Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 94309132

GI number: 94309132

Start: 193852

End: 195690

Strand: Direct

Name: glmS [H]

Synonym: Rmet_0187

Alternate gene names: 94309132

Gene position: 193852-195690 (Clockwise)

Preceding gene: 94309131

Following gene: 94309133

Centisome position: 4.94

GC content: 66.72

Gene sequence:

>1839_bases
ATGTGTGGCATCGTTGGGGCGGTCTCTCACCGCAATATCGTTCCTGTCCTGATCGAAGGCCTGCGCCGCCTTGAGTACCG
TGGCTACGATTCCTGCGGCGTGGCCGTGGTGCGTGACGGTATTCTCGAGCGCGCCCGTACCGTATCGCGCGTGGCCGAAC
TGGACGCGCAGACGCAATCGTCTGGCCTGGCCGGCCACATCGGCATCGCGCACACGCGCTGGGCGACGCACGGCAAGCCG
GACACCGTCAACGCCCACCCGCACTTCTCGGACGAGACCATCGCGCTCGTTCACAACGGCATCATCGAGAACTACGAGCC
GCTGCGCGACGAACTGCGCGCGGTCGGGTACGGTTTCGAATCGCAGACTGATACTGAAGTGGTGGCGCACCTGATCCACC
AGGCTTACACGTACCCGAGCAGCGCCACGCGAGGCGACCTGTTCGGCGCGGTGCGCGCGGTCACCAAGCGCCTGCATGGC
GCCTACGCGATCGCCGTGGTGGCCAAGGACCAGCCGGACGTGGTGGTCGGCGCGCGCGCCGGCTCGCCGCTGGTGGTGGC
ACTGGGCGAGGACGAATCGTTCCTGGCCTCTGACGCGCTGGCCGTGGCCGGCACCGCCAACCGCATCATCTATCTGGAAG
AGGGCGACGTGGTCGAGATCTCGCGCGGTGGCGCGCGGATTCGCGACGTGCACGATCACGAGGTCGAGCGCGAAGCGCGC
GTGGTGGAAGCCCACGCCGCCGCGGTGGAACTGGGCCCGTACCGGCACTTCATGCAGAAGGAAATCTTCGAGCAGCCGCG
CGCGCTGGGCGACACGCTGGAAGGCATCTCCGCGATCACGCCCGAGCTGTTCGGTGAGAACGCCGCGCAGGTGTTCTCGG
AAATCGACAGTGTGCTGATCCTGGCCTGCGGCACGAGCTACTACTCGGGCTGCACGGCCAAGTACTGGCTCGAATCGATC
GCGAAGATCCCGACCCAGGTGGAAGTGGCCAGCGAATACCGCTATCGCGACACCGTGCCGAACCCGCGCGCGCTGGTGGT
GGTGATTTCGCAGTCGGGCGAGACGGCCGACACGATGGCCGCGCTGCGTCATGCCCGCTCACTGGGCCACACGCACACGC
TGGCCGTCTGCAACGTGGCGACGAGCGCCATGGTGCGTGAGACCGAGCTGAGCTTCCTGACACGCGCCGGTACCGAGATC
GGCGTGGCGTCGACCAAGGCCTTCACGACACAACTGGCCGCGCTGTACATGCTGACGCTGGCGCTGGCCAAGGTGCGCGG
CTACCTGACCGATGCGCAGGAAGCCGAAGCCCTGACCAACCTCCGCCACCTGCCGGCCGCGCTGCATGGCGTGCTGGCGC
TGGAGCCGCAGATCATCGCGTGGTCGGAAGACTTCGCGCGCCGCGAGAACGCGCTGTTCCTGGGGCGCGGCCTGCATTAC
CCGATCGCCCTGGAAGGCGCGCTCAAGCTCAAGGAAATCTCGTACATCCACGCTGAAGCCTATCCGGCCGGCGAACTCAA
GCACGGCCCGCTGGCGCTCGTGACCGAGGCGATGCCGGTGGTGACCGTAGCGCCGAACGACGCGCTGCTGGAGAAGCTGA
AGTCGAACATCCAGGAAGTGCGCGCCCGCGGTGGCCGTCTCTATGTGTTCGCCGACTCGGATACGCATATCCAGTCGTCG
GATGGCATCCAGGTGATCCGGTTGCCGGAGCACTATGGTGCGCTGTCCCCGATCCTGCATGTGGTGCCGCTGCAACTGCT
GGCGTATCACACCGCCTGCGCACGCGGTACCGACGTCGACAAGCCGCGCAACCTGGCCAAGTCGGTGACGGTGGAGTAA

Upstream 100 bases:

>100_bases
CGCCGGCTGACAAGCTGACGTTGTCGCGCGCCAAGCAGATGACCCTGGATGCGTGGCAGCGTCCGGTCAAGCAACCGAAG
AAATAAGAGGGGTTCAAAAC

Downstream 100 bases:

>100_bases
GCGCGGCCGTCCTGCTGTTTCCTCTCCTCTTTATCCTCGCCTCGGTCGTGACGTTGGTTTGGACACGTCCGCCGTGGCGA
CGGAACTGTGACGGTCTGCT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGAVSHRNIVPVLIEGLRRLEYRGYDSCGVAVVRDGILERARTVSRVAELDAQTQSSGLAGHIGIAHTRWATHGKP
DTVNAHPHFSDETIALVHNGIIENYEPLRDELRAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGDLFGAVRAVTKRLHG
AYAIAVVAKDQPDVVVGARAGSPLVVALGEDESFLASDALAVAGTANRIIYLEEGDVVEISRGGARIRDVHDHEVEREAR
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGISAITPELFGENAAQVFSEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARSLGHTHTLAVCNVATSAMVRETELSFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGYLTDAQEAEALTNLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQSS
DGIQVIRLPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGAVSHRNIVPVLIEGLRRLEYRGYDSCGVAVVRDGILERARTVSRVAELDAQTQSSGLAGHIGIAHTRWATHGKP
DTVNAHPHFSDETIALVHNGIIENYEPLRDELRAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGDLFGAVRAVTKRLHG
AYAIAVVAKDQPDVVVGARAGSPLVVALGEDESFLASDALAVAGTANRIIYLEEGDVVEISRGGARIRDVHDHEVEREAR
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGISAITPELFGENAAQVFSEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARSLGHTHTLAVCNVATSAMVRETELSFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGYLTDAQEAEALTNLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQSS
DGIQVIRLPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_612_residues
MCGIVGAVSHRNIVPVLIEGLRRLEYRGYDSCGVAVVRDGILERARTVSRVAELDAQTQSSGLAGHIGIAHTRWATHGKP
DTVNAHPHFSDETIALVHNGIIENYEPLRDELRAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGDLFGAVRAVTKRLHG
AYAIAVVAKDQPDVVVGARAGSPLVVALGEDESFLASDALAVAGTANRIIYLEEGDVVEISRGGARIRDVHDHEVEREAR
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGISAITPELFGENAAQVFSEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARSLGHTHTLAVCNVATSAMVRETELSFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGYLTDAQEAEALTNLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQSS
DGIQVIRLPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=36.734693877551, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=36.4825581395349, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=54.0584415584416, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=38.2830626450116, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=37.3549883990719, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=37.3549883990719, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17554892, Length=258, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=455, Percent_Identity=37.1428571428571, Blast_Score=270, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=434, Percent_Identity=30.184331797235, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=38.1642512077295, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=176, Percent_Identity=29.5454545454545, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.3372093023256, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI28573187, Length=257, Percent_Identity=26.0700389105058, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66259; Mature: 66259

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSHRNIVPVLIEGLRRLEYRGYDSCGVAVVRDGILERARTVSRVAELDAQTQS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCC
SGLAGHIGIAHTRWATHGKPDTVNAHPHFSDETIALVHNGIIENYEPLRDELRAVGYGFE
CCCEEECCCEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSATRGDLFGAVRAVTKRLHGAYAIAVVAKDQPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECC
GSPLVVALGEDESFLASDALAVAGTANRIIYLEEGDVVEISRGGARIRDVHDHEVEREAR
CCCEEEEECCCCCHHHHCCEEEECCCCEEEEEECCCEEEEECCCCEECCCCHHHHHHHHH
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGISAITPELFGENAAQVFSEIDSVLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARSLGHTHTLAVCNVATSAMVRETELSFLTRAGTEIGVASTKAFTTQLAALYMLTL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ALAKVRGYLTDAQEAEALTNLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGLHY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHHHCCCCEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGRLYVFADSDTHIQSSDGIQVIRLPEHYGALSPILHVVPLQLLAYHTACARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSHRNIVPVLIEGLRRLEYRGYDSCGVAVVRDGILERARTVSRVAELDAQTQS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCC
SGLAGHIGIAHTRWATHGKPDTVNAHPHFSDETIALVHNGIIENYEPLRDELRAVGYGFE
CCCEEECCCEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSATRGDLFGAVRAVTKRLHGAYAIAVVAKDQPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECC
GSPLVVALGEDESFLASDALAVAGTANRIIYLEEGDVVEISRGGARIRDVHDHEVEREAR
CCCEEEEECCCCCHHHHCCEEEECCCCEEEEEECCCEEEEECCCCEECCCCHHHHHHHHH
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGISAITPELFGENAAQVFSEIDSVLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARSLGHTHTLAVCNVATSAMVRETELSFLTRAGTEIGVASTKAFTTQLAALYMLTL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ALAKVRGYLTDAQEAEALTNLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGLHY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHHHCCCCEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGRLYVFADSDTHIQSSDGIQVIRLPEHYGALSPILHVVPLQLLAYHTACARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]