPEPHRVFPEWHRVTGDEGLVMFSLFGP
DTLKELRAAFADVDLDAHTMRFVDMHDIGDMLVHSGWSTPVMDMETLTVTYESPENLLREVQSFGGFRRPGAVGLRGRRW
YRAVLAALERQRNADGVIPLTFEIVYGHAWKLAPRGRQATDDQGRAVVPVDSIGRARPRP
>Mature_299_residues
PPARLTRLAFDRRSPSFGQLDFLLGEIGQRMHERMDVVKLTPRRAIDIGCGHGQGLAGLRARFPDAQIAGLDISGAMLQQ
AGQRDPQRRPGWIGRLLGKRPMFDLVQGDLATLPFGAASFDLLWSNLALHWHPEPHRVFPEWHRVTGDEGLVMFSLFGPD
TLKELRAAFADVDLDAHTMRFVDMHDIGDMLVHSGWSTPVMDMETLTVTYESPENLLREVQSFGGFRRPGAVGLRGRRWY
RAVLAALERQRNADGVIPLTFEIVYGHAWKLAPRGRQATDDQGRAVVPVDSIGRARPRP

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=294, Percent_Identity=25.1700680272109, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI86792933, Length=294, Percent_Identity=23.1292517006803, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786994, Length=146, Percent_Identity=33.5616438356164, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535003, Length=304, Percent_Identity=27.9605263157895, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922210, Length=274, Percent_Identity=29.9270072992701, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 33612; Mature: 33481

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPARLTRLAFDRRSPSFGQLDFLLGEIGQRMHERMDVVKLTPRRAIDIGCGHGQGLAGL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCHH
RARFPDAQIAGLDISGAMLQQAGQRDPQRRPGWIGRLLGKRPMFDLVQGDLATLPFGAAS
HHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHCCCHHHCCCCCHH
FDLLWSNLALHWHPEPHRVFPEWHRVTGDEGLVMFSLFGPDTLKELRAAFADVDLDAHTM
HHHHHHCCEEEECCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHE
RFVDMHDIGDMLVHSGWSTPVMDMETLTVTYESPENLLREVQSFGGFRRPGAVGLRGRRW
EEEEHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHH
YRAVLAALERQRNADGVIPLTFEIVYGHAWKLAPRGRQATDDQGRAVVPVDSIGRARPRP
HHHHHHHHHHHCCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCCEEEEHHHCCCCCCCC
>Mature Secondary Structure 
PPARLTRLAFDRRSPSFGQLDFLLGEIGQRMHERMDVVKLTPRRAIDIGCGHGQGLAGL
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCHH
RARFPDAQIAGLDISGAMLQQAGQRDPQRRPGWIGRLLGKRPMFDLVQGDLATLPFGAAS
HHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHCCCHHHCCCCCHH
FDLLWSNLALHWHPEPHRVFPEWHRVTGDEGLVMFSLFGPDTLKELRAAFADVDLDAHTM
HHHHHHCCEEEECCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHE
RFVDMHDIGDMLVHSGWSTPVMDMETLTVTYESPENLLREVQSFGGFRRPGAVGLRGRRW
EEEEHHHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHH
YRAVLAALERQRNADGVIPLTFEIVYGHAWKLAPRGRQATDDQGRAVVPVDSIGRARPRP
HHHHHHHHHHHCCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCCEEEEHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]